Pharmaceutical Quality (Industry)
1.0.0 - STU1

Pharmaceutical Quality (Industry), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/uv-dx-pq/ and changes regularly. See the Directory of published versions

## : Example: Bundle - Process Validation, substance - XML Representation

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    <Bundle xmlns="http://hl7.org/fhir">
      <!--  Substance Process Validation  -->
      <id value="bundle-product-process-validation-pq-ex2-sub"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"/>
      </meta>
      <type value="collection"/>
      <entry>
        <fullUrl value="urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f"/>
        <resource>
          <PlanDefinition>
            <!-- validationProtocol -->
            <id value="2038e4c7-22b8-4c56-2d28-6c077648763f"/>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><a name="hc2038e4c7-22b8-4c56-2d28-6c077648763f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource PlanDefinition &quot;2038e4c7-22b8-4c56-2d28-6c077648763f&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#workflow-definition; <a href="CodeSystem-pharmaceutical-plan-type.html">Pharmaceutical Plan Type Codes</a>#process-validation &quot;Process Validation&quot;)</span></p><p><b>status</b>: active</p><p><b>subject</b>: See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><blockquote><p><b>Extension - Process Parameters PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Mix speed <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-process-parameter.html">Process Parameter Codes</a>#SPEED)</span></p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1500 rpm</p></blockquote><p><b>prefix</b>: 1</p><p><b>title</b>: Step 1 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Particle Size Reduction <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#particleSizeReduction)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 In-Process Control Data</p><p><b>code</b>: Step 1 In-Process Control Data <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#Step1In-ProcessControlData)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 DS Release Testing Results</p><p><b>code</b>: Step 1 DS Release Testing Results <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#Step1DSReleaseTestingResults)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d">http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e">http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><p><b>prefix</b>: 2</p><p><b>title</b>: Step 2 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Drying <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#drying)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote></div>
            </text>
            <!-- http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f -->
            <url
                 value="http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
            <title value="DP PROCESS VALIDATION"/>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
                <code value="workflow-definition"/>
                <display value="Workflow Definition"/>
              </coding>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-plan-type"/>
                <code value="process-validation"/>
                <display value="Process Validation"/>
              </coding>
            </type>
            <status value="active"/>
            <subjectReference>
              <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
              <reference
                         value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
            </subjectReference>
            <description
                         value="Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies..."/>
            <action>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
                <valueCoding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step-scale"/>
                  <code value="PROD"/>
                  <display value="Production Scale"/>
                </valueCoding>
              </extension>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-parameters-pq">
                <extension url="parameter">
                  <valueCodeableConcept>
                    <coding>
                      <system
                              value="http://terminology.hl7.org/CodeSystem/process-parameter"/>
                      <code value="SPEED"/>
                      <display value="Mix speed"/>
                    </coding>
                  </valueCodeableConcept>
                </extension>
                <extension url="value">
                  <valueQuantity>
                    <value value="1500"/>
                    <unit value="rpm"/>
                  </valueQuantity>
                </extension>
              </extension>
              <prefix value="1"/>
              <title value="Step 1 Yield"/>
              <description value="Description of this step"/>
              <!-- text value="Step 2 in the process - free text is possible"/ -->
              <code>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
                  <code value="particleSizeReduction"/>
                  <display value="Particle Size Reduction"/>
                </coding>
              </code>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/startingMaterial -->
                      <reference
                                 value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
                    </valueReference>
                  </extension>
                  <display value="Starting material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="StartingMaterial"/>
                    <display value="Starting Material"/>
                  </coding>
                </role>
              </participant>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/intermediateMaterial -->
                      <reference
                                 value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
                    </valueReference>
                  </extension>
                  <display value="Intermediate material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="IntermediateMaterial"/>
                    <display value="Intermediate Material"/>
                  </coding>
                </role>
              </participant>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/resultingMaterial -->
                      <reference
                                 value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821154"/>
                    </valueReference>
                  </extension>
                  <display value="Resulting material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="ResultingMaterial"/>
                    <display value="Resulting Material"/>
                  </coding>
                </role>
              </participant>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/Step1Yield -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
              </action>
            </action>
            <action>
              <title value="Step 1 In-Process Control Data"/>
              <code>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
                  <code value="Step1In-ProcessControlData"/>
                  <display value="Step 1 In-Process Control Data"/>
                </coding>
              </code>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/ResidualWaterContent -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
              </action>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/ResidualStartingMaterial1byHPLC -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
              </action>
            </action>
            <action>
