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Order for opioid analgesic with ambulatory misuse potential	Yes	Order for opioid analgesics with ambulatory misuse potential	Opioid analgesics with ambulatory misuse potential	MedicationRequest	MedicationRequest.medication, and MedicationRequest.category
No evidence of current naloxone medications?	Yes	Find evidence of naloxone medication prescription (an active medication order for naloxone)	Naloxone medications	MedicationRequest	MedicationRequest.medication, and MedicationRequest.authoredOn
Currently receiving benzodiazepine or other central nervous system depressant medications?	Yes	Find evidence of benzodiazepine prescription (an active medication order for benzodiazepine or other central nervous system depressant medications)	Benzodiazepine or other central nervous system depressant medications	MedicationRequest	MedicationRequest.medication, MedicationRequest.category, and MedicationRequest.authoredOn
MME (morphine milligram equivalents > 50)	Yes	Determine MME from existing active prescriptions (recommendation 4 & 5), or future scope; dispensed medications, or patient-reported medications		MedicationRequest	MedicationRequest.medication, MedicationRequest.category, MedicationRequest.authoredOn, and MedicationRequest.dosageInstruction
History of conditions documenting substance use disorder?	Yes	Find evidence of conditions documenting substance use in the problem list or past medical history, including history of overdose	Conditions documenting substance misuse disorder	Condition Procedure	Condition.code, Condition.category, and Procedure.code
Diagnosis with a sleep-disordered breathing condition?	Yes	Find documentation of an active sleep-disordered breathing condition	Conditions documenting sleep-disordered breathing	TBD	TBD