{ "resourceType" : "Group", "id" : "588218", "meta" : { "versionId" : "7", "lastUpdated" : "2026-08-15T16:32:10.010Z", "profile" : ["http://hl7.org/fhir/uv/ebm/StructureDefinition/pico-specification"] }, "language" : "en", "text" : { "status" : "extensions", "div" : "

Generated Narrative: Group 588218

version: 7; Last updated: 2026-08-15 16:32:10+0000

Profile: PICOSpecification

Artifact Author: Khalid Shahin:

ArtifactRecorder: Khalid Shahin:

CiteAs:

PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk [Database Entry: FHIR Group Resource]. Contributors: Khalid Shahin [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 588218. Revised 2026-08-15. Available at: https://fevir.net/resources/Group/588218. Computable resource at: https://fevir.net/resources/Group/588218#json.

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ArtifactPublicationStatus: Active

url: https://fevir.net/resources/Group/588218

identifier: FEvIR Object Identifier/588218, http://example.org/fhir/sid/pico-register/PICO-2026-0142\u00a0(use:\u00a0official,\u00a0)

title: PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk

status: Active

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

description:

This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide.

\n

copyright:

Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).

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membership: Conceptual

combinationMethod: All of

characteristic

code: Population

value: Hypertension with systolic blood pressure 130-180 mmHg and at least one additional cardiovascular risk factor

exclude: false

description:

Adults with a measured systolic blood pressure between 130 and 180 mmHg inclusive, together with at least one of: clinical or subclinical cardiovascular disease, chronic kidney disease with eGFR 20-59 mL/min/1.73 m2, a 10-year Framingham risk score of 15 percent or greater, or age 75 years or older.

\n

characteristic

code: Age Range

value: 50-? years

exclude: false

description:

Aged 50 years or older at the time of eligibility assessment. No upper age limit is applied.

\n

characteristic

code: Intervention

value: Intensive blood-pressure control: antihypertensive therapy titrated to a systolic target below 120 mmHg

exclude: false

description:

Any antihypertensive regimen titrated at monthly intervals to achieve and maintain a systolic blood pressure below 120 mmHg. The specific agents used are not constrained by this question.

\n

characteristic

code: Comparator

value: Standard blood-pressure control: antihypertensive therapy titrated to a systolic target below 140 mmHg

exclude: false

description:

Any antihypertensive regimen titrated to achieve and maintain a systolic blood pressure below 140 mmHg, reflecting the guideline-recommended target in force at the time the question was formulated.

\n

characteristic

code: Outcome Measure

value: Major adverse cardiovascular events: composite of myocardial infarction, other acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes

exclude: false

description:

Time to first occurrence of any component of the composite, adjudicated by a committee unaware of treatment assignment. Individual components are reported as separate outcome measures in the evidence report.

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RelativeTimes

-Offset[x]
*No display for Duration (value: 5; unit: years; system: http://unitsofmeasure.org; code: a)
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Computable resource at: https://fevir.net/resources/Group/588218#json." }, { "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status", "valueCodeableConcept" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type", "code" : "active", "display" : "Active" }] } }], "url" : "https://fevir.net/resources/Group/588218", "identifier" : [{ "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/v2-0203", "code" : "ACSN", "display" : "Accession ID" }], "text" : "FEvIR Object Identifier" }, "system" : "https://fevir.net/FOI", "value" : "588218", "assigner" : { "display" : "Computable Publishing LLC" } }, { "use" : "official", "system" : "http://example.org/fhir/sid/pico-register", "value" : "PICO-2026-0142" }], "title" : "PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk", "status" : "active", "publisher" : "Computable Publishing LLC", "contact" : [{ "telecom" : [{ "system" : "email", "value" : "support@computablepublishing.com" }] }], "description" : "This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide.", "copyright" : "Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).", "membership" : "conceptual", "combinationMethod" : "all-of", "characteristic" : [{ "code" : { "coding" : [{ "system" : "https://fevir.net/resources/CodeSystem/179423", "code" : "population", "display" : "Population" }] }, "valueCodeableConcept" : { "coding" : [{ "system" : "http://snomed.info/sct", "code" : "38341003", "display" : "Hypertensive disorder, systemic arterial" }], "text" : "Hypertension with systolic blood pressure 130-180 mmHg and at least one additional cardiovascular risk factor" }, "exclude" : false, "description" : "Adults with a measured systolic blood pressure between 130 and 180 mmHg inclusive, together with at least one of: clinical or subclinical cardiovascular disease, chronic kidney disease with eGFR 20-59 mL/min/1.73 m2, a 10-year Framingham risk score of 15 percent or greater, or age 75 years or older." }, { "code" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/usage-context-type", "code" : "age", "display" : "Age Range" }] }, "valueRange" : { "low" : { "value" : 50, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" } }, "exclude" : false, "description" : "Aged 50 years or older at the time of eligibility assessment. No upper age limit is applied." }, { "code" : { "coding" : [{ "system" : "https://fevir.net/resources/CodeSystem/179423", "code" : "intervention", "display" : "Intervention" }] }, "valueCodeableConcept" : { "text" : "Intensive blood-pressure control: antihypertensive therapy titrated to a systolic target below 120 mmHg" }, "exclude" : false, "description" : "Any antihypertensive regimen titrated at monthly intervals to achieve and maintain a systolic blood pressure below 120 mmHg. The specific agents used are not constrained by this question." }, { "code" : { "coding" : [{ "system" : "https://fevir.net/resources/CodeSystem/179423", "code" : "comparator", "display" : "Comparator" }] }, "valueCodeableConcept" : { "text" : "Standard blood-pressure control: antihypertensive therapy titrated to a systolic target below 140 mmHg" }, "exclude" : false, "description" : "Any antihypertensive regimen titrated to achieve and maintain a systolic blood pressure below 140 mmHg, reflecting the guideline-recommended target in force at the time the question was formulated." }, { "code" : { "coding" : [{ "system" : "https://fevir.net/resources/CodeSystem/179423", "code" : "outcome-measure", "display" : "Outcome Measure" }] }, "valueCodeableConcept" : { "text" : "Major adverse cardiovascular events: composite of myocardial infarction, other acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes" }, "exclude" : false, "description" : "Time to first occurrence of any component of the composite, adjudicated by a committee unaware of treatment assignment. Individual components are reported as separate outcome measures in the evidence report.", "relativeTime" : [{ "offsetDuration" : { "value" : 5, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" } }] }] }