Pharmaceutical Quality (Industry)
1.0.0 - STU1

Pharmaceutical Quality (Industry), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/uv-dx-pq/ and changes regularly. See the Directory of published versions

## : Example: Bundle - Process Validation, substance - JSON Representation

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    {
      "resourceType" : "Bundle",
      "id" : "bundle-product-process-validation-pq-ex2-sub",
      "meta" : //  Substance Process Validation
      {
        "profile" : [
          🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"
        ]
      },
      "type" : "collection",
      "entry" : [
        {
          "fullUrl" : "urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f",
          "resource" : {
            "resourceType" : "PlanDefinition",
            "id" : "2038e4c7-22b8-4c56-2d28-6c077648763f",
            "text" : // validationProtocol
            {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f\"> </a><p><b>Generated Narrative: PlanDefinition</b><a name=\"2038e4c7-22b8-4c56-2d28-6c077648763f\"> </a><a name=\"hc2038e4c7-22b8-4c56-2d28-6c077648763f\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource PlanDefinition &quot;2038e4c7-22b8-4c56-2d28-6c077648763f&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#workflow-definition; <a href=\"CodeSystem-pharmaceutical-plan-type.html\">Pharmaceutical Plan Type Codes</a>#process-validation &quot;Process Validation&quot;)</span></p><p><b>status</b>: active</p><p><b>subject</b>: See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><blockquote><p><b>Extension - Process Parameters PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Mix speed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-process-parameter.html\">Process Parameter Codes</a>#SPEED)</span></p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1500 rpm</p></blockquote><p><b>prefix</b>: 1</p><p><b>title</b>: Step 1 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Particle Size Reduction <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-step.html\">Manufacturing Step Codes</a>#particleSizeReduction)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 In-Process Control Data</p><p><b>code</b>: Step 1 In-Process Control Data <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-step.html\">Manufacturing Step Codes</a>#Step1In-ProcessControlData)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</a></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72\">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 DS Release Testing Results</p><p><b>code</b>: Step 1 DS Release Testing Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-step.html\">Manufacturing Step Codes</a>#Step1DSReleaseTestingResults)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\">http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</a></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d\">http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</a></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e\">http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><p><b>prefix</b>: 2</p><p><b>title</b>: Step 2 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Drying <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-step.html\">Manufacturing Step Codes</a>#drying)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-manufacturing-participant-role.html\">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><a href=\"http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\">http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote></div>"
            },
            "url" : "http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f",
            "title" : "DP PROCESS VALIDATION",
            "type" : // http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f
            {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
                  "code" : "workflow-definition",
                  "display" : "Workflow Definition"
                },
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-plan-type",
                  "code" : "process-validation",
                  "display" : "Process Validation"
                }
              ]
            },
            "status" : "active",
            "subjectReference" : {
              "reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
            },
            "description" : "Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...",
            "action" : [
              // SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq",
                    "valueCoding" : {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step-scale",
                      "code" : "PROD",
                      "display" : "Production Scale"
                    }
                  },
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-parameters-pq",
                    "extension" : [
                      {
                        "url" : "parameter",
                        "valueCodeableConcept" : {
                          "coding" : [
                            {
                              "system" : "http://terminology.hl7.org/CodeSystem/process-parameter",
                              "code" : "SPEED",
                              "display" : "Mix speed"
                            }
                          ]
                        }
                      },
                      {
                        "url" : "value",
                        "valueQuantity" : {
                          "value" : 1500,
                          "unit" : "rpm"
                        }
                      }
                    ]
                  }
                ],
                "prefix" : "1",
                "title" : "Step 1 Yield",
                "description" : "Description of this step",
                "code" : // text value="Step 2 in the process - free text is possible"/
                {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step",
                      "code" : "particleSizeReduction",
                      "display" : "Particle Size Reduction"
                    }
                  ]
                },
                "participant" : [
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
                          }
                        }
                      ],
                      "display" : "Starting material"
                    },
                    "role" : // SubstanceDefinition/startingMaterial
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "StartingMaterial",
                          "display" : "Starting Material"
                        }
                      ]
                    }
                  },
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
                          }
                        }
                      ],
                      "display" : "Intermediate material"
                    },
                    "role" : // SubstanceDefinition/intermediateMaterial
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "IntermediateMaterial",
                          "display" : "Intermediate Material"
                        }
                      ]
                    }
                  },
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821154"
                          }
                        }
                      ],
                      "display" : "Resulting material"
                    },
                    "role" : // SubstanceDefinition/resultingMaterial
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "ResultingMaterial",
                          "display" : "Resulting Material"
                        }
                      ]
                    }
                  }
                ],
                "action" : [
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
                  }
                ]
              },
              // ObservationDefinition/Step1Yield
              {
                "title" : "Step 1 In-Process Control Data",
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step",
                      "code" : "Step1In-ProcessControlData",
                      "display" : "Step 1 In-Process Control Data"
                    }
                  ]
                },
                "action" : [
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
                  },
                  // ObservationDefinition/ResidualWaterContent
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"
