Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
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{
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"text" : {
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"text" : {
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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{
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},
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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"text" : {
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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},
{
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"assigner" : {
"display" : "Computable Publishing LLC"
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},
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},
{
"title" : "Sample Size",
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"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313965-comparative-eidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
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"identifier" : {
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"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Certainty of Evidence",
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313965-comparative-eidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Assertion",
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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"display" : "Assertion"
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},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313965-comparative-eidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
}
]
},
{
"title" : "Health-related quality of life",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
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},
"focus" : {
🔗 "reference" : "EvidenceVariable/236983",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109587",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Health-related quality of life"
},
"section" : [
{
"title" : "Outcome",
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Health-related quality of life</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236983",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109587",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Health-related quality of life"
}
]
},
{
"title" : "Sample Size",
"code" : {
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No sample size data found.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236984",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result Without Treatment",
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
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]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparator-onlidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in GLP-1 RA Group in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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"display" : "Result with intervention alone"
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]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-intervention-oidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Health-related quality of life in SGLT2 inhibitors Group in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result With Treatment--Derived",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparator-onlidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in GLP-1 RA Group in Adults with type 2 diabetes"
},
{
🔗 "reference" : "Evidence/236984",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>standardized mean difference 0.01 ( -0.19 to 0.2)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236984",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236984",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Assertion",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>There may be no important difference between SGLT2 inhibitors and GLP-1 receptor agonists on health-related quality of life.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236984",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109587-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
}
]
},
{
"title" : "Body weight",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
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]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236986",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109588",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Body weight"
},
"section" : [
{
"title" : "Outcome",
"code" : {
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Body weight</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236986",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109588",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Body weight"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>2 studies, 1139 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236987",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparator-onlidence",
"assigner" : {
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},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Body weight in GLP-1 RA Group in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result With Treatment--Observed",
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
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}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-intervention-oidence",
"assigner" : {
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},
"display" : "MAGIC-derived InterventionOnlyEvidence: Body weight in SGLT2 inhibitors Group in Adults with type 2 diabetes"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
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],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"entry" : [
{
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparator-onlidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Body weight in GLP-1 RA Group in Adults with type 2 diabetes"
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{
🔗 "reference" : "Evidence/236987",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparative-evidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>difference in means -0.47 Kg ( -0.09 Kg to -0.85 Kg)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236987",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236987",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
},
{
"title" : "Assertion",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>SGLT2 inhibitors probably reduce body weight compared with GLP-1 receptor agonists.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236987",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109588-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"
}
]
}
]
}
]
},
{
"title" : "Groups",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "groups",
"display" : "Groups"
}
]
},
"section" : [
{
"title" : "Total Group",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "population",
"display" : "Population"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"emptyReason" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/list-empty-reason",
"code" : "notstarted",
"display" : "Not Started"
}
]
}
},
{
"title" : "Intervention Group",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "intervention-group",
"display" : "Intervention Group"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"emptyReason" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/list-empty-reason",
"code" : "notstarted",
"display" : "Not Started"
}
]
}
},
{
"title" : "Comparator Group",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "comparator-group",
"display" : "Comparator Group"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"emptyReason" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/list-empty-reason",
"code" : "notstarted",
"display" : "Not Started"
}
]
}
},
{
"title" : "Group Assignment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "GroupAssignment",
"display" : "GroupAssignment"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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