@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/genomics-reporting/Parameters/FindSubjectMolecConseqOutput> a fhir:Parameters ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "FindSubjectMolecConseqOutput"] ; # 
  fhir:parameter ( [
     fhir:name [ fhir:v "consequence" ] ;
     fhir:Parameters.parameter.resource ( [
       a fhir:Observation ;
       fhir:id [ fhir:v "MC1" ] ;
       fhir:meta [
         fhir:profile ( [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence>
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">NM_001395525.1:c.-281+2T&gt;C - intronic_variant:loss_of_function_variant</div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:status [ fhir:v "final" ] ;
       fhir:category ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
           ] ;
           fhir:code [ fhir:v "laboratory" ]
         ] )
       ] [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
           ] ;
           fhir:code [ fhir:v "GE" ]
         ] )
       ] ) ;
       fhir:code [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
           ] ;
           fhir:code [ fhir:v "molecular-consequence" ]
         ] )
       ] ;
       fhir:subject [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> ;
         fhir:reference [ fhir:v "Patient/HG00403" ]
       ] ;
       fhir:effective [
         a fhir:DateTime ;
         fhir:v "2023-04-01"^^xsd:date
       ] ;
       fhir:performer ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
         fhir:reference [ fhir:v "Organization/ExampleOrg" ]
       ] ) ;
       fhir:interpretation ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction"^^xsd:anyURI ;
             fhir:l <http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction>
           ] ;
           fhir:code [ fhir:v "HIGH" ] ;
           fhir:display [ fhir:v "High" ]
         ] )
       ] ) ;
       fhir:derivedFrom ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/variantExampleMC> ;
         fhir:reference [ fhir:v "Observation/variantExampleMC" ]
       ] ) ;
       fhir:component ( [
         fhir:code [
           fhir:coding ( [
             a loinc:51958-7 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "51958-7" ] ;
             fhir:display [ fhir:v "Transcript reference sequence [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ;
               fhir:l <http://www.ncbi.nlm.nih.gov/refseq>
             ] ;
             fhir:code [ fhir:v "NM_001395525.1" ] ;
             fhir:display [ fhir:v "NM_001395525.1" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
               fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
             ] ;
             fhir:code [ fhir:v "feature-consequence" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO:0001575" ] ;
             fhir:display [ fhir:v "splice_donor_variant" ]
           ] [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO:0001627" ] ;
             fhir:display [ fhir:v "intron_variant" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
               fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
             ] ;
             fhir:code [ fhir:v "functional-effect" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO_0002054" ] ;
             fhir:display [ fhir:v "loss_of_function_variant" ]
           ] )
         ]
       ] )
     ] )
  ] [
     fhir:name [ fhir:v "consequence" ] ;
     fhir:Parameters.parameter.resource ( [
       a fhir:Observation ;
       fhir:id [ fhir:v "MC2" ] ;
       fhir:meta [
         fhir:profile ( [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence>
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">NM_001366781.1:c.90T&gt;C - synonymous_variant</div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:status [ fhir:v "final" ] ;
       fhir:category ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
           ] ;
           fhir:code [ fhir:v "laboratory" ]
         ] )
       ] [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
           ] ;
           fhir:code [ fhir:v "GE" ]
         ] )
       ] ) ;
       fhir:code [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
           ] ;
           fhir:code [ fhir:v "molecular-consequence" ]
         ] )
       ] ;
       fhir:subject [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> ;
         fhir:reference [ fhir:v "Patient/HG00403" ]
       ] ;
       fhir:effective [
         a fhir:DateTime ;
         fhir:v "2023-04-01"^^xsd:date
       ] ;
       fhir:performer ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
         fhir:reference [ fhir:v "Organization/ExampleOrg" ]
       ] ) ;
       fhir:interpretation ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction"^^xsd:anyURI ;
             fhir:l <http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction>
           ] ;
           fhir:code [ fhir:v "LOW" ] ;
           fhir:display [ fhir:v "Low" ]
         ] )
       ] ) ;
       fhir:derivedFrom ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/variantExampleMC> ;
         fhir:reference [ fhir:v "Observation/variantExampleMC" ]
       ] ) ;
       fhir:component ( [
         fhir:code [
           fhir:coding ( [
             a loinc:48004-6 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "48004-6" ]
           ] ) ;
           fhir:text [ fhir:v "coding HGVS" ]
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ;
               fhir:l <http://varnomen.hgvs.org>
             ] ;
             fhir:code [ fhir:v "NM_001366781.1:c.90T>C" ] ;
             fhir:display [ fhir:v "NM_001366781.1:c.90T>C" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:51958-7 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "51958-7" ] ;
             fhir:display [ fhir:v "Transcript reference sequence [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ;
               fhir:l <http://www.ncbi.nlm.nih.gov/refseq>
             ] ;
