{
  "resourceType" : "Observation",
  "id" : "observation-her2-fish-example",
  "meta" : {
    "profile" : ["https://hl7.lt/fhir/lab/StructureDefinition/her2-fish-observation-lt-lab"]
  },
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xml:lang=\"en\" lang=\"en\"><hr/><p><b>English</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: Observation observation-her2-fish-example</b></p><a name=\"observation-her2-fish-example\"> </a><a name=\"hcobservation-her2-fish-example\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Language: en</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-her2-fish-observation-lt-lab.html\">Observation: HER2 FISH/CISH/SISH Molecular Test</a></p></div><p><b>status</b>: Final</p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 31150-6}\">ERBB2 gene duplication [Presence] in Tissue by FISH</span></p><p><b>subject</b>: <a href=\"Patient-patient-example.html\">Jonas Petrauskas(official) Male, DoB: 1985-01-01 ( http://hospital-lt.lt/patient-id#HOSPLT-10005\u00a0(use:\u00a0usual,\u00a0))</a></p><p><b>effective</b>: 2025-01-20 14:00:00+0200</p><p><b>performer</b>: <a href=\"Practitioner-practitioner-example.html\">Practitioner Registrar</a></p><p><b>method</b>: <span title=\"Codes:\">FISH</span></p><p><b>specimen</b>: <a href=\"Specimen-specimen-right-breast-example.html\">Specimen: identifier = http://hospital.lt/sid/specimen-number#barcode12345; accessionIdentifier = B26-6526; status = available; type = Specimen from breast obtained by biopsy</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 85318-4}\">ERBB2 gene duplication [Presence] in Breast cancer specimen by FISH</span></p><p><b>value</b>: 2.1 copies/nucleus<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code{copies}/nucleus = '{copies}/nucleus')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 85319-2}\">HER2 [Presence] in Breast cancer specimen by Immune stain</span></p><p><b>value</b>: 1.8 copies/nucleus<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code{copies}/nucleus = '{copies}/nucleus')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 49683-6}\">ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH</span></p><p><b>value</b>: 1.17 ratio<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code{ratio} = '{ratio}')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 85320-0}\">Foci [Type] in Breast cancer specimen by Light microscopy</span></p><p><b>value</b>: <span title=\"Codes:{https://tx.hl7.lt/fhir/CodeSystem/her2-fish-result negative}\">Negative (HER2&lt;4, HER2/CEP17&lt;2)</span></p></blockquote></div>"
  },
  "status" : "final",
  "code" : {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "31150-6",
      "display" : "ERBB2 gene duplication [Presence] in Tissue by FISH"
    }]
  },
  "subject" : {
    "reference" : "Patient/patient-example"
  },
  "effectiveDateTime" : "2025-01-20T14:00:00+02:00",
  "performer" : [{
    "reference" : "Practitioner/practitioner-example"
  }],
  "method" : {
    "text" : "FISH"
  },
  "specimen" : {
    "reference" : "Specimen/specimen-right-breast-example"
  },
  "component" : [{
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "85318-4",
        "display" : "ERBB2 gene duplication [Presence] in Breast cancer specimen by FISH"
      }]
    },
    "valueQuantity" : {
      "value" : 2.1,
      "unit" : "copies/nucleus",
      "system" : "http://unitsofmeasure.org",
      "code" : "{copies}/nucleus"
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "85319-2",
        "display" : "HER2 [Presence] in Breast cancer specimen by Immune stain"
      }]
    },
    "valueQuantity" : {
      "value" : 1.8,
      "unit" : "copies/nucleus",
      "system" : "http://unitsofmeasure.org",
      "code" : "{copies}/nucleus"
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "49683-6",
        "display" : "ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH"
      }]
    },
    "valueQuantity" : {
      "value" : 1.17,
      "unit" : "ratio",
      "system" : "http://unitsofmeasure.org",
      "code" : "{ratio}"
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "85320-0",
        "display" : "Foci [Type] in Breast cancer specimen by Light microscopy"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "https://tx.hl7.lt/fhir/CodeSystem/her2-fish-result",
        "code" : "negative",
        "display" : "Negative (HER2<4, HER2/CEP17<2)"
      }]
    }
  }]
}