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    v: Generated Narrative: PublicationRecord 111 version: 20; Last updated: 2026-08-06 21:20:32+0000 ArtifactPublicationStatus: Active url: https://fevir.net/resources/PublicationRecord/111 identifier: FEvIR Object Identifier/111 title: SMR-excluded Tlayjeh H J Infect Public Health 33008778 status: Active date: 2021-09-24 12:05:20+0000 author: Brian S. Alper: publisher: Computable Publishing LLC contact: support@computablepublishing.com description: A systematic review included in the Steroids SMR Project UseContexts - Code Value[x] * UsageContextType: program (Program) Steroids SMR Project copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/ Summaries - Style Text * Computable Publishing Association of corticosteroids use and outcomes in COVID-19 patients: A systematic review and meta-analysis [Journal Article]. In: Journal of infection and public health, PMID 33008778. Published September 29, 2020. Available at: https://doi.org/10.1016/j.jiph.2020.09.008. RelatesTos - Extension Type Target[x] * Derived From 33008778 Medline Base citedArtifact identifier: https://pubmed.ncbi.nlm.nih.gov/33008778, pii/S1876-0341(20)30663-8, https://doi.org/10.1016/j.jiph.2020.09.008, https://www.ncbi.nlm.nih.gov/pmc//PMC7522674 Titles - Type Language Text * primary-human-use English Association of corticosteroids use and outcomes in COVID-19 patients: A systematic review and meta-analysis. Abstracts - Type Text Copyright * Primary human use BACKGROUND: To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients. METHODS: We searched Medline, Embase, EBM Reviews, Scopus, Web of Science, and preprints up to July 20, 2020. We included observational studies and randomized controlled trials (RCT) that assessed COVID-19 patients treated with CST. We pooled adjusted effect estimates of mortality and other outcomes using a random effect model, among studies at low or moderate risk for bias. We assessed the …
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      v: **BACKGROUND:** To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients. **METHODS:** We searched Medline, Embase, EBM Reviews, Scopus, Web of Science, and preprints up to July 20, 2020. We included observational studies and randomized controlled trials (RCT) that assessed COVID-19 patients treated with CST. We pooled adjusted effect estimates of mortality and other outcomes using a random effect model, among studies at low or moderate risk for bias. We assessed the certainty of evidence for each outcome using the GRADE approach. **RESULTS:** Out of 1067 citations screened for eligibility, one RCT and 19 cohort studies were included (16,977 hospitalized patients). Ten studies (1 RCT and 9 cohorts) with 10,278 patients examined the effect of CST on short term mortality. The pooled adjusted RR was 0.92 (95% CI 0.69-1.22, I2 = 81.94%). This effect was observed across all stages of disease severity. Four cohort studies examined the effect of CST on composite outcome of death, ICU admission and mechanical ventilation need. The pooled adjusted RR was 0.41(0.23-0.73, I2 = 78.69%). Six cohort studies examined the effect of CST on delayed viral clearance. The pooled adjusted RR was 1.47(95% CI 1.11-1.93, I2 = 43.38%). **CONCLUSION:** In this systematic review, as of July 2020, heterogeneous and low certainty cumulative evidence based on observational studies and one RCT suggests that CST was not associated with reduction in short-term mortality but possibly with a delay in viral clearance in patients hospitalized with COVID-19 of different severities. However, the discordant results between the single RCT and observational studies as well as the heterogeneity observed across observational studies, call for caution in using observational data and suggests the need for more RCTs to identify the clinical and biochemical characteristics of patients' population that could benefit from CST.
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      v: Pneumonia, Viral
  coding:
    system:
      v: https://www.nlm.nih.gov/mesh
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    code:
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    display:
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classifier: D016032
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    code:
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    display:
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classifier: http://id.nlm.nih.gov/mesh/D000086402
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      l: mesh
    code:
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classifier: D016896
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    code:
      v: D016896
    display:
      v: Treatment Outcome

type:
  text:
    v: Steroids SMR project use
classifier:
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    v: Excluded primary article

type:
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classifier: D016428
  coding:
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      l: mesh
    code:
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    display:
      v: Journal Article
classifier: D017418
  coding:
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    code:
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    display:
      v: Meta-Analysis
classifier: http://id.nlm.nih.gov/mesh/D000078182
  coding:
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    code:
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    display:
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classifier:
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    display:
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type:
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classifier:
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    display:
      v: IM

type:
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    v: Funding
classifier:
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complete:
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entry:
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  forename initials:
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  affiliation:
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      v: affiliation: Department of Intensive Care, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
entry:
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  forename initials:
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  affiliation:
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      v: College of Medicine, Al Faisal University, Riyadh, Saudi Arabia.
entry:
  contributor:
    display:
      v: Mushira A Enani
  forename initials:
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  affiliation:
    display:
      v: Infectious Diseases Section, Department of Medical Specialties, King Fahad Medical City, Riyadh, Saudi Arabia.
entry:
  contributor:
    display:
      v: Alya Alruwaili
  forename initials:
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  affiliation:
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entry:
  contributor:
    display:
      v: Rana Tleyjeh
  forename initials:
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  affiliation:
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      v: College of Medicine, Al Faisal University, Riyadh, Saudi Arabia.
entry:
  contributor:
    display:
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  forename initials:
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  affiliation:
    display:
      v: Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
entry:
  contributor:
    display:
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  forename initials:
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  affiliation:
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      v: Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, USA.
entry:
  contributor:
    display:
      v: Yaseen M Arabi
  forename initials:
    v: YM
  affiliation:
    display:
      v: Department of Intensive Care, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
entry:
  contributor:
    display:
      v: Tarek Kashour
  forename initials:
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  affiliation:
    display:
      v: Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University Medical City, Riyadh, Saudi Arabia.
entry:
  contributor:
    display:
      v: Imad M Tleyjeh
  forename initials:
    v: IM
  affiliation:
    display:
      v: College of Medicine, Al Faisal University, Riyadh, Saudi Arabia; Infectious Diseases Section, Department of Medical Specialties, King Fahad Medical City, Riyadh, Saudi Arabia; Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Division of Epidemiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: Tleyjeh.Imad@mayo.edu.