http://hl7.org.nz/fhir/ig/cca/PlanDefinition/52451000210102
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node role: treeRoot
id:
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meta:
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text:
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  div:
    v: GU PROS Castration resistant Metastatic - abiraterone and dexamethasone Treatment Overview This regimen is for corticosteroid switch after progression on abiraterone plus prEDNISone. Cycle 1 (and all further cycles) - 28 days Cycle length: 28 Cycle details Cycle 1 (and all further cycles) - 28 days Medication Dose Route Days Max Duration abiraterone * 1000 mg flat Once daily oral administration 1 to 28 dexamethasone * 500 microgram flat Once daily oral administration 1 to 28 Full details Cycle 1 (and all further cycles) - 28 days Day: 1 Medication Dose Route Max duration Details abiraterone * 1000 mg flat Once daily oral administration Instructions: Take each dose on an empty stomach - one hour before OR two hours after food. Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment. dexamethasone * 500 microgram flat Once daily oral administration Instructions: Take with food. Do not stop taking this medicine without consulting your doctor. Day: 2 Medication Dose Route Max duration Details abiraterone * 1000 mg flat Once daily oral administration Instructions: Take each dose on an empty stomach - one hour before OR two hours after food. Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment. dexamethasone * 500 microgram flat Once daily oral administration Instructions: Take with food. Do not stop taking this medicine without consulting your doctor. Day: 3 Medication Dose Route Max duration Details abiraterone * 1000 mg flat Once daily oral administration Instructions: Take each dose on an empty stomach - one hour before OR two hours after food. Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment. dexamethasone * 500 microgram flat Onc…
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    v: The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
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version:
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name:
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title:
  v: GU PROS Castration resistant Metastatic - abiraterone and dexamethasone
subtitle:
  v: Urogenital Prostate Castration resistant Metastatic - abiraterone and dexamethasone
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status:
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date:
  v: 2026-05-21T02:29:02+00:00
publisher:
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description:
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copyright:
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author:
  name:
    v: New Zealand Medicines Formulary LP
related artifact:
  type:
    v: citation
  display:
    v: 1. Fenioux C, Louvet C, Charton E, et al. Switch from abiraterone plus prednisone to abiraterone plus dexamethasone at asymptomatic PSA progression in patients with metastatic castration-resistant prostate cancer. BJU Int. 2019;123(2):300-306. doi:10.1111/bju.14511, PMID: 30099821
  url:
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    l: https://pubmed.ncbi.nlm.nih.gov/30099821

http://snomed.info/id/229797004
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code:
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v: Once daily

v: 386359008

v: 1000

v: mg flat

v: 258684004

http://snomed.info/id/229797004
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code:
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v: Once daily

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v: 500

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v: 258685003

type:
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display:
  v: 2. Romero-Laorden N, Lozano R, Jayaram A, et al. Phase II pilot study of the prednisone to dexamethasone switch in metastatic castration-resistant prostate cancer (mCRPC) patients with limited progression on abiraterone plus prednisone (SWITCH study). Br J Cancer. 2018;119(9):1052-1059. doi:10.1038/s41416-018-0123-9, PMID: 30131546
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    l: https://pubmed.ncbi.nlm.nih.gov/30131546

type:
  v: citation
display:
  v: 3. Roviello G, Sobhani N, Corona SP, D'Angelo A. Corticosteroid switch after progression on abiraterone acetate plus prednisone. Int J Clin Oncol. 2020 Feb;25(2):240-246. doi: 10.1007/s10147-019-01577-w. Epub 2019 Nov 8., PMID: 31705219
url:
  v: https://pubmed.ncbi.nlm.nih.gov/31705219
  l: https://pubmed.ncbi.nlm.nih.gov/31705219
document:
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type:
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display:
  v: 4. Attard G, Merseburger AS, Arlt W, Sternberg CN, Feyerabend S, Berruti A, Joniau S, Géczi L, Lefresne F, Lahaye M, Shelby FN, Pissart G, Chua S, Jones RJ, Tombal B. Assessment of the Safety of Glucocorticoid Regimens in Combination With Abiraterone Acetate: A Randomized, Open-Label Phase 2 Study. JAMA Oncol. 2019 Jun 27;5(8):1159–67. doi: 10.1001/jamaoncol.2019.1011. Epub ahead of print. Erratum in: JAMA Oncol. 2019 Aug 1;5(8):1232., PMID: 31246234
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    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 3
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 4
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 5
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 6
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 7
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 8
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 9
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 10
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 11
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 12
  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take with food. Do not stop taking this medicine without consulting your doctor.
  url:
    v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
    l: sact-timing-of-days
extension:
  extension:
    url:
      v: day
      l: day
    value: Integer
      v: 13
  extension:
    url:
      v: instructions
      l: instructions
    value: String
definition: Canonical

String
v: Take with food. Do not stop taking this medicine without consulting your doctor.

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 14
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 15
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 16
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 17
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 18
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 19
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 20
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 21
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 22
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 23
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 24
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 25
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 26
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 27
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days

extension:
  url:
    v: day
    l: day
  value: Integer
    v: 28
extension:
  url:
    v: instructions
    l: instructions
  value: String
    v: Take with food. Do not stop taking this medicine without consulting your doctor.
url:
  v: http://hl7.org.nz/fhir/StructureDefinition/sact-timing-of-days
  l: sact-timing-of-days