              <title value="Step 1 DS Release Testing Results"/>
              <code>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
                  <code value="Step1DSReleaseTestingResults"/>
                  <display value="Step 1 DS Release Testing Results"/>
                </coding>
              </code>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/AppearanceSubstance -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
              </action>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/IdentificationSubstance -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
              </action>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/AssaySubstance -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
              </action>
            </action>
            <action>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
                <valueCoding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step-scale"/>
                  <code value="PROD"/>
                  <display value="Production Scale"/>
                </valueCoding>
              </extension>
              <prefix value="2"/>
              <title value="Step 2 Yield"/>
              <description value="Description of this step"/>
              <!-- text value="Step 2 in the process - free text is possible"/ -->
              <code>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
                  <code value="drying"/>
                  <display value="Drying"/>
                </coding>
              </code>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/startingMaterialStep2 -->
                      <reference
                                 value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
                    </valueReference>
                  </extension>
                  <display value="Starting material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="StartingMaterial"/>
                    <display value="Starting Material"/>
                  </coding>
                </role>
              </participant>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/intermediateMaterialStep2 -->
                      <reference
                                 value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
                    </valueReference>
                  </extension>
                  <display value="Intermediate material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="IntermediateMaterial"/>
                    <display value="Intermediate Material"/>
                  </coding>
                </role>
              </participant>
              <participant>
                <typeReference>
                  <extension
                             url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                    <valueReference>
                      <!-- SubstanceDefinition/resultingMaterialStep2 -->
                      <reference
                                 value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821154"/>
                    </valueReference>
                  </extension>
                  <display value="Resulting material"/>
                </typeReference>
                <role>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                    <code value="ResultingMaterial"/>
                    <display value="Resulting Material"/>
                  </coding>
                </role>
              </participant>
              <action>
                <code>
                  <text value="Test"/>
                </code>
                <!-- ObservationDefinition/Step2Yield -->
                <definitionCanonical
                                     value="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
              </action>
            </action>
          </PlanDefinition>
        </resource>
      </entry>
      <!--  Diagnostic report doesn't carry much extra value but does collect all the observations  -->
      <entry>
        <fullUrl value="urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd"/>
        <resource>
          <DiagnosticReport>
            <!--  ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
                         however the observations themselves do have subjects  -->
            <id value="processValidationReport"/>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_processValidationReport"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name="processValidationReport"> </a><a name="hcprocessValidationReport"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport &quot;processValidationReport&quot; </p></div><p><b>Triggered by</b>: See on this page: PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-report-type.html">Pharmaceutical Report Type Codes</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li>See on this page: Observation/9c56948c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56968a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56978a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56968c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56978c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56948d-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948b-2a39-6609-1c01-4d197ea57a33</li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy">
              <valueReference>
                <!-- PlanDefinition/validationProtocol -->
                <reference
                           value="PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
              </valueReference>
            </extension>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-report-type"/>
                <code value="Process Validation Report"/>
                <display value="Process Validation Report"/>
              </coding>
            </code>
            <effectiveDateTime value="2020-12"/>
            <result>
              <!-- Observation/step1Yield1 -->
              <reference
                         value="Observation/9c56948c-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/step1Yield2 -->
              <reference
                         value="Observation/9c56948a-2b39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/step1Yield3 -->
              <reference
                         value="Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/residualWaterContent1 -->
              <reference
                         value="Observation/9c56958c-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/residualWaterContent2 -->
              <reference
                         value="Observation/9c56968a-2b39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/residualWaterContent3 -->
              <reference
                         value="Observation/9c56978a-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/appearanceSubstance1 -->
              <reference
                         value="Observation/9c56948c-2a39-6609-2c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/appearanceSubstance2 -->
              <reference
                         value="Observation/9c56948c-2a49-6609-2c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/appearanceSubstance3 -->
              <reference
                         value="Observation/9c56948c-2a39-6609-2c01-4d197eb57a33"/>
            </result>
            <result>
              <!-- Observation/identificationSubstance1 -->
              <reference
                         value="Observation/9c56958c-2a39-6609-2c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/identificationSubstance2 -->
              <reference
                         value="Observation/9c56968c-2a49-6609-2c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/identificationSubstance3 -->
              <reference
                         value="Observation/9c56978c-2a39-6609-2c01-4d197eb57a33"/>
