{
  "resourceType" : "Bundle",
  "id" : "bundle-complexVariant-nonHGVS",
  "type" : "transaction",
  "entry" : [{
    "fullUrl" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "Inline-Instance-for-complexVariant-nonHGVS-1",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-complexVariant-nonHGVS-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-complexVariant-nonHGVS-1</b></p><a name=\"Inline-Instance-for-complexVariant-nonHGVS-1\"> </a><a name=\"hcInline-Instance-for-complexVariant-nonHGVS-1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeac\">John Storm(official) Male, DoB: 1986-12-31</a></p><p><b>effective</b>: 2019-03-05</p><p><b>issued</b>: 2019-03-05 16:04:44+0000</p><p><b>performer</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeab\">Organization aTypingLab Inc</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript ref sequence ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_022787.3}\">NM_022787.3</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81254-5}\">Genomic allele start-end</span></p><p><b>value</b>: 769-769</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69547-8}\">Genomic ref allele [ID]</span></p><p><b>value</b>: G</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69551-0}\">Genomic alt allele [ID]</span></p><p><b>value</b>: A</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 53034-5}\">Allelic state</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6706-1}\">Heterozygous</span></p></blockquote></div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "69548-6",
          "display" : "Genetic variant assessment"
        }]
      },
      "subject" : {
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeac"
      },
      "effectiveDateTime" : "2019-03-05",
      "issued" : "2019-03-05T16:04:44+00:00",
      "performer" : [{
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeab"
      }],
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA9633-4",
          "display" : "Present"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "51958-7",
            "display" : "Transcript ref sequence ID"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.ncbi.nlm.nih.gov/refseq",
            "code" : "NM_022787.3",
            "display" : "NM_022787.3"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "81254-5"
          }]
        },
        "valueRange" : {
          "low" : {
            "value" : 769
          },
          "high" : {
            "value" : 769
          }
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69547-8",
            "display" : "Genomic ref allele [ID]"
          }]
        },
        "valueString" : "G"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69551-0",
            "display" : "Genomic alt allele [ID]"
          }]
        },
        "valueString" : "A"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "53034-5",
            "display" : "Allelic state"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6706-1",
            "display" : "Heterozygous"
          }]
        }
      }]
    },
    "request" : {
      "method" : "POST",
      "url" : "Observation"
    }
  },
  {
    "fullUrl" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "Inline-Instance-for-complexVariant-nonHGVS-2",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-complexVariant-nonHGVS-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-complexVariant-nonHGVS-2</b></p><a name=\"Inline-Instance-for-complexVariant-nonHGVS-2\"> </a><a name=\"hcInline-Instance-for-complexVariant-nonHGVS-2\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeac\">John Storm(official) Male, DoB: 1986-12-31</a></p><p><b>effective</b>: 2019-03-05</p><p><b>issued</b>: 2019-03-05 16:04:44+0000</p><p><b>performer</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeab\">Organization aTypingLab Inc</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript ref sequence ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_022787.3}\">NM_022787.3</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81254-5}\">Genomic allele start-end</span></p><p><b>value</b>: 53-53</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69547-8}\">Genomic ref allele [ID]</span></p><p><b>value</b>: A</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69551-0}\">Genomic alt allele [ID]</span></p><p><b>value</b>: G</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 53034-5}\">Allelic state</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6706-1}\">Heterozygous</span></p></blockquote></div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "69548-6",
          "display" : "Genetic variant assessment"
        }]
      },
      "subject" : {
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeac"
      },
      "effectiveDateTime" : "2019-03-05",
      "issued" : "2019-03-05T16:04:44+00:00",
      "performer" : [{
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeab"
      }],
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA9633-4",
          "display" : "Present"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "51958-7",
            "display" : "Transcript ref sequence ID"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.ncbi.nlm.nih.gov/refseq",
            "code" : "NM_022787.3",
            "display" : "NM_022787.3"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "81254-5"
          }]
        },
        "valueRange" : {
          "low" : {
            "value" : 53
          },
          "high" : {
            "value" : 53
          }
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69547-8",
            "display" : "Genomic ref allele [ID]"
