<?xml version="1.0" encoding="UTF-8"?>

<ClinicalUseDefinition xmlns="http://hl7.org/fhir">
  <id value="example-interaction"/>
  <meta>
    <profile value="http://hl7.org/fhir/uv/order-catalog/StructureDefinition/InteractionDefinition"/>
  </meta>
  <language value="en-US"/>
  <text>
    <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml" xml:lang="en-US" lang="en-US">
            <p>Drug interaction: Clarithromycin and Warfarin - increased anticoagulant effect</p>
        </div>
  </text>
  <type value="interaction"/>
  <interaction>
    <interactant>
      <itemCodeableConcept>
        <coding>
          <system value="http://snomed.info/sct"/>
          <code value="387487009"/>
          <display value="Clarithromycin"/>
        </coding>
      </itemCodeableConcept>
    </interactant>
    <interactant>
      <itemCodeableConcept>
        <coding>
          <system value="http://snomed.info/sct"/>
          <code value="372756006"/>
          <display value="Warfarin"/>
        </coding>
      </itemCodeableConcept>
    </interactant>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/interaction-type"/>
        <code value="drug-drug"/>
        <display value="drug to drug interaction"/>
      </coding>
    </type>
    <effect>
      <concept>
        <coding>
          <system value="http://snomed.info/sct"/>
          <code value="419511003"/>
          <display value="Propensity to adverse reactions to drug"/>
        </coding>
        <text value="Increased anticoagulant effect and risk of bleeding"/>
      </concept>
    </effect>
  </interaction>
</ClinicalUseDefinition>