//早期乳癌_Pertuzumab與Trastuzumab_皮下(SC)給付規定

library BCPertuzumabTrastuzumabSCRule1 version '1.0.0'

using FHIR version '4.0.1'

include FHIRHelpers version '4.0.1' called FHIRHelpers

include BCCodeConcept version '1.0.0' called CodeConcept

include BCReusable version '1.0.0' called Reusable

context Patient



//============================================
// 主要規定一：初次使用條件
//============================================

/*規則1*/

define "ICD代碼檢核_布林值": Reusable."ICD-10使用C50"

define "醫令類別為1_布林值":Reusable."醫令類別為1"

//1條件1:本藥品及化學療法併用
define "1條件1=PertuzumabTrastuzumabSC之用藥申請與化學療法併用":
  Reusable."HasConcurrentMedicationOrder"(CodeConcept."L01FY01", CodeConcept."併用化學治療法")
  and Reusable."醫令類別為1"



//1條件2:具HER2過度表現(IHC3+或FISH+)
define "1條件2=檢驗檢查-具HER2過度表現":
  Reusable."HasHER2OverexpressionTest"

define "1條件2=基因檢測-具HER2過度表現":
  Reusable."HasHER2OverexpressionGene"

define "1條件2=具HER2過度表現":
  "1條件2=檢驗檢查-具HER2過度表現"
  or "1條件2=基因檢測-具HER2過度表現"


//1條件3:具腋下淋巴結轉移
define "1條件3=具腋下淋巴結轉移(癌症分期分數或結果為N>=1)":
  exists (
    [Observation] O
      where exists (
        O.code.coding Cdg
          where Cdg.code = '399390009'
            and Cdg in CodeConcept.SNOMED
      )
        and O.value is not null
        and O.value is FHIR.string
        and Matches((O.value as FHIR.string).value, '.*N[^0][a-zA-Z]?.*')
  )


//1條件4:無遠處臟器轉移之早期乳癌病人
//1條件4-1
define "1條件4-1=3個月內影像報告":
Reusable."HasRecentImageReport"("本次申請起始日期", 90)

//1條件4-2
define "1條件4-2=癌症分期分數或結果為M=0":
  Reusable."癌症分期分數或結果為M=0"

//1條件4-3(檢查報告)
define "1條件4-3=3個月內有檢查報告":
Reusable."HasRecentMolecularReport"("本次申請起始日期", 90)


define "1條件4=無遠處臟器轉移之早期乳癌病人":
  "ICD代碼檢核_布林值"
  and "1條件4-2=癌症分期分數或結果為M=0"
  and "1條件4-3=3個月內有檢查報告" 
  or "1條件4-1=3個月內影像報告"


//規則1
define "規則1":
"1條件1=PertuzumabTrastuzumabSC之用藥申請與化學療法併用"
and "1條件2=具HER2過度表現"
and "1條件3=具腋下淋巴結轉移(癌症分期分數或結果為N>=1)"
and "1條件4=無遠處臟器轉移之早期乳癌病人"

/*規則2*/

//手術(或其他處置)日期
define "手術日期(opdate)":
  Max(
    flatten(
      [Claim] C
        return (
          C.procedure Proc
            where Proc.date is not null
            return FHIRHelpers.ToDateTime(Proc.date)
        )
    )
  )

define "手術(或其他處置)項目":
  exists (
  [Claim] C
    where exists (
      C.procedure Proc
        where exists (
          ((Proc.procedure as FHIR.CodeableConcept).coding) Cdg
            where Cdg is not null
              and (Cdg.code in CodeConcept."ICD10PCS2023Image"
                or Cdg.code in CodeConcept."ICD10PCS2014Image")
              and Cdg.code in CodeConcept."ProcedureCodes"
        )
    )
  )


//2條件1
//2條件1-1:使用於術前輔助治療
define "2條件1-1=使用於術前輔助治療":
  exists (
    [MedicationRequest] MRTrastuzumab
      where MRTrastuzumab.intent = 'order'
        and Reusable."HasValidTiming"(MRTrastuzumab)
        and exists (
          MRTrastuzumab.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept."併用化學治療法"
        )
        and Reusable."醫令類別為1"
        and (start of (MRTrastuzumab.dosageInstruction[0].timing.repeat.bounds as Period)) < "手術日期(opdate)"
        and "手術(或其他處置)項目"
  )