          }]
        },
        "valueString" : "A"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69551-0",
            "display" : "Genomic alt allele [ID]"
          }]
        },
        "valueString" : "G"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "53034-5",
            "display" : "Allelic state"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6706-1",
            "display" : "Heterozygous"
          }]
        }
      }]
    },
    "request" : {
      "method" : "POST",
      "url" : "Observation"
    }
  },
  {
    "fullUrl" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12a",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "Inline-Instance-for-complexVariant-nonHGVS-3",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-complexVariant-nonHGVS-3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-complexVariant-nonHGVS-3</b></p><a name=\"Inline-Instance-for-complexVariant-nonHGVS-3\"> </a><a name=\"hcInline-Instance-for-complexVariant-nonHGVS-3\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-genotype.html\">Genotype</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84413-4}\">Genotype display name</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeac\">John Storm(official) Male, DoB: 1986-12-31</a></p><p><b>effective</b>: 2019-03-05</p><p><b>issued</b>: 2019-03-05 16:04:44+0000</p><p><b>performer</b>: <a href=\"Bundle-bundle-CYP2C19.html#urn-uuid-19ac0aeb-6bd4-4e92-a891-d44a807bfeab\">Organization aTypingLab Inc</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/clinvar RCV000664188.1}\">NM_022787.3(NMNAT1):c.[53A&gt;G];[769G&gt;A] AND Cone-rod dystrophy</span></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12e\">unpacked representation of NM_022787.3:c.53A&gt;G</a></li><li><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">unpacked representation of NM_022787.3:c.769G&gt;A</a></li></ul></div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "84413-4"
        }]
      },
      "subject" : {
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeac"
      },
      "effectiveDateTime" : "2019-03-05",
      "issued" : "2019-03-05T16:04:44+00:00",
      "performer" : [{
        "reference" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeab"
      }],
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://www.ncbi.nlm.nih.gov/clinvar",
          "code" : "RCV000664188.1",
          "display" : "NM_022787.3(NMNAT1):c.[53A>G];[769G>A] AND Cone-rod dystrophy"
        }]
      },
      "hasMember" : [{
        "reference" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e",
        "display" : "unpacked representation of NM_022787.3:c.53A>G"
      },
      {
        "reference" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d",
        "display" : "unpacked representation of NM_022787.3:c.769G>A"
      }]
    },
    "request" : {
      "method" : "POST",
      "url" : "Observation"
    }
  },
  {
    "fullUrl" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeab",
    "resource" : {
      "resourceType" : "Organization",
      "id" : "performingLab",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_performingLab\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Organization performingLab</b></p><a name=\"performingLab\"> </a><a name=\"hcperformingLab\"> </a><p><b>name</b>: aTypingLab Inc</p><p><b>alias</b>: aTL</p><p><b>telecom</b>: ph: 1-800-555-1234(Work)</p><p><b>address</b>: 123 Main St, Sometown, ND 99999(work)</p></div>"
      },
      "name" : "aTypingLab Inc",
      "alias" : ["aTL"],
      "telecom" : [{
        "system" : "phone",
        "value" : "1-800-555-1234",
        "use" : "work",
        "rank" : 1
      }],
      "address" : [{
        "use" : "work",
        "type" : "both",
        "text" : "123 Main St, Sometown, ND 99999",
        "line" : ["123 Main St"],
        "city" : "Sometown",
        "state" : "ND",
        "postalCode" : "99999",
        "country" : "USA"
      }]
    },
    "request" : {
      "method" : "POST",
      "url" : "Organization"
    }
  },
  {
    "fullUrl" : "urn:uuid:19ac0aeb-6bd4-4e92-a891-d44a807bfeac",
    "resource" : {
      "resourceType" : "Patient",
      "id" : "patient",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_patient\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient patient</b></p><a name=\"patient\"> </a><a name=\"hcpatient\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">John Storm(official) Male, DoB: 1986-12-31</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Ways to contact the Patient\">Contact Detail</td><td colspan=\"3\"><ul><li>ph: 1-800-555-1234(Work)</li><li>123 Main St, Sometown, ND 99999(work)</li></ul></td></tr></table></div>"
      },
      "name" : [{
        "use" : "official",
        "text" : "John Storm",
        "family" : "Storm",
        "given" : ["John"]
      },
      {
        "use" : "nickname",
        "text" : "Johnny Storm",
        "family" : "Storm",
        "given" : ["Johnny"]
      },
      {
        "use" : "nickname",
        "text" : "The Human Torch"
      }],
      "telecom" : [{
        "system" : "phone",
        "value" : "1-800-555-1234",
        "use" : "work",
        "rank" : 1
      }],
      "gender" : "male",
      "birthDate" : "1986-12-31",
      "address" : [{
        "use" : "work",
        "type" : "both",
        "text" : "123 Main St, Sometown, ND 99999",
        "line" : ["123 Main St"],
        "city" : "Sometown",
        "state" : "ND",
        "postalCode" : "99999",
        "country" : "USA"
      }]
    },
    "request" : {
      "method" : "POST",
      "url" : "Patient"
    }
  }]
}