InteractionDefinition
type: StructureDefinition
node role: treeRoot
id:
  v: InteractionDefinition
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: StructureDefinition InteractionDefinition Name Flags Card. Type Description & Constraints<img src="[binary]" alt="doco" style="background-color: inherit"/> ClinicalUseDefinition 0..* ClinicalUseDefinition A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure #xD; type 1..1 code indication | contraindication | interaction | undesirable-effect | warning Required Pattern: interaction #xD; contraindication 0..0 Specifics for when this is a contraindication #xD; indication 0..0 Specifics for when this is an indication #xD; interaction 1..1 BackboneElement Specifics for when this is an interaction #xD; undesirableEffect 0..0 A possible negative outcome from the use of this treatment #xD; warning 0..0 Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness' #xD; <img src="[binary]" alt="doco" style="background-color: inherit"/> Documentation for this format
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-wg
    l: structuredefinition-wg
  value: Code
    v: oo
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm
    l: structuredefinition-fmm
  value: Integer
    v: 2
    extension:
      url:
        v: http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom
        l: structuredefinition-conformance-derivedFrom
      value: Canonical
        v: http://hl7.org/fhir/uv/order-catalog/ImplementationGuide/ig-uv-order-catalog
        l: ig-uv-order-catalog
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status
    l: structuredefinition-standards-status
  value: Code
    v: trial-use
    extension:
      url:
        v: http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom
        l: structuredefinition-conformance-derivedFrom
      value: Canonical
        v: http://hl7.org/fhir/uv/order-catalog/ImplementationGuide/ig-uv-order-catalog
        l: ig-uv-order-catalog
url:
  v: http://hl7.org/fhir/uv/order-catalog/StructureDefinition/InteractionDefinition
  l: InteractionDefinition
identifier:
  system:
    v: urn:ietf:rfc:3986
    l: 3986
  value:
    v: urn:oid:2.16.840.1.113883.4.642.40.55.42.12
version:
  v: 1.0.0
name:
  v: InteractionDefinition
title:
  v: ClinicalUseDefinition as an interaction
status:
  v: active
date:
  v: 2026-06-03T16:34:09+00:00
publisher:
  v: HL7 International / Orders and Observations
contact:
  telecom:
    system:
      v: url
    value:
      v: http://www.hl7.org/Special/committees/orders
description:
  v: This profile constrains the base resource ClinicalUseDefinition to represent an interaction associated with a healthcare item (medication, device, test, service ...) described in a catalog
jurisdiction:
  coding:
    system:
      v: http://unstats.un.org/unsd/methods/m49/m49.htm
      l: m49.htm
    code:
      v: 001
fhir version:
  v: 5.0.0
mapping:
  identity:
    v: idmp
  uri:
    v: https://en.wikipedia.org/wiki/Identification_of_medicinal_products
    l: Identification of medicinal products
  name:
    v: IDMP Mapping
mapping:
  identity:
    v: rim
  uri:
    v: http://hl7.org/v3
    l: v3
  name:
    v: RIM Mapping
mapping:
  identity:
    v: workflow
  uri:
    v: http://hl7.org/fhir/workflow
    l: workflow
  name:
    v: Workflow Pattern
mapping:
  identity:
    v: w5
  uri:
    v: http://hl7.org/fhir/fivews
    l: fivews
  name:
    v: FiveWs Pattern Mapping
kind:
  v: resource
abstract:
  v: false
type:
  v: ClinicalUseDefinition
  l: ClinicalUseDefinition
base definition:
  v: http://hl7.org/fhir/StructureDefinition/ClinicalUseDefinition
  l: ClinicalUseDefinition
derivation:
  v: constraint
snapshot:
  extension:
    url:
      v: http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version
      l: snapshot-base-version
    value: String
      v: 5.0.0
  element:
    id:
      v: ClinicalUseDefinition
    path:
      v: ClinicalUseDefinition
    short:
      v: A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure
    definition:
      v: A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.
    min:
      v: 0
    max:
      v: *
    base:
      path:
        v: ClinicalUseDefinition
      min:
        v: 0
      max:
        v: *
    constraint:
      key:
        v: cud-1
      severity:
        v: error
      human:
        v: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance
      expression:
        v: (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
      source:
        v: http://hl7.org/fhir/StructureDefinition/ClinicalUseDefinition
        l: ClinicalUseDefinition
    constraint:
      key:
        v: dom-2
      severity:
        v: error
      human:
        v: If the resource is contained in another resource, it SHALL NOT contain nested Resources
      expression:
        v: contained.contained.empty()
      source:
        v: http://hl7.org/fhir/StructureDefinition/DomainResource
        l: DomainResource
    constraint:
      key:
        v: dom-3
      severity:
        v: error
      human:
        v: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
      expression:
        v: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
      source:
        v: http://hl7.org/fhir/StructureDefinition/DomainResource
        l: DomainResource
    constraint:
      key:
        v: dom-4
      severity:
        v: error
      human:
        v: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
      expression:
        v: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
      source:
        v: http://hl7.org/fhir/StructureDefinition/DomainResource
        l: DomainResource
    constraint:
      key:
        v: dom-5
      severity:
        v: error

