http://hl7.org.nz/fhir/ig/cca/PlanDefinition/52401000210103
type: PlanDefinition
node role: treeRoot
id:
  v: 52401000210103
meta:
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    l: CcaPlanDefinition
text:
  status:
    v: extensions
  div:
    v: LUNG NSCLC NON-Metastatic - alectinib Treatment Overview Cycle 1 (and all further cycles) - 28 days Cycle length: 28 Cycle details Cycle 1 (and all further cycles) - 28 days Medication Dose Route Days Max Duration alectinib 600 mg flat Twice daily oral administration 1 to 28 loperamide 2 mg flat oral administration 1 domperidone 10 mg flat Three times daily oral administration 1 Full details Cycle 1 (and all further cycles) - 28 days Day: 1 Medication Dose Route Max duration Details alectinib 600 mg flat Twice daily oral administration Instructions: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. loperamide 2 mg flat oral administration Instructions: Take TWO capsules (=4 mg) at onset of loose bowel motions and a further ONE capsule (=2 mg) for every loose bowel motion (maximum of EIGHT capsules in 24 hours), or use as directed by oncologist or haematologist. domperidone 10 mg flat Three times daily oral administration Instructions: When required for nausea and/or vomiting. Day: 2 Medication Dose Route Max duration Details alectinib 600 mg flat Twice daily oral administration Instructions: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Day: 3 Medication Dose Route Max duration Details alectinib 600 mg flat Twice daily oral administration Instructions: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Day: 4 Medication Dose Route Max duration Details alectinib 600 mg flat Twice daily oral administration Instructions: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Day: 5 Medication Dose Route Max duration Details alectinib 600 mg flat Twice daily o…
contained: ActivityDefinition
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  extension:
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    value: Boolean
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  product: CodeableConcept
    coding:
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        l: nzmt
      code:
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      display:
        v: alectinib
    text:
      v: alectinib
  dosage:
    text:
      v: 600 mg flat Twice daily by oral administration
    timing:
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        coding: http://snomed.info/id/229799001
    route:
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      text:
        v: oral administration
    dose and rate:
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      display:
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  dosage:
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      text:
        v: oral administration
    dose and rate:
      dose: Quantity
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        v: oral administration
    dose and rate:
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extension:
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  value: CodeableConcept
    coding: http://snomed.info/id/372087000
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    text:
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extension:
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    l: sact-disclaimer
  value: Markdown
    v: The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
extension:
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    value: CodeableConcept
      coding: http://snomed.info/id/128333008
      text:
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    value: CodeableConcept
      coding: http://snomed.info/id/723509005
      text:
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    l: sact-support-factor
extension:
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      l: factor
    value: CodeableConcept
      coding: http://snomed.info/id/419219000
      text:
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    value: CodeableConcept
      coding: http://snomed.info/id/255605001
      text:
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    l: sact-support-factor
url:
  v: https://fhir.nzf.org.nz/fhir/PlanDefinition/52401000210103
  l: https://fhir.nzf.org.nz/fhir/PlanDefinition/52401000210103
identifier:
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    l: sct
  value:
    v: 52401000210103
version:
  v: 0.1.0
name:
  v: LUNG NSCLC NON-Metastatic - alectinib
title:
  v: LUNG NSCLC NON-Metastatic - alectinib
subtitle:
  v: Respiratory Non small cell lung cancer NON-Metastatic - alectinib
type:
  coding:
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      l: plan-definition-type
    code:
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http://snomed.info/id/229799001
system:
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  l: sct
code:
  v: 229799001

v: Twice daily

v: 386359008

v: 600

v: mg flat

v: 258684004

v: 386359008

v: 2

v: mg flat

v: 258684004

http://snomed.info/id/229798009
system:
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  l: sct
code:
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v: Three times daily

v: 386359008

v: 10

v: mg flat

v: 258684004

v: 128333008

v: 723509005

v: 419219000

v: 255605001

v: active

v: 2026-05-21T02:29:02+00:00

v: Te Aho o Te Kahu, Cancer Control Agency

v: A drug treatment regimen for Respiratory Non small cell lung cancer NON-Metastatic - alectinib

code:
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  code:
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value: CodeableConcept
  coding: http://snomed.info/id/449096009
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      l: sct
    code:
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  text:
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code:
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  code:
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value: CodeableConcept
  coding: http://snomed.info/id/254637007
    system:
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      l: sct
    code:
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  text:
    v: Non small cell lung cancer

v: All rights reserved.

name:
  v: New Zealand Medicines Formulary LP

type:
  v: citation
display:
  v: 1. Peters, S., D. R. Camidge, A. T. Shaw, et al. 2017. "Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer." N Engl J Med 377(9):829-838., PMID: 28586279
url:
  v: https://pubmed.ncbi.nlm.nih.gov/28586279
  l: https://pubmed.ncbi.nlm.nih.gov/28586279
document:
  url:
    v: https://pubmed.ncbi.nlm.nih.gov/28586279
    l: https://pubmed.ncbi.nlm.nih.gov/28586279

type:
  v: citation
display:
  v: 2. Hida, T., H. Nokihara, M. Kondo et al. 2017. "Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial." Lancet 390(10089):29-39., PMID: 28501140
url:
  v: https://pubmed.ncbi.nlm.nih.gov/28501140
  l: https://pubmed.ncbi.nlm.nih.gov/28501140
document:
  url:
    v: https://pubmed.ncbi.nlm.nih.gov/28501140
    l: https://pubmed.ncbi.nlm.nih.gov/28501140

type:
  v: citation
display:
  v: 3. Camidge, D. R, Rafal D, Solange P, 2019. "Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-Positive Advanced Non–Small Cell Lung Cancer in the Global Phase III ALEX Study." Journal of Thoracic Oncology 14(7):1233-1243., PMID: 30902613
url:
  v: https://pubmed.ncbi.nlm.nih.gov/30902613
  l: https://pubmed.ncbi.nlm.nih.gov/30902613
document:
  url:
    v: https://pubmed.ncbi.nlm.nih.gov/30902613
    l: https://pubmed.ncbi.nlm.nih.gov/30902613

type:
  v: citation
display:
  v: 4. Roche Products (New Zealand) Limited. Alecensa New Zealand Data Sheet 16 August 2018. https://www.medsafe.govt.nz/profs/Datasheet/a/alecensacap.pdf (Accessed 02 December 2020)

prefix:
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description:
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timing: Timing
  repeat:
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    duration unit:
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selection behavior:
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action:
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        v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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        l: instructions
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        v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
  definition: Canonical

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  value: Integer
    v: 13
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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  value: Integer
    v: 25
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    l: instructions
  value: String
    v: Take with food. Swallow whole, do not crush or chew. Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
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  value: Integer
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extension:
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    url:
      v: day
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    value: Integer
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  extension:
    url:
      v: instructions
      l: instructions
    value: String
      v: Take TWO capsules (=4 mg) at onset of loose bowel motions and a further ONE capsule (=2 mg) for every loose bowel motion (maximum of EIGHT capsules in 24 hours), or use as directed by oncologist or haematologist.
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definition: Canonical

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      v: When required for nausea and/or vomiting.
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definition: Canonical