//2條件1-2:經外科手術後達病理上完全緩解者（pCR）
define "2條件1-2=經外科手術後達病理上完全緩解者（pCR）":
  exists (
    [DiagnosticReport] O2
      where exists (
          O2.code.coding Cdg
            where Cdg in CodeConcept.LOINC
              and Cdg.code = '66110-8'
        )
        and O2.effective is not null
        and FHIRHelpers.ToDateTime(O2.effective) > "手術日期(opdate)"
        and (
          O2.conclusion is not null
          and Matches(O2.conclusion, '(?i).*(pCR).*') 
        )
        and "手術(或其他處置)項目"
  )


//2條件1-3 / 2條件2-2 共用規則：療程上限18個（不含日期篩選，由各條件自行加）
// 每周療程: count(MR where count=1) ≤ 18 且 sum(useEdate-useSdate) ≤ 126天
define "每周療程得使用至18個療程為上限":
  Count(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept.L01FY01
        )
        and MR.dosageInstruction[0].timing.repeat.count = 1
  ) <= 18
  and Sum(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept.L01FY01
        )
        and MR.dosageInstruction[0].timing.repeat.count = 1
        and MR.dosageInstruction[0].timing.repeat.bounds is Period
        and (start of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        and (end of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
      return all
        difference in days between
          FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
          )
          and FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
          )
  ) <= 126

// 每三周療程: 同一起始日視為同一療程，僅保留結束日最晚的代表醫令後，count ≤ 18 且 sum(useEdate-useSdate) ≤ 378天
define "每三周療程得使用至18個療程為上限":
  // 計算每三周療程的代表療程數
  Count(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept.L01FY01
        )
        and MR.dosageInstruction[0].timing.repeat.period = 3
        and MR.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
        and Reusable."HasValidTiming"(MR)
        // 若同一起始日有多筆醫令，只保留結束日最晚者作為該療程代表
        and FHIRHelpers.ToDateTime(
          (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
        ) =
          Max(
            [MedicationRequest] MRSameCourse
              where MRSameCourse.intent = 'plan'
                and exists (
                  MRSameCourse.medication.coding SameCdg
                    where SameCdg in CodeConcept.NHIMedication
                      and SameCdg.code in CodeConcept.L01FY01
                )
                and MRSameCourse.dosageInstruction[0].timing.repeat.period = 3
                and MRSameCourse.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
                and Reusable."HasValidTiming"(MRSameCourse)
                and FHIRHelpers.ToDateTime(
                  (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).start
                ) = FHIRHelpers.ToDateTime(
                  (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
                )
              return FHIRHelpers.ToDateTime(
                (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).end
              )
          )
  ) <= 18
  // 僅累加代表療程的天數，避免同一療程重複加總
  and Sum(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept.L01FY01
        )
        and MR.dosageInstruction[0].timing.repeat.period = 3
        and MR.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
        and MR.dosageInstruction[0].timing.repeat.bounds is Period
        and (start of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        and (end of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        // 若同一起始日有多筆醫令，只保留結束日最晚者作為該療程代表
        and FHIRHelpers.ToDateTime(
          (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
        ) =
          Max(
            [MedicationRequest] MRSameCourse
              where MRSameCourse.intent = 'plan'
                and exists (
                  MRSameCourse.medication.coding SameCdg
                    where SameCdg in CodeConcept.NHIMedication
                      and SameCdg.code in CodeConcept.L01FY01
                )
                and MRSameCourse.dosageInstruction[0].timing.repeat.period = 3
                and MRSameCourse.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
                and Reusable."HasValidTiming"(MRSameCourse)
                and FHIRHelpers.ToDateTime(
                  (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).start
                ) = FHIRHelpers.ToDateTime(
                  (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
                )
              return FHIRHelpers.ToDateTime(
                (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).end
              )
          )
      return all
        difference in days between
          FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
          )
          and FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
          )
  ) <= 378

define "2條件1-3/2條件2-2=療程上限為18個療程":
  "每周療程得使用至18個療程為上限"
  or "每三周療程得使用至18個療程為上限"


define "2條件1=使用於術前輔助治療，經外科手術後達病理上完全緩解者（pCR），得繼續使用至18個療程為上限":
"2條件1-1=使用於術前輔助治療"
and "2條件1-2=經外科手術後達病理上完全緩解者（pCR）"
and "2條件1-3/2條件2-2=療程上限為18個療程"