            </result>
            <result>
              <!-- Observation/step2Yield1 -->
              <reference
                         value="Observation/9c56948d-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/step2Yield2 -->
              <reference
                         value="Observation/9c56948c-2b39-6609-1c01-4d197ea57a33"/>
            </result>
            <result>
              <!-- Observation/step2Yield3 -->
              <reference
                         value="Observation/9c56948b-2a39-6609-1c01-4d197ea57a33"/>
            </result>
            <conclusion
                        value="The samples have been assessed and the conclusion is..."/>
          </DiagnosticReport>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        <resource>
          <ObservationDefinition>
            <!-- AppearanceSubstance -->
            <id value="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a><a name="hcfc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc07b5d5-9fe1-92c2-2d06-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></p><p><b>title</b>: Appearance</p><p><b>status</b>: active</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>method</b>: Visual inspection <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72 -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
            <title value="Appearance"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Appearance"/>
                <display value="Appearance"/>
              </coding>
              <text value="Appearance"/>
            </code>
            <method>
              <text value="Visual inspection"/>
            </method>
            <qualifiedValue>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
                <valueString
                             value="White to off-white, to red, to orange, to brown solid"/>
              </extension>
            </qualifiedValue>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        <resource>
          <ObservationDefinition>
            <!-- IdentificationSubstance -->
            <id value="3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a><a name="hc3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;3b1e878e-4bc9-8864-862f-e28b21233e8d&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></p><p><b>title</b>: ID by HPLC</p><p><b>status</b>: active</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>method</b>: ID by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
            <title value="ID by HPLC"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="IDT"/>
                <display value="Identification"/>
              </coding>
              <text value="ID by HPLC"/>
            </code>
            <method>
              <text value="ID by UHPLC"/>
            </method>
            <qualifiedValue>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
                <valueString value="Conforms to standard"/>
              </extension>
            </qualifiedValue>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
        <resource>
          <ObservationDefinition>
            <!-- AssaySubstance -->
            <id value="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a><a name="hc12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;12e7e672-40a6-4036-3c1f-b8ba6a7d045e&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></p><p><b>title</b>: Assay by HPLC (as is) (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Assay by HPLC (as is) (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY &quot;Assay&quot;)</span></p><p><b>method</b>: Assay by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>95-101 %</td></tr></table></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
            <title value="Assay by HPLC (as is) (w/w%)"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="ASSAY"/>
                <display value="Assay"/>
              </coding>
              <text value="Assay by HPLC (as is) (w/w%)"/>
            </code>
            <method>
              <text value="Assay by UHPLC"/>
            </method>
            <qualifiedValue>
              <range>
                <low>
                  <value value="95"/>
                  <unit value="%"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="%"/>
                </low>
                <high>
                  <value value="101"/>
                  <unit value="%"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="%"/>
                </high>
              </range>
            </qualifiedValue>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        <resource>
          <ObservationDefinition>
            <!-- Step1Yield -->
            <id value="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a><a name="hcfd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fd17b5d6-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72 -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
            <title value="Yield (%)"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        <resource>
          <ObservationDefinition>
            <!-- Step2Yield -->
            <id value="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a><a name="hcfd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fd17b5d7-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72 -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
            <title value="Yield (%)"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        <resource>
          <ObservationDefinition>
            <!-- ResidualWaterContent -->
            <id value="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a><a name="hcfc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc27b5d6-9fe1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Residual Water Content (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Residual Water Content (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-7.15</td></tr></table></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72 -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
            <title value="Residual Water Content (w/w%)"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="ResidualWaterContent"/>
                <display value="Residual Water Content (w/w%)"/>
              </coding>
              <text value="Residual Water Content (w/w%)"/>
            </code>
            <qualifiedValue>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality"/>
                    <code value="Non-critical"/>
                    <display value="Non-critical"/>
                  </coding>
                  <text value="Non-critical"/>
                </valueCodeableConcept>
              </extension>
              <range>
                <high>
                  <value value="7.15"/>
                  <unit value="%"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="%"/>
                </high>
              </range>
            </qualifiedValue>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
        <resource>
          <ObservationDefinition>
            <!-- ResidualStartingMaterial1byHPLC -->
            <id value="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a><a name="hcfc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc27b5d6-9ff1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)</p><p><b>status</b>: active</p><p><b>code</b>: Reaction conversion: Residual Starting Material 1 by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Reaction conversion: Residual Starting Material 1 by HPLC)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-23</td></tr></table></div>
            </text>
            <!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72 -->
            <url
                 value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
