Pharmaceutical Quality (Industry)
1.0.0 - STU1

Pharmaceutical Quality (Industry), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/uv-dx-pq/ and changes regularly. See the Directory of published versions

## : Example: Bundle - Impurities, substance - XML Representation

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    <Bundle xmlns="http://hl7.org/fhir">
      <!--  Substance Impurities  -->
      <id value="bundle-product-impurities-pq-ex2-sub"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-impurities-pq"/>
      </meta>
      <type value="collection"/>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-70f9-647b0ea97adb"/>
        <resource>
          <SubstanceDefinition>
            <id value="substance1"/>
            <text>
              <status value="extensions"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_substance1"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="substance1"> </a><a name="hcsubstance1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;substance1&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/062bf235-44e2-55c4-9213-bbe5e12d5620</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatolol</td></tr></table><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Enantiomer of API SM <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-impurity-origin.html">Impurity Origin Codes</a>#enantiomer &quot;Enantiomer&quot;)</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad1</p><p><b>type</b>: Impurity Of <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html">Substance Relationship Type</a>#Impurity; <a href="CodeSystem-impurity-type.html">Impurity Type Codes</a>#CH-IMP &quot;Chiral Impurity&quot;)</span></p><p><b>amount</b>: ND</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Step 1a Process Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-impurity-origin.html">Impurity Origin Codes</a>#process &quot;Process Impurity&quot;)</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad2</p><p><b>type</b>: Impurity Of <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html">Substance Relationship Type</a>#Impurity; <a href="CodeSystem-impurity-type.html">Impurity Type Codes</a>#PR-IMP &quot;Process impurity&quot;)</span></p><p><b>amount</b>: Range: ND-0.2%</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Step 1a Process Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-impurity-origin.html">Impurity Origin Codes</a>#process &quot;Process Impurity&quot;)</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad9</p><p><b>type</b>: Impurity Of <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html">Substance Relationship Type</a>#Impurity; <a href="CodeSystem-impurity-type.html">Impurity Type Codes</a>#PR-IMP &quot;Process impurity&quot;)</span></p><p><b>amount</b>: Range: ND–0.3%</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: API Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-impurity-origin.html">Impurity Origin Codes</a>#starting-material &quot;Starting Material&quot;)</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad3</p><p><b>type</b>: Impurity Of <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html">Substance Relationship Type</a>#Impurity; <a href="CodeSystem-impurity-type.html">Impurity Type Codes</a>#ST-IMP &quot;Starting material, forced degradation product&quot;)</span></p><p><b>amount</b>: Observed only during stress studies</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: API Process Intermediate <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-impurity-origin.html">Impurity Origin Codes</a>#intermediate-material &quot;Intermediate Material&quot;)</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad4</p><p><b>type</b>: Impurity Of <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html">Substance Relationship Type</a>#Impurity; <a href="CodeSystem-impurity-type.html">Impurity Type Codes</a>#INT-IMP &quot;Process intermediate, forced degradation product&quot;)</span></p><p><b>amount</b>: Observed only during stress studies</p></blockquote></div>
            </text>
            <manufacturer>
              <!-- Organization/substance-manufacturer -->
              <reference
                         value="Organization/062bf235-44e2-55c4-9213-bbe5e12d5620"/>
            </manufacturer>
            <name>
              <name value="Stelbatolol"/>
            </name>
            <relationship>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/impurity-origin"/>
                    <code value="enantiomer"/>
                    <display value="Enantiomer"/>
                  </coding>
                  <text value="Enantiomer of API SM"/>
                </valueCodeableConcept>
              </extension>
              <substanceDefinitionReference>
                <!-- SubstanceDefinition/impurityEnantiomer -->
                <reference
                           value="SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
              </substanceDefinitionReference>
              <type>
                <!--  two codes here, one is more specialised than the other  -->
                <coding>
                  <system
                          value="http://hl7.org/fhir/substance-relationship-type"/>
                  <code value="Impurity"/>
                  <display value="Impurity Of"/>
                </coding>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/impurity-type"/>
                  <code value="CH-IMP"/>
                  <display value="Chiral Impurity"/>
                </coding>
              </type>
              <amountString value="ND"/>
            </relationship>
            <relationship>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/impurity-origin"/>
                    <code value="process"/>
                    <display value="Process Impurity"/>
                  </coding>
                  <text value="Step 1a Process Impurity"/>
                </valueCodeableConcept>
              </extension>
              <substanceDefinitionReference>
                <!-- SubstanceDefinition/impurity1 -->
                <reference
                           value="SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
              </substanceDefinitionReference>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/substance-relationship-type"/>
                  <code value="Impurity"/>
                  <display value="Impurity Of"/>
                </coding>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/impurity-type"/>
                  <code value="PR-IMP"/>
                  <display value="Process impurity"/>
                </coding>
              </type>
              <amountString value="Range: ND-0.2%"/>
            </relationship>
            <relationship>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/impurity-origin"/>