v: If a resource is contained in another resource, it SHALL NOT have a security label

v: contained.meta.security.empty()

extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice
    l: elementdefinition-bestpractice
  value: Boolean
    v: true
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation
    l: elementdefinition-bestpractice-explanation
  value: Markdown
    v: When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time.
key:
  v: dom-6
severity:
  v: warning
human:
  v: A resource should have narrative for robust management
expression:
  v: text.`div`.exists()
source:
  v: http://hl7.org/fhir/StructureDefinition/DomainResource
  l: DomainResource

v: false

v: false

v: false

identity:
  v: rim
map:
  v: Entity, Role, or Act

identity:
  v: workflow
map:
  v: Definition

identity:
  v: w5
map:
  v: clinical.general

identity:
  v: idmp
map:
  v: Contraindication, Therapeutic Indication, Interactions, Undesirable Effects

id:
  v: ClinicalUseDefinition.id
path:
  v: ClinicalUseDefinition.id
short:
  v: Logical id of this artifact
definition:
  v: The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.
comment:
  v: Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Resource.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
      l: structuredefinition-fhir-type
    value: Url
      v: id
      l: id
  code:
    v: http://hl7.org/fhirpath/System.String
    l: System.String
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true

id:
  v: ClinicalUseDefinition.meta
path:
  v: ClinicalUseDefinition.meta
short:
  v: Metadata about the resource
definition:
  v: The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Resource.meta
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Meta
    l: Meta
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true

id:
  v: ClinicalUseDefinition.implicitRules
path:
  v: ClinicalUseDefinition.implicitRules
short:
  v: A set of rules under which this content was created
definition:
  v: A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.
comment:
  v: Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Resource.implicitRules
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: uri
    l: uri
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: true
is modifier reason:
  v: This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation
is summary:
  v: true

id:
  v: ClinicalUseDefinition.language
path:
  v: ClinicalUseDefinition.language
short:
  v: Language of the resource content
definition:
  v: The base language in which the resource is written.
comment:
  v: Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Resource.language
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: code
    l: code
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: false
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: Language
  strength:
    v: required
  description:
    v: IETF language tag for a human language
  value set:
    v: http://hl7.org/fhir/ValueSet/all-languages|5.0.0
    l: http://hl7.org/fhir/ValueSet/all-languages
  additional:
    purpose:
      v: starter
    value set:
      v: http://hl7.org/fhir/ValueSet/languages|5.0.0
      l: http://hl7.org/fhir/ValueSet/languages

id:
  v: ClinicalUseDefinition.text
path:
  v: ClinicalUseDefinition.text
short:
  v: Text summary of the resource, for human interpretation
definition:
  v: A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.
comment:
  v: Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later.
alias:
  v: narrative
alias:
  v: html
alias:
  v: xhtml
alias:
  v: display
min:
  v: 0
max:
  v: 1
base:
  path:
    v: DomainResource.text
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Narrative
    l: Narrative
condition:
  v: dom-6
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: Act.text?