            <title
                   value="Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)"/>
            <status value="active"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code
                      value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
                <display
                         value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
              </coding>
              <text
                    value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
            </code>
            <qualifiedValue>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality"/>
                    <code value="critical"/>
                    <display value="Critical"/>
                  </coding>
                  <text value="Critical"/>
                </valueCodeableConcept>
              </extension>
              <range>
                <high>
                  <value value="23"/>
                  <unit value="%"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="%"/>
                </high>
              </range>
            </qualifiedValue>
          </ObservationDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- appearanceSubstance1 -->
            <id value="9c56948c-2a39-6609-2c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197ea57a33"> </a><a name="hc9c56948c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/AppearanceSubstance -->
              <reference
                         value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Appearance"/>
                <display value="Appearance"/>
              </coding>
              <text value="Appearance"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-1 -->
              <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Off-white solid"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948c-2a49-6609-2c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- appearanceSubstance2 -->
            <id value="9c56948c-2a49-6609-2c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a49-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a49-6609-2c01-4d197ea57a33"> </a><a name="hc9c56948c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/AppearanceSubstance -->
              <reference
                         value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Appearance"/>
                <display value="Appearance"/>
              </coding>
              <text value="Appearance"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-2 -->
              <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Off-white solid"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197eb57a33"/>
        <resource>
          <Observation>
            <!-- appearanceSubstance3 -->
            <id value="9c56948c-2a39-6609-2c01-4d197eb57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-2c01-4d197eb57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197eb57a33"> </a><a name="hc9c56948c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/AppearanceSubstance -->
              <reference
                         value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Appearance"/>
                <display value="Appearance"/>
              </coding>
              <text value="Appearance"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-3 -->
              <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Off-white solid"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56958c-2a39-6609-2c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- identificationSubstance1 -->
            <id value="9c56958c-2a39-6609-2c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56958c-2a39-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-2c01-4d197ea57a33"> </a><a name="hc9c56958c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56958c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/IdentificationSubstance -->
              <reference
                         value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="IDT"/>
                <display value="Identification"/>
              </coding>
              <text value="ID by HPLC"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-1 -->
              <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Conforms"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56968c-2a49-6609-2c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- identificationSubstance2 -->
            <id value="9c56968c-2a49-6609-2c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56968c-2a49-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56968c-2a49-6609-2c01-4d197ea57a33"> </a><a name="hc9c56968c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56968c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/IdentificationSubstance -->
              <reference
                         value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="IDT"/>
                <display value="Identification"/>
              </coding>
              <text value="ID by HPLC"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-2 -->
              <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Conforms"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56978c-2a39-6609-2c01-4d197eb57a33"/>
        <resource>
          <Observation>
            <!-- identificationSubstance3 -->
            <id value="9c56978c-2a39-6609-2c01-4d197eb57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56978c-2a39-6609-2c01-4d197eb57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56978c-2a39-6609-2c01-4d197eb57a33"> </a><a name="hc9c56978c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56978c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Does not conform</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/IdentificationSubstance -->
              <reference
                         value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="IDT"/>
                <display value="Identification"/>
              </coding>
              <text value="ID by HPLC"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-3 -->
              <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueString value="Does not conform"/>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948c-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step1Yield1 -->
            <id value="9c56948c-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 75 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step1Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-1 -->
              <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="75"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948a-2b39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step1Yield2 -->
            <id value="9c56948a-2b39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948a-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948a-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 77 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step1Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-2 -->
              <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="77"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step1Yield3 -->
            <id value="9c56948a-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948a-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948a-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 76 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step1Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-3 -->
              <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="76"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948d-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step2Yield1 -->
