# Additive/Preservative (2.8 - 2.0.0) - HL7 v2.8 Vocabulary v0.1.0

* [**Table of Contents**](toc.md)
* [**Artifacts Summary**](artifacts.md)
* **Additive/Preservative (2.8 - 2.0.0)**

## CodeSystem: Additive/Preservative (2.8 - 2.0.0) (Experimental) 

| | |
| :--- | :--- |
| *Official URL*:http://terminology.hl7.org/v2plusvocab/CodeSystem/additivePreservative | *Version*:2.0.0 |
| Active as of 2026-01-27 | *Computable Name*:AdditivePreservative |
| *Other Identifiers:*OID:2.16.840.1.113883.18.229 | |
| **Copyright/Legal**: HL7 Inc., 2026 | |

 
HL7-defined code system of concepts specifying any additive introduced to the specimen before or at the time of collection. These additives may be introduced in order to preserve, maintain or enhance the particular nature or component of the specimen. Used in HL7 Version 2.x messaging in the SPM and SAC segments. 

 This Code system is referenced in the content logical definition of the following value sets: 

* [Hl7VSadditivePreservative](ValueSet-hl7VSadditivePreservative.md)



## Resource Content

```json
{
  "resourceType" : "CodeSystem",
  "id" : "additivePreservative",
  "extension" : [
    {
      "url" : "http://terminology.hl7.org/v2plusvocab/StructureDefinition/codesystem-v2versionCreated",
      "valueString" : "2.8"
    },
    {
      "url" : "http://terminology.hl7.org/v2plusvocab/StructureDefinition/codesystem-versionHistory",
      "valueString" : "generate correct history somehow"
    },
    {
      "url" : "http://terminology.hl7.org/v2plusvocab/StructureDefinition/codesystem-tableNo",
      "valueString" : "0371"
    }
  ],
  "url" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/additivePreservative",
  "identifier" : [
    {
      "system" : "urn:ietf:rfc:3986",
      "value" : "urn:oid:2.16.840.1.113883.18.229"
    }
  ],
  "version" : "2.0.0",
  "name" : "AdditivePreservative",
  "title" : "Additive/Preservative (2.8 - 2.0.0)",
  "status" : "active",
  "experimental" : true,
  "date" : "2026-01-27T19:37:03+00:00",
  "publisher" : "HL7/FO",
  "contact" : [
    {
      "name" : "HL7/FO",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org"
        }
      ]
    }
  ],
  "description" : "HL7-defined code system of concepts specifying any additive introduced to the specimen before or at the time of collection.  These additives may be introduced in order to preserve, maintain or enhance the particular nature or component of the specimen.  Used in HL7 Version 2.x messaging in the SPM and SAC segments.",
  "copyright" : "HL7 Inc., 2026",
  "caseSensitive" : true,
  "compositional" : false,
  "content" : "complete",
  "property" : [
    {
      "code" : "versionIntroduced",
      "uri" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/Property#versionIntroduced",
      "description" : "version when was this code introduced",
      "type" : "string"
    },
    {
      "code" : "versionDeprecated",
      "uri" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/Property#versionDeprecated",
      "description" : "version when was this code deprecated",
      "type" : "string"
    },
    {
      "code" : "status",
      "uri" : "http://hl7.org/fhir/concept-properties#status",
      "description" : "A code that indicates the status of the concept. Typical values are active, experimental, deprecated, and retired",
      "type" : "code"
    },
    {
      "code" : "comment",
      "uri" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/Property#comment",
      "description" : "A string that provides additional detail pertinent to the use or understanding of the concept",
      "type" : "string"
    },
    {
      "code" : "usage",
      "uri" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/Property#usage",
      "description" : "usage notes for this code",
      "type" : "string"
    },
    {
      "code" : "modified",
      "uri" : "http://terminology.hl7.org/v2plusvocab/CodeSystem/Property#modified",
      "description" : "date of last modification",
      "type" : "dateTime"
    }
  ],
  "concept" : [
    {
      "code" : "ACDA",
      "display" : "ACD Solution A",
      "definition" : "ACD Solution A",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Yellow top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "ACDB",
      "display" : "ACD Solution B",
      "definition" : "ACD Solution B",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Yellow top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "ACET",
      "display" : "Acetic Acid",
      "definition" : "Acetic Acid",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Urine preservative"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "AMIES",
      "display" : "Amies transport medium",
      "definition" : "Amies transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Protozoa"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "BACTM",
      "display" : "Bacterial Transport medium",
      "definition" : "Bacterial Transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Microbiological culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "BF10",
      "display" : "Buffered 10% formalin",
      "definition" : "Buffered 10% formalin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Tissue"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "BOR",
      "display" : "Borate Boric Acid",
      "definition" : "Borate Boric Acid",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "24HR Urine Additive"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "BOUIN",