                  }
                ]
              },
              // ObservationDefinition/ResidualStartingMaterial1byHPLC
              {
                "title" : "Step 1 DS Release Testing Results",
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step",
                      "code" : "Step1DSReleaseTestingResults",
                      "display" : "Step 1 DS Release Testing Results"
                    }
                  ]
                },
                "action" : [
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
                  },
                  // ObservationDefinition/AppearanceSubstance
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
                  },
                  // ObservationDefinition/IdentificationSubstance
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"
                  }
                ]
              },
              // ObservationDefinition/AssaySubstance
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq",
                    "valueCoding" : {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step-scale",
                      "code" : "PROD",
                      "display" : "Production Scale"
                    }
                  }
                ],
                "prefix" : "2",
                "title" : "Step 2 Yield",
                "description" : "Description of this step",
                "code" : // text value="Step 2 in the process - free text is possible"/
                {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-step",
                      "code" : "drying",
                      "display" : "Drying"
                    }
                  ]
                },
                "participant" : [
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
                          }
                        }
                      ],
                      "display" : "Starting material"
                    },
                    "role" : // SubstanceDefinition/startingMaterialStep2
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "StartingMaterial",
                          "display" : "Starting Material"
                        }
                      ]
                    }
                  },
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
                          }
                        }
                      ],
                      "display" : "Intermediate material"
                    },
                    "role" : // SubstanceDefinition/intermediateMaterialStep2
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "IntermediateMaterial",
                          "display" : "Intermediate Material"
                        }
                      ]
                    }
                  },
                  {
                    "typeReference" : {
                      "extension" : [
                        {
                          "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
                          "valueReference" : {
                            "reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821154"
                          }
                        }
                      ],
                      "display" : "Resulting material"
                    },
                    "role" : // SubstanceDefinition/resultingMaterialStep2
                    {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/manufacturing-participant-role",
                          "code" : "ResultingMaterial",
                          "display" : "Resulting Material"
                        }
                      ]
                    }
                  }
                ],
                "action" : [
                  {
                    "code" : {
                      "text" : "Test"
                    },
                    "definitionCanonical" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
                  }
                ]
              }
            ]
          }
        },
        // ObservationDefinition/Step2Yield
        {
          "fullUrl" : "urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd",
          "resource" : {
            "resourceType" : "DiagnosticReport",
            "id" : "processValidationReport",
            "text" : //  ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
                         however the observations themselves do have subjects
            {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_processValidationReport\"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name=\"processValidationReport\"> </a><a name=\"hcprocessValidationReport\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport &quot;processValidationReport&quot; </p></div><p><b>Triggered by</b>: See on this page: PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-pharmaceutical-report-type.html\">Pharmaceutical Report Type Codes</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li>See on this page: Observation/9c56948c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56968a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56978a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56968c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56978c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56948d-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948b-2a39-6609-1c01-4d197ea57a33</li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy",
                "valueReference" : {
                  "reference" : "PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"
                }
              }
            ],
            "status" : "final",
            "code" : // PlanDefinition/validationProtocol
            {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-report-type",
                  "code" : "Process Validation Report",
                  "display" : "Process Validation Report"
                }
              ]
            },
            "effectiveDateTime" : "2020-12",
            "result" : [
              {
                "reference" : "Observation/9c56948c-2a39-6609-1c01-4d197ea57a33"
              },
              // Observation/step1Yield1
              {
                "reference" : "Observation/9c56948a-2b39-6609-1c01-4d197ea57a33"
              },
              // Observation/step1Yield2
              {
                "reference" : "Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"
              },
              // Observation/step1Yield3
              {
                "reference" : "Observation/9c56958c-2a39-6609-1c01-4d197ea57a33"
              },
              // Observation/residualWaterContent1
              {
                "reference" : "Observation/9c56968a-2b39-6609-1c01-4d197ea57a33"
              },
              // Observation/residualWaterContent2
              {
                "reference" : "Observation/9c56978a-2a39-6609-1c01-4d197ea57a33"
              },
              // Observation/residualWaterContent3
              {
                "reference" : "Observation/9c56948c-2a39-6609-2c01-4d197ea57a33"
              },
              // Observation/appearanceSubstance1
              {
                "reference" : "Observation/9c56948c-2a49-6609-2c01-4d197ea57a33"
              },
              // Observation/appearanceSubstance2
              {
                "reference" : "Observation/9c56948c-2a39-6609-2c01-4d197eb57a33"
              },
              // Observation/appearanceSubstance3
              {
                "reference" : "Observation/9c56958c-2a39-6609-2c01-4d197ea57a33"
              },
              // Observation/identificationSubstance1
              {
                "reference" : "Observation/9c56968c-2a49-6609-2c01-4d197ea57a33"
              },
              // Observation/identificationSubstance2
              {
                "reference" : "Observation/9c56978c-2a39-6609-2c01-4d197eb57a33"
              },
              // Observation/identificationSubstance3
              {
                "reference" : "Observation/9c56948d-2a39-6609-1c01-4d197ea57a33"
              },
              // Observation/step2Yield1
              {
                "reference" : "Observation/9c56948c-2b39-6609-1c01-4d197ea57a33"
              },
              // Observation/step2Yield2
              {
                "reference" : "Observation/9c56948b-2a39-6609-1c01-4d197ea57a33"
              }
            ],
            "conclusion" : "The samples have been assessed and the conclusion is..."