id:
  v: ClinicalUseDefinition.contained
path:
  v: ClinicalUseDefinition.contained
short:
  v: Contained, inline Resources
definition:
  v: These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.
comment:
  v: This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.
alias:
  v: inline resources
alias:
  v: anonymous resources
alias:
  v: contained resources
min:
  v: 0
max:
  v: *
base:
  path:
    v: DomainResource.contained
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Resource
    l: Resource
condition:
  v: dom-2
condition:
  v: dom-4
condition:
  v: dom-3
condition:
  v: dom-5
must support:
  v: false
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.extension
path:
  v: ClinicalUseDefinition.extension
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: DomainResource.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
must support:
  v: false
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.modifierExtension
path:
  v: ClinicalUseDefinition.modifierExtension
short:
  v: Extensions that cannot be ignored
definition:
  v: May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: DomainResource.modifierExtension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
must support:
  v: false
is modifier:
  v: true
is modifier reason:
  v: Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them
is summary:
  v: true
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.identifier
path:
  v: ClinicalUseDefinition.identifier
short:
  v: Business identifier for this issue
definition:
  v: Business identifier for this issue.
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.identifier
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Identifier
    l: Identifier
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: workflow
  map:
    v: Definition.identifier
mapping:
  identity:
    v: w5
  map:
    v: FiveWs.class
mapping:
  identity:
    v: idmp
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.type
path:
  v: ClinicalUseDefinition.type
short:
  v: indication | contraindication | interaction | undesirable-effect | warning
definition:
  v: indication | contraindication | interaction | undesirable-effect | warning.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.type
  min:
    v: 1
  max:
    v: 1
type:
  code:
    v: code
    l: code
pattern: Code
  v: interaction
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: ClinicalUseDefinitionType
  strength:
    v: required
  description:
    v: Overall defining type of this clinical use definition.
  value set:
    v: http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0
    l: http://hl7.org/fhir/ValueSet/clinical-use-definition-type
mapping:
  identity:
    v: idmp
  map:
    v: (the type of IDMP class, out of Contraindication, Therapeutic Indication, Interactions, Undesirable Effects)

id:
  v: ClinicalUseDefinition.category
path:
  v: ClinicalUseDefinition.category
short:
  v: A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
definition:
  v: A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy and Lactation", "Overdose", "Effects on Ability to Drive and Use Machines".
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.category
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: CodeableConcept
    l: CodeableConcept
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: ClinicalUseDefinitionCategory
  strength:
    v: preferred
  description:
    v: A categorisation for a clinical use information item.
  value set:
    v: http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0
    l: http://hl7.org/fhir/ValueSet/clinical-use-definition-category
mapping:
  identity:
    v: idmp
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.subject
path:
  v: ClinicalUseDefinition.subject
short:
  v: The medication, product, substance, device, procedure etc. for which this is an indication
definition:
  v: The medication, product, substance, device, procedure etc. for which this is an indication.
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.subject
  min:
    v: 0
  max:
    v: *
type:
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id:
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comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
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comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
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id:
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id:
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    v: Contraindication.Disease Status

id:
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path:
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id:
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    v: All FHIR elements must have a @value or children
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id:
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id:
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comment:
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comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
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    v: Classification of relationship between a therapy and a contraindication or an indication.
  value set:
    v: http://hl7.org/fhir/ValueSet/therapy-relationship-type|5.0.0
    l: http://hl7.org/fhir/ValueSet/therapy-relationship-type
mapping:
  identity:
    v: idmp
  map:
    v: Other Therapy Specifics.Therapy Relationship Type

