Miscellaneous ePI Test
0.1.0 - CI Build

Miscellaneous ePI Test, published by . This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/cander2/epi-test/ and changes regularly. See the Directory of published versions

Example Bundle: TSZ 0818 Bundle UK EN - PIL Talzenna

Composition category:
Composition status: final


Narrative Text


What is in this leaflet

  1. What Talzenna is and what it is used for
  2. What you need to know before you take Talzenna
  3. How to take Talzenna
  4. Possible side effects
  5. How to store Talzenna
  6. Contents of the pack and other information

1. What Talzenna is and what it is used for

What Talzenna is and how it works

Talzenna contains the active substance talazoparib. It is a type of anticancer medicine known as a ‘PARP (poly-ADP ribose polymerase) inhibitor’.

Patients with changes (mutations) in genes called BRCA are at risk of developing some forms of cancer. Talzenna works by blocking PARP, which is an enzyme that repairs damaged DNA in certain cancer cells. As a result, the cancer cells can no longer repair themselves and they die.

What Talzenna is used for

Talzenna is used to treat adults with breast cancer of a type known as HER2-negative breast cancer who have an abnormal inherited BRCA gene.

Talzenna is used when the cancer has spread beyond the original tumour or to other parts of the body.

Your healthcare provider will perform a test to make sure that Talzenna is right for you.

If you have any questions about how Talzenna works or why this medicine has been prescribed for you, ask your doctor.

2. What you need to know before you take Talzenna

Do not take Talzenna

  • If you are allergic to talazoparib or any of the other ingredients of this medicine (listed in section 6)
  • f you are breast-feeding.

Warnings and precautions

Talk to your doctor, pharmacist or nurse before taking Talzenna and during your treatment if you experience signs or symptoms described in this section.

Low blood cell counts

Talzenna lowers your blood cell counts, such as your red blood cell count (anaemia), white blood cell count (neutropenia), or blood platelet count (thrombocytopenia). Signs and symptoms you need to look out for include:

  • Anaemia: Being short of breath, feeling very tired, pale skin, or fast heartbeat – these may be signs of a low red blood cell count
  • Neutropenia: Infection, developing chills or shivering, or fever – these may be signs of a low white blood cell count
  • Thrombocytopenia: Bruising or bleeding for longer than usual if you hurt yourself – these may be signs of a low blood platelet count

Talzenna lowers your blood cell counts, such as your red blood cell count (anaemia), white blood cell count (neutropenia), or blood platelet count (thrombocytopenia). Signs and symptoms you need to look out for include:

Product Information

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Clinical Information