                    <code value="process"/>
                    <display value="Process Impurity"/>
                  </coding>
                  <text value="Step 1a Process Impurity"/>
                </valueCodeableConcept>
              </extension>
              <substanceDefinitionReference>
                <!-- SubstanceDefinition/impurity2 -->
                <reference
                           value="SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
              </substanceDefinitionReference>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/substance-relationship-type"/>
                  <code value="Impurity"/>
                  <display value="Impurity Of"/>
                </coding>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/impurity-type"/>
                  <code value="PR-IMP"/>
                  <display value="Process impurity"/>
                </coding>
              </type>
              <amountString value="Range: ND–0.3%"/>
            </relationship>
            <relationship>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/impurity-origin"/>
                    <code value="starting-material"/>
                    <display value="Starting Material"/>
                  </coding>
                  <text value="API Starting Material"/>
                </valueCodeableConcept>
              </extension>
              <substanceDefinitionReference>
                <!-- SubstanceDefinition/impurityNapthol -->
                <reference
                           value="SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
              </substanceDefinitionReference>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/substance-relationship-type"/>
                  <code value="Impurity"/>
                  <display value="Impurity Of"/>
                </coding>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/impurity-type"/>
                  <code value="ST-IMP"/>
                  <display value="Starting material, forced degradation product"/>
                </coding>
              </type>
              <amountString value="Observed only during stress studies"/>
            </relationship>
            <relationship>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq">
                <valueCodeableConcept>
                  <coding>
                    <system
                            value="http://terminology.hl7.org/CodeSystem/impurity-origin"/>
                    <code value="intermediate-material"/>
                    <display value="Intermediate Material"/>
                  </coding>
                  <text value="API Process Intermediate"/>
                </valueCodeableConcept>
              </extension>
              <substanceDefinitionReference>
                <!-- SubstanceDefinition/impurityPropanol -->
                <reference
                           value="SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
              </substanceDefinitionReference>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/substance-relationship-type"/>
                  <code value="Impurity"/>
                  <display value="Impurity Of"/>
                </coding>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/impurity-type"/>
                  <code value="INT-IMP"/>
                  <display
                           value="Process intermediate, forced degradation product"/>
                </coding>
              </type>
              <amountString value="Observed only during stress studies"/>
            </relationship>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
        <resource>
          <SubstanceDefinition>
            <!-- impurityEnantiomer -->
            <id value="03d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="03d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a><a name="hc03d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;03d68d1c-162c-8b6e-80f9-647b0ea97ad1&quot; </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Enantiomeric purity by LC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: Mass spectrometry <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Amount</b></td></tr><tr><td style="display: none">*</td><td>295.80 g/mole<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Document</b></td></tr><tr><td style="display: none">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad1</td></tr></table></blockquote><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>R-enantiomer of stelbatalol</td></tr></table></div>
            </text>
            <characterization>
              <technique>
                <text value="Enantiomeric purity by LC"/>
              </technique>
            </characterization>
            <characterization>
              <technique>
                <text value="Mass spectrometry"/>
              </technique>
            </characterization>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="1233444"/>
                  <display value="Rule-based (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123555"/>
                  <display value="Statistical (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123556"/>
                  <display value="ICH M7 Classification"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="class-5"/>
                  <display value="Class 5"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123557"/>
                  <display value="Mutagenicity Comment"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <text
                      value="Treated as non-mutagenic due to lack of alerting structure"/>
              </valueCodeableConcept>
            </property>
            <molecularWeight>
              <amount>
                <value value="295.80"/>
                <unit value="g/mole"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="g/mol"/>
              </amount>
            </molecularWeight>
            <structure>
              <representation>
                <document>
                  <!-- DocumentReference/impurityEnantiomerdoc -->
                  <reference
                             value="DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
                </document>
              </representation>
            </structure>
            <name>
              <name value="R-enantiomer of stelbatalol"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
        <resource>
          <DocumentReference>
            <!-- impurityEnantiomerdoc -->
            <id value="13d68d1c-162c-8b6e-80f9-647b0ea97ad1"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a><p><b>Generated Narrative: DocumentReference</b><a name="13d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a><a name="hc13d68d1c-162c-8b6e-80f9-647b0ea97ad1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DocumentReference &quot;13d68d1c-162c-8b6e-80f9-647b0ea97ad1&quot; </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style="display: none">*</td><td>image/x-png</td><td>(base64 data - 4429 bytes)</td></tr></table></blockquote></div>