id:
  v: ClinicalUseDefinition.contraindication.otherTherapy.treatment
path:
  v: ClinicalUseDefinition.contraindication.otherTherapy.treatment
short:
  v: Reference to a specific medication, substance etc. as part of an indication or contraindication
definition:
  v: Reference to a specific medication (active substance, medicinal product or class of products, biological, food etc.) as part of an indication or contraindication.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.contraindication.otherTherapy.treatment
  min:
    v: 1
  max:
    v: 1
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/MedicinalProductDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/MedicinalProductDefinition
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/Medication|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/Medication
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/Substance|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/Substance
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/SubstanceDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/SubstanceDefinition
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/NutritionProduct|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/NutritionProduct
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ActivityDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ActivityDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: Therapy
  strength:
    v: example
  description:
    v: A therapy.
  value set:
    v: http://hl7.org/fhir/ValueSet/therapy|5.0.0
    l: http://hl7.org/fhir/ValueSet/therapy
mapping:
  identity:
    v: idmp
  map:
    v: Other Therapy Specifics.Medication

id:
  v: ClinicalUseDefinition.indication
path:
  v: ClinicalUseDefinition.indication
short:
  v: Specifics for when this is an indication
definition:
  v: Specifics for when this is an indication.
min:
  v: 0
max:
  v: 0
base:
  path:
    v: ClinicalUseDefinition.indication
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: BackboneElement
    l: BackboneElement
condition:
  v: cud-1
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication

id:
  v: ClinicalUseDefinition.indication.id
path:
  v: ClinicalUseDefinition.indication.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
      l: structuredefinition-fhir-type
    value: Url
      v: string
      l: string
  code:
    v: http://hl7.org/fhirpath/System.String
    l: System.String
condition:
  v: ele-1
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.indication.extension
path:
  v: ClinicalUseDefinition.indication.extension
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.indication.modifierExtension
path:
  v: ClinicalUseDefinition.indication.modifierExtension
short:
  v: Extensions that cannot be ignored even if unrecognized
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
alias:
  v: extensions
alias:
  v: user content
alias:
  v: modifiers
min:
  v: 0
max:
  v: *
base:
  path:
    v: BackboneElement.modifierExtension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: true
is modifier reason:
  v: Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
is summary:
  v: true
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.indication.diseaseSymptomProcedure
path:
  v: ClinicalUseDefinition.indication.diseaseSymptomProcedure
short:
  v: The situation that is being documented as an indicaton for this item
definition:
  v: The situation that is being documented as an indicaton for this item.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.indication.diseaseSymptomProcedure
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ObservationDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: DiseaseSymptomProcedure
  strength:
    v: example
  description:
    v: A symptom, disease or procedure.
  value set:
    v: http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0
    l: http://hl7.org/fhir/ValueSet/disease-symptom-procedure
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Indication as "Disease / Symptom / Procedure", and Therapeutic Indication.Indication Text

id:
  v: ClinicalUseDefinition.indication.diseaseStatus
path:
  v: ClinicalUseDefinition.indication.diseaseStatus
short:
  v: The status of the disease or symptom for the indication
definition:
  v: The status of the disease or symptom for the indication, for example "chronic" or "metastatic".
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.indication.diseaseStatus
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ObservationDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: DiseaseStatus
  strength:
    v: example
  description:
    v: The status of a disease or symptom.
  value set:
    v: http://hl7.org/fhir/ValueSet/disease-status|5.0.0
    l: http://hl7.org/fhir/ValueSet/disease-status
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Disease Status

id:
  v: ClinicalUseDefinition.indication.comorbidity
path:
  v: ClinicalUseDefinition.indication.comorbidity
short:
  v: A comorbidity or coinfection as part of the indication
definition:
  v: A comorbidity (concurrent condition) or coinfection as part of the indication.
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.indication.comorbidity
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ObservationDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: DiseaseSymptomProcedure
  strength:
    v: example
  description:
    v: A symptom, disease or procedure.
  value set:
    v: http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0
    l: http://hl7.org/fhir/ValueSet/disease-symptom-procedure
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Comorbidity