//2條件2
//2條件2-1:若未接受術前輔助治療，即先行手術者

define "2條件2-1=未接受術前輔助治療，即先行手術者":
  not exists (
    [MedicationRequest] MR
      where MR.intent = 'order'
        and MR.status = 'completed'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept."併用化學治療法"
        )
        and FHIRHelpers.ToDateTime((MR.dosageInstruction[0].timing.repeat.bounds as Period).start) < "手術日期(opdate)"
        and "手術(或其他處置)項目"
  )


define "2條件2-2=可給予術後輔助治療以18個療程為使用上限":
  "2條件1-3/2條件2-2=療程上限為18個療程"
  and exists (
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and Cdg.code in CodeConcept.L01FY01
        )
        and MR.dosageInstruction[0].timing.repeat.bounds is Period
        and FHIRHelpers.ToDateTime((MR.dosageInstruction[0].timing.repeat.bounds as Period).start) > "手術日期(opdate)"
  )

define "2條件2=若未接受術前輔助治療，即先行手術者，可給予術後輔助治療，以18個療程為使用上限":
"2條件2-1=未接受術前輔助治療，即先行手術者"
and "2條件2-2=可給予術後輔助治療以18個療程為使用上限"

//規則2
define "規則2":
"2條件1=使用於術前輔助治療，經外科手術後達病理上完全緩解者（pCR），得繼續使用至18個療程為上限" or "2條件2=若未接受術前輔助治療，即先行手術者，可給予術後輔助治療，以18個療程為使用上限"

// 主要規定一
define "主要規定一":
"規則1" and "規則2"


//============================================
// 主要規定二：續用條件－治療持續給付
//============================================

//條件1:每24週須檢附療效評估資料再次申請，若疾病有惡化情形即不應再行申請
// 本次申請紀錄（以最新一筆申請作為本次申請）
define "本次申請紀錄":
  Reusable."LatestMedicationPlan"(CodeConcept.L01FY01)

define "本次申請起始日期":
  Reusable."GetStartTime"("本次申請紀錄")

// 前次申請紀錄（本次申請之前最近一次的申請）
define "前次申請紀錄":
  Reusable."LatestMedicationPlanBefore"(CodeConcept.L01FY01, "本次申請起始日期")

// 檢查本次申請療程長度是否在24週內
define "規則1-1=每24週須再次申請並檢附療效評估資料":
  Reusable."醫令類別為1" 
  and Reusable."續用註記為2"
  and "本次申請紀錄" is not null
  and Reusable."HasMedicationPlanPeriodWithinDays"(CodeConcept.L01FY01, 168)


//條件2:疾病有惡化情形須停止使用

// 取得前次治療紀錄（最近一次已完成的治療）
define "前次治療紀錄":
  Reusable."LatestCompletedMedicationOrderBefore"(CodeConcept.L01FY01, "本次申請起始日期")

// 前次用藥開始日期
define "前次用藥開始日期":
  Reusable."GetStartTime"("前次治療紀錄")

// 規則1-2: 疾病有惡化情形須停止使用(續用須檢附前次治療後影像學報告)
define "規則1-2=疾病有惡化情形須停止使用":
  Reusable."HasImageReportBetweenPreviousTreatmentAndCurrentApply"(CodeConcept.L01FY01)

// 主要規定二
define "主要規定二":
Reusable."續用註記為2"
and Reusable."醫令類別為1"
and "本次申請紀錄" is not null
and "規則1-1=每24週須再次申請並檢附療效評估資料"
and "規則1-2=疾病有惡化情形須停止使用"


//============================================
// 主要規定三：藥品使用規則
//============================================

//三種用藥選擇合併療程計算，上限為18個療程
// 每周療程: count(MR where count=1) ≤ 18 且 sum(useEdate-useSdate) ≤ 126天
define "三種用藥合併每周療程上限18個療程":
  Count(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and (Cdg.code in CodeConcept.L01FY01
                or Cdg.code in CodeConcept.L01FD01
                or Cdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
        )
        and MR.dosageInstruction[0].timing.repeat.count = 1
        and Reusable."醫令類別為1"
  ) <= 18
  and Sum(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and (Cdg.code in CodeConcept.L01FY01
                or Cdg.code in CodeConcept.L01FD01
                or Cdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
        )
        and MR.dosageInstruction[0].timing.repeat.count = 1
        and MR.dosageInstruction[0].timing.repeat.bounds is Period
        and (start of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        and (end of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
      return all
        difference in days between
          FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
          )
          and FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
          )
  ) <= 126

