@startuml mappingResearchStudy

map "ContactDetail" as Contact #back:AliceBlue;header:LightSkyBlue;line:blue {
    Nom => name :  string [0..1] 
    Télécommunication => telecom :  ContactPoint [0..*]  
    Type => <&plus> ECLAIREContacType :  CodeableConcept [0..1] \n ("Public"/"Scientific")
    Adresse => <&plus> ECLAIREContactAddress : Address [0..1]
    Affiliation => <&plus> ECLAIREContactAffiliation : string [0..1]
    Nom => <&plus> ECLAIREContactName : HumanName [0..1]
}

map "HumanName" as slice_name #back:AliceBlue;header:LightSkyBlue;line:blue {
    Nom de famille (Last name) => family : string [0..1]
    Prénom (First name) \n Deuxième prénom (Middle name) => given : string [0..*]
}

map "<&layers> Slice identifier" as slice_identifier #back:AliceBlue;header:LightSkyBlue;line:blue {
    Identifiant principal => idPrimary [0..1]
    Identifiant secondaire => idSecondary [0..*]
}

map "<&layers> Slice condition" as slice_condition #back:AliceBlue;header:LightSkyBlue;line:blue {
    Code MedDRA => medDRACondition [0..*]
    Pathologie => diseaseCondition [0..*]
}

map "<&plus> ECLAIRELabel" as label #back:AliceBlue;header:LightSkyBlue;line:blue {
    Type => labelType : CodeableConcept [0..1]
    Valeur => labelValue : string [0..1]
}

map "Group" as Group #back:TECHNOLOGY;header:LightGreen {
    Identifiant* => identifier : Identifier [0..*] 
    Type de groupe* => type : code [1..1] = "Person" 
    Groupe actif* => actual : boolean [1..1] = "True"
    Effectif à recruter => quantity : unsignedInt [0..1] 
    Critères \n Age \n Genre \n Groupe de sujet => \n characteristic : BackboneElement [0..*] 
}

map "Characteristic" as Characteristic #back:TECHNOLOGY;header:LightGreen {
    Type  => code : CodeableConcept [1..1] 
    Valeur => value[x] : [1..1] 
    Exclusion => exclude : boolean [1..1] 
}

map "Organization" as Organization #back:BUSINESS;header:Gold {
    Identifiant* => identifier : Identifier [0..*] 
    Nom => name : string [0..1] 
    Adresse => address : Address [0..*] 
    Contact => contact : BackboneElement [0..*] 
}

map "Location" as Location #back:MistyRose;header:Violet {
    Identifiant* => identifier : Identifier [0..*] 
    Nom => name : string [0..1] 
    Adresse => address : Address [0..1] 
    Contact => telecom : ContactPoint [0..*]
}

map "Telecom" as Telecom #back:MistyRose;header:Violet {
    Système  => system : code [0..1] 
    Valeur => value : string [0..1] 
    Nom => <&plus> ECLAIRESiteContactName : HumanName [0..1] 
}

map "EssaiClinique : ResearchStudy" as RS #back:AliceBlue;header:LightSkyBlue;line:blue {
    Identifiant (Primary and Secondary Identifying Numbers) => <&layers> identifier : Identifier [0..*]  
    Date de révision technique => meta.lastUpdated : instant [0..1]  
    Date de révision fonctionnelle => <&plus> ECLAIREReviewDate : instant [0..1] 
    Nom de l'essai (Scientifique title) => title : string [0..1] 
    Autres noms de l'essai (Public title) => <&plus> R5 ECLAIRELabel : Extension R5 ResearchStudy.label [0..*] 
    Statut de l'essai => status : code [1..1]
    Phase de l'essai (Study type : phase) => phase : CodeableConcept [0..1] 
    Type d'essai (Study type : type of study) => category : CodeableConcept [0..*] 
    Sujet concerné (Health Condition(s) or Problem(s) Studied) => <&layers> condition : CodeableConcept [0..*] (MeDRA) 
    Domaine thérapeutique* => <&plus> ECLAIRETherapeuticArea : string [0..1] 
    Résumé de l'essai => description : markdown [0..1] 
    Texte bref décrivant l'essai (Brief summary) => <&plus> R5 ECLAIREDescriptionSummary : Extension R5 ResearchStudy.descriptionSummary [0..1]
    Période prévisionnelle de recrutement => <&plus> ECLAIRERecruitmentPeriod : period [0..1]  
    Date prévisionnelle de fin de l'essai (Completion date) => period.end : dateTime [0..1]
    Contact (Contact for public / scientific queries) => contact : ContactDetail [0..*] 
    Participants (Key Inclusion and Exclusion Criteria, Sample size) => enrollment : Reference(Group) [0..*] 
    Lieux => site : Reference(Location) [0..*] 
    Pays de recrutement (Countries of Recruitment) => location : CodeableConcept [0..*]
    Promoteur principal (Primary sponsor) => sponsor : Reference(Organization) [0..1]  
    Promoteur secondaire (Secondary Sponsor(s)) => <&plus> ECLAIRESecondarySponsor  : Reference(Organization) [0..*]  
    Publications et résumé des résultats (Publications about the study and Summary results) => relatedArtifact : RelatedArtifact [0..*]
}


RS *-[#Violet,dashed,thickness=4]-> Location
RS *-[#LightGreen,dashed,thickness=4]-> Group 
RS *-[#Gold,dashed,thickness=4]-> Organization

slice_identifier -[#lightBlue,thickness=2] RS
RS -[#lightBlue,thickness=2] slice_condition
Contact --[#lightBlue,thickness=2] RS
label --[#lightBlue,thickness=2] RS
slice_name --[#lightBlue,thickness=2] Contact

Group -[hidden] Organization

Group::Critères --[#LightGreen,thickness=2]> Characteristic
Location::Contact --[#Violet,thickness=2]> Telecom


legend top left
  <&layers> : slice
  <&plus> : extension
  ~* : pas d'équivalence Santé.fr ni WHO
  <:warning:> : en discussion
endlegend

@enduml