id:
  v: ClinicalUseDefinition.indication.intendedEffect
path:
  v: ClinicalUseDefinition.indication.intendedEffect
short:
  v: The intended effect, aim or strategy to be achieved
definition:
  v: The intended effect, aim or strategy to be achieved.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.indication.intendedEffect
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ObservationDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: ProductIntendedUse
  strength:
    v: preferred
  description:
    v: The overall intended use of a product.
  value set:
    v: http://hl7.org/fhir/ValueSet/product-intended-use|5.0.0
    l: http://hl7.org/fhir/ValueSet/product-intended-use
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Intended Effect

id:
  v: ClinicalUseDefinition.indication.duration[x]
path:
  v: ClinicalUseDefinition.indication.duration[x]
short:
  v: Timing or duration information
definition:
  v: Timing or duration information, that may be associated with use with the indicated condition e.g. Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months).
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.indication.duration[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Range
    l: Range
type:
  code:
    v: string
    l: string
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Timing / Duration

id:
  v: ClinicalUseDefinition.indication.undesirableEffect
path:
  v: ClinicalUseDefinition.indication.undesirableEffect
short:
  v: An unwanted side effect or negative outcome of the subject of this resource when being used for this indication
definition:
  v: An unwanted side effect or negative outcome that may happen if you use the drug (or other subject of this resource) for this indication.
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.indication.undesirableEffect
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Reference
    l: Reference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ClinicalUseDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ClinicalUseDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Undesirable Effects

id:
  v: ClinicalUseDefinition.indication.applicability
path:
  v: ClinicalUseDefinition.indication.applicability
short:
  v: An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
definition:
  v: An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements.
comment:
  v: The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.indication.applicability
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Expression
    l: Expression
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: idmp
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.indication.otherTherapy
path:
  v: ClinicalUseDefinition.indication.otherTherapy
short:
  v: The use of the medicinal product in relation to other therapies described as part of the indication
definition:
  v: Information about the use of the medicinal product in relation to other therapies described as part of the indication.
min:
  v: 0
max:
  v: *
base:
  path:
    v: ClinicalUseDefinition.indication.otherTherapy
  min:
    v: 0
  max:
    v: *
content reference:
  v: http://hl7.org/fhir/StructureDefinition/ClinicalUseDefinition#ClinicalUseDefinition.contraindication.otherTherapy
  l: ClinicalUseDefinition.contraindication.otherTherapy
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: Therapeutic Indication.Other Therapy Specifics

id:
  v: ClinicalUseDefinition.interaction
path:
  v: ClinicalUseDefinition.interaction
short:
  v: Specifics for when this is an interaction
definition:
  v: Specifics for when this is an interaction.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.interaction
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: BackboneElement
    l: BackboneElement
condition:
  v: cud-1
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: Interactions

id:
  v: ClinicalUseDefinition.interaction.id
path:
  v: ClinicalUseDefinition.interaction.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
      l: structuredefinition-fhir-type
    value: Url
      v: string
      l: string
  code:
    v: http://hl7.org/fhirpath/System.String
    l: System.String
condition:
  v: ele-1
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.interaction.extension
path:
  v: ClinicalUseDefinition.interaction.extension
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.interaction.modifierExtension
path:
  v: ClinicalUseDefinition.interaction.modifierExtension
short:
  v: Extensions that cannot be ignored even if unrecognized
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
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alias:
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    l: Extension
constraint:
  key:
    v: ele-1
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    v: error
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    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
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    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
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    v: error
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    l: Extension
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is summary:
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mapping:
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    v: rim
  map:
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id:
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path:
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  v: The specific medication, product, food etc. or laboratory test that interacts
definition:
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id:
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path:
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      v: string
      l: string
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id:
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short:
  v: Additional content defined by implementations
definition:
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comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
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id:
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path:
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short:
  v: Extensions that cannot be ignored even if unrecognized
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
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    v: All FHIR elements must have a @value or children
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    v: hasValue() or (children().count() > id.count())
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    v: Must have either extensions or value[x], not both
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  v: Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
is summary:
  v: true
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.interaction.interactant.item[x]
path:
  v: ClinicalUseDefinition.interaction.interactant.item[x]
short:
  v: The specific medication, product, food etc. or laboratory test that interacts
definition:
  v: The specific medication, product, food, substance etc. or laboratory test that interacts.
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    l: http://hl7.org/fhir/StructureDefinition/MedicinalProductDefinition
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/Medication|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/Medication
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/Substance|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/Substance
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/NutritionProduct|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/NutritionProduct
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct
  target profile:
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    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
type:
  code:
    v: CodeableConcept
    l: CodeableConcept
constraint:
  key:
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    v: All FHIR elements must have a @value or children
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    l: Element
must support:
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      l: elementdefinition-bindingName
    value: String
      v: Interactant
  strength:
    v: example
  description:
    v: An interactant - a substance that may have a clinically significant effect on another.
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    v: http://hl7.org/fhir/ValueSet/interactant|5.0.0
    l: http://hl7.org/fhir/ValueSet/interactant
mapping:
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    v: idmp
  map:
    v: Interactions.Interactant and Interactions.Interactions Text