// 每三周療程: 同一起始日視為同一療程，僅保留結束日最晚的代表醫令後，count ≤ 18 且 sum(useEdate-useSdate) ≤ 378天
define "三種用藥合併每三周療程上限18個療程":
  // 計算三種用藥合併後的代表療程數
  Count(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and (Cdg.code in CodeConcept.L01FY01
                or Cdg.code in CodeConcept.L01FD01
                or Cdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
        )
        and MR.dosageInstruction[0].timing.repeat.period = 3
        and MR.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
        and Reusable."醫令類別為1"
        and Reusable."HasValidTiming"(MR)
        // 若同一起始日有多筆藥物，只保留結束日最晚者作為該療程代表
        and FHIRHelpers.ToDateTime(
          (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
        ) =
          Max(
            [MedicationRequest] MRSameCourse
              where MRSameCourse.intent = 'plan'
                and exists (
                  MRSameCourse.medication.coding SameCdg
                    where SameCdg in CodeConcept.NHIMedication
                      and (SameCdg.code in CodeConcept.L01FY01
                        or SameCdg.code in CodeConcept.L01FD01
                        or SameCdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
                )
                and MRSameCourse.dosageInstruction[0].timing.repeat.period = 3
                and MRSameCourse.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
                and Reusable."醫令類別為1"
                and Reusable."HasValidTiming"(MRSameCourse)
                and FHIRHelpers.ToDateTime(
                  (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).start
                ) = FHIRHelpers.ToDateTime(
                  (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
                )
              return FHIRHelpers.ToDateTime(
                (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).end
              )
          )
  ) <= 18
  // 僅累加代表療程的天數，避免同一療程重複加總
  and Sum(
    [MedicationRequest] MR
      where MR.intent = 'plan'
        and exists (
          MR.medication.coding Cdg
            where Cdg in CodeConcept.NHIMedication
              and (Cdg.code in CodeConcept.L01FY01
                or Cdg.code in CodeConcept.L01FD01
                or Cdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
        )
        and MR.dosageInstruction[0].timing.repeat.period = 3
        and MR.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
        and MR.dosageInstruction[0].timing.repeat.bounds is Period
        and (start of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        and (end of (MR.dosageInstruction[0].timing.repeat.bounds as Period)) is not null
        // 若同一起始日有多筆藥物，只保留結束日最晚者作為該療程代表
        and FHIRHelpers.ToDateTime(
          (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
        ) =
          Max(
            [MedicationRequest] MRSameCourse
              where MRSameCourse.intent = 'plan'
                and exists (
                  MRSameCourse.medication.coding SameCdg
                    where SameCdg in CodeConcept.NHIMedication
                      and (SameCdg.code in CodeConcept.L01FY01
                        or SameCdg.code in CodeConcept.L01FD01
                        or SameCdg.code in CodeConcept.L01FD01andL01FD02exceptKC011362B5)
                )
                and MRSameCourse.dosageInstruction[0].timing.repeat.period = 3
                and MRSameCourse.dosageInstruction[0].timing.repeat.periodUnit.value = 'wk'
                and Reusable."醫令類別為1"
                and Reusable."HasValidTiming"(MRSameCourse)
                and FHIRHelpers.ToDateTime(
                  (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).start
                ) = FHIRHelpers.ToDateTime(
                  (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
                )
              return FHIRHelpers.ToDateTime(
                (MRSameCourse.dosageInstruction[0].timing.repeat.bounds as Period).end
              )
          )
      return all
        difference in days between
          FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).start
          )
          and FHIRHelpers.ToDateTime(
            (MR.dosageInstruction[0].timing.repeat.bounds as Period).end
          )
  ) <= 378

define "主要規定三":
  "三種用藥合併每周療程上限18個療程"
  or "三種用藥合併每三周療程上限18個療程"