          }
        },
        // Observation/step2Yield3
        {
          "fullUrl" : "urn:uuid:fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
            "text" : // AppearanceSubstance
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\"> </a><a name=\"hcfc07b5d5-9fe1-92c2-2d06-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;fc07b5d5-9fe1-92c2-2d06-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></p><p><b>title</b>: Appearance</p><p><b>status</b>: active</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>method</b>: Visual inspection <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
            "title" : "Appearance",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Appearance",
                  "display" : "Appearance"
                }
              ],
              "text" : "Appearance"
            },
            "method" : {
              "text" : "Visual inspection"
            },
            "qualifiedValue" : [
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
                    "valueString" : "White to off-white, to red, to orange, to brown solid"
                  }
                ]
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:3b1e878e-4bc9-8864-862f-e28b21233e8d",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "3b1e878e-4bc9-8864-862f-e28b21233e8d",
            "text" : // IdentificationSubstance
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"3b1e878e-4bc9-8864-862f-e28b21233e8d\"> </a><a name=\"hc3b1e878e-4bc9-8864-862f-e28b21233e8d\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;3b1e878e-4bc9-8864-862f-e28b21233e8d&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></p><p><b>title</b>: ID by HPLC</p><p><b>status</b>: active</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>method</b>: ID by UHPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d",
            "title" : "ID by HPLC",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "IDT",
                  "display" : "Identification"
                }
              ],
              "text" : "ID by HPLC"
            },
            "method" : {
              "text" : "ID by UHPLC"
            },
            "qualifiedValue" : [
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
                    "valueString" : "Conforms to standard"
                  }
                ]
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
            "text" : // AssaySubstance
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_12e7e672-40a6-4036-3c1f-b8ba6a7d045e\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"12e7e672-40a6-4036-3c1f-b8ba6a7d045e\"> </a><a name=\"hc12e7e672-40a6-4036-3c1f-b8ba6a7d045e\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;12e7e672-40a6-4036-3c1f-b8ba6a7d045e&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></p><p><b>title</b>: Assay by HPLC (as is) (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Assay by HPLC (as is) (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#ASSAY &quot;Assay&quot;)</span></p><p><b>method</b>: Assay by UHPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>95-101 %</td></tr></table></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
            "title" : "Assay by HPLC (as is) (w/w%)",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "ASSAY",
                  "display" : "Assay"
                }
              ],
              "text" : "Assay by HPLC (as is) (w/w%)"
            },
            "method" : {
              "text" : "Assay by UHPLC"
            },
            "qualifiedValue" : [
              {
                "range" : {
                  "low" : {
                    "value" : 95,
                    "unit" : "%",
                    "system" : "http://unitsofmeasure.org",
                    "code" : "%"
                  },
                  "high" : {
                    "value" : 101,
                    "unit" : "%",
                    "system" : "http://unitsofmeasure.org",
                    "code" : "%"
                  }
                }
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
            "text" : // Step1Yield
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\"> </a><a name=\"hcfd17b5d6-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;fd17b5d6-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
            "title" : "Yield (%)",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
            "text" : // Step2Yield
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\"> </a><a name=\"hcfd17b5d7-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;fd17b5d7-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
            "title" : "Yield (%)",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
            "text" : // ResidualWaterContent
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\"> </a><a name=\"hcfc27b5d6-9fe1-91c2-2d16-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;fc27b5d6-9fe1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Residual Water Content (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Residual Water Content (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#ResidualWaterContent)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>?-7.15</td></tr></table></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
            "title" : "Residual Water Content (w/w%)",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "ResidualWaterContent",
                  "display" : "Residual Water Content (w/w%)"
                }
              ],
              "text" : "Residual Water Content (w/w%)"
            },
            "qualifiedValue" : [
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq",
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality",
                          "code" : "Non-critical",
                          "display" : "Non-critical"
                        }
                      ],
                      "text" : "Non-critical"
                    }
                  }
                ],
                "range" : {
                  "high" : {
                    "value" : 7.15,
                    "unit" : "%",
                    "system" : "http://unitsofmeasure.org",
                    "code" : "%"
                  }
                }
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
          "resource" : {
            "resourceType" : "ObservationDefinition",
            "id" : "fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
            "text" : // ResidualStartingMaterial1byHPLC
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ObservationDefinition_fc27b5d6-9ff1-91c2-2d16-57cb5b295e72\"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9ff1-91c2-2d16-57cb5b295e72\"> </a><a name=\"hcfc27b5d6-9ff1-91c2-2d16-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition &quot;fc27b5d6-9ff1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)</p><p><b>status</b>: active</p><p><b>code</b>: Reaction conversion: Residual Starting Material 1 by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Reaction conversion: Residual Starting Material 1 by HPLC)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>?-23</td></tr></table></div>"
            },
            "url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
            "title" : "Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)",
            "status" : "active",
            "code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Reaction conversion: Residual Starting Material 1 by HPLC",
                  "display" : "Reaction conversion: Residual Starting Material 1 by HPLC"
                }
              ],
              "text" : "Reaction conversion: Residual Starting Material 1 by HPLC"
            },
            "qualifiedValue" : [
              {
                "extension" : [
                  {
                    "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq",
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality",
                          "code" : "critical",
                          "display" : "Critical"
                        }
                      ],
                      "text" : "Critical"
                    }
                  }
                ],
                "range" : {
                  "high" : {
                    "value" : 23,
                    "unit" : "%",
