PanCareSurPass Project HL7 FHIR Implementation Guide
1.0.0 - release 150

PanCareSurPass Project HL7 FHIR Implementation Guide, published by PanCareSurPass Project. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/pcsp/ and changes regularly. See the Directory of published versions

## Logical Model: FrontLineTreatment - XML Profile

Active as of 2026-01-16

XML representation of the FrontLineTreatment logical model.

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    <StructureDefinition xmlns="http://hl7.org/fhir">
      <id value="FrontLineTreatment"/>
      <text>
        <status value="extensions"/>
        <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: StructureDefinition FrontLineTreatment</b></p><table border="0" cellpadding="0" cellspacing="0" style="border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;"><tr style="border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top"><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="The logical name of the element">Name</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Information about the use of the element">Flags</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Minimum and Maximum # of times the element can appear in the instance">Card.</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px; width: 100px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Reference to the type of the element">Type</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Additional information about the element">Description &amp; Constraints</a><span style="float: right"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64, " alt="doco" style="background-color: inherit"/></a></span></th></tr><tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_element.gif" alt="." style="background-color: white; background-color: inherit" title="Element" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment" title="Front Line Treatment. The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment. If it does not cure the disease or it causes severe side effects, other treatment may be added or used instead. Also called induction therapy, primary therapy, and primary treatment.">FrontLineTreatment</a><a name="FrontLineTreatment"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="opacity: 0.5">0</span><span style="opacity: 0.5">..</span><span style="opacity: 0.5">*</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://build.fhir.org/types.html#Base">Base</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Front Line Treatment</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck11.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.followedProtocol" title="Followed Protocol">followedProtocol</a><a name="FrontLineTreatment.followedProtocol"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Followed Protocol<br/></td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.followedProtocol.type" title="2 =&gt; Trial/protocol
    2 =&gt; Personalized
    3 =&gt; Guidelines
    -9922 =&gt; NK">type</a><a name="FrontLineTreatment.followedProtocol.type"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Protocole type</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.followedProtocol.name" title="Protocole name">name</a><a name="FrontLineTreatment.followedProtocol.name"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Protocole name</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.followedProtocol.description" title="If a specific trial/protocol was used, please specify.
    In case of relapse/progression during front line treatment,please report both the name of the front line as well of the salvage treatment
    If personalized, please specify.  ">description</a><a name="FrontLineTreatment.followedProtocol.description"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Protocol name or description</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.followedProtocol.arm" title="If the trial was randomized, please define randomization arm">arm</a><a name="FrontLineTreatment.followedProtocol.arm"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Group/Arm/Randomization</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.dateEOT" title="It might be the date of first elective end of treatment, or that of the second (or further) end of treatment after the first one. If the date is unkown or partially missed insert the year at the best of your knowledge.">dateEOT</a><a name="FrontLineTreatment.dateEOT"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#dateTime">dateTime</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Date of end of treatment</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.isChemotherapy" title="Chemotherapy ?">isChemotherapy</a><a name="FrontLineTreatment.isChemotherapy"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Chemotherapy ?</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.isStemCellTransplantation" title="Stem Cell transplantation ?">isStemCellTransplantation</a><a name="FrontLineTreatment.isStemCellTransplantation"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Stem Cell transplantation ?</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.isRadiotherapy" title="Radiotherapy ?">isRadiotherapy</a><a name="FrontLineTreatment.isRadiotherapy"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Radiotherapy ?</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.isMajorSurgery" title="Major Surgery ?">isMajorSurgery</a><a name="FrontLineTreatment.isMajorSurgery"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Major Surgery ?</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck01.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse" title="Details not provided for relapses after EOT">notForRelapse</a><a name="FrontLineTreatment.notForRelapse"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Details not provided for relapses after EOT</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse.completeRemission" title="Complete remission">completeRemission</a><a name="FrontLineTreatment.notForRelapse.completeRemission"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Complete remission</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse.completeRemission.status" title="Complete remission (Yes/No)">status</a><a name="FrontLineTreatment.notForRelapse.completeRemission.status"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#dateTime">dateTime</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Complete remission (Yes/No)</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse.completeRemission.description" title="Textual description in case of no remission">description</a><a name="FrontLineTreatment.notForRelapse.completeRemission.description"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Textual description in case of no remission</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT" title="Progression/relapse during frontline treatment ?">isProgressionRelapseDuringFLT</a><a name="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Progression/relapse during frontline treatment ?</td></tr>
