Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix mesh: <http://id.nlm.nih.gov/mesh/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "179621"] ; # fhir:meta [ fhir:versionId [ fhir:v "19" ] ; fhir:lastUpdated [ fhir:v "2025-10-13T12:34:35.118Z"^^xsd:dateTime ] ; ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation> ] ) ] ; # fhir:language [ fhir:v "en"] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en\" lang=\"en\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179621</b></p><a name=\"179621\"> </a><a name=\"hc179621\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 19; Last updated: 2025-10-13 12:34:35+0000; Language: en</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Citation/179621\">https://fevir.net/resources/Citation/179621</a></p><p><b>identifier</b>: FEvIR Object Identifier/179621, <code>https://pubmed.ncbi.nlm.nih.gov</code>/26028518</p><p><b>title</b>: 26028518 Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial.</p><p><b>status</b>: Active</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://terminology.hl7.org/7.1.0/CodeSystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type: fevir-platform-use</a> (FEvIR Platform Use)</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2015-09-28</p><p><b>lastReviewDate</b>: 2024-08-05</p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --> 2015-04-15</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-revised}\">PubMed Pubstatus of Revised</span></p><p><b>period</b>: ?? --> 2015-05-06</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --> 2015-05-08</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2015-06-02 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2015-06-02 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2015-09-29 06:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26028518, <code>https://doi.org</code>/10.1016/S1470-2045(15)00011-X, pii/S1470-2045(15)00011-X</p><p><b>relatedIdentifier</b>: <code>https://clinicaltrials.gov</code>/NCT00055731</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/title-type primary}\">Primary title</span></td><td><div><p>Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type primary-human-use}\">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Early risk-stratified chemotherapy is a standard treatment for breast, colorectal, and lung cancers, but not for high-risk localised prostate cancer. Combined docetaxel and estramustine improves survival in patients with castration-resistant prostate cancer. We assessed the effects of combined docetaxel and estramustine on relapse in patients with high-risk localised prostate cancer.\n<strong>METHODS:</strong> We did this randomised phase 3 trial at 26 hospitals in France. We enrolled patients with treatment-naive prostate cancer and at least one risk factor (ie, stage T3-T4 disease, Gleason score of ≥8, prostate-specific antigen concentration >20 ng/mL, or pathological node-positive). All patients underwent a staging pelvic lymph node dissection. Patients were randomly assigned (1:1) to either androgen deprivation therapy (ADT; goserelin 10·8 mg every 3 months for 3 years) plus four cycles of docetaxel on day 2 at a dose of 70 mg/m(2) and estramustine 10 mg/kg per day on days 1-5, every 3 weeks, or ADT only. The randomisation was done centrally by computer, stratified by risk factor. Local treatment was administered at 3 months. Neither patients nor investigators were masked to treatment allocation. The primary endpoint was relapse-free survival in the intention-to-treat population. Follow-up for other endpoints is ongoing. This study is registered with ClinicalTrials.gov, number NCT00055731.\n<strong>FINDINGS:</strong> We randomly assigned 207 patients to the ADT plus docetaxel and estramustine group and 206 to the ADT only group. Median follow-up was 8·8 years (IQR 8·1-9·7). 88 (43%) of 207 patients in the ADT plus docetaxel and estramustine group had an event (relapse or death) versus 111 (54%) of 206 in the ADT only group. 8-year relapse-free survival was 62% (95% CI 55-69) in the ADT plus docetaxel and estramustine group versus 50% (44-57) in the ADT only group (adjusted hazard ratio [HR] 0·71, 95% CI 0·54-0·94, p=0·017). Of patients who were treated with radiotherapy and had data available, 31 (21%) of 151 in the ADT plus docetaxel and estramustine group versus 26 (18%) of 143 in the ADT only group reported a grade 2 or higher long-term side-effect (p=0·61). We recorded no excess second cancers (26 [13%] of 207 vs 22 [11%] of 206; p=0·57), and there were no treatment-related deaths.\n<strong>INTERPRETATION:</strong> Docetaxel-based chemotherapy improves relapse-free survival in patients with high-risk localised prostate cancer. Longer follow-up is needed to assess whether this benefit translates into improved metastasis-free survival and overall survival.\n<strong>FUNDING:</strong> Ligue Contre le Cancer, Sanofi-Aventis, AstraZeneca, Institut National du Cancer.</p>\n</div></td><td><div><p>Copyright © 2015 Elsevier Ltd. All rights reserved.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Lancet Oncol. 2015 Jul;16(7):741-2. doi: 10.1016/S1470-2045(15)00012-1.</p>\n</div><p><b>target</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26028517/\">https://pubmed.ncbi.nlm.nih.gov/26028517/</a></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Rev Urol. 2015 Jul;12(7):358. doi: 10.1038/nrurol.2015.146.</p>\n</div><p><b>target</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26077993/\">https://pubmed.ncbi.nlm.nih.gov/26077993/</a></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2015 Dec;68(6):1098-9. doi: 10.1016/j.eururo.2015.08.047.</p>\n</div><p><b>target</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26545569/\">https://pubmed.ncbi.nlm.nih.gov/26545569/</a></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Rev Clin Oncol. 2015 Dec;12(12):687-8. doi: 10.1038/nrclinonc.2015.192.</p>\n</div><p><b>target</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26552950/\">https://pubmed.ncbi.nlm.nih.gov/26552950/</a></p></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1474-5488, ISOAbbreviation/Lancet Oncol, ISSN Linking/1470-2045, Medline Title Abbreviation/Lancet Oncol, NLM Unique ID/100957246</p><p><b>title</b>: The Lancet. Oncology</p><p><b>publisherLocation</b>: England</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 16</p><p><b>issue</b>: 7</p><p><b>articleDate</b>: 2015-07</p><p><b>pageString</b>: 787-94</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2015-05-28</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26028518/\">https://pubmed.ncbi.nlm.nih.gov/26028518/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/S1470-2045(15)00011-X\">https://doi.org/10.1016/S1470-2045(15)00011-X</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 15H5577CQD}, {https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 35LT29625A}, {https://www.nlm.nih.gov/mesh D004961}\">Estramustine</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances EC 3.4.21.77}, {https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179621/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017428}\">Clinical Trial, Phase III</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D003160}\">Comparative Study</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016428}\">Journal Article</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016448}\">Multicenter Study</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor0\">Fizazi K</a></p><p><b>forenameInitials</b>: K</p><p><b>affiliation</b>: Institut Gustave Roussy, Villejuif, France. Electronic address: karim.fizazi@gustaveroussy.fr.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor1\">Faivre L</a