                    "system" : "http://unitsofmeasure.org",
                    "code" : "%"
                  }
                }
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948c-2a39-6609-2c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948c-2a39-6609-2c01-4d197ea57a33",
            "text" : // appearanceSubstance1
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948c-2a39-6609-2c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-2c01-4d197ea57a33\"> </a><a name=\"hc9c56948c-2a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/AppearanceSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Appearance",
                  "display" : "Appearance"
                }
              ],
              "text" : "Appearance"
            },
            "subject" : {
              "reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-1
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Off-white solid"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56948c-2a49-6609-2c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948c-2a49-6609-2c01-4d197ea57a33",
            "text" : // appearanceSubstance2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948c-2a49-6609-2c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a49-6609-2c01-4d197ea57a33\"> </a><a name=\"hc9c56948c-2a49-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/AppearanceSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Appearance",
                  "display" : "Appearance"
                }
              ],
              "text" : "Appearance"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-2
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Off-white solid"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56948c-2a39-6609-2c01-4d197eb57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948c-2a39-6609-2c01-4d197eb57a33",
            "text" : // appearanceSubstance3
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948c-2a39-6609-2c01-4d197eb57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-2c01-4d197eb57a33\"> </a><a name=\"hc9c56948c-2a39-6609-2c01-4d197eb57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/AppearanceSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Appearance",
                  "display" : "Appearance"
                }
              ],
              "text" : "Appearance"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-3
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Off-white solid"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56958c-2a39-6609-2c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56958c-2a39-6609-2c01-4d197ea57a33",
            "text" : // identificationSubstance1
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56958c-2a39-6609-2c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56958c-2a39-6609-2c01-4d197ea57a33\"> </a><a name=\"hc9c56958c-2a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56958c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
            },
            "status" : "final",
            "code" : // ObservationDefinition/IdentificationSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "IDT",
                  "display" : "Identification"
                }
              ],
              "text" : "ID by HPLC"
            },
            "subject" : {
              "reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-1
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Conforms"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56968c-2a49-6609-2c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56968c-2a49-6609-2c01-4d197ea57a33",
            "text" : // identificationSubstance2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56968c-2a49-6609-2c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56968c-2a49-6609-2c01-4d197ea57a33\"> </a><a name=\"hc9c56968c-2a49-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56968c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
            },
            "status" : "final",
            "code" : // ObservationDefinition/IdentificationSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "IDT",
                  "display" : "Identification"
                }
              ],
              "text" : "ID by HPLC"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-2
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Conforms"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56978c-2a39-6609-2c01-4d197eb57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56978c-2a39-6609-2c01-4d197eb57a33",
            "text" : // identificationSubstance3
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56978c-2a39-6609-2c01-4d197eb57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56978c-2a39-6609-2c01-4d197eb57a33\"> </a><a name=\"hc9c56978c-2a39-6609-2c01-4d197eb57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56978c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Does not conform</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
            },
            "status" : "final",
            "code" : // ObservationDefinition/IdentificationSubstance
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "IDT",
                  "display" : "Identification"
                }
              ],
              "text" : "ID by HPLC"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-3
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueString" : "Does not conform"
          }
        },
        // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
        {
          "fullUrl" : "urn:uuid:9c56948c-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948c-2a39-6609-1c01-4d197ea57a33",
            "text" : // step1Yield1
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948c-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948c-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 75 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step1Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-1
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 75,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948a-2b39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948a-2b39-6609-1c01-4d197ea57a33",
            "text" : // step1Yield2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948a-2b39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2b39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948a-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 77 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step1Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-2
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 77,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948a-2a39-6609-1c01-4d197ea57a33",
            "text" : // step1Yield3
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948a-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948a-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 76 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step1Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-3
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 76,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948d-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948d-2a39-6609-1c01-4d197ea57a33",
            "text" : // step2Yield1
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948d-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948d-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948d-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948d-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9754-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 85 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step2Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178763-81c5-5656-9754-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-step2-1
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 85,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948c-2b39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948c-2b39-6609-1c01-4d197ea57a33",
            "text" : // step2Yield2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948c-2b39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2b39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948c-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948c-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9764-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 87 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step2Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d5-5656-9764-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-step2-2
