Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan

Page standards status: Informative

Raw json | Download

{
  "resourceType" : "Evidence",
  "id" : "397479",
  "meta" : {
    "versionId" : "5",
    "lastUpdated" : "2026-06-06T18:58:12.460Z"
  },
  "language" : "en",
  "text" : {
    "status" : "extensions",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 397479</b></p><a name=\"397479\"> </a><a name=\"hc397479\"> </a><div style=\"display: inline-block; background-color: #fbffeb; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 5; Last updated: 2026-06-06 18:58:12+0000</p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"Evidence-397479.html\">Evidence Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan</a></p><p><b>identifier</b>: FEvIR Object Identifier/397479, <a href=\"http://terminology.hl7.org/7.5.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.22.67</p><p><b>version</b>: 1.0.0-ballot3</p><p><b>name</b>: Evidence_for_Results_for_Add_on_Amlodipine_at_6_weeks_in_GroupAssignment_Quadpill_vs_Candesartan</p><p><b>title</b>: Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan</p><p><b>citeAs</b>: </p><div><p>Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 397479. Revised 2026-06-06. Available at: https://fevir.net/resources/Evidence/397479. Computable resource at: https://fevir.net/resources/Evidence/397479#json.</p>\n</div><p><b>status</b>: Active</p><p><b>date</b>: 2026-11-05 14:34:28+0000</p><p><b>author</b>: Brian S. Alper, MD, MSPH: </p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Target[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-relationship-type part-of}\">Part Of</span></td><td><a href=\"Composition-375280.html\">Outcome Measure Report for QUARTET USA Trial</a></td></tr></table><p><b>description</b>: </p><div><p>This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: Population</p><p><b>observed</b>: the study group</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: Exposure</p><p><b>observed</b>: <a href=\"EvidenceVariable-375183.html\">GroupAssignment: Quadpill vs. Candesartan</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-375203.html\">Add-on Amlodipine at 6 weeks</a></p></blockquote><blockquote><p><b>statistic</b></p><p><b>statisticType</b>: <span title=\"Codes:{https://fevir.net/sevco STATO:0000182}\">odds ratio</span></p><p><b>quantity</b>: 0.08</p><p><b>numberAffected</b>: 22</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>NumberOfParticipants</b></td><td><b>KnownDataCount</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>62</td><td>62</td></tr></table><blockquote><p><b>attributeEstimate</b></p><p><b>type</b>: <span title=\"Codes:{https://fevir.net/sevco STATO:0000196}\">confidence interval</span></p><p><b>level</b>: 0.95</p><p><b>range</b>: 0.02-0.41</p></blockquote><blockquote><p><b>attributeEstimate</b></p><p><b>type</b>: <span title=\"Codes:{https://fevir.net/sevco STATO:0000700}\">p-value</span></p><p><b>quantity</b>: 0.003</p></blockquote></blockquote></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status",
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type",
            "code" : "active",
            "display" : "Active"
          }
        ]
      }
    }
  ],
  "url" : "https://fevir.net/resources/Evidence/397479",
  "identifier" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }
        ],
        "text" : "FEvIR Object Identifier"
      },
      "system" : "https://fevir.net/FOI",
      "value" : "397479",
      "assigner" : {
        "display" : "Computable Publishing LLC"
      }
    },
    {
      "system" : "urn:ietf:rfc:3986",
      "value" : "urn:oid:2.16.840.1.113883.4.642.40.44.22.67"
    }
  ],
  "version" : "1.0.0-ballot3",
  "name" : "Evidence_for_Results_for_Add_on_Amlodipine_at_6_weeks_in_GroupAssignment_Quadpill_vs_Candesartan",
  "title" : "Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan",
  "citeAs" : "Evidence for Results for Add-on Amlodipine at 6 weeks in GroupAssignment: Quadpill vs. Candesartan [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 397479. Revised 2026-06-06. Available at: https://fevir.net/resources/Evidence/397479. Computable resource at: https://fevir.net/resources/Evidence/397479#json.",
  "status" : "active",
  "date" : "2026-11-05T14:34:28+00:00",
  "author" : [
    {
      "name" : "Brian S. Alper, MD, MSPH"
    }
  ],
  "publisher" : "HL7 International / Clinical Decision Support",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Decision Support",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/dss"
        }
      ]
    }
  ],
  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "relatesTo" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/artifact-relationship-type",
            "code" : "part-of",
            "display" : "Part Of"
          }
        ]
      },
      "targetReference" : {
        🔗 "reference" : "Composition/375280",
        "type" : "Composition",
        "display" : "Outcome Measure Report for QUARTET USA Trial"
      }
    }
  ],
  "description" : "This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.",
  "variableDefinition" : [
    {
      "variableRole" : "population",
      "observed" : {
        "display" : "the study group"
      }
    },
    {
      "variableRole" : "exposure",
      "observed" : {
        🔗 "reference" : "EvidenceVariable/375183",
        "type" : "EvidenceVariable",
        "display" : "GroupAssignment: Quadpill vs. Candesartan"
      }
    },
    {
      "variableRole" : "outcome",
      "observed" : {
        🔗 "reference" : "EvidenceVariable/375203",
        "type" : "EvidenceVariable",
        "display" : "Add-on Amlodipine at 6 weeks"
      }
    }
  ],
  "statistic" : [
    {
      "statisticType" : {
        "coding" : [
          {
            "system" : "https://fevir.net/sevco",
            "code" : "STATO:0000182",
            "display" : "odds ratio"
          }
        ]
      },
      "quantity" : {
        "value" : 0.08
      },
      "numberAffected" : 22,
      "sampleSize" : {
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/number-analyzed",
            "valueUnsignedInt" : 60
          }
        ],
        "numberOfParticipants" : 62,
        "knownDataCount" : 62
      },
      "attributeEstimate" : [
        {
          "type" : {
            "coding" : [
              {
                "system" : "https://fevir.net/sevco",
                "code" : "STATO:0000196",
                "display" : "confidence interval"
              }
            ]
          },
          "level" : 0.95,
          "range" : {
            "low" : {
              "value" : 0.02
            },
            "high" : {
              "value" : 0.41
            }
          }
        },
        {
          "type" : {
            "coding" : [
              {
                "system" : "https://fevir.net/sevco",
                "code" : "STATO:0000700",
                "display" : "p-value"
              }
            ]
          },
          "quantity" : {
            "value" : 0.003
          }
        }
      ]
    }
  ]
}