{
  "resourceType" : "Parameters",
  "id" : "FindSubjectTxImplicationsOutput",
  "parameter" : [{
    "name" : "implication",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "TherapeuticImplicationExample",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">Therapeutic Implication</div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "therapeutic-implication"
        }]
      },
      "subject" : {
        "reference" : "Patient/HG00403"
      },
      "effectiveDateTime" : "2023-07-01",
      "performer" : [{
        "reference" : "Organization/ExampleOrg"
      }],
      "derivedFrom" : [{
        "reference" : "Observation/VariantExample"
      }],
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
            "code" : "therapeutic-implication"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6677-4",
            "display" : "Responsive"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "51963-7",
            "display" : "Medication assessed"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
            "code" : "480167",
            "display" : "Lapatinib"
          }]
        }
      }]
    }
  },
  {
    "name" : "variant",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "variantExample",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">Variant</div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "69548-6",
          "display" : "Genetic variant assessment"
        }]
      },
      "subject" : {
        "reference" : "Patient/HG00403"
      },
      "effectiveDateTime" : "2023-07-01",
      "performer" : [{
        "reference" : "Organization/ExampleOrg"
      }],
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA9633-4",
          "display" : "Present"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48002-0",
            "display" : "Genomic source class [Type]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6684-0",
            "display" : "Somatic"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48013-7",
            "display" : "Genomic reference sequence ID"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.ncbi.nlm.nih.gov/refseq",
            "code" : "NC_000017.11"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69547-8",
            "display" : "Genomic Ref allele [ID]"
          }]
        },
        "valueString" : "ATTGAGGGAAAACACAT"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69551-0",
            "display" : "Genomic Alt allele [ID]"
          }]
        },
        "valueString" : "T"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "92822-6",
            "display" : "Genomic coord system"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA30100-4",
            "display" : "0-based interval counting"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "81254-5"
          }],
          "text" : "Genomic allele start-end"
        },
        "valueRange" : {
          "low" : {
            "value" : 39723965
          }
        }
      }]
    }
  }]
}