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 87,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56948b-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56948b-2a39-6609-1c01-4d197ea57a33",
            "text" : // step2Yield3
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56948b-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56948b-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56948b-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56948b-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-6656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 86 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/Step2Yield
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "Yield (%)",
                  "display" : "Yield (%)"
                }
              ],
              "text" : "Yield (%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d6-6656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-step2-3
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 86,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56958c-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56958c-2a39-6609-1c01-4d197ea57a33",
            "text" : // residualWaterContent1
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56958c-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56958c-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56958c-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56958c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.9 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/ResidualWaterContent
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "ResidualWaterContent",
                  "display" : "Residual Water Content (w/w%)"
                }
              ],
              "text" : "ResidualWaterContent (w/w%)"
            },
            "subject" : {
              "reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-1
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 6.9,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56968a-2b39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56968a-2b39-6609-1c01-4d197ea57a33",
            "text" : // residualWaterContent2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56968a-2b39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56968a-2b39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56968a-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56968a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 7.0 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/ResidualWaterContent
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "ResidualWaterContent",
                  "display" : "Residual Water Content (w/w%)"
                }
              ],
              "text" : "ResidualWaterContent (w/w%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-2
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 7.0,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:9c56978a-2a39-6609-1c01-4d197ea57a33",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "9c56978a-2a39-6609-1c01-4d197ea57a33",
            "text" : // residualWaterContent3
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_9c56978a-2a39-6609-1c01-4d197ea57a33\"> </a><p><b>Generated Narrative: Observation</b><a name=\"9c56978a-2a39-6609-1c01-4d197ea57a33\"> </a><a name=\"hc9c56978a-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation &quot;9c56978a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq-example.html\">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.8 %</p></div>"
            },
            "instantiatesReference" : {
              "reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
            },
            "status" : "final",
            "code" : // ObservationDefinition/ResidualWaterContent
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example",
                  "code" : "ResidualWaterContent",
                  "display" : "Residual Water Content (w/w%)"
                }
              ],
              "text" : "ResidualWaterContent (w/w%)"
            },
            "subject" : {
              "reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
            },
            "effectiveDateTime" : "2023-01-01T12:00:00Z",
            "performer" : [
              // Substance/actual-batch-substance-itermediate-3
              {
                "reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
              }
            ],
            "valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "value" : 6.8,
              "unit" : "%"
            }
          }
        },
        {
          "fullUrl" : "urn:uuid:23dbbd32-2962-9fc3-40b1-67e864f21cd2",
          "resource" : {
            "resourceType" : "Organization",
            "id" : "23dbbd32-2962-9fc3-40b1-67e864f21cd2",
            "text" : // substance-manufacturer
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2\"> </a><p><b>Generated Narrative: Organization</b><a name=\"23dbbd32-2962-9fc3-40b1-67e864f21cd2\"> </a><a name=\"hc23dbbd32-2962-9fc3-40b1-67e864f21cd2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization &quot;23dbbd32-2962-9fc3-40b1-67e864f21cd2&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-pharmaceutical-organization-type.html\">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
            },
            "identifier" : [
              {
                "system" : "urn:oid:2.16.840.1.113883.4.82",
                "value" : "3003040516"
              }
            ],
            "active" : true,
            "type" : [
              //  FDA establishment identifier
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type",
                    "code" : "drug-substance-manufacture",
                    "display" : "Drug Substance Manufacture"
                  }
                ]
              }
            ],
            "name" : "AAA Molybdenum Products, Inc.",
            "contact" : [
              {
                "address" : {
                  "line" : [
                    "7233 W 116th Pl",
                    "Ste C"
                  ],
                  "city" : "Broomfield",
                  "state" : "Colorado",
                  "postalCode" : "80020",
                  "country" : "USA"
                }
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08",
          "resource" : {
            "resourceType" : "Organization",
            "id" : "378fbe5f-5926-3a5c-4c64-5428df877b08",
            "text" : // testing lab
            // 378fbe5f-5926-3a5c-4c64-5428df877b08
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\"> </a><p><b>Generated Narrative: Organization</b><a name=\"378fbe5f-5926-3a5c-4c64-5428df877b08\"> </a><a name=\"hc378fbe5f-5926-3a5c-4c64-5428df877b08\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization &quot;378fbe5f-5926-3a5c-4c64-5428df877b08&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3007270600</p><p><b>active</b>: true</p><p><b>type</b>: Analytical Testing - Release <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-pharmaceutical-organization-type.html\">Pharmaceutical Organization Type Codes</a>#analytical-testing-release)</span></p><p><b>name</b>: Testing Lab</p></div>"
            },
            "identifier" : [
              {
                "system" : "urn:oid:2.16.840.1.113883.4.82",
                "value" : "3007270600"
              }
            ],
            "active" : true,
            "type" : [
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type",
                    "code" : "analytical-testing-release",
                    "display" : "Analytical Testing - Release"
                  }
                ]
              }
            ],
            "name" : "Testing Lab"
          }
        },
        {
          "fullUrl" : "urn:uuid:57a9af63-315d-1585-a261-0e337b289390",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "57a9af63-315d-1585-a261-0e337b289390",