    <tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck000.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-FrontLineTreatment-definitions.html#FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT" title="Progression/relapse after first elective end of treatment ?">isProgressionRelapseAfterFLT</a><a name="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Progression/relapse after first elective end of treatment ?</td></tr>
    <tr><td colspan="5" class="hierarchy"><br/><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64, " alt="doco" style="background-color: inherit"/> Documentation for this format</a></td></tr></table></div>
      </text>
      <url
           value="http://hl7.eu/fhir/ig/pcsp/StructureDefinition/FrontLineTreatment"/>
      <version value="1.0.0"/>
      <name value="FrontLineTreatment"/>
      <title value="Front Line Treatment"/>
      <status value="active"/>
      <date value="2026-01-16T12:01:48+00:00"/>
      <publisher value="PanCareSurPass Project"/>
      <contact>
        <name value="PanCareSurPass Project"/>
        <telecom>
          <system value="url"/>
          <value value="https://www.pancaresurpass.eu/"/>
        </telecom>
      </contact>
      <contact>
        <name value="PanCareSurPass Project"/>
        <telecom>
          <system value="url"/>
          <value value="https://www.pancaresurpass.eu/"/>
        </telecom>
      </contact>
      <description
                   value="Front Line Treatment. The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment. If it does not cure the disease or it causes severe side effects, other treatment may be added or used instead. Also called induction therapy, primary therapy, and primary treatment."/>
      <jurisdiction>
        <coding>
          <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
          <code value="150"/>
          <display value="Europe"/>
        </coding>
      </jurisdiction>
      <fhirVersion value="4.0.1"/>
      <mapping>
        <identity value="fhir"/>
        <uri value="hl7.org/fhir/r4"/>
        <name value="FrontLineTreatment model to PCSP HL7 FHIR R4 Profiles"/>
      </mapping>
      <kind value="logical"/>
      <abstract value="false"/>
      <type
            value="http://hl7.eu/fhir/ig/pcsp/StructureDefinition/FrontLineTreatment"/>
      <baseDefinition value="http://hl7.org/fhir/StructureDefinition/Base"/>
      <derivation value="specialization"/>
      <snapshot>
        <extension
                   url="http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version">
          <valueString value="4.0.1"/>
        </extension>
        <element id="FrontLineTreatment">
          <path value="FrontLineTreatment"/>
          <short value="Front Line Treatment"/>
          <definition
                      value="Front Line Treatment. The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment. If it does not cure the disease or it causes severe side effects, other treatment may be added or used instead. Also called induction therapy, primary therapy, and primary treatment."/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="Base"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <isModifier value="false"/>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp')"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol">
          <path value="FrontLineTreatment.followedProtocol"/>
          <short value="Followed Protocol"/>
          <definition value="Followed Protocol"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="FrontLineTreatment.followedProtocol"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="BackboneElement"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <mapping>
            <identity value="fhir"/>
            <map value=".instantiatesCanonical"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="PlanDefinition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/PlanDefinition-flt-eu-pcsp')"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.id">
          <path value="FrontLineTreatment.followedProtocol.id"/>
          <representation value="xmlAttr"/>
          <short value="Unique id for inter-element referencing"/>
          <definition
                      value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="Element.id"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
              <valueUrl value="string"/>
            </extension>
            <code value="http://hl7.org/fhirpath/System.String"/>
          </type>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.extension">
          <path value="FrontLineTreatment.followedProtocol.extension"/>
          <slicing>
            <discriminator>
              <type value="value"/>
              <path value="url"/>
            </discriminator>
            <description value="Extensions are always sliced by (at least) url"/>
            <rules value="open"/>
          </slicing>
          <short value="Additional content defined by implementations"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="Element.extension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.modifierExtension">
          <path value="FrontLineTreatment.followedProtocol.modifierExtension"/>
          <short value="Extensions that cannot be ignored even if unrecognized"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <requirements
                        value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R4/extensibility.html#modifierExtension)."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <alias value="modifiers"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="BackboneElement.modifierExtension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="true"/>
          <isModifierReason
                            value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
          <isSummary value="true"/>
          <mapping>
            <identity value="rim"/>
            <map value="N/A"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.type">
          <path value="FrontLineTreatment.followedProtocol.type"/>
          <short value="Protocole type"/>
          <definition
                      value="2 =&gt; Trial/protocol
    2 =&gt; Personalized
    3 =&gt; Guidelines
    -9922 =&gt; NK"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.followedProtocol.type"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".type"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.name">
          <path value="FrontLineTreatment.followedProtocol.name"/>
          <short value="Protocole name"/>
          <definition value="Protocole name"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.followedProtocol.name"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".title"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.description">
          <path value="FrontLineTreatment.followedProtocol.description"/>
          <short value="Protocol name or description"/>
          <definition
                      value="If a specific trial/protocol was used, please specify.