      "display" : "Bouin's solution",
      "definition" : "Bouin's solution",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Tissue"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "BSKM",
      "display" : "Buffered skim milk",
      "definition" : "Buffered skim milk",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Viral isolation"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "C32",
      "display" : "3.2%  Citrate",
      "definition" : "3.2%  Citrate",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Blue top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "C38",
      "display" : "3.8% Citrate",
      "definition" : "3.8% Citrate",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Blue top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "CARS",
      "display" : "Carson's Modified 10% formalin",
      "definition" : "Carson's Modified 10% formalin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Tissue"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "CARY",
      "display" : "Cary Blair Medium",
      "definition" : "Cary Blair Medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Stool Cultures"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "CHLTM",
      "display" : "Chlamydia transport medium",
      "definition" : "Chlamydia transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Chlamydia culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "CTAD",
      "display" : "CTAD (this should be spelled out if not universally understood)",
      "definition" : "CTAD (this should be spelled out if not universally understood)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Blue top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "EDTK",
      "display" : "Potassium/K EDTA",
      "definition" : "Potassium/K EDTA",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Deprecated. Replaced by EDTK15 and EDTK75"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "EDTK15",
      "display" : "Potassium/K EDTA 15%",
      "definition" : "Potassium/K EDTA 15%",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Purple top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "EDTK75",
      "display" : "Potassium/K EDTA 7.5%",
      "definition" : "Potassium/K EDTA 7.5%",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Purple top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "EDTN",
      "display" : "Sodium/Na EDTA",
      "definition" : "Sodium/Na EDTA",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Dark Blue top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "ENT",
      "display" : "Enteric bacteria transport medium",
      "definition" : "Enteric bacteria transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Bacterial culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "ENT+",
      "display" : "Enteric plus",
      "definition" : "Enteric plus",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Stool Cultures"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "F10",
      "display" : "10% Formalin",
      "definition" : "10% Formalin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Tissue preservative"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "FDP",
      "display" : "Thrombin NIH; soybean trypsin inhibitor (Fibrin Degradation Products)",
      "definition" : "Thrombin NIH; soybean trypsin inhibitor (Fibrin Degradation Products)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Dark Blue top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "FL10",
      "display" : "Sodium Fluoride, 10mg",
      "definition" : "Sodium Fluoride, 10mg",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Urine"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "FL100",
      "display" : "Sodium Fluoride, 100mg",
      "definition" : "Sodium Fluoride, 100mg",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Urine"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "HCL6",
      "display" : "6N HCL",
      "definition" : "6N HCL",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "24 HR Urine Additive"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "HEPA",
      "display" : "Ammonium heparin",
      "definition" : "Ammonium heparin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Green top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "HEPL",
      "display" : "Lithium/Li  Heparin",
      "definition" : "Lithium/Li  Heparin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Green top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "HEPN",
      "display" : "Sodium/Na  Heparin",
      "definition" : "Sodium/Na  Heparin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Green top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.4"
        }
      ]
    },
    {
      "code" : "HNO3",
      "display" : "Nitric Acid",
      "definition" : "Nitric Acid",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Urine"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "JKM",
      "display" : "Jones Kendrick Medium",
      "definition" : "Jones Kendrick Medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Bordetella pertussis"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "KARN",
      "display" : "Karnovsky's fixative",
      "definition" : "Karnovsky's fixative",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Tissue"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "KOX",
      "display" : "Potassium Oxalate",