            "meta" : // substancedefinition-component-substance-dxpq-ex1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"57a9af63-315d-1585-a261-0e337b289390\"> </a><a name=\"hc57a9af63-315d-1585-a261-0e337b289390\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;57a9af63-315d-1585-a261-0e337b289390&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-SubstanceDefinition-component-substance-drug-pq.html\">SubstanceDefinition - Component Substance Drug PQ</a></p></div><p><b>manufacturer</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatolol</td></tr></table></div>"
            },
            "manufacturer" : [
              {
                "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
              }
            ],
            "name" : [
              // Organization/organization-dxpq-ex1
              {
                "name" : "Stelbatolol"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821153",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-7cb8-428e-83f7-8a205f821153",
            "text" : // startingMaterial
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821153\"> </a><a name=\"hcc458791f-7cb8-428e-83f7-8a205f821153\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatosubstance</td></tr></table></div>"
            },
            "manufacturer" : [
              {
                "reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
              }
            ],
            "name" : [
              // Organization/substance-manufacturer
              {
                "name" : "Stelbatosubstance"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc178762-81c5-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81c5-5656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-starting-1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81c5-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81c5-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178762-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.1 kg</p></blockquote><p><b>identifier</b>: Start1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-01"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 8.1,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start1Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterial
        {
          "fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81d5-5656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-starting-2
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81d5-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178762-81d5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.2 kg</p></blockquote><p><b>identifier</b>: Start2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-01"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 8.2,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterial
        {
          "fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-23c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81d5-5656-9744-23c7ad1e595b",
            "meta" : // actual-batch-substance-starting-3
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81d5-5656-9744-23c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-23c7ad1e595b\"> </a><a name=\"hcfc178762-81d5-5656-9744-23c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.3 kg</p></blockquote><p><b>identifier</b>: Start3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-01"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 8.3,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start3Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterial
        {
          "fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821154",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-7cb8-428e-83f7-8a205f821154",
            "text" : // resultingMaterial
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821154\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821154\"> </a><a name=\"hcc458791f-7cb8-428e-83f7-8a205f821154\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Resultothane</td></tr></table></div>"
            },
            "name" : [
              {
                "name" : "Resultothane"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821155",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-7cb8-428e-83f7-8a205f821155",
            "text" : // intermediateMaterial
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821155\"> </a><a name=\"hcc458791f-7cb8-428e-83f7-8a205f821155\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Processohol</td></tr></table></div>"
            },
            "manufacturer" : [
              {
                "reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
              }
            ],
            "name" : [
              // Organization/substance-manufacturer
              {
                "name" : "Processohol"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc178763-81c5-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178763-81c5-5656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178763-81c5-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178763-81c5-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178763-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178763-81c5-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 9.1,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81c5-5656-9744-13c7ad1e595b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-1
              //  local extension
              {
                "value" : "Intermed1Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterial
        {
          "fullUrl" : "urn:uuid:fc178764-81d5-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178764-81d5-5656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-2
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178764-81d5-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d5-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178764-81d5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178764-81d5-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 9.2,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81d5-5656-9744-13c7ad1e595b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-2
              //  local extension
              {
                "value" : "Intermed2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterial
        {
          "fullUrl" : "urn:uuid:fc178764-81d6-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178764-81d6-5656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-3
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178764-81d6-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d6-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178764-81d6-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178764-81d6-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e595b</p><p><b>identifier</b>: Intermed3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 9.3,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81d5-5656-9744-23c7ad1e595b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-3
              //  local extension
              {
                "value" : "Intermed3Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterial
        {
          "fullUrl" : "urn:uuid:c458791f-8cb8-428e-83f7-8a205f821153",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-8cb8-428e-83f7-8a205f821153",
            "text" : // startingMaterialStep2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-8cb8-428e-83f7-8a205f821153\"> </a><a name=\"hcc458791f-8cb8-428e-83f7-8a205f821153\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatosubstance2</td></tr></table></div>"
            },
            "manufacturer" : [
              {
                "reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
              }
            ],
            "name" : [
              // Organization/substance-manufacturer
              {
                "name" : "Stelbatosubstance2"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc178762-81c5-5656-9744-13c7ad2e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81c5-5656-9744-13c7ad2e595b",
            "meta" : // actual-batch-substance-starting-step2-1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81c5-5656-9744-13c7ad2e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81c5-5656-9744-13c7ad2e595b\"> </a><a name=\"hcfc178762-81c5-5656-9744-13c7ad2e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad2e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.1 kg</p></blockquote><p><b>identifier</b>: Start1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-02"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 7.1,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start1Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterialStep2