            <id value="9c56948d-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948d-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948d-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948d-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948d-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9754-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 85 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step2Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-step2-1 -->
              <reference value="Substance/fc178763-81c5-5656-9754-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="85"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948c-2b39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step2Yield2 -->
            <id value="9c56948c-2b39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948c-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9764-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 87 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step2Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-step2-2 -->
              <reference value="Substance/fc178764-81d5-5656-9764-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="87"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56948b-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- step2Yield3 -->
            <id value="9c56948b-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948b-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948b-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948b-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948b-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-6656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 86 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/Step2Yield -->
              <reference
                         value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="Yield (%)"/>
                <display value="Yield (%)"/>
              </coding>
              <text value="Yield (%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-step2-3 -->
              <reference value="Substance/fc178764-81d6-6656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="86"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56958c-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- residualWaterContent1 -->
            <id value="9c56958c-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56958c-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56958c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56958c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.9 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/ResidualWaterContent -->
              <reference
                         value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="ResidualWaterContent"/>
                <display value="Residual Water Content (w/w%)"/>
              </coding>
              <text value="ResidualWaterContent (w/w%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-1 -->
              <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="6.9"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56968a-2b39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- residualWaterContent2 -->
            <id value="9c56968a-2b39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56968a-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56968a-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56968a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56968a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 7.0 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/ResidualWaterContent -->
              <reference
                         value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="ResidualWaterContent"/>
                <display value="Residual Water Content (w/w%)"/>
              </coding>
              <text value="ResidualWaterContent (w/w%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-2 -->
              <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="7.0"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:9c56978a-2a39-6609-1c01-4d197ea57a33"/>
        <resource>
          <Observation>
            <!-- residualWaterContent3 -->
            <id value="9c56978a-2a39-6609-1c01-4d197ea57a33"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56978a-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56978a-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56978a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56978a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.8 %</p></div>
            </text>
            <instantiatesReference>
              <!-- ObservationDefinition/ResidualWaterContent -->
              <reference
                         value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
            </instantiatesReference>
            <status value="final"/>
            <code>
              <coding>
                <system
                        value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
                <code value="ResidualWaterContent"/>
                <display value="Residual Water Content (w/w%)"/>
              </coding>
              <text value="ResidualWaterContent (w/w%)"/>
            </code>
            <subject>
              <!-- Substance/actual-batch-substance-itermediate-3 -->
              <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
            </subject>
            <effectiveDateTime value="2023-01-01T12:00:00Z"/>
            <performer>
              <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
              <reference
                         value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            </performer>
            <valueQuantity>
              <value value="6.8"/>
              <unit value="%"/>
            </valueQuantity>
          </Observation>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        <resource>
          <Organization>
            <!-- substance-manufacturer -->
            <id value="23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a><p><b>Generated Narrative: Organization</b><a name="23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a><a name="hc23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;23dbbd32-2962-9fc3-40b1-67e864f21cd2&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
            </text>
            <identifier>
              <!--  FDA establishment identifier  -->
              <system value="urn:oid:2.16.840.1.113883.4.82"/>
              <value value="3003040516"/>
            </identifier>
            <active value="true"/>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
                <code value="drug-substance-manufacture"/>
                <display value="Drug Substance Manufacture"/>
              </coding>
            </type>
            <name value="AAA Molybdenum Products, Inc."/>
            <contact>
              <address>
                <line value="7233 W 116th Pl"/>
                <line value="Ste C"/>
                <city value="Broomfield"/>
                <state value="Colorado"/>
                <postalCode value="80020"/>
                <country value="USA"/>
              </address>
            </contact>
          </Organization>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        <resource>
          <Organization>
            <!-- testing lab -->
            <!-- 378fbe5f-5926-3a5c-4c64-5428df877b08 -->
            <id value="378fbe5f-5926-3a5c-4c64-5428df877b08"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><p><b>Generated Narrative: Organization</b><a name="378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><a name="hc378fbe5f-5926-3a5c-4c64-5428df877b08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;378fbe5f-5926-3a5c-4c64-5428df877b08&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3007270600</p><p><b>active</b>: true</p><p><b>type</b>: Analytical Testing - Release <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#analytical-testing-release)</span></p><p><b>name</b>: Testing Lab</p></div>
