@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/genomics-reporting/Observation/TxImp04> a fhir:Observation ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "TxImp04"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication>
     ] )
  ] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">Poor metabolizer of Escitalopram</div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact>
     ] ;
     fhir:value [
       a fhir:RelatedArtifact ;
       fhir:type [ fhir:v "citation" ] ;
       fhir:url [
         fhir:v "https://cpicpgx.org/guidelines/guideline-for-selective-serotonin-reuptake-inhibitors-and-cyp2d6-and-cyp2c19/"^^xsd:anyURI ;
         fhir:l <https://cpicpgx.org/guidelines/guideline-for-selective-serotonin-reuptake-inhibitors-and-cyp2d6-and-cyp2c19/>
       ]
     ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
       ] ;
       fhir:code [ fhir:v "laboratory" ]
     ] )
  ] [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
       ] ;
       fhir:code [ fhir:v "GE" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
       ] ;
       fhir:code [ fhir:v "therapeutic-implication" ]
     ] )
  ] ; # 
  fhir:subject [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/CGPatientExample01> ;
     fhir:reference [ fhir:v "Patient/CGPatientExample01" ]
  ] ; # 
  fhir:effective [
     a fhir:DateTime ;
     fhir:v "2019-04-01"^^xsd:date
  ] ; # 
  fhir:performer ( [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> ;
     fhir:reference [ fhir:v "Organization/ExampleOrg" ]
  ] ) ; # 
  fhir:derivedFrom ( [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/Pgx-geno-1001> ;
     fhir:reference [ fhir:v "Observation/Pgx-geno-1001" ]
  ] ) ; # 
  fhir:component ( [
     fhir:code [
       fhir:coding ( [
         a loinc:51963-7 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "51963-7" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
           fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
         ] ;
         fhir:code [ fhir:v "321988" ] ;
         fhir:display [ fhir:v "escitalopram" ]
       ] )
     ]
  ] [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
         ] ;
         fhir:code [ fhir:v "therapeutic-implication" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         a loinc:LA9657-3 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "LA9657-3" ] ;
         fhir:display [ fhir:v "Poor metabolizer" ]
       ] )
     ]
  ] [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
         ] ;
         fhir:code [ fhir:v "conclusion-string" ]
       ] )
     ] ;
     fhir:value [
       a fhir:String ;
       fhir:v "For escitalopram, a 50% reduction in starting dose is recommended with therapeutic drug monitoring to guide dose adjustment or select an alternate drug not predominantly metabolized by CYP2C19. Refer to current guidelines for dosage and recommendations at https://cpicpgx.org/guidelines/guideline-for-selective-serotonin-reuptake-inhibitors-and-cyp2d6-and-cyp2c19/. If CYP2D6 genotyping is available, refer to the current guidelines for dosing recommendations."
     ]
  ] ) . # 

<http://hl7.org/fhir/uv/genomics-reporting/Patient/CGPatientExample01> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Organization/ExampleOrg> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Observation/Pgx-geno-1001> a fhir:Uv .

# -------------------------------------------------------------------------------------