    In case of relapse/progression during front line treatment,please report both the name of the front line as well of the salvage treatment
    If personalized, please specify."/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.followedProtocol.description"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".description"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.arm">
          <path value="FrontLineTreatment.followedProtocol.arm"/>
          <short value="Group/Arm/Randomization"/>
          <definition
                      value="If the trial was randomized, please define randomization arm"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.followedProtocol.arm"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value=".extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/procedure-fltArm').valueString"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.dateEOT">
          <path value="FrontLineTreatment.dateEOT"/>
          <short value="Date of end of treatment"/>
          <definition
                      value="It might be the date of first elective end of treatment, or that of the second (or further) end of treatment after the first one. If the date is unkown or partially missed insert the year at the best of your knowledge."/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.dateEOT"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="dateTime"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="Procedure.performedPeriod.end"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isChemotherapy">
          <path value="FrontLineTreatment.isChemotherapy"/>
          <short value="Chemotherapy ?"/>
          <definition value="Chemotherapy ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.isChemotherapy"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="MedicationAdministration.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/MedicationAdministration-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isStemCellTransplantation">
          <path value="FrontLineTreatment.isStemCellTransplantation"/>
          <short value="Stem Cell transplantation ?"/>
          <definition value="Stem Cell transplantation ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.isStemCellTransplantation"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-sct-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isRadiotherapy">
          <path value="FrontLineTreatment.isRadiotherapy"/>
          <short value="Radiotherapy ?"/>
          <definition value="Radiotherapy ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.isRadiotherapy"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-radiotheraphy-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isMajorSurgery">
          <path value="FrontLineTreatment.isMajorSurgery"/>
          <short value="Major Surgery ?"/>
          <definition value="Major Surgery ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.isMajorSurgery"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').exists().not() [No Case, implicit]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp')..where(code = 'no-known-procedures').exists() [No Case, explicit]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').where(code != 'no-known-procedures' or code != 'no-procedure-info').exists() [Yes Case]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').where(code = 'no-procedure-info').exists() [Unk case]"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse">
          <path value="FrontLineTreatment.notForRelapse"/>
          <short value="Details not provided for relapses after EOT"/>
          <definition value="Details not provided for relapses after EOT"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.notForRelapse"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="BackboneElement"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
        </element>
        <element id="FrontLineTreatment.notForRelapse.id">
          <path value="FrontLineTreatment.notForRelapse.id"/>
          <representation value="xmlAttr"/>
          <short value="Unique id for inter-element referencing"/>
          <definition
                      value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="Element.id"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
              <valueUrl value="string"/>
            </extension>
            <code value="http://hl7.org/fhirpath/System.String"/>
          </type>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.extension">
          <path value="FrontLineTreatment.notForRelapse.extension"/>
          <slicing>
            <discriminator>
              <type value="value"/>
              <path value="url"/>
            </discriminator>
            <description value="Extensions are always sliced by (at least) url"/>
            <rules value="open"/>
          </slicing>
          <short value="Additional content defined by implementations"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="Element.extension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.modifierExtension">
          <path value="FrontLineTreatment.notForRelapse.modifierExtension"/>
          <short value="Extensions that cannot be ignored even if unrecognized"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <requirements
                        value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R4/extensibility.html#modifierExtension)."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <alias value="modifiers"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="BackboneElement.modifierExtension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="true"/>
          <isModifierReason
                            value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
          <isSummary value="true"/>
          <mapping>
            <identity value="rim"/>
            <map value="N/A"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.completeRemission">
          <path value="FrontLineTreatment.notForRelapse.completeRemission"/>
          <short value="Complete remission"/>
          <definition value="Complete remission"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="FrontLineTreatment.notForRelapse.completeRemission"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="BackboneElement"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.completeRemission.id">
          <path value="FrontLineTreatment.notForRelapse.completeRemission.id"/>
          <representation value="xmlAttr"/>
          <short value="Unique id for inter-element referencing"/>
          <definition
                      value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path value="Element.id"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
              <valueUrl value="string"/>
            </extension>
            <code value="http://hl7.org/fhirpath/System.String"/>
          </type>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.completeRemission.extension">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.extension"/>
          <slicing>
            <discriminator>
              <type value="value"/>
              <path value="url"/>
            </discriminator>
            <description value="Extensions are always sliced by (at least) url"/>
            <rules value="open"/>
          </slicing>