            </text>
            <identifier>
              <system value="urn:oid:2.16.840.1.113883.4.82"/>
              <value value="3007270600"/>
            </identifier>
            <active value="true"/>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
                <code value="analytical-testing-release"/>
                <display value="Analytical Testing - Release"/>
              </coding>
            </type>
            <name value="Testing Lab"/>
          </Organization>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:57a9af63-315d-1585-a261-0e337b289390"/>
        <resource>
          <SubstanceDefinition>
            <!-- substancedefinition-component-substance-dxpq-ex1 -->
            <id value="57a9af63-315d-1585-a261-0e337b289390"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-drug-pq"/>
            </meta>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="57a9af63-315d-1585-a261-0e337b289390"> </a><a name="hc57a9af63-315d-1585-a261-0e337b289390"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;57a9af63-315d-1585-a261-0e337b289390&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-SubstanceDefinition-component-substance-drug-pq.html">SubstanceDefinition - Component Substance Drug PQ</a></p></div><p><b>manufacturer</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatolol</td></tr></table></div>
            </text>
            <manufacturer>
              <!-- Organization/organization-dxpq-ex1 -->
              <reference
                         value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
            </manufacturer>
            <name>
              <name value="Stelbatolol"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821153"/>
        <resource>
          <SubstanceDefinition>
            <!-- startingMaterial -->
            <id value="c458791f-7cb8-428e-83f7-8a205f821153"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821153"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance</td></tr></table></div>
            </text>
            <manufacturer>
              <!-- Organization/substance-manufacturer -->
              <reference
                         value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
            </manufacturer>
            <name>
              <name value="Stelbatosubstance"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-1 -->
            <id value="fc178762-81c5-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.1 kg</p></blockquote><p><b>identifier</b>: Start1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-01"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="8.1"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start1Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-2 -->
            <id value="fc178762-81d5-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178762-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.2 kg</p></blockquote><p><b>identifier</b>: Start2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-01"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="8.2"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-3 -->
            <id value="fc178762-81d5-5656-9744-23c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-23c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e595b"> </a><a name="hcfc178762-81d5-5656-9744-23c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.3 kg</p></blockquote><p><b>identifier</b>: Start3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-01"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="8.3"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start3Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821154"/>
        <resource>
          <SubstanceDefinition>
            <!-- resultingMaterial -->
            <id value="c458791f-7cb8-428e-83f7-8a205f821154"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821154"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821154"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Resultothane</td></tr></table></div>
            </text>
            <name>
              <name value="Resultothane"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821155"/>
        <resource>
          <SubstanceDefinition>
            <!-- intermediateMaterial -->
            <id value="c458791f-7cb8-428e-83f7-8a205f821155"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821155"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Processohol</td></tr></table></div>
            </text>
            <manufacturer>
              <!-- Organization/substance-manufacturer -->
              <reference
                         value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
            </manufacturer>
            <name>
              <name value="Processohol"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178763-81c5-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-1 -->
            <id value="fc178763-81c5-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178763-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178763-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178763-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="9.1"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-1 -->
                <reference
                           value="Substance/fc178762-81c5-5656-9744-13c7ad1e595b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed1Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178764-81d5-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-2 -->
            <id value="fc178764-81d5-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="9.2"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-2 -->
                <reference
                           value="Substance/fc178762-81d5-5656-9744-13c7ad1e595b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178764-81d6-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-3 -->
            <id value="fc178764-81d6-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d6-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-5656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d6-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d6-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e595b</p><p><b>identifier</b>: Intermed3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="9.3"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-3 -->
                <reference
                           value="Substance/fc178762-81d5-5656-9744-23c7ad1e595b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed3Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterial -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821153"/>
        <resource>
          <SubstanceDefinition>
            <!-- startingMaterialStep2 -->
            <id value="c458791f-8cb8-428e-83f7-8a205f821153"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821153"> </a><a name="hcc458791f-8cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance2</td></tr></table></div>
            </text>
            <manufacturer>
              <!-- Organization/substance-manufacturer -->
              <reference
                         value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
            </manufacturer>
            <name>
              <name value="Stelbatosubstance2"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad2e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-step2-1 -->