id:
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path:
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short:
  v: The type of the interaction e.g. drug-drug interaction, drug-lab test interaction
definition:
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  v: false
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binding:
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      v: InteractionType
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    v: A categorisation for an interaction between two substances.
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    l: http://hl7.org/fhir/ValueSet/interaction-type
mapping:
  identity:
    v: idmp
  map:
    v: Interactions.Interactions Type

id:
  v: ClinicalUseDefinition.interaction.effect
path:
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definition:
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    v: All FHIR elements must have a @value or children
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    l: http://hl7.org/fhir/ValueSet/interaction-effect
mapping:
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    v: idmp
  map:
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id:
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    value: String
      v: UndesirableEffectSymptom
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    l: http://hl7.org/fhir/ValueSet/interaction-incidence
mapping:
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  map:
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id:
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id:
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id:
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  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
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    v: All FHIR elements must have a @value or children
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  v: Extensions that cannot be ignored even if unrecognized
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  v: May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
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    v: error
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    v: All FHIR elements must have a @value or children
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  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: true
is modifier reason:
  v: Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
is summary:
  v: true
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.undesirableEffect.symptomConditionEffect
path:
  v: ClinicalUseDefinition.undesirableEffect.symptomConditionEffect
short:
  v: The situation in which the undesirable effect may manifest
definition:
  v: The situation in which the undesirable effect may manifest.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.undesirableEffect.symptomConditionEffect
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableReference
    l: CodeableReference
  target profile:
    v: http://hl7.org/fhir/StructureDefinition/ObservationDefinition|5.0.0
    l: http://hl7.org/fhir/StructureDefinition/ObservationDefinition
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: UndesirableEffectSymptom
  strength:
    v: example
  description:
    v: An undesirable effect of clinical use.
  value set:
    v: http://hl7.org/fhir/ValueSet/undesirable-effect-symptom|5.0.0
    l: http://hl7.org/fhir/ValueSet/undesirable-effect-symptom
mapping:
  identity:
    v: idmp
  map:
    v: Undesirable Effects.Undesirable Effect as "Symptom / Condition / Effect"

id:
  v: ClinicalUseDefinition.undesirableEffect.classification
path:
  v: ClinicalUseDefinition.undesirableEffect.classification
short:
  v: High level classification of the effect
definition:
  v: High level classification of the effect.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.undesirableEffect.classification
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableConcept
    l: CodeableConcept
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: UndesirableEffectClassification
  strength:
    v: example
  description:
    v: A categorisation for an undesirable effect.
  value set:
    v: http://hl7.org/fhir/ValueSet/undesirable-effect-classification|5.0.0
    l: http://hl7.org/fhir/ValueSet/undesirable-effect-classification
mapping:
  identity:
    v: idmp
  map:
    v: Undesirable Effects.Symptom / Condition / Effect Classification

