# Clarithromycin oral antibacterial - Order Catalog Implementation Guide v1.0.0

* [**Table Content**](toc.md)
* [**Artifacts Summary**](artifacts.md)
* **Clarithromycin oral antibacterial**

## Example MedicationKnowledge: Clarithromycin oral antibacterial

| |
| :--- |
| *Page standards status:*[Informative](http://hl7.org/fhir/R5/versions.html#std-process) |

Language: en-US

Profile: [item in a catalog of drugs](StructureDefinition-DrugKnowledge.md)

**Reference to a catalog**: [Composition Drugs authorized for prescription in Healthyland](Composition-example-medication-catalog-header.md)

**code**: Clarithromycin 25 mg/mL oral suspension

**intendedJurisdiction**: Healthyland

**name**: CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension

**productType**: Generic product

> **indicationGuideline**

### Indications

| | |
| :--- | :--- |
| - | **Reference** |
| * | [ClinicalUseDefinition: type = indication](ClinicalUseDefinition-example-bacterial-pharyngitis-indication.md) |
| * | [ClinicalUseDefinition: type = indication](ClinicalUseDefinition-example-acute-otitis-media-indication.md) |
| * | [ClinicalUseDefinition: type = indication](ClinicalUseDefinition-example-bacterial-sinusitis-indication.md) |

> **dosingGuideline**

### PatientCharacteristics

| | | |
| :--- | :--- | :--- |
| - | **Type** | **Value[x]** |
| * | Age | 0.5-12 years |



> **medicineClassification****type**: Anatomical Therapeutic Chemical (ATC)**source**: [https://www.whocc.no/atc/structure_and_principles/](https://www.whocc.no/atc/structure_and_principles/)**classification**: Clarithromycin

> **medicineClassification****type**: SNOMED CT drug dispositions**source**: [https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product](https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product)**classification**: Substance with antibacterial mechanism of action (substance)

> **packaging**

### Costs

| | | | | |
| :--- | :--- | :--- | :--- | :--- |
| - | **EffectiveDate** | **Type** | **Source** | **Cost[x]** |
| * | 2021-02-01 --> (ongoing) | public price | Healthyland Drug Administration | €5.18(EUR) |
| * | 2020-09-30 --> 2021-01-31 | public price | Healthyland Drug Administration | €5.20(EUR) |
| * | 2010-03-01 --> (ongoing) | manufacturers' cost | Healthyland Drug Administration | €4.40(EUR) |

**packagedProduct**: [PackagedProductDefinition Package for CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension in 100 ml HDPE bottle](PackagedProductDefinition-example-drug-package-clarithromycin.md)

**clinicalUseIssue**: [ClinicalUseDefinition: type = contraindication](ClinicalUseDefinition-example-allergy-contraindication.md)

> **definitional****doseForm**: Granules for oral suspension**intendedRoute**: Oral route
> **ingredient**

### Items

| | |
| :--- | :--- |
| - | **Concept** |
| * | Clarithromycin |

**type**: active ingredient - basis of strength**strength**: 25 milligram (Details: UCUM codemg = 'mg')/1 milliliter (Details: UCUM codemL = 'mL')

