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    v: Generated Narrative: Citation 179626 version: 20; Last updated: 2025-10-13 12:34:35+0000 Profile: JournalArticleCitation ArtifactPublicationStatus: Active url: Citation 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. identifier: FEvIR Object Identifier/179626, https://pubmed.ncbi.nlm.nih.gov/22056152, <a href="http://terminology.hl7.org/7.0.1/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt #xD;#xA;#xD;#xA;This oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: #xD;#xA;#xD;#xA;Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.#xD;#xA;#xD;#xA;This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.15.21 version: 1.0.0-ballot3 title: 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. status: Active date: 2026-01-13 11:03:07+0000 author: Computable Publishing®: MEDLINE-to-FEvIR Converter: publisher: HL7 International / Clinical Decision Support contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss description: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide. UseContexts - Code Value[x] * Citation Classification Type: fevir-platform-use (FEvIR Platform Use) Medline Base jurisdic…
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    v: **BACKGROUND:** Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer. **METHODS:** Patients with: locally advanced (T3 or T4) prostate cancer (n=1057); or organ-confined disease (T2) with either a prostate-specific antigen (PSA) concentration more than 40 ng/mL (n=119) or PSA concentration more than 20 ng/mL and a Gleason score of 8 or higher (n=25), were randomly assigned (done centrally with stratification and dynamic minimisation, not masked) to receive lifelong ADT and RT (65-69 Gy to the prostate and seminal vesicles, 45 Gy to the pelvic nodes). The primary endpoint was overall survival. The results presented here are of an interim analysis planned for when two-thirds of the events for the final analysis were recorded. All efficacy analyses were done by intention to treat and were based on data from all patients. This trial is registered at controlledtrials.com as ISRCTN24991896 and Clinicaltrials.gov as NCT00002633. **RESULTS:** Between 1995 and 2005, 1205 patients were randomly assigned (602 in the ADT only group and 603 in the ADT and RT group); median follow-up was 6·0 years (IQR 4·4-8·0). At the time of analysis, a total of 320 patients had died, 175 in the ADT only group and 145 in the ADT and RT group. The addition of RT to ADT improved overall survival at 7 years (74%, 95% CI 70-78 vs 66%, 60-70; hazard ratio [HR] 0·77, 95% CI 0·61-0·98, p=0·033). Both toxicity and health-related quality-of-life results showed a small effect of RT on late gastrointestinal toxicity (rectal bleeding grade >3, three patients (0·5%) in the ADT only group, two (0·3%) in the ADT and RT group; diarrhoea grade >3, four patients (0·7%) vs eight (1·3%); urinary toxicity grade >3, 14 patients (2·3%) in both groups). **INTERPRETATION:** The benefits of combined modality tre…
  copyright:
    v: Copyright © 2011 Elsevier Ltd. All rights reserved.
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    l: contributor9
    reference:
      v: #contributor9
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Swanson G
  forename initials:
    v: G
entry:
  contributor:
    l: contributor10
    reference:
      v: #contributor10
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Barber J
  forename initials:
    v: J
entry:
  contributor:
    l: contributor11
    reference:
      v: #contributor11
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Hiltz A
  forename initials:
    v: A
entry:
  contributor:
    l: contributor12
    reference:
      v: #contributor12
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Parmar MK
  forename initials:
    v: MK
entry:
  contributor:
    l: contributor13
    reference:
      v: #contributor13
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Sathya J
  forename initials:
    v: J
entry:
  contributor:
    l: contributor14
    reference:
      v: #contributor14
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Anderson J
  forename initials:
    v: J
entry:
  contributor:
    l: contributor15
    reference:
      v: #contributor15
    type:
      v: Practitioner
      l: Practitioner
    display:
      v: Hayter C
  forename initials:
    v: C
entry:
  contributor:
    l: contributor16
    reference:
      v: #contributor16

v: Practitioner
l: Practitioner

v: Hetherington J

v: J

contributor:
  l: contributor17
  reference:
    v: #contributor17
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Sydes MR
forename initials:
  v: MR

contributor:
  l: contributor18
  reference:
    v: #contributor18
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Parulekar W
forename initials:
  v: W

contributor:
  l: contributor19
  reference:
    v: #contributor19
  type:
    v: Organization
    l: Organization
  display:
    v: NCIC CTG PR.3/MRC UK PR07 investigators