            </text>
            <status value="current"/>
            <content>
              <attachment>
                <contentType value="image/x-png"/>
                <data
                      value=" "/>
              </attachment>
            </content>
          </DocumentReference>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
        <resource>
          <SubstanceDefinition>
            <!-- impurity1 -->
            <id value="03d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="03d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a><a name="hc03d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;03d68d1c-162c-8b6e-80f9-647b0ea97ad2&quot; </p></div><h3>Characterizations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Technique</b></td></tr><tr><td style="display: none">*</td><td>Organic impurities by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Amount</b></td></tr><tr><td style="display: none">*</td><td>344.4 g/mole<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Document</b></td></tr><tr><td style="display: none">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad2</td></tr></table></blockquote><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Impurity 1</td></tr></table></div>
            </text>
            <characterization>
              <technique>
                <text value="Organic impurities by HPLC"/>
              </technique>
            </characterization>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="1233444"/>
                  <display value="Rule-based (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123555"/>
                  <display value="Statistical (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123556"/>
                  <display value="ICH M7 Classification"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="class-5"/>
                  <display value="Class 5"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123557"/>
                  <display value="Mutagenicity Comment"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <text
                      value="Treated as non-mutagenic due to lack of alerting structure"/>
              </valueCodeableConcept>
            </property>
            <molecularWeight>
              <amount>
                <value value="344.4"/>
                <unit value="g/mole"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="g/mol"/>
              </amount>
            </molecularWeight>
            <structure>
              <representation>
                <document>
                  <!-- DocumentReference/impurity1doc -->
                  <reference
                             value="DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
                </document>
              </representation>
            </structure>
            <name>
              <name value="Impurity 1"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
        <resource>
          <DocumentReference>
            <!-- impurity1doc -->
            <id value="13d68d1c-162c-8b6e-80f9-647b0ea97ad2"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a><p><b>Generated Narrative: DocumentReference</b><a name="13d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a><a name="hc13d68d1c-162c-8b6e-80f9-647b0ea97ad2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DocumentReference &quot;13d68d1c-162c-8b6e-80f9-647b0ea97ad2&quot; </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style="display: none">*</td><td>image/x-png</td><td>(base64 data - 7004 bytes)</td></tr></table></blockquote></div>
            </text>
            <status value="current"/>
            <content>
              <attachment>
                <contentType value="image/x-png"/>
                <data
                      value=" "/>
              </attachment>
            </content>
          </DocumentReference>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
        <resource>
          <SubstanceDefinition>
            <!-- impurity2 -->
            <id value="03d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="03d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a><a name="hc03d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;03d68d1c-162c-8b6e-80f9-647b0ea97ad9&quot; </p></div><h3>Characterizations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Technique</b></td></tr><tr><td style="display: none">*</td><td>Organic impurities by LC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Amount</b></td></tr><tr><td style="display: none">*</td><td>459.58 g/mole<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Document</b></td></tr><tr><td style="display: none">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad9</td></tr></table></blockquote><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Impurity 2</td></tr></table></div>
            </text>
            <characterization>
              <technique>
                <text value="Organic impurities by LC"/>
              </technique>
            </characterization>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="1233444"/>
                  <display value="Rule-based (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123555"/>
                  <display value="Statistical (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123556"/>
                  <display value="ICH M7 Classification"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="class-5"/>
                  <display value="Class 5"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123557"/>
                  <display value="Mutagenicity Comment"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <text
                      value="Treated as non-mutagenic due to lack of alerting structure"/>
              </valueCodeableConcept>
            </property>
            <molecularWeight>
              <amount>
                <value value="459.58"/>
                <unit value="g/mole"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="g/mol"/>
              </amount>
            </molecularWeight>
            <structure>
              <representation>
                <document>
                  <!-- DocumentReference/impurity2doc -->
                  <reference
                             value="DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
                </document>
              </representation>
            </structure>
            <name>
              <name value="Impurity 2"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
        <resource>
          <DocumentReference>
            <!-- impurity2doc -->