            <id value="fc178762-81c5-5656-9744-13c7ad2e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81c5-5656-9744-13c7ad2e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad2e595b"> </a><a name="hcfc178762-81c5-5656-9744-13c7ad2e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad2e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.1 kg</p></blockquote><p><b>identifier</b>: Start1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-02"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="7.1"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start1Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e596b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-step2-2 -->
            <id value="fc178762-81d5-5656-9744-13c7ad1e596b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-13c7ad1e596b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e596b"> </a><a name="hcfc178762-81d5-5656-9744-13c7ad1e596b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e596b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.2 kg</p></blockquote><p><b>identifier</b>: Start2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-02"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="7.2"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start2Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e597b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-starting-step2-3 -->
            <id value="fc178762-81d5-5656-9744-23c7ad1e597b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-23c7ad1e597b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e597b"> </a><a name="hcfc178762-81d5-5656-9744-23c7ad1e597b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e597b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.3 kg</p></blockquote><p><b>identifier</b>: Start3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-02"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="7.3"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <identifier>
              <value value="Start3Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/startingMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-7cb8-428e-84f7-8a205f821155"/>
        <resource>
          <SubstanceDefinition>
            <!-- intermediateMaterialStep2 -->
            <id value="c458791f-7cb8-428e-84f7-8a205f821155"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-84f7-8a205f821155"> </a><a name="hcc458791f-7cb8-428e-84f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-84f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ProcessoholStep2</td></tr></table></div>
            </text>
            <manufacturer>
              <!-- Organization/substance-manufacturer -->
              <reference
                         value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
            </manufacturer>
            <name>
              <name value="ProcessoholStep2"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178763-81c5-5656-9754-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-step2-1 -->
            <id value="fc178763-81c5-5656-9754-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178763-81c5-5656-9754-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9754-13c7ad1e595b"> </a><a name="hcfc178763-81c5-5656-9754-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178763-81c5-5656-9754-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad2e595b</p><p><b>identifier</b>: Intermed1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="10.1"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-step2-1 -->
                <reference
                           value="Substance/fc178762-81c5-5656-9744-13c7ad2e595b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed1Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178764-81d5-5656-9764-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-step2-2 -->
            <id value="fc178764-81d5-5656-9764-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d5-5656-9764-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9764-13c7ad1e595b"> </a><a name="hcfc178764-81d5-5656-9764-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d5-5656-9764-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e596b</p><p><b>identifier</b>: Intermed2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="10.2"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-step2-2 -->
                <reference
                           value="Substance/fc178762-81d5-5656-9744-13c7ad1e596b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed2Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc178764-81d6-6656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-itermediate-step2-3 -->
            <id value="fc178764-81d6-6656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d6-6656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-6656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d6-6656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d6-6656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e597b</p><p><b>identifier</b>: Intermed3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="10.3"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
              <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
              <valueReference>
                <!-- Substance/actual-batch-substance-starting-step2-3 -->
                <reference
                           value="Substance/fc178762-81d5-5656-9744-23c7ad1e597b"/>
              </valueReference>
            </extension>
            <identifier>
              <value value="Intermed3Step2Amgen"/>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/intermediateMaterialStep2 -->
                <reference
                           value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821154"/>
        <resource>
          <SubstanceDefinition>
            <!-- resultingMaterialStep2 -->
            <id value="c458791f-8cb8-428e-83f7-8a205f821154"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821154"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821154"> </a><a name="hcc458791f-8cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ResultothaneStep2</td></tr></table></div>
            </text>
            <name>
              <name value="ResultothaneStep2"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
        <resource>
          <Organization>
            <!-- id value="substance-manufacturer"/ -->
            <!-- organization-dxpq-ex1 -->
            <id value="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-drug-pq"/>
            </meta>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a><p><b>Generated Narrative: Organization</b><a name="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a><a name="hc49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;49d2f0c0-4b28-9271-8aaf-2996a8b9739c&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Organization-drug-pq.html">Organization - Drug PQ</a></p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
            </text>
            <identifier>
              <!--  FDA establishment identifier  -->
              <system value="urn:oid:2.16.840.1.113883.4.82"/>
              <value value="3003040516"/>
            </identifier>
            <active value="true"/>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
                <code value="drug-substance-manufacture"/>
                <display value="Drug Substance Manufacture"/>
              </coding>
            </type>
            <name value="AAA Molybdenum Products, Inc."/>
            <contact>
              <address>
                <line value="7233 W 116th Pl"/>
                <line value="Ste C"/>
                <city value="Broomfield"/>
                <state value="Colorado"/>
                <postalCode value="80020"/>
                <country value="USA"/>
              </address>
            </contact>
          </Organization>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b"/>