        {
          "fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-13c7ad1e596b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81d5-5656-9744-13c7ad1e596b",
            "meta" : // actual-batch-substance-starting-step2-2
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81d5-5656-9744-13c7ad1e596b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-13c7ad1e596b\"> </a><a name=\"hcfc178762-81d5-5656-9744-13c7ad1e596b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e596b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.2 kg</p></blockquote><p><b>identifier</b>: Start2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-02"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 7.2,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start2Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterialStep2
        {
          "fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-23c7ad1e597b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178762-81d5-5656-9744-23c7ad1e597b",
            "meta" : // actual-batch-substance-starting-step2-3
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178762-81d5-5656-9744-23c7ad1e597b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-23c7ad1e597b\"> </a><a name=\"hcfc178762-81d5-5656-9744-23c7ad1e597b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e597b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.3 kg</p></blockquote><p><b>identifier</b>: Start3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-02"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 7.3,
                      "unit" : "kg"
                    }
                  }
                ]
              }
            ],
            "identifier" : [
              {
                "value" : "Start3Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
              }
            }
          }
        },
        // SubstanceDefinition/startingMaterialStep2
        {
          "fullUrl" : "urn:uuid:c458791f-7cb8-428e-84f7-8a205f821155",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-7cb8-428e-84f7-8a205f821155",
            "text" : // intermediateMaterialStep2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-84f7-8a205f821155\"> </a><a name=\"hcc458791f-7cb8-428e-84f7-8a205f821155\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-84f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>ProcessoholStep2</td></tr></table></div>"
            },
            "manufacturer" : [
              {
                "reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
              }
            ],
            "name" : [
              // Organization/substance-manufacturer
              {
                "name" : "ProcessoholStep2"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc178763-81c5-5656-9754-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178763-81c5-5656-9754-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-step2-1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178763-81c5-5656-9754-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178763-81c5-5656-9754-13c7ad1e595b\"> </a><a name=\"hcfc178763-81c5-5656-9754-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178763-81c5-5656-9754-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad2e595b</p><p><b>identifier</b>: Intermed1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 10.1,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81c5-5656-9744-13c7ad2e595b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-step2-1
              //  local extension
              {
                "value" : "Intermed1Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterialStep2
        {
          "fullUrl" : "urn:uuid:fc178764-81d5-5656-9764-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178764-81d5-5656-9764-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-step2-2
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178764-81d5-5656-9764-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d5-5656-9764-13c7ad1e595b\"> </a><a name=\"hcfc178764-81d5-5656-9764-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178764-81d5-5656-9764-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e596b</p><p><b>identifier</b>: Intermed2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 10.2,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81d5-5656-9744-13c7ad1e596b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-step2-2
              //  local extension
              {
                "value" : "Intermed2Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterialStep2
        {
          "fullUrl" : "urn:uuid:fc178764-81d6-6656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc178764-81d6-6656-9744-13c7ad1e595b",
            "meta" : // actual-batch-substance-itermediate-step2-3
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc178764-81d6-6656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d6-6656-9744-13c7ad1e595b\"> </a><a name=\"hcfc178764-81d6-6656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc178764-81d6-6656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e597b</p><p><b>identifier</b>: Intermed3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 10.3,
                      "unit" : "kg"
                    }
                  }
                ]
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
                "valueReference" : //  assumes 1 to 1, could also be done via a Procedure but overkill
                {
                  "reference" : "Substance/fc178762-81d5-5656-9744-23c7ad1e597b"
                }
              }
            ],
            "identifier" : [
              // Substance/actual-batch-substance-starting-step2-3
              //  local extension
              {
                "value" : "Intermed3Step2Amgen"
              }
            ],
            "instance" : true,
            "code" : {
              "reference" : {
                "reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
              }
            }
          }
        },
        // SubstanceDefinition/intermediateMaterialStep2
        {
          "fullUrl" : "urn:uuid:c458791f-8cb8-428e-83f7-8a205f821154",
          "resource" : {
            "resourceType" : "SubstanceDefinition",
            "id" : "c458791f-8cb8-428e-83f7-8a205f821154",
            "text" : // resultingMaterialStep2
            {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821154\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-8cb8-428e-83f7-8a205f821154\"> </a><a name=\"hcc458791f-8cb8-428e-83f7-8a205f821154\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>ResultothaneStep2</td></tr></table></div>"
            },
            "name" : [
              {
                "name" : "ResultothaneStep2"
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
          "resource" : {
            "resourceType" : "Organization",
            "id" : "49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
            "meta" : // id value="substance-manufacturer"/
            // organization-dxpq-ex1
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-drug-pq"
              ]
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\"> </a><p><b>Generated Narrative: Organization</b><a name=\"49d2f0c0-4b28-9271-8aaf-2996a8b9739c\"> </a><a name=\"hc49d2f0c0-4b28-9271-8aaf-2996a8b9739c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization &quot;49d2f0c0-4b28-9271-8aaf-2996a8b9739c&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Organization-drug-pq.html\">Organization - Drug PQ</a></p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-pharmaceutical-organization-type.html\">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
            },
            "identifier" : [
              {
                "system" : "urn:oid:2.16.840.1.113883.4.82",
                "value" : "3003040516"
              }
            ],
            "active" : true,
            "type" : [
              //  FDA establishment identifier
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type",
                    "code" : "drug-substance-manufacture",
                    "display" : "Drug Substance Manufacture"
                  }
                ]
              }
            ],
            "name" : "AAA Molybdenum Products, Inc.",