//============================================
// 列出「符合」項目判斷式
//============================================

define function "符合項目"():
  // 主要規定一：初次使用條件
  (if Reusable."初次申請" and (
    "規則1" or "規則2"
  )
    then '<主要規定一：初次使用條件>\n' +
         (if "ICD代碼檢核_布林值"
           then '● 規則1-0：ICD代碼為C50\n' else '') +
         (if "1條件1=PertuzumabTrastuzumabSC之用藥申請與化學療法併用"
           then '● 規則1-條件1：本藥品與化學療法併用\n' else '') +
         (if "1條件2=具HER2過度表現"
           then '● 規則1-條件2：具HER2過度表現（IHC3+或FISH+）\n' else '') +
         (if "1條件3=具腋下淋巴結轉移(癌症分期分數或結果為N>=1)"
           then '● 規則1-條件3：具腋下淋巴結轉移（N≥1）\n' else '') +
         (if "1條件4-1=3個月內影像報告"
           then '● 規則1-條件4-1：3個月內影像報告\n' else '') +
         (if "1條件4-2=癌症分期分數或結果為M=0"
           then '● 規則1-條件4-2：癌症分期M=0（無遠處臟器轉移）\n' else '') +
         (if "1條件4-3=3個月內有檢查報告"
           then '● 規則1-條件4-3：3個月內有檢查報告\n' else '') +
         (if "2條件1-1=使用於術前輔助治療"
           then '● 規則2-條件1-1：使用於術前輔助治療\n' else '') +
         (if "2條件1-2=經外科手術後達病理上完全緩解者（pCR）"
           then '● 規則2-條件1-2：術後達病理完全緩解（pCR）\n' else '') +
         (if "2條件1-3/2條件2-2=療程上限為18個療程"
           then '● 規則2-條件1-3/2-2：療程≤18個療程\n' else '') +
         (if "2條件2-1=未接受術前輔助治療，即先行手術者"
           then '● 規則2-條件2-1：未接受術前輔助治療，先行手術\n' else '') +
         (if "2條件2-2=可給予術後輔助治療以18個療程為使用上限"
           then '● 規則2-條件2-2：術後輔助治療起始日大於手術日期且療程≤18個療程\n' else '') +
         '\n'
    else '') +

  // 主要規定二：續用條件
  (if Reusable."續用申請" and (
    "規則1-1=每24週須再次申請並檢附療效評估資料" or
    "規則1-2=疾病有惡化情形須停止使用"
  )
    then '<主要規定二：續用條件－治療持續給付>\n' +
         (if "規則1-1=每24週須再次申請並檢附療效評估資料"
           then '● 續用規則1-1：於24週內再次申請並檢附療效評估資料\n' else '') +
         (if "規則1-2=疾病有惡化情形須停止使用"
           then '● 續用規則1-2：已檢附前次治療後影像學報告，確認無惡化\n' else '') +
         '\n'
    else '') +

  // 主要規定三：藥品使用規則
  (if "主要規定三"
    then '<主要規定三：藥品使用規則>\n' +
         (if "三種用藥合併每周療程上限18個療程"
           then '● 規則3：每周療程合計≤18個療程且總日數≤126天\n' else '') +
         (if "三種用藥合併每三周療程上限18個療程"
           then '● 規則3：每三周療程合計≤18個療程且總日數≤378天\n' else '') +
         '\n'
    else '')


//============================================
// 列出「不符合」項目判斷式 - 代碼或條件不符
//============================================

define function "不符合項目_代碼或條件不符"():
  // 主要規定一：初次使用條件 - 代碼條件不符
  (if Reusable."初次申請" and (
    not "ICD代碼檢核_布林值" or
    not "1條件2=具HER2過度表現" or
    not "1條件3=具腋下淋巴結轉移(癌症分期分數或結果為N>=1)" or
    not "1條件4-2=癌症分期分數或結果為M=0"
  )
    then '<主要規定一：初次使用條件>\n' +
         (if not "ICD代碼檢核_布林值"
           then '▲ 規則1-0：主要疾病之ICD代碼未使用C50\n' else '') +
         (if not "1條件2=具HER2過度表現"
           then '▲ 規則1-條件2：HER2未過度表現或未提供（需IHC3+或FISH+）\n' else '') +
         (if not "1條件3=具腋下淋巴結轉移(癌症分期分數或結果為N>=1)"
           then '▲ 規則1-條件3：癌症分期不符合（需N≥1，具腋下淋巴結轉移）\n' else '') +
         (if not "1條件4-2=癌症分期分數或結果為M=0"
           then '▲ 規則1-條件4：癌症分期不符合（M需為0，無遠處臟器轉移）\n' else '') +
         '\n'
    else '') +