        <resource>
          <Substance>
            <!-- <id value="actual-batch-substance"/> -->
            <!-- substance-dxpq-ex1-unlinked -->
            <id value="fc078762-81c5-5656-9744-13c7ad1e595b"/>
            <meta>
              <profile
                       value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
            </meta>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc078762-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc078762-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc078762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc078762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.1 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB1Amgen, SUB1SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-07"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="5.1"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
              <extension url="batchUtilization">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                    <code value="C133991"/>
                    <display value="Development"/>
                  </coding>
                </valueCodeableConcept>
              </extension>
              <extension url="assignedManufacturer">
                <valueReference>
                  <!-- Organization/organization-dxpq-ex1 -->
                  <reference
                             value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
                </valueReference>
              </extension>
            </extension>
            <!--  local extension  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
              <valueDateTime value="2019-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
              <valueDateTime value="2022-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
              <valueQuantity>
                <value value="4.8"/>
                <unit value="kg"/>
              </valueQuantity>
            </extension>
            <identifier>
              <value value="SUB1Amgen"/>
            </identifier>
            <identifier>
              <value value="SUB1SiteA"/>
              <assigner>
                <!-- Organization/organization-dxpq-ex1 -->
                <reference
                           value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
              </assigner>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
                <reference
                           value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-2-unlinked -->
            <id value="cb31d747-2338-88d5-342c-8e9c097e4dad"/>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_cb31d747-2338-88d5-342c-8e9c097e4dad"> </a><p><b>Generated Narrative: Substance</b><a name="cb31d747-2338-88d5-342c-8e9c097e4dad"> </a><a name="hccb31d747-2338-88d5-342c-8e9c097e4dad"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;cb31d747-2338-88d5-342c-8e9c097e4dad&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.2 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB2Amgen, SUB2SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-07"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="5.2"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
              <extension url="batchUtilization">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                    <code value="C133991"/>
                    <display value="Development"/>
                  </coding>
                </valueCodeableConcept>
              </extension>
              <extension url="assignedManufacturer">
                <valueReference>
                  <!-- Organization/organization-dxpq-ex1 -->
                  <reference
                             value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
                </valueReference>
              </extension>
            </extension>
            <!--  local extensions  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
              <valueDateTime value="2019-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
              <valueDateTime value="2022-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
              <valueQuantity>
                <value value="4.8"/>
                <unit value="kg"/>
              </valueQuantity>
            </extension>
            <identifier>
              <value value="SUB2Amgen"/>
            </identifier>
            <identifier>
              <value value="SUB2SiteA"/>
              <assigner>
                <!-- Organization/organization-dxpq-ex1 -->
                <reference
                           value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
              </assigner>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
                <reference
                           value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
        <resource>
          <Substance>
            <!-- actual-batch-substance-3-unlinked -->
            <id value="1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a><p><b>Generated Narrative: Substance</b><a name="1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a><a name="hc1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;1551f97b-6f6d-825e-1fb3-44b0b090808c&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.3 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB3Amgen, SUB3SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
            </text>
            <extension
                       url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
              <extension url="manufacturingDate">
                <valueDateTime value="2019-09-07"/>
              </extension>
              <extension url="batchQuantity">
                <valueQuantity>
                  <value value="5.3"/>
                  <unit value="kg"/>
                </valueQuantity>
              </extension>
              <extension url="batchUtilization">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                    <code value="C133991"/>
                    <display value="Development"/>
                  </coding>
                </valueCodeableConcept>
              </extension>
              <extension url="assignedManufacturer">
                <valueReference>
                  <!-- Organization/organization-dxpq-ex1 -->
                  <reference
                             value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
                </valueReference>
              </extension>
            </extension>
            <!--  local extensions  -->
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
              <valueDateTime value="2019-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
              <valueDateTime value="2022-09-08"/>
            </extension>
            <extension
                       url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
              <valueQuantity>
                <value value="4.8"/>
                <unit value="kg"/>
              </valueQuantity>
            </extension>
            <identifier>
              <value value="SUB3Amgen"/>
            </identifier>
            <identifier>
              <value value="SUB3SiteA"/>
              <assigner>
                <!-- Organization/organization-dxpq-ex1 -->
                <reference
                           value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
              </assigner>
            </identifier>
            <instance value="true"/>
            <code>
              <reference>
                <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
                <reference
                           value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
              </reference>
            </code>
          </Substance>
        </resource>
      </entry>
    </Bundle>