             fhir:code [ fhir:v "NM_001366781.1" ] ;
             fhir:display [ fhir:v "NM_001366781.1" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
               fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
             ] ;
             fhir:code [ fhir:v "feature-consequence" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO:0001819" ] ;
             fhir:display [ fhir:v "synonymous_variant" ]
           ] )
         ]
       ] )
     ] )
  ] [
     fhir:name [ fhir:v "consequence" ] ;
     fhir:Parameters.parameter.resource ( [
       a fhir:Observation ;
       fhir:id [ fhir:v "MC3" ] ;
       fhir:meta [
         fhir:profile ( [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence>
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">Molecular Consequence</div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:status [ fhir:v "final" ] ;
       fhir:category ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
           ] ;
           fhir:code [ fhir:v "laboratory" ]
         ] )
       ] [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
           ] ;
           fhir:code [ fhir:v "GE" ]
         ] )
       ] ) ;
       fhir:code [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
           ] ;
           fhir:code [ fhir:v "molecular-consequence" ]
         ] )
       ] ;
       fhir:subject [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> ;
         fhir:reference [ fhir:v "Patient/HG00403" ]
       ] ;
       fhir:effective [
         a fhir:DateTime ;
         fhir:v "2023-04-01"^^xsd:date
       ] ;
       fhir:performer ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
         fhir:reference [ fhir:v "Organization/ExampleOrg" ]
       ] ) ;
       fhir:interpretation ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction"^^xsd:anyURI ;
             fhir:l <http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction>
           ] ;
           fhir:code [ fhir:v "MOD" ] ;
           fhir:display [ fhir:v "Modifier" ]
         ] )
       ] ) ;
       fhir:derivedFrom ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/variantExampleMC> ;
         fhir:reference [ fhir:v "Observation/variantExampleMC" ]
       ] ) ;
       fhir:component ( [
         fhir:code [
           fhir:coding ( [
             a loinc:48004-6 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "48004-6" ]
           ] ) ;
           fhir:text [ fhir:v "coding HGVS" ]
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ;
               fhir:l <http://varnomen.hgvs.org>
             ] ;
             fhir:code [ fhir:v "NM_001395543.1:c.-171T>C" ] ;
             fhir:display [ fhir:v "NM_001395543.1:c.-171T>C" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:51958-7 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "51958-7" ] ;
             fhir:display [ fhir:v "Transcript reference sequence [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ;
               fhir:l <http://www.ncbi.nlm.nih.gov/refseq>
             ] ;
             fhir:code [ fhir:v "NM_001395543.1" ] ;
             fhir:display [ fhir:v "NM_001395543.1" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
               fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
             ] ;
             fhir:code [ fhir:v "feature-consequence" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO:0001623" ] ;
             fhir:display [ fhir:v "5_prime_UTR_variant" ]
           ] )
         ]
       ] )
     ] )
  ] [
     fhir:name [ fhir:v "consequence" ] ;
     fhir:Parameters.parameter.resource ( [
       a fhir:Observation ;
       fhir:id [ fhir:v "MC4" ] ;
       fhir:meta [
         fhir:profile ( [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence>
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">Molecular Consequence</div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:status [ fhir:v "final" ] ;
       fhir:category ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
           ] ;
           fhir:code [ fhir:v "laboratory" ]
         ] )
       ] [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
           ] ;
           fhir:code [ fhir:v "GE" ]
         ] )
       ] ) ;
       fhir:code [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
           ] ;
           fhir:code [ fhir:v "molecular-consequence" ]
         ] )
       ] ;
       fhir:subject [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> ;
         fhir:reference [ fhir:v "Patient/HG00403" ]
       ] ;
       fhir:effective [
         a fhir:DateTime ;
         fhir:v "2023-04-01"^^xsd:date
       ] ;
       fhir:performer ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
         fhir:reference [ fhir:v "Organization/ExampleOrg" ]
       ] ) ;
       fhir:interpretation ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction"^^xsd:anyURI ;
             fhir:l <http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction>
           ] ;
           fhir:code [ fhir:v "MOD" ] ;
           fhir:display [ fhir:v "Modifier" ]
         ] )
       ] ) ;
       fhir:derivedFrom ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/variantExampleMC> ;
         fhir:reference [ fhir:v "Observation/variantExampleMC" ]
       ] ) ;
       fhir:component ( [
         fhir:code [
           fhir:coding ( [
             a loinc:51958-7 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "51958-7" ] ;
             fhir:display [ fhir:v "Transcript reference sequence [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ;
               fhir:l <http://www.ncbi.nlm.nih.gov/refseq>
             ] ;
             fhir:code [ fhir:v "NM_001395544.1" ] ;
             fhir:display [ fhir:v "NM_001395544.1" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
               fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
             ] ;