          <short value="Additional content defined by implementations"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="Element.extension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="false"/>
          <isSummary value="false"/>
          <mapping>
            <identity value="rim"/>
            <map value="n/a"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.completeRemission.modifierExtension">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.modifierExtension"/>
          <short value="Extensions that cannot be ignored even if unrecognized"/>
          <definition
                      value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
          <comment
                   value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
          <requirements
                        value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R4/extensibility.html#modifierExtension)."/>
          <alias value="extensions"/>
          <alias value="user content"/>
          <alias value="modifiers"/>
          <min value="0"/>
          <max value="*"/>
          <base>
            <path value="BackboneElement.modifierExtension"/>
            <min value="0"/>
            <max value="*"/>
          </base>
          <type>
            <code value="Extension"/>
          </type>
          <constraint>
            <key value="ele-1"/>
            <severity value="error"/>
            <human value="All FHIR elements must have a @value or children"/>
            <expression
                        value="hasValue() or (children().count() &gt; id.count())"/>
            <xpath value="@value|f:*|h:div"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
          </constraint>
          <constraint>
            <key value="ext-1"/>
            <severity value="error"/>
            <human value="Must have either extensions or value[x], not both"/>
            <expression value="extension.exists() != value.exists()"/>
            <xpath
                   value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
            <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
          </constraint>
          <isModifier value="true"/>
          <isModifierReason
                            value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
          <isSummary value="true"/>
          <mapping>
            <identity value="rim"/>
            <map value="N/A"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.completeRemission.status">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.status"/>
          <short value="Complete remission (Yes/No)"/>
          <definition value="Complete remission (Yes/No)"/>
          <min value="1"/>
          <max value="1"/>
          <base>
            <path
                  value="FrontLineTreatment.notForRelapse.completeRemission.status"/>
            <min value="1"/>
            <max value="1"/>
          </base>
          <type>
            <code value="dateTime"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome.coding"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.completeRemission.description">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.description"/>
          <short value="Textual description in case of no remission"/>
          <definition value="Textual description in case of no remission"/>
          <min value="1"/>
          <max value="1"/>
          <base>
            <path
                  value="FrontLineTreatment.notForRelapse.completeRemission.description"/>
            <min value="1"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome.text"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT">
          <path
                value="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT"/>
          <short value="Progression/relapse during frontline treatment ?"/>
          <definition value="Progression/relapse during frontline treatment ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path
                  value="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Condition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Condition-primaryCancer-eu-pcsp').where( (extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/condition-previousStatus').valueCode = #replaspe or #recurrence) and  ( onsetDateTime &lt; Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp').performedPeriod.end) ).exists()"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT">
          <path
                value="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT"/>
          <short
                 value="Progression/relapse after first elective end of treatment ?"/>
          <definition
                      value="Progression/relapse after first elective end of treatment ?"/>
          <min value="0"/>
          <max value="1"/>
          <base>
            <path
                  value="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT"/>
            <min value="0"/>
            <max value="1"/>
          </base>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Condition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Condition-primaryCancer-eu-pcsp').where( (extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/condition-previousStatus').valueCode = #replaspe or #recurrence) and  ( onsetDateTime &gt;= Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp').performedPeriod.end) ).exists()"/>
          </mapping>
        </element>
      </snapshot>
      <differential>
        <element id="FrontLineTreatment">
          <path value="FrontLineTreatment"/>
          <short value="Front Line Treatment"/>
          <definition
                      value="Front Line Treatment. The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment. If it does not cure the disease or it causes severe side effects, other treatment may be added or used instead. Also called induction therapy, primary therapy, and primary treatment."/>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp')"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol">
          <path value="FrontLineTreatment.followedProtocol"/>
          <short value="Followed Protocol"/>
          <definition value="Followed Protocol"/>
          <min value="0"/>
          <max value="*"/>
          <type>
            <code value="BackboneElement"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".instantiatesCanonical"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="PlanDefinition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/PlanDefinition-flt-eu-pcsp')"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.type">
          <path value="FrontLineTreatment.followedProtocol.type"/>
          <short value="Protocole type"/>
          <definition
                      value="2 =&gt; Trial/protocol
    2 =&gt; Personalized
    3 =&gt; Guidelines
    -9922 =&gt; NK"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".type"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.name">
          <path value="FrontLineTreatment.followedProtocol.name"/>
          <short value="Protocole name"/>
          <definition value="Protocole name"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".title"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.description">
          <path value="FrontLineTreatment.followedProtocol.description"/>
          <short value="Protocol name or description"/>
          <definition
                      value="If a specific trial/protocol was used, please specify.
