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    v: Generated Narrative: PublicationRecord 367878 version: 11; Last updated: 2025-10-13 12:34:35+0000 Profile: JournalArticleCitation ArtifactPublicationStatus: Active url: https://fevir.net/resources/PublicationRecord/367878 identifier: FEvIR Object Identifier/367878, https://pubmed.ncbi.nlm.nih.gov/38584159 title: 38584159 Efficacy and safety of a four-drug, quarter-dose treatment for hypertension: the QUARTET USA randomized trial. status: Active author: Computable Publishing®: MEDLINE-to-FEvIR Converter: publisher: Computable Publishing LLC contact: support@computablepublishing.com description: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide. UseContexts - Code Value[x] * Citation Classification Type: fevir-platform-use (FEvIR Platform Use) Medline Base copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/ approvalDate: 2024-06-04 lastReviewDate: 2024-06-19 classification type: Citation Source classifier: MEDLINE classification type: MEDLINE Citation Owner classifier: National Library of Medicine, Index Section currentState: Medline Citation Status of Medline, PubMed PublicationStatus of ppublish statusDate activity: PubMed Pubstatus of Received period: ?? --> 2024-01-19 statusDate activity: PubMed Pubstatus of Accepted period: ?? --> 2024-03-01 statusDate activity: PubMed Pubstatus of Revised period: ?? --> 2024-02-23 statusDate activity: PubMed Pubstatus of Medline period: ?? --> 2024-06-05 02:18:00+0000 statusDate activity: PubMed Pubstatus of Pubmed period: ?? --> 2024-04-08 00:42:00+0000 statusDate activity: PubMed Pubstatus of Entrez period: ?? --> 2024-04-07 23:04:00+0000 statusDate activity: PubMed Pubstatus of PMC release period: ?? --> 2024-04-08 citedArtifact identifier: https://pubmed.ncbi.nlm.nih.gov/38584159, https://www.ncbi.nlm.nih.gov/pmc//PMC11150153, https://doi.org/10.1038/s41440-024-01658-y, pii/10.1038/s41440-024-01658-y relatedIdentifier: <a href="http://terminology.hl7.org/7.3.0/NamingSystem-Cl…
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    v: Efficacy and safety of a four-drug, quarter-dose treatment for hypertension: the QUARTET USA randomized trial.
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    v: New approaches are needed to lower blood pressure (BP) given persistently low control rates. QUARTET USA sought to evaluate the effect of four-drug, quarter-dose BP lowering combination in patients with hypertension. QUARTET USA was a randomized (1:1), double-blinded trial conducted in federally qualified health centers among adults with hypertension. Participants received either a quadpill of candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg or candesartan 8 mg for 12 weeks. If BP was >130/>80 mm Hg at 6 weeks in either arm, then participants received open label add-on amlodipine 5 mg. The primary outcome was mean change in systolic blood pressure (SBP) at 12 weeks, controlling for baseline BP. Secondary outcomes included mean change in diastolic blood pressure (DBP), and safety included serious adverse events, relevant adverse drug effects, and electrolyte abnormalities. Among 62 participants randomized between August 2019-May 2022 (n = 32 intervention, n = 30 control), mean (SD) age was 52 (11.5) years, 45% were female, 73% identified as Hispanic, and 18% identified as Black. Baseline mean (SD) SBP was 138.1 (11.2) mmHg, and baseline mean (SD) DBP was 84.3 (10.5) mmHg. In a modified intention-to-treat analysis, there was no significant difference in SBP (-4.8 mm Hg [95% CI: -10.8, 1.3, p = 0.123] and a -4.9 mmHg (95% CI: -8.6, -1.3, p = 0.009) greater mean DBP change in the intervention arm compared with the control arm at 12 weeks. Adverse events did not differ significantly between arms. The quadpill had a similar SBP and greater DBP lowering effect compared with candesartan 8 mg. Trial registration number: NCT03640312.
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  display:
    v: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

contributor:
  l: contributor15
  reference:
    v: #contributor15
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Vu MH
forename initials:
  v: MH
affiliation:
  display:
    v: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

contributor:
  l: contributor16
  reference:
    v: #contributor16
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Chow CK
forename initials:
  v: CK
affiliation:
  display:
    v: Westmead Applied Research Centre, University of Sydney, Westmead, NSW, Australia.

contributor:
  l: contributor17
  reference:
    v: #contributor17
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Ciolino JD
forename initials:
  v: JD
affiliation:
  display:
    v: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
affiliation:
  display:
    v: Northwestern University Data Analysis and Coordinating Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.