{ "resourceType" : "MedicationKnowledge", "id" : "example-drug-clarithromycin-25mg-granule-suspension", "meta" : { "profile" : ["http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge"] }, "language" : "en-US", "text" : { "status" : "extensions", "div" : "

Generated Narrative: MedicationKnowledge example-drug-clarithromycin-25mg-granule-suspension

Language: en-US

Profile: item in a catalog of drugs

Reference to a catalog: Composition Drugs authorized for prescription in Healthyland

code: Clarithromycin 25 mg/mL oral suspension

intendedJurisdiction: Healthyland

name: CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension

productType: Generic product

indicationGuideline

Indications

-Reference
*ClinicalUseDefinition: type = indication
*ClinicalUseDefinition: type = indication
*ClinicalUseDefinition: type = indication

dosingGuideline

PatientCharacteristics

-TypeValue[x]
*Age0.5-12 years

medicineClassification

type: Anatomical Therapeutic Chemical (ATC)

source: https://www.whocc.no/atc/structure_and_principles/

classification: Clarithromycin

medicineClassification

type: SNOMED CT drug dispositions

source: https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product

classification: Substance with antibacterial mechanism of action (substance)

packaging

Costs

-EffectiveDateTypeSourceCost[x]
*2021-02-01 --> (ongoing)public priceHealthyland Drug Administration€5.18 (EUR)
*2020-09-30 --> 2021-01-31public priceHealthyland Drug Administration€5.20 (EUR)
*2010-03-01 --> (ongoing)manufacturers' costHealthyland Drug Administration€4.40 (EUR)

packagedProduct: PackagedProductDefinition Package for CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension in 100 ml HDPE bottle

clinicalUseIssue: ClinicalUseDefinition: type = contraindication

definitional

doseForm: Granules for oral suspension

intendedRoute: Oral route

ingredient

Items

-Concept
*Clarithromycin

type: active ingredient - basis of strength

strength: 25 milligram (Details: UCUM codemg = 'mg')/1 milliliter (Details: UCUM codemL = 'mL')

ingredient

Items

-Concept
*Sucrose

type: inactive ingredient

" }, "extension" : [{ "url" : "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference", "valueReference" : { "reference" : "Composition/example-medication-catalog-header" } }], "code" : { "coding" : [{ "system" : "http://snomed.info/sct", "code" : "769316002", "display" : "Clarithromycin 25 mg/mL oral suspension" }] }, "intendedJurisdiction" : [{ "text" : "Healthyland" }], "name" : ["CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension"], "productType" : [{ "text" : "Generic product" }], "indicationGuideline" : [{ "indication" : [{ "reference" : { "reference" : "ClinicalUseDefinition/example-bacterial-pharyngitis-indication" } }, { "reference" : { "reference" : "ClinicalUseDefinition/example-acute-otitis-media-indication" } }, { "reference" : { "reference" : "ClinicalUseDefinition/example-bacterial-sinusitis-indication" } }], "dosingGuideline" : [{ "patientCharacteristic" : [{ "type" : { "coding" : [{ "system" : "http://loinc.org", "code" : "30525-0", "display" : "Age" }] }, "valueRange" : { "low" : { "value" : 0.5, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" }, "high" : { "value" : 12, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" } } }] }] }], "medicineClassification" : [{ "type" : { "text" : "Anatomical Therapeutic Chemical (ATC)" }, "sourceUri" : "https://www.whocc.no/atc/structure_and_principles/", "classification" : [{ "coding" : [{ "system" : "http://www.whocc.no/atc", "code" : "J01FA09", "display" : "Clarithromycin" }] }] }, { "type" : { "text" : "SNOMED CT drug dispositions" }, "sourceUri" : "https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product", "classification" : [{ "coding" : [{ "system" : "http://snomed.info/sct", "code" : "419241000", "display" : "Substance with antibacterial mechanism of action (substance)" }] }] }], "packaging" : [{ "cost" : [{ "effectiveDate" : [{ "start" : "2021-02-01" }], "type" : { "text" : "public price" }, "source" : "Healthyland Drug Administration", "costMoney" : { "value" : 5.18, "currency" : "EUR" } }, { "effectiveDate" : [{ "start" : "2020-09-30", "end" : "2021-01-31" }], "type" : { "text" : "public price" }, "source" : "Healthyland Drug Administration", "costMoney" : { "value" : 5.2, "currency" : "EUR" } }, { "effectiveDate" : [{ "start" : "2010-03-01" }], "type" : { "text" : "manufacturers' cost" }, "source" : "Healthyland Drug Administration", "costMoney" : { "value" : 4.4, "currency" : "EUR" } }], "packagedProduct" : { "reference" : "PackagedProductDefinition/example-drug-package-clarithromycin" } }], "clinicalUseIssue" : [{ "reference" : "ClinicalUseDefinition/example-allergy-contraindication" }], "definitional" : { "doseForm" : { "coding" : [{ "system" : "http://snomed.info/sct", "code" : "385029002", "display" : "Granules for oral suspension" }, { "system" : "http://standardterms.edqm.eu", "code" : "10113000", "display" : "Granules for oral suspension" }] }, "intendedRoute" : [{ "coding" : [{ "system" : "http://snomed.info/sct", "code" : "26643006", "display" : "Oral route" }] }], "ingredient" : [{ "item" : { "concept" : { "coding" : [{ "system" : "http://snomed.info/sct", "code" : "387487009", "display" : "Clarithromycin" }] } }, "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass", "code" : "ACTIB", "display" : "active ingredient - basis of strength" }] }, "strengthRatio" : { "numerator" : { "value" : 25, "unit" : "milligram", "system" : "http://unitsofmeasure.org", "code" : "mg" }, "denominator" : { "value" : 1, "unit" : "milliliter", "system" : "http://unitsofmeasure.org", "code" : "mL" } } }, { "item" : { "concept" : { "coding" : [{ "system" : "http://snomed.info/sct", "code" : "11320009", "display" : "Sucrose" }] } }, "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass", "code" : "IACT", "display" : "inactive ingredient" }] } }] } }