id:
  v: ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence
path:
  v: ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence
short:
  v: How often the effect is seen
definition:
  v: How often the effect is seen.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableConcept
    l: CodeableConcept
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: UndesirablEffectFrequency
  strength:
    v: example
  description:
    v: A categorisation for a frequency of occurence of an undesirable effect.
  value set:
    v: http://hl7.org/fhir/ValueSet/undesirable-effect-frequency|5.0.0
    l: http://hl7.org/fhir/ValueSet/undesirable-effect-frequency
mapping:
  identity:
    v: idmp
  map:
    v: Undesirable Effects.Frequency of Occurrence

id:
  v: ClinicalUseDefinition.warning
path:
  v: ClinicalUseDefinition.warning
short:
  v: Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
definition:
  v: A critical piece of information about environmental, health or physical risks or hazards that serve as caution to the user. For example 'Do not operate heavy machinery', 'May cause drowsiness', or 'Get medical advice/attention if you feel unwell'.
min:
  v: 0
max:
  v: 0
base:
  path:
    v: ClinicalUseDefinition.warning
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: BackboneElement
    l: BackboneElement
condition:
  v: cud-1
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.warning.id
path:
  v: ClinicalUseDefinition.warning.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
      l: structuredefinition-fhir-type
    value: Url
      v: string
      l: string
  code:
    v: http://hl7.org/fhirpath/System.String
    l: System.String
condition:
  v: ele-1
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.warning.extension
path:
  v: ClinicalUseDefinition.warning.extension
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.warning.modifierExtension
path:
  v: ClinicalUseDefinition.warning.modifierExtension
short:
  v: Extensions that cannot be ignored even if unrecognized
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
requirements:
  v: Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).
alias:
  v: extensions
alias:
  v: user content
alias:
  v: modifiers
min:
  v: 0
max:
  v: *
base:
  path:
    v: BackboneElement.modifierExtension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
    l: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension
    l: Extension
is modifier:
  v: true
is modifier reason:
  v: Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
is summary:
  v: true
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: ClinicalUseDefinition.warning.description
path:
  v: ClinicalUseDefinition.warning.description
short:
  v: A textual definition of this warning, with formatting
definition:
  v: A textual definition of this warning, with formatting.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.warning.description
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: markdown
    l: markdown
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
mapping:
  identity:
    v: idmp
  map:
    v: n/a

id:
  v: ClinicalUseDefinition.warning.code
path:
  v: ClinicalUseDefinition.warning.code
short:
  v: A coded or unformatted textual definition of this warning
definition:
  v: A coded or unformatted textual definition of this warning.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: ClinicalUseDefinition.warning.code
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableConcept
    l: CodeableConcept
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element
    l: Element
must support:
  v: false
is modifier:
  v: false
is summary:
  v: true
binding:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName
      l: elementdefinition-bindingName
    value: String
      v: WarningType
  strength:
    v: example
  description:
    v: Classification of warning type.
  value set:
    v: http://hl7.org/fhir/ValueSet/warning-type|5.0.0
    l: http://hl7.org/fhir/ValueSet/warning-type
mapping:
  identity:
    v: idmp
  map:
    v: n/a

element:
  id:
    v: ClinicalUseDefinition
  path:
    v: ClinicalUseDefinition
element:
  id:
    v: ClinicalUseDefinition.type
  path:
    v: ClinicalUseDefinition.type
  pattern: Code
    v: interaction
element:
  id:
    v: ClinicalUseDefinition.contraindication
  path:
    v: ClinicalUseDefinition.contraindication
  max:
    v: 0
element:
  id:
    v: ClinicalUseDefinition.indication
  path:
    v: ClinicalUseDefinition.indication
  max:
    v: 0
element:
  id:
    v: ClinicalUseDefinition.interaction
  path:
    v: ClinicalUseDefinition.interaction
  min:
    v: 1
element:
  id:
    v: ClinicalUseDefinition.undesirableEffect
  path:
    v: ClinicalUseDefinition.undesirableEffect
  max:
    v: 0
element:
  id:
    v: ClinicalUseDefinition.warning
  path:
    v: ClinicalUseDefinition.warning
  max:
    v: 0