  // 主要規定三：藥品使用規則 - 代碼條件不符
  (if not "主要規定三"
    then '<主要規定三：藥品使用規則>\n' +
         '▲ 規則3：三種用藥（PertuzumabTrastuzumabSC/Pertuzumab與Trastuzumab/Trastuzumab）合計療程超過18個療程\n' +
         '\n'
    else '')


//============================================
// 列出「不符合」項目判斷式 - 必要資料未填寫
//============================================

define function "不符合項目_必要資料未填寫"():
  // 主要規定一：初次使用條件 - 必要資料未填寫
  (if Reusable."初次申請" and (
    not "1條件1=PertuzumabTrastuzumabSC之用藥申請與化學療法併用" or
    not ("1條件4-1=3個月內影像報告" or "1條件4-3=3個月內有檢查報告") or
    not "規則2"
  )
    then '<主要規定一：初次使用條件>\n' +
         (if not "1條件1=PertuzumabTrastuzumabSC之用藥申請與化學療法併用"
           then '▲ 規則1-條件1：未申請本藥品與化學療法併用\n' else '') +
         (if not ("1條件4-1=3個月內影像報告" or "1條件4-3=3個月內有檢查報告")
           then '▲ 規則1-條件4：未提供3個月內影像報告或檢查報告\n' else '') +
         (if not "2條件1-2=經外科手術後達病理上完全緩解者（pCR）" and not "2條件2-1=未接受術前輔助治療，即先行手術者"
           then '▲ 規則2：未提供術前輔助治療pCR資料，亦不符合先行手術後輔助治療條件\n' else '') +
         '\n'
    else '') +

  // 主要規定二：續用條件 - 必要資料未填寫
  (if Reusable."續用申請" and (
    not "規則1-1=每24週須再次申請並檢附療效評估資料" or
    not "規則1-2=疾病有惡化情形須停止使用"
  )
    then '<主要規定二：續用條件－治療持續給付>\n' +
         (if not "規則1-1=每24週須再次申請並檢附療效評估資料"
           then '▲ 續用規則1-1：未於24週內再次申請或未檢附療效評估資料\n' else '') +
         (if not "規則1-2=疾病有惡化情形須停止使用"
           then '▲ 續用規則1-2：未提供前次治療後影像學報告\n' else '') +
         '\n'
    else '')


//============================================
// 審核結果
//============================================

define "乳癌PertuzumabTrastuzumabSC申請結果_布林":
  case
    when Reusable."初次申請" then (
      "主要規定一" and
      "主要規定三"
    )
    when Reusable."續用申請" then (
      "主要規定二" and
      "主要規定三"
    )
    else false
  end

define "乳癌PertuzumabTrastuzumabSC申請之CQL檢核結果":
  if (
    Reusable."初次申請" and
    "主要規定一" and
    "主要規定三"
  )
  then '✓通過：初次使用－早期乳癌 PertuzumabTrastuzumabSC 用藥申請'

  else if (
    Reusable."續用申請" and
    "主要規定二" and
    "主要規定三"
  )
  then '✓通過：續用－早期乳癌 PertuzumabTrastuzumabSC 用藥申請'

  else if Reusable."初次申請"
  then '✖不通過：初次使用－早期乳癌 PertuzumabTrastuzumabSC 用藥申請'

  else if Reusable."續用申請"
  then '✖不通過：續用－早期乳癌 PertuzumabTrastuzumabSC 用藥申請'

  else '✖不通過：無法判定申請類型－早期乳癌 PertuzumabTrastuzumabSC 用藥申請'


//============================================
// 報告總結
//============================================

define "報告總結":
  '\n=== 早期乳癌之PertuzumabTrastuzumabSC 申請審核報告 ===\n' +
  '\n【申請類型】' + Reusable."申請類型" + '\n' +
  '\n【●符合項目】\n' +
  (if "符合項目"() = '' then '無\n' else "符合項目"()) +
  '\n【▲不符合項目 - 代碼或條件不符】\n' +
  (if "不符合項目_代碼或條件不符"() = '' then '無\n' else "不符合項目_代碼或條件不符"()) +
  '\n【▲不符合項目 - 必要資料未填寫】\n' +
  (if "不符合項目_必要資料未填寫"() = '' then '無\n' else "不符合項目_必要資料未填寫"()) +
  '\n【申請結果】\n' +
  "乳癌PertuzumabTrastuzumabSC申請之CQL檢核結果" +
  '\n===============================================\n'

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