HL7 Electronic Health Record System Functional Model, Release 2.1.1
2.1.1 - Normative

HL7 Electronic Health Record System Functional Model, Release 2.1.1, published by HL7 International / Electronic Health Records. This guide is not an authorized publication; it is the continuous build for version 2.1.1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ehrsfm-ig/ and changes regularly. See the Directory of published versions

## Requirements: CP.4.2.1 Medication Interaction and Allergy Checking (Function)

Official URL: http://hl7.org/ehrs/uv/ehrsfmr2/Requirements/EHRSFMR2-CP.4.2.1 | Version: 2.1.1
Standards status: Normative Active as of 2025-12-13 | Computable Name: CP_4_2_1_Medication_Interaction_and_Allergy_Checking

Provide alerts for potential medication interactions and medication allergy reactions.

Description I:

Check and provide alerts at the time of medication order based upon coded, active and non-active medications for possible interactions, allergies, sensitivities, intolerances, and other adverse reactions.

Criteria N:

CP.4.2.1#01 | SHALL | The system SHALL conform to function CPS.4.2.1 (Support for Medication Interaction and Allergy Checking) to determine allergic reactions, drug-drug interactions, and other potential adverse reactions, and render alerts or notifications when new medications are ordered.
CP.4.2.1#02 | SHALL | The system SHALL conform to function CP.1.2 (Manage Allergy, Intolerance and Adverse Reaction List) to provide the ability to manage interaction and allergy checking and render alerts and notifications when new medications are ordered.
CP.4.2.1#03 | MAY | The system MAY provide the ability to render an alert, at the time a new medication is prescribed/ordered, that drug interaction, allergy, and formulary checking will not be performed against uncoded or free text medication(s).
CP.4.2.1#04 | MAY dependent | The system MAY provide the ability to render a notification, at the time a new uncoded medication is prescribed/ordered, that drug interaction, allergy, and formulary checking will not be performed, according to scope of practice, organizational policy, and/or jurisdictional law.
CP.4.2.1#05 | SHALL dependent | The system SHALL provide the ability to render and tag as inactive recently inactivated medications for inclusion in current medication screening according to scope of practice, organizational policy, and/or jurisdictional law.