Generated Narrative: PublicationRecord 33399 version: 32; Last updated: 2026-06-26 20:08:34+0000 Profile: JournalArticleCitation ArtifactPublicationStatus: Active url: https://fevir.net/resources/PublicationRecord/33399 identifier: FEvIR Object Identifier/33399, https://pubmed.ncbi.nlm.nih.gov/35243488 title: 35243488 Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis. status: Active author: Computable Publishing®: MEDLINE-to-FEvIR Converter: publisher: Computable Publishing LLC contact: support@computablepublishing.com description: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide. UseContexts - Code Value[x] * Citation Classification Type: fevir-platform-use (FEvIR Platform Use) Medline Base copyright: Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse). approvalDate: 2022-05-24 lastReviewDate: 2022-07-24 classification type: Citation Source classifier: MEDLINE classification type: MEDLINE Citation Owner classifier: National Library of Medicine, Index Section currentState: Medline Citation Status of Medline, PubMed PublicationStatus of ppublish statusDate activity: PubMed Pubstatus of Received period: ?? --> 2021-05-24 statusDate activity: PubMed Pubstatus of Revised period: ?? --> 2022-02-02 statusDate activity: PubMed Pubstatus of Accepted period: ?? --> 2022-02-03 statusDate activity: PubMed Pubstatus of Pubmed period: ?? --> 2022-03-05 06:00:00+0000 statusDate activity: PubMed Pubstatus of Medline period: ?? --> 2022-05-25 06:00:00+0000 statusDate activity: PubMed Pubstatus of Entrez period: ?? --> 2022-03-04 05:44:00+0000 statusDate activity: PubMed Pubstatus of PMC release period: ?? --> 2022-03-04 citedArtifact identifier: https://pubmed.ncbi.nlm.nih.gov/35243488, https://www.ncbi.nlm.nih.gov/pmc//PMC9123239, https://doi.org/10.1093/eurheartj/ehac071, pii/6542137 Titles - Type Language Text * Primary title English Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis. Abstracts - Type Text Copyright * Primary human use AIMS: Obesity is a global health problem, associated with significant morbidity and mortality, often due to cardiovascular (CV) diseases. While bariatric surgery is increasingly performed in patients with obesity and reduces CV risk factors, its effect on CV disease is not established. We conducted a systematic review and meta-analysis to evaluate the effect of bariatric surgery on CV outcomes, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. METHODS AND RESULTS: PubMed and Embase were searched for literature until August 2021 which compared bariatric surgery patients to non-surgical controls. Outcomes of interest were all-cause and CV mortality, atrial fibrillation (AF), heart failure (HF), myocardial infarction, and stroke. We included 39 studies, all prospective or retrospective cohort studies, but randomized outcome trials were not available. Bariatric surgery was associated with a beneficial effect on all-cause mortality [pooled hazard ratio (HR) of 0.55; 95% confidence interval (CI) 0.49-0.62, P < 0.001 vs. controls], and CV mortality (HR 0.59, 95% CI 0.47-0.73, P < 0.001). In addition, bariatric surgery was also associated with a reduced incidence of HF (HR 0.50, 95% CI 0.38-0.66, P < 0.001), myocardial infarction (HR 0.58, 95% CI 0.43-0.76, P < 0.001), and stroke (HR 0.64, 95% CI 0.53-0.77, P < 0.001), while its association with AF was not statistically significant (HR 0.82, 95% CI 0.64-1.06, P = 0.12). CONCLUSION: The present systematic review and meta-analysis suggests that bariatric surgery is associated with reduced all-cause and CV mortality, and lowered incidence of several CV diseases in patients with obesity. Bariatric surgery should therefore be considered in these patients. © The Author(s) 2022. 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Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. entry contributor: Gorter TM forenameInitials: TM affiliation: Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. entry contributor: van Woerden G forenameInitials: G affiliation: Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. entry contributor: de Boer RA forenameInitials: RA affiliation: Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. entry contributor: Rienstra M forenameInitials: M affiliation: Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. entry contributor: Hazebroek EJ forenameInitials: EJ affiliation: Department of Surgery/Vitalys Clinic, Rijnstate Hospital Arnhem, Arnhem, The Netherlands. Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands. entry contributor: van Veldhuisen DJ forenameInitials: DJ affiliation: Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. 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35243488 Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis.
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Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis.
**AIMS:** Obesity is a global health problem, associated with significant morbidity and mortality, often due to cardiovascular (CV) diseases. While bariatric surgery is increasingly performed in patients with obesity and reduces CV risk factors, its effect on CV disease is not established. We conducted a systematic review and meta-analysis to evaluate the effect of bariatric surgery on CV outcomes, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. **METHODS AND RESULTS:** PubMed and Embase were searched for literature until August 2021 which compared bariatric surgery patients to non-surgical controls. Outcomes of interest were all-cause and CV mortality, atrial fibrillation (AF), heart failure (HF), myocardial infarction, and stroke. We included 39 studies, all prospective or retrospective cohort studies, but randomized outcome trials were not available. Bariatric surgery was associated with a beneficial effect on all-cause mortality [pooled hazard ratio (HR) of 0.55; 95% confidence interval (CI) 0.49-0.62, P < 0.001 vs. controls], and CV mortality (HR 0.59, 95% CI 0.47-0.73, P < 0.001). In addition, bariatric surgery was also associated with a reduced incidence of HF (HR 0.50, 95% CI 0.38-0.66, P < 0.001), myocardial infarction (HR 0.58, 95% CI 0.43-0.76, P < 0.001), and stroke (HR 0.64, 95% CI 0.53-0.77, P < 0.001), while its association with AF was not statistically significant (HR 0.82, 95% CI 0.64-1.06, P = 0.12). **CONCLUSION:** The present systematic review and meta-analysis suggests that bariatric surgery is associated with reduced all-cause and CV mortality, and lowered incidence of several CV diseases in patients with obesity. Bariatric surgery should therefore be considered in these patients.
© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.
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Department of Surgery/Vitalys Clinic, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.
Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.