> **ingredient**

### Items

| | |
| :--- | :--- |
| - | **Concept** |
| * | Sucrose |

**type**: inactive ingredient



## Resource Content

```json
{
  "resourceType" : "MedicationKnowledge",
  "id" : "example-drug-clarithromycin-25mg-granule-suspension",
  "meta" : {
    "profile" : ["http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge"]
  },
  "language" : "en-US",
  "extension" : [{
    "url" : "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference",
    "valueReference" : {
      "reference" : "Composition/example-medication-catalog-header"
    }
  }],
  "code" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "769316002",
      "display" : "Clarithromycin 25 mg/mL oral suspension"
    }]
  },
  "intendedJurisdiction" : [{
    "text" : "Healthyland"
  }],
  "name" : ["CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension"],
  "productType" : [{
    "text" : "Generic product"
  }],
  "indicationGuideline" : [{
    "indication" : [{
      "reference" : {
        "reference" : "ClinicalUseDefinition/example-bacterial-pharyngitis-indication"
      }
    },
    {
      "reference" : {
        "reference" : "ClinicalUseDefinition/example-acute-otitis-media-indication"
      }
    },
    {
      "reference" : {
        "reference" : "ClinicalUseDefinition/example-bacterial-sinusitis-indication"
      }
    }],
    "dosingGuideline" : [{
      "patientCharacteristic" : [{
        "type" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "30525-0",
            "display" : "Age"
          }]
        },
        "valueRange" : {
          "low" : {
            "value" : 0.5,
            "unit" : "years",
            "system" : "http://unitsofmeasure.org",
            "code" : "a"
          },
          "high" : {
            "value" : 12,
            "unit" : "years",
            "system" : "http://unitsofmeasure.org",
            "code" : "a"
          }
        }
      }]
    }]
  }],
  "medicineClassification" : [{
    "type" : {
      "text" : "Anatomical Therapeutic Chemical (ATC)"
    },
    "sourceUri" : "https://www.whocc.no/atc/structure_and_principles/",
    "classification" : [{
      "coding" : [{
        "system" : "http://www.whocc.no/atc",
        "code" : "J01FA09",
        "display" : "Clarithromycin"
      }]
    }]
  },
  {
    "type" : {
      "text" : "SNOMED CT drug dispositions"
    },
    "sourceUri" : "https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product",
    "classification" : [{
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "419241000",
        "display" : "Substance with antibacterial mechanism of action (substance)"
      }]
    }]
  }],
  "packaging" : [{
    "cost" : [{
      "effectiveDate" : [{
        "start" : "2021-02-01"
      }],
      "type" : {
        "text" : "public price"
      },
      "source" : "Healthyland Drug Administration",
      "costMoney" : {
        "value" : 5.18,
        "currency" : "EUR"
      }
    },
    {
      "effectiveDate" : [{
        "start" : "2020-09-30",
        "end" : "2021-01-31"
      }],
      "type" : {
        "text" : "public price"
      },
      "source" : "Healthyland Drug Administration",
      "costMoney" : {
        "value" : 5.2,
        "currency" : "EUR"
      }
    },
    {
      "effectiveDate" : [{
        "start" : "2010-03-01"
      }],
      "type" : {
        "text" : "manufacturers' cost"
      },
      "source" : "Healthyland Drug Administration",
      "costMoney" : {
        "value" : 4.4,
        "currency" : "EUR"
      }
    }],
    "packagedProduct" : {
      "reference" : "PackagedProductDefinition/example-drug-package-clarithromycin"
    }
  }],
  "clinicalUseIssue" : [{
    "reference" : "ClinicalUseDefinition/example-allergy-contraindication"
  }],
  "definitional" : {
    "doseForm" : {
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "385029002",
        "display" : "Granules for oral suspension"
      },
      {
        "system" : "http://standardterms.edqm.eu",
        "code" : "10113000",
        "display" : "Granules for oral suspension"
      }]
    },
    "intendedRoute" : [{
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "26643006",
        "display" : "Oral route"
      }]
    }],
    "ingredient" : [{
      "item" : {
        "concept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "387487009",
            "display" : "Clarithromycin"
          }]
        }
      },
      "type" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
          "code" : "ACTIB",
          "display" : "active ingredient - basis of strength"
        }]
      },
      "strengthRatio" : {
        "numerator" : {
          "value" : 25,
          "unit" : "milligram",
          "system" : "http://unitsofmeasure.org",
          "code" : "mg"
        },
        "denominator" : {
          "value" : 1,
          "unit" : "milliliter",
          "system" : "http://unitsofmeasure.org",
          "code" : "mL"
        }
      }
    },
    {
      "item" : {
        "concept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "11320009",
            "display" : "Sucrose"
          }]
        }
      },
      "type" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
          "code" : "IACT",
          "display" : "inactive ingredient"
        }]
      }
    }]
  }
}

```
