ArtifactPublicationStatus: Active

url: https://fevir.net/resources/PublicationRecord/7638

identifier: FEvIR Object Identifier/7638

title: Citation for FEvIR Evidence 7637: Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19

status: Active

date: 2022-01-10 13:30:43+0000

author: Brian S. Alper:

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

description:

UseContexts

copyright:

Summaries

Classifications

citedArtifact

identifier: FEvIR Object Identifier/7637

relatedIdentifier: https://doi.org/10.1056/NEJMoa2105911

StatusDates

-	Activity	Actual	Period
*	Created	true	2021-08-05 --> (ongoing)

title

type: Primary title, Human use

language: English

text:

Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-19

title

type: Different text in an earlier version

language: English

text:

Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19

abstract

type: description, Description

language: English

text:

Patients who were hospitalized for COVID-19 and who were not critically ill were randomized in a response-adaptive manner to therapeutic-dose anticoagulation with heparin vs. usual-care pharmacologic thromboprophylaxis. The outcome reported here is the effect on organ support-free days (i.e. days without oxygen delivered by high-flow nasal cannula, noninvasive or invasive mechanical ventilation, or the use of vasopressors or inotropes). The statistical result was a median adjusted odds ratio 1.27 (95% credible interval 1.03 to 1.58), based on 1,740 events among 2,219 participants with known outcome out of 2,244 enrolled participants. The probability of superiority of therapeutic-dose anticoagulation with heparin was 98.6%. The risk of bias in this effect estimate is of extremely serious concern based on a serious concern for confounding covariate bias (confounding difference in calendar time), a very serious concern for performance bias (inadequate blinding of intervention deliverers who may determine the outcome based in part on exposure status), and very serious concern for analysis bias (bias related to selection of the analysis, and early trial termination).

abstract

type: assertion, Assertion

language: English

text:

It is uncertain whether therapeutic-dose anticoagulation with heparin affects the rate of organ support-free days in hospitalized patients with COVID-19 who are not critically ill.

RelatesTos

-	Type	Classifier	Citation	Target[x]
*	Cites	Journal Article	Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 [Journal Article]. Contributors: The ATTACC, ACTIV-4a, and REMAP-CAP Investigators. In: The New England Journal of Medicine, DOI 10.1056/NEJMoa2105911. Published August 04, 2021. Available at: https://doi.org/10.1056/NEJMoa2105911.	PublicationRecord Anticoagulation for COVID-19 Combined RCTs in NEJM

publicationForm

PublishedIns

-	Type	Title	Publisher	PublisherLocation
*	Database	Fast Evidence Interoperability Resources (FEvIR) Platform	Computable Publishing LLC	Franklin, NC, USA

articleDate: 2021-08-05

lastRevisionDate: 2021-08-25

language: English

copyright:

https://creativecommons.org/licenses/by-nc-sa/4.0/

webLocation

classifier: Computable resource, JSON

url: Evidence Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-19

classification

type: Knowledge Artifact Type

classifier: FHIR Resource

classification

type: fhir-resource

classifier: Evidence

contributorship

complete: true

entry

contributor: Brian S Alper (https://orcid.org/#0000-0003-4300-4928)

forenameInitials: BS

affiliation:

• Computable Publishing LLC
• Scientific Knowledge Accelerator Foundation
• COVID-19 Knowledge Accelerator

contributionType: Conceptualization, Data curation, Investigation, Methodology, Software, Writing - original draft

role: Author/Creator

ContributionInstances

-	Type	Time
*	defined-in-text	2021-08-05

correspondingContact: true

entry

contributor: Janice Tufte (https://orcid.org/#0000-0002-4346-3238)

affiliation: Hassanah Consulting

contributionType: Writing - review & editing, Formal analysis, Investigation, Validation

role: Reviewer

contributionInstance

type: Reviewed

time: 2021-08-05

contributionInstance

type: Reviewed

time: 2021-08-06

entry

contributor: Harold Lehmann

affiliation: Johns Hopkins University

contributionType: Investigation, Methodology, Writing - original draft

role: Author/Creator

entry

contributor: Ahmad Sofi-Mahmudi

affiliation: Cochrane Iran Associate Centre

contributionType: Investigation, Methodology, Validation, Writing - review & editing

role: Author/Creator

entry

contributor: Joanne Dehnbostel

affiliation: Computable Publishing LLC

contributionType: Project administration, Investigation, Writing - review & editing

role: Author/Creator

entry

contributor: Vignesh Subbian

affiliation: University of Arizona

contributionType: Formal analysis, Investigation, Writing - review & editing

role: Reviewer

ContributionInstances

-	Type	Time
*	Reviewed	2021-08-07

entry

contributor: Ilkka Kunnamo (https://orcid.org/#0000-0002-4817-6991)

affiliation:

• Duodecim Medical Publications Ltd., Finland
• Scientific Knowledge Accelerator Foundation

contributionType: Writing - review & editing

role: Author/Creator

ContributionInstances

-	Type	Time
*	Reviewed	2021-08-09

entry

contributor: Bhagvan Kommadi

affiliation: Value Momentum

contributionType: Methodology, Validation

role: Reviewer

entry

contributor: Alfonso Iorio

affiliation: McMaster University

contributionType: Formal analysis, Writing - review & editing

role: Reviewer

entry

contributor: Muhammad Afzal

affiliation: Sejong University, Seoul, South Korea

contributionType: Formal analysis, Writing - review & editing

role: Reviewer

entry

contributor: Kenneth J Wilkins

affiliation: National Institute of Diabetes & Digestive & Kidney Diseases

contributionType: Formal analysis, Writing - review & editing

role: Reviewer

entry

contributor: Surbhi Shah

affiliation: Mayo Clinic Arizona

contributionType: Writing - review & editing, defined-in-text

role: Reviewer

entry

contributor: Amy Price

contributionType: Writing - review & editing

role: Reviewer

Generated Narrative: Practitioner #contributor0

Brian S Alper (https://orcid.org/#0000-0003-4300-4928)

---

Contact Detail

balper@computablepublishing.com

Generated Narrative: Practitioner #contributor1

Janice Tufte (https://orcid.org/#0000-0002-4346-3238)

---

Contact Detail

hassanahseattle@gmail.com

Generated Narrative: Practitioner #contributor2

Harold Lehmann

---

Contact Detail

lehmann@jhmi.edu

Generated Narrative: Practitioner #contributor3

Ahmad Sofi-Mahmudi

---

Contact Detail

a.sofimahmudi@gmail.com

Generated Narrative: Practitioner #contributor4

Joanne Dehnbostel

---

Contact Detail

jdehnbostel@computablepublishing.com

Generated Narrative: Practitioner #contributor5

Vignesh Subbian

---

Contact Detail

vsubbian@arizona.edu

Generated Narrative: Practitioner #contributor6

Ilkka Kunnamo (https://orcid.org/#0000-0002-4817-6991)

---

Contact Detail

ilkka.kunnamo@duodecim.fi

Generated Narrative: Practitioner #contributor7

Bhagvan Kommadi

---

Contact Detail

bhagvanarch@gmail.com

Generated Narrative: Practitioner #contributor8

Alfonso Iorio

---

Generated Narrative: Practitioner #contributor9

Muhammad Afzal

---

Contact Detail

afzalse@gmail.com

Generated Narrative: Practitioner #contributor10

Kenneth J Wilkins

---

Generated Narrative: Practitioner #contributor11

Surbhi Shah

---

Generated Narrative: Practitioner #contributor12

Amy Price

---