            <id value="13d68d1c-162c-8b6e-80f9-647b0ea97ad9"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a><p><b>Generated Narrative: DocumentReference</b><a name="13d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a><a name="hc13d68d1c-162c-8b6e-80f9-647b0ea97ad9"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DocumentReference &quot;13d68d1c-162c-8b6e-80f9-647b0ea97ad9&quot; </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style="display: none">*</td><td>image/x-png</td><td>(base64 data - 7149 bytes)</td></tr></table></blockquote></div>
            </text>
            <status value="current"/>
            <content>
              <attachment>
                <contentType value="image/x-png"/>
                <data
                      value=" "/>
              </attachment>
            </content>
          </DocumentReference>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
        <resource>
          <SubstanceDefinition>
            <!-- impurityNapthol -->
            <id value="03d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="03d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a><a name="hc03d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;03d68d1c-162c-8b6e-80f9-647b0ea97ad3&quot; </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Organic impurities by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: Chromatographic retention <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Amount</b></td></tr><tr><td style="display: none">*</td><td>144.173 g/mole<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><blockquote><p><b>representation</b></p><p><b>document</b>: See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad3</p></blockquote><blockquote><p><b>representation</b></p><p><b>type</b>: SMILES <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-representation-format.html">Substance Representation Format</a>#SMILES)</span></p><p><b>representation</b>: OC1=CC2=C(C=C1)C=CC=C2</p></blockquote><blockquote><p><b>representation</b></p><p><b>type</b>: InChI <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-substance-representation-format.html">Substance Representation Format</a>#InChI)</span></p><p><b>representation</b>: 1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H</p></blockquote></blockquote><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>2-Naphthol <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-CAS.html">Chemical abstract codes</a>#135-19-3)</span></td></tr></table><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>β-naphthol</td></tr></table></div>
            </text>
            <characterization>
              <technique>
                <text value="Organic impurities by HPLC"/>
              </technique>
            </characterization>
            <characterization>
              <technique>
                <text value="Chromatographic retention"/>
              </technique>
            </characterization>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="1233444"/>
                  <display value="Rule-based (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123555"/>
                  <display value="Statistical (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="negative"/>
                  <display value="Negative"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123556"/>
                  <display value="ICH M7 Classification"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="class-5"/>
                  <display value="Class 5"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123557"/>
                  <display value="Mutagenicity Comment"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <text
                      value="Treated as non-mutagenic due to lack of alerting structure"/>
              </valueCodeableConcept>
            </property>
            <molecularWeight>
              <amount>
                <value value="144.173"/>
                <unit value="g/mole"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="g/mol"/>
              </amount>
            </molecularWeight>
            <structure>
              <representation>
                <document>
                  <!-- DocumentReference/impurityNaptholDoc -->
                  <reference
                             value="DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
                </document>
              </representation>
              <representation>
                <type>
                  <coding>
                    <system
                            value="http://hl7.org/fhir/substance-representation-format"/>
                    <code value="SMILES"/>
                    <display value="SMILES"/>
                  </coding>
                </type>
                <representation value="OC1=CC2=C(C=C1)C=CC=C2"/>
              </representation>
              <representation>
                <type>
                  <coding>
                    <system
                            value="http://hl7.org/fhir/substance-representation-format"/>
                    <code value="InChI"/>
                    <display value="InChI"/>
                  </coding>
                </type>
                <representation
                                value="1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H"/>
              </representation>
            </structure>
            <code>
              <code>
                <coding>
                  <system value="http://terminology.hl7.org/CodeSystem/CAS"/>
                  <code value="135-19-3"/>
                  <display value="2-Naphthol"/>
                </coding>
              </code>
            </code>
            <name>
              <name value="β-naphthol"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
        <resource>
          <DocumentReference>
            <!-- impurityNaptholDoc -->
            <id value="13d68d1c-162c-8b6e-80f9-647b0ea97ad3"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a><p><b>Generated Narrative: DocumentReference</b><a name="13d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a><a name="hc13d68d1c-162c-8b6e-80f9-647b0ea97ad3"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DocumentReference &quot;13d68d1c-162c-8b6e-80f9-647b0ea97ad3&quot; </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style="display: none">*</td><td>image/x-png</td><td>(base64 data - 4093 bytes)</td></tr></table></blockquote></div>
            </text>
            <status value="current"/>
            <content>
              <attachment>
                <contentType value="image/x-png"/>
                <data
                      value=" "/>
              </attachment>
            </content>
          </DocumentReference>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
        <resource>
          <SubstanceDefinition>