    In case of relapse/progression during front line treatment,please report both the name of the front line as well of the salvage treatment
    If personalized, please specify.  "/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value=".description"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.followedProtocol.arm">
          <path value="FrontLineTreatment.followedProtocol.arm"/>
          <short value="Group/Arm/Randomization"/>
          <definition
                      value="If the trial was randomized, please define randomization arm"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="string"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value=".extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/procedure-fltArm').valueString"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.dateEOT">
          <path value="FrontLineTreatment.dateEOT"/>
          <short value="Date of end of treatment"/>
          <definition
                      value="It might be the date of first elective end of treatment, or that of the second (or further) end of treatment after the first one. If the date is unkown or partially missed insert the year at the best of your knowledge."/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="dateTime"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="Procedure.performedPeriod.end"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isChemotherapy">
          <path value="FrontLineTreatment.isChemotherapy"/>
          <short value="Chemotherapy ?"/>
          <definition value="Chemotherapy ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="MedicationAdministration.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/MedicationAdministration-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isStemCellTransplantation">
          <path value="FrontLineTreatment.isStemCellTransplantation"/>
          <short value="Stem Cell transplantation ?"/>
          <definition value="Stem Cell transplantation ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-sct-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isRadiotherapy">
          <path value="FrontLineTreatment.isRadiotherapy"/>
          <short value="Radiotherapy ?"/>
          <definition value="Radiotherapy ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-radiotheraphy-eu-pcsp').exists()"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.isMajorSurgery">
          <path value="FrontLineTreatment.isMajorSurgery"/>
          <short value="Major Surgery ?"/>
          <definition value="Major Surgery ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').exists().not() [No Case, implicit]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp')..where(code = 'no-known-procedures').exists() [No Case, explicit]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').where(code != 'no-known-procedures' or code != 'no-procedure-info').exists() [Yes Case]"/>
          </mapping>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-surgery-eu-pcsp').where(code = 'no-procedure-info').exists() [Unk case]"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse">
          <path value="FrontLineTreatment.notForRelapse"/>
          <short value="Details not provided for relapses after EOT"/>
          <definition value="Details not provided for relapses after EOT"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="BackboneElement"/>
          </type>
        </element>
        <element id="FrontLineTreatment.notForRelapse.completeRemission">
          <path value="FrontLineTreatment.notForRelapse.completeRemission"/>
          <short value="Complete remission"/>
          <definition value="Complete remission"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="BackboneElement"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome"/>
          </mapping>
        </element>
        <element id="FrontLineTreatment.notForRelapse.completeRemission.status">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.status"/>
          <short value="Complete remission (Yes/No)"/>
          <definition value="Complete remission (Yes/No)"/>
          <min value="1"/>
          <max value="1"/>
          <type>
            <code value="dateTime"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome.coding"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.completeRemission.description">
          <path
                value="FrontLineTreatment.notForRelapse.completeRemission.description"/>
          <short value="Textual description in case of no remission"/>
          <definition value="Textual description in case of no remission"/>
          <min value="1"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map value="outcome.text"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT">
          <path
                value="FrontLineTreatment.notForRelapse.isProgressionRelapseDuringFLT"/>
          <short value="Progression/relapse during frontline treatment ?"/>
          <definition value="Progression/relapse during frontline treatment ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Condition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Condition-primaryCancer-eu-pcsp').where( (extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/condition-previousStatus').valueCode = #replaspe or #recurrence) and  ( onsetDateTime &lt; Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp').performedPeriod.end) ).exists()"/>
          </mapping>
        </element>
        <element
                 id="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT">
          <path
                value="FrontLineTreatment.notForRelapse.isProgressionRelapseAfterFLT"/>
          <short
                 value="Progression/relapse after first elective end of treatment ?"/>
          <definition
                      value="Progression/relapse after first elective end of treatment ?"/>
          <min value="0"/>
          <max value="1"/>
          <type>
            <code value="CodeableConcept"/>
          </type>
          <mapping>
            <identity value="fhir"/>
            <map
                 value="Condition.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Condition-primaryCancer-eu-pcsp').where( (extension('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/condition-previousStatus').valueCode = #replaspe or #recurrence) and  ( onsetDateTime &gt;= Procedure.conformsTo('http://hl7.eu/fhir/ig/pcsp/StructureDefinition/Procedure-flt-eu-pcsp').performedPeriod.end) ).exists()"/>
          </mapping>
        </element>
      </differential>
    </StructureDefinition>