             fhir:code [ fhir:v "feature-consequence" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.sequenceontology.org"^^xsd:anyURI ;
               fhir:l <http://www.sequenceontology.org>
             ] ;
             fhir:code [ fhir:v "SO:0001627" ] ;
             fhir:display [ fhir:v "intron_variant" ]
           ] )
         ]
       ] )
     ] )
  ] [
     fhir:name [ fhir:v "variant" ] ;
     fhir:Parameters.parameter.resource ( [
       a fhir:Observation ;
       fhir:id [ fhir:v "variantExampleMC" ] ;
       fhir:meta [
         fhir:profile ( [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant>
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">Variant</div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:status [ fhir:v "final" ] ;
       fhir:category ( [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
           ] ;
           fhir:code [ fhir:v "laboratory" ]
         ] )
       ] [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
           ] ;
           fhir:code [ fhir:v "GE" ]
         ] )
       ] ) ;
       fhir:code [
         fhir:coding ( [
           a loinc:69548-6 ;
           fhir:system [
             fhir:v "http://loinc.org"^^xsd:anyURI ;
             fhir:l <http://loinc.org>
           ] ;
           fhir:code [ fhir:v "69548-6" ] ;
           fhir:display [ fhir:v "Genetic variant assessment" ]
         ] )
       ] ;
       fhir:subject [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> ;
         fhir:reference [ fhir:v "Patient/HG00403" ]
       ] ;
       fhir:effective [
         a fhir:DateTime ;
         fhir:v "2023-04-01"^^xsd:date
       ] ;
       fhir:performer ( [
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
         fhir:reference [ fhir:v "Organization/ExampleOrg" ]
       ] ) ;
       fhir:value [
         a fhir:CodeableConcept ;
         fhir:coding ( [
           a loinc:LA9633-4 ;
           fhir:system [
             fhir:v "http://loinc.org"^^xsd:anyURI ;
             fhir:l <http://loinc.org>
           ] ;
           fhir:code [ fhir:v "LA9633-4" ] ;
           fhir:display [ fhir:v "Present" ]
         ] )
       ] ;
       fhir:component ( [
         fhir:code [
           fhir:coding ( [
             a loinc:48002-0 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "48002-0" ] ;
             fhir:display [ fhir:v "Genomic source class" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             a loinc:LA6683-2 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "LA6683-2" ] ;
             fhir:display [ fhir:v "Germline" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:48013-7 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "48013-7" ] ;
             fhir:display [ fhir:v "Genomic reference sequence ID" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ;
               fhir:l <http://www.ncbi.nlm.nih.gov/refseq>
             ] ;
             fhir:code [ fhir:v "NC_000001.10" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:53034-5 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "53034-5" ] ;
             fhir:display [ fhir:v "Allelic state" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             a loinc:LA6706-1 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "LA6706-1" ] ;
             fhir:display [ fhir:v "Heterozygous" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:81252-9 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "81252-9" ] ;
             fhir:display [ fhir:v "Discrete genetic variant" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             fhir:system [
               fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ;
               fhir:l <http://varnomen.hgvs.org>
             ] ;
             fhir:code [ fhir:v "NC_000001.10:g.86852621A>G" ] ;
             fhir:display [ fhir:v "NC_000001.10:g.86852621A>G" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:81258-6 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "81258-6" ] ;
             fhir:display [ fhir:v "Sample VAF" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Quantity ;
           fhir:value [ fhir:v 0.6 ] ;
           fhir:unit [ fhir:v "relative frequency of a particular allele in the specimen" ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "1" ]
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:69547-8 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "69547-8" ] ;
             fhir:display [ fhir:v "Genomic Ref allele [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:String ;
           fhir:v "A"
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:69551-0 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "69551-0" ] ;
             fhir:display [ fhir:v "Genomic Alt allele [ID]" ]
           ] )
         ] ;
         fhir:value [
           a fhir:String ;
           fhir:v "G"
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:92822-6 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "92822-6" ] ;
             fhir:display [ fhir:v "Genomic coord system" ]
           ] )
         ] ;
         fhir:value [
           a fhir:CodeableConcept ;
           fhir:coding ( [
             a loinc:LA30100-4 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "LA30100-4" ] ;
             fhir:display [ fhir:v "0-based interval counting" ]
           ] )
         ]
       ] [
         fhir:code [
           fhir:coding ( [
             a loinc:81254-5 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "81254-5" ] ;
             fhir:display [ fhir:v "Genomic allele start-end" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Range ;
           fhir:low [
             fhir:value [ fhir:v "86852620"^^xsd:decimal ]
           ]
         ]
       ] )
     ] )
  ] ) . # 

<http://hl7.org/fhir/uv/genomics-reporting/Patient/HG00403> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Observation/variantExampleMC> a fhir:Uv .

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