            <!-- impurityPropanol -->
            <id value="03d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="03d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a><a name="hc03d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;03d68d1c-162c-8b6e-80f9-647b0ea97ad4&quot; </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Impurity content by LC-MS <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: UV spectroscopy <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: NMR spectroscopy <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Positive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#positive)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Positive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#positive)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-value-pq-example.html">Substance Property Value - example</a>#class-2)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-substance-property-pq-example.html">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Control at or below qualification threshold <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Amount</b></td></tr><tr><td style="display: none">*</td><td>245.32 g/mole<span style="background: LightGoldenRodYellow"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Document</b></td></tr><tr><td style="display: none">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad4</td></tr></table></blockquote><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>1-(Ethylamino)-3-(2-naphthyloxy)-2-propanol</td></tr></table></div>
            </text>
            <characterization>
              <technique>
                <text value="Impurity content by LC-MS"/>
              </technique>
            </characterization>
            <characterization>
              <technique>
                <text value="UV spectroscopy"/>
              </technique>
            </characterization>
            <characterization>
              <technique>
                <text value="NMR spectroscopy"/>
              </technique>
            </characterization>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="1233444"/>
                  <display value="Rule-based (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="positive"/>
                  <display value="Positive"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123555"/>
                  <display value="Statistical (Q)Sar"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="positive"/>
                  <display value="Positive"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123556"/>
                  <display value="ICH M7 Classification"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"/>
                  <code value="class-2"/>
                  <display value="Class 2"/>
                </coding>
              </valueCodeableConcept>
            </property>
            <property>
              <type>
                <coding>
                  <system
                          value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"/>
                  <code value="123557"/>
                  <display value="Mutagenicity Comment"/>
                </coding>
              </type>
              <valueCodeableConcept>
                <text value="Control at or below qualification threshold"/>
              </valueCodeableConcept>
            </property>
            <molecularWeight>
              <amount>
                <value value="245.32"/>
                <unit value="g/mole"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="g/mol"/>
              </amount>
            </molecularWeight>
            <structure>
              <representation>
                <document>
                  <!-- DocumentReference/impurityPropanolDoc -->
                  <reference
                             value="DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
                </document>
              </representation>
            </structure>
            <!--  not in CAS  -->
            <name>
              <name value="1-(Ethylamino)-3-(2-naphthyloxy)-2-propanol"/>
            </name>
          </SubstanceDefinition>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
        <resource>
          <DocumentReference>
            <!-- impurityPropanolDoc -->
            <id value="13d68d1c-162c-8b6e-80f9-647b0ea97ad4"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a><p><b>Generated Narrative: DocumentReference</b><a name="13d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a><a name="hc13d68d1c-162c-8b6e-80f9-647b0ea97ad4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DocumentReference &quot;13d68d1c-162c-8b6e-80f9-647b0ea97ad4&quot; </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style="display: none">*</td><td>image/x-png</td><td>(base64 data - 5119 bytes)</td></tr></table></blockquote></div>
            </text>
            <status value="current"/>
            <content>
              <attachment>
                <contentType value="image/x-png"/>
                <data
                      value=" "/>
              </attachment>
            </content>
          </DocumentReference>
        </resource>
      </entry>
      <entry>
        <fullUrl value="urn:uuid:062bf235-44e2-55c4-9213-bbe5e12d5620"/>
        <resource>
          <Organization>
            <!-- substance-manufacturer -->
            <id value="062bf235-44e2-55c4-9213-bbe5e12d5620"/>
            <text>
              <status value="generated"/>
              <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_062bf235-44e2-55c4-9213-bbe5e12d5620"> </a><p><b>Generated Narrative: Organization</b><a name="062bf235-44e2-55c4-9213-bbe5e12d5620"> </a><a name="hc062bf235-44e2-55c4-9213-bbe5e12d5620"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;062bf235-44e2-55c4-9213-bbe5e12d5620&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
            </text>
            <identifier>
              <!--  FDA establishment identifier  -->
              <system value="urn:oid:2.16.840.1.113883.4.82"/>
              <value value="3003040516"/>
            </identifier>
            <active value="true"/>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
                <code value="drug-substance-manufacture"/>
                <display value="Drug Substance Manufacture"/>
              </coding>
            </type>
            <name value="AAA Molybdenum Products, Inc."/>
            <contact>
              <address>
                <line value="7233 W 116th Pl"/>
                <line value="Ste C"/>
                <city value="Broomfield"/>
                <state value="Colorado"/>
                <postalCode value="80020"/>
                <country value="USA"/>
              </address>
            </contact>
          </Organization>
        </resource>
      </entry>
    </Bundle>