            "contact" : [
              {
                "address" : {
                  "line" : [
                    "7233 W 116th Pl",
                    "Ste C"
                  ],
                  "city" : "Broomfield",
                  "state" : "Colorado",
                  "postalCode" : "80020",
                  "country" : "USA"
                }
              }
            ]
          }
        },
        {
          "fullUrl" : "urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "fc078762-81c5-5656-9744-13c7ad1e595b",
            "meta" : // <id value="actual-batch-substance"/>
            // substance-dxpq-ex1-unlinked
            {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_fc078762-81c5-5656-9744-13c7ad1e595b\"> </a><p><b>Generated Narrative: Substance</b><a name=\"fc078762-81c5-5656-9744-13c7ad1e595b\"> </a><a name=\"hcfc078762-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;fc078762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.1 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB1Amgen, SUB1SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-07"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 5.1,
                      "unit" : "kg"
                    }
                  },
                  {
                    "url" : "batchUtilization",
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
                          "code" : "C133991",
                          "display" : "Development"
                        }
                      ]
                    }
                  },
                  {
                    "url" : "assignedManufacturer",
                    "valueReference" : {
                      "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                    }
                  }
                ]
              },
              // Organization/organization-dxpq-ex1
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
                "valueDateTime" : "2019-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
                "valueDateTime" : "2022-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
                "valueQuantity" : {
                  "value" : 4.8,
                  "unit" : "kg"
                }
              }
            ],
            "identifier" : [
              //  local extension
              {
                "value" : "SUB1Amgen"
              },
              {
                "value" : "SUB1SiteA",
                "assigner" : {
                  "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                }
              }
            ],
            "instance" : true,
            "code" : // Organization/organization-dxpq-ex1
            {
              "reference" : {
                "reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
              }
            }
          }
        },
        // SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
        {
          "fullUrl" : "urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "cb31d747-2338-88d5-342c-8e9c097e4dad",
            "text" : // actual-batch-substance-2-unlinked
            {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_cb31d747-2338-88d5-342c-8e9c097e4dad\"> </a><p><b>Generated Narrative: Substance</b><a name=\"cb31d747-2338-88d5-342c-8e9c097e4dad\"> </a><a name=\"hccb31d747-2338-88d5-342c-8e9c097e4dad\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;cb31d747-2338-88d5-342c-8e9c097e4dad&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.2 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB2Amgen, SUB2SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-07"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 5.2,
                      "unit" : "kg"
                    }
                  },
                  {
                    "url" : "batchUtilization",
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
                          "code" : "C133991",
                          "display" : "Development"
                        }
                      ]
                    }
                  },
                  {
                    "url" : "assignedManufacturer",
                    "valueReference" : {
                      "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                    }
                  }
                ]
              },
              // Organization/organization-dxpq-ex1
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
                "valueDateTime" : "2019-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
                "valueDateTime" : "2022-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
                "valueQuantity" : {
                  "value" : 4.8,
                  "unit" : "kg"
                }
              }
            ],
            "identifier" : [
              //  local extensions
              {
                "value" : "SUB2Amgen"
              },
              {
                "value" : "SUB2SiteA",
                "assigner" : {
                  "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                }
              }
            ],
            "instance" : true,
            "code" : // Organization/organization-dxpq-ex1
            {
              "reference" : {
                "reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
              }
            }
          }
        },
        // SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
        {
          "fullUrl" : "urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c",
          "resource" : {
            "resourceType" : "Substance",
            "id" : "1551f97b-6f6d-825e-1fb3-44b0b090808c",
            "text" : // actual-batch-substance-3-unlinked
            {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Substance_1551f97b-6f6d-825e-1fb3-44b0b090808c\"> </a><p><b>Generated Narrative: Substance</b><a name=\"1551f97b-6f6d-825e-1fb3-44b0b090808c\"> </a><a name=\"hc1551f97b-6f6d-825e-1fb3-44b0b090808c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance &quot;1551f97b-6f6d-825e-1fb3-44b0b090808c&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.3 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB3Amgen, SUB3SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
                "extension" : [
                  {
                    "url" : "manufacturingDate",
                    "valueDateTime" : "2019-09-07"
                  },
                  {
                    "url" : "batchQuantity",
                    "valueQuantity" : {
                      "value" : 5.3,
                      "unit" : "kg"
                    }
                  },
                  {
                    "url" : "batchUtilization",
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
                          "code" : "C133991",
                          "display" : "Development"
                        }
                      ]
                    }
                  },
                  {
                    "url" : "assignedManufacturer",
                    "valueReference" : {
                      "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                    }
                  }
                ]
              },
              // Organization/organization-dxpq-ex1
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
                "valueDateTime" : "2019-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
                "valueDateTime" : "2022-09-08"
              },
              {
                "url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
                "valueQuantity" : {
                  "value" : 4.8,
                  "unit" : "kg"
                }
              }
            ],
            "identifier" : [
              //  local extensions
              {
                "value" : "SUB3Amgen"
              },
              {
                "value" : "SUB3SiteA",
                "assigner" : {
                  "reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
                }
              }
            ],
            "instance" : true,
            "code" : // Organization/organization-dxpq-ex1
            {
              "reference" : {
                "reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
              }
            }
          }
        }
      ]
    }