<?xml version="1.0" encoding="UTF-8"?>

<ValueSet xmlns="http://hl7.org/fhir">
  <id value="imm-pat-pk-measurement-vs"/>
  <text>
    <status value="extensions"/><div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: ValueSet imm-pat-pk-measurement-vs</b></p><a name="imm-pat-pk-measurement-vs"> </a><a name="hcimm-pat-pk-measurement-vs"> </a><p>This value set includes codes based on the following rules:</p><ul><li>Include these codes as defined in <a href="http://loinc.org"><code>http://loinc.org</code></a><span title="Version is not explicitly stated. No matching Code System found"> version Not Stated (use latest from terminology server)</span><table class="none"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td></tr><tr><td><a href="https://loinc.org/77348-1/">77348-1</a></td><td>Tacrolimus [Mass/volume] in Blood --trough</td></tr><tr><td><a href="https://loinc.org/53828-0/">53828-0</a></td><td>cycloSPORINE [Mass/volume] in Blood --trough</td></tr><tr><td><a href="https://loinc.org/115766-8/">115766-8</a></td><td>Sirolimus --trough [Mass/volume] of Blood</td></tr><tr><td><a href="https://loinc.org/77349-9/">77349-9</a></td><td>Everolimus [Mass/volume] in Blood by LC/MS/MS --trough</td></tr><tr><td><a href="https://loinc.org/72667-9/">72667-9</a></td><td>Mycophenolate [Mass/volume] in Serum or Plasma --trough</td></tr><tr><td><a href="https://loinc.org/32997-9/">32997-9</a></td><td>cycloSPORINE [Mass/volume] in Blood --2 hours post dose</td></tr><tr><td><a href="https://loinc.org/92727-7/">92727-7</a></td><td>Tacrolimus [AUC] in Blood</td></tr><tr><td><a href="https://loinc.org/99413-7/">99413-7</a></td><td>cycloSPORINE [AUC] in Blood</td></tr><tr><td><a href="https://loinc.org/115789-0/">115789-0</a></td><td>Mycophenolate [AUC] of Blood</td></tr></table></li><li>Include these codes as defined in <a href="CodeSystem-imm-pat-pk-type-cs.html"><code>https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/imm-pat-pk-type-cs</code></a><span title="Version is not explicitly stated, which means it is fixed to the version provided in this specification"> version &#x1F4E6;0.1.0-ci-build</span><table class="none"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td><a href="CodeSystem-imm-pat-pk-type-cs.html#imm-pat-pk-type-cs-auc">auc</a></td><td style="color: #cccccc">Pharmacokinetic AUC</td><td>Area under the concentration-time curve (pharmacokinetic exposure).</td></tr></table></li></ul></div>
  </text>
  <url value="https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/ValueSet/imm-pat-pk-measurement-vs"/>
  <version value="0.1.0-ci-build"/>
  <name value="ImmPatPKMeasurementVS"/>
  <title value="Immunosuppressant PK Measurement ValueSet"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-09-28T06:51:47+00:00"/>
  <publisher value="Protect Child"/>
  <contact>
    <name value="Protect Child"/>
    <telecom>
      <system value="url"/>
      <value value="https://protect-child.eu/"/>
    </telecom>
  </contact>
  <description value="LOINC codes for immunosuppressant pharmacokinetic measurements — trough (C0), 2 h post-dose (C2) and AUC — one per drug. ImmPatPKTypeCS#auc is retained for sirolimus and everolimus, for which LOINC has no AUC code."/>
  <compose>
    <include>
      <system value="http://loinc.org"/>
      <concept>
        <code value="77348-1"/>
        <display value="Tacrolimus [Mass/volume] in Blood --trough"/>
      </concept>
      <concept>
        <code value="53828-0"/>
        <display value="cycloSPORINE [Mass/volume] in Blood --trough"/>
      </concept>
      <concept>
        <code value="115766-8"/>
        <display value="Sirolimus --trough [Mass/volume] of Blood"/>
      </concept>
      <concept>
        <code value="77349-9"/>
        <display value="Everolimus [Mass/volume] in Blood by LC/MS/MS --trough"/>
      </concept>
      <concept>
        <code value="72667-9"/>
        <display value="Mycophenolate [Mass/volume] in Serum or Plasma --trough"/>
      </concept>
      <concept>
        <code value="32997-9"/>
        <display value="cycloSPORINE [Mass/volume] in Blood --2 hours post dose"/>
      </concept>
      <concept>
        <code value="92727-7"/>
        <display value="Tacrolimus [AUC] in Blood"/>
      </concept>
      <concept>
        <code value="99413-7"/>
        <display value="cycloSPORINE [AUC] in Blood"/>
      </concept>
      <concept>
        <code value="115789-0"/>
        <display value="Mycophenolate [AUC] of Blood"/>
      </concept>
    </include>
    <include>
      <system value="https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/imm-pat-pk-type-cs"/>
      <concept>
        <code value="auc"/>
      </concept>
    </include>
  </compose>
</ValueSet>