      "definition" : "Potassium Oxalate",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Gray top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "LIA",
      "display" : "Lithium iodoacetate",
      "definition" : "Lithium iodoacetate",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Gray top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "M4",
      "display" : "M4",
      "definition" : "M4",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Microbiological culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "M4RT",
      "display" : "M4-RT",
      "definition" : "M4-RT",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Microbiological culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "M5",
      "display" : "M5",
      "definition" : "M5",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Microbiological culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "MICHTM",
      "display" : "Michel's transport medium",
      "definition" : "Michel's transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "IF tests"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "MMDTM",
      "display" : "MMD transport medium",
      "definition" : "MMD transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Immunofluorescence"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "NAF",
      "display" : "Sodium Fluoride",
      "definition" : "Sodium Fluoride",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Gray top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "NAPS",
      "display" : "Sodium polyanethol sulfonate 0.35% in 0.85% sodium chloride",
      "definition" : "Sodium polyanethol sulfonate 0.35% in 0.85% sodium chloride",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Yellow (Blood Culture)"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "NONE",
      "display" : "None",
      "definition" : "None",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Red or Pink top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "PAGE",
      "display" : "Pages's Saline",
      "definition" : "Pages's Saline",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Acanthaoemba"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "PHENOL",
      "display" : "Phenol",
      "definition" : "Phenol",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "24 Hr Urine Additive"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "PVA",
      "display" : "PVA (polyvinylalcohol)",
      "definition" : "PVA (polyvinylalcohol)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "O&P"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "RLM",
      "display" : "Reagan Lowe Medium",
      "definition" : "Reagan Lowe Medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Bordetella pertussis cultures"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "SILICA",
      "display" : "Siliceous earth, 12 mg",
      "definition" : "Siliceous earth, 12 mg",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Gray top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "SPS",
      "display" : "SPS(this should be spelled out if not universally understood)",
      "definition" : "SPS(this should be spelled out if not universally understood)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Anticoagulant w/o bacteriocidal properties"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "SST",
      "display" : "Serum Separator Tube (Polymer Gel)",
      "definition" : "Serum Separator Tube (Polymer Gel)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "'Tiger' Top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "STUTM",
      "display" : "Stuart transport medium",
      "definition" : "Stuart transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Bacterial culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "THROM",
      "display" : "Thrombin",
      "definition" : "Thrombin",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Orange or Grey/Yellow (STAT Chem)"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "THYMOL",
      "display" : "Thymol",
      "definition" : "Thymol",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "24 Hr Urine Additive"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "THYO",
      "display" : "Thyoglycollate broth",
      "definition" : "Thyoglycollate broth",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Bacterial Isolation"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "TOLU",
      "display" : "Toluene",
      "definition" : "Toluene",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "24 Hr Urine Additive"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "URETM",
      "display" : "Ureaplasma transport medium",
      "definition" : "Ureaplasma transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Ureaplasma culture"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "VIRTM",
      "display" : "Viral Transport medium",
      "definition" : "Viral Transport medium",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Virus cultures"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    },
    {
      "code" : "WEST",
      "display" : "Buffered Citrate (Westergren Sedimentation Rate)",
      "definition" : "Buffered Citrate (Westergren Sedimentation Rate)",
      "property" : [
        {
          "code" : "usage",
          "valueString" : "Black top tube"
        },
        {
          "code" : "versionIntroduced",
          "valueString" : "2.5"
        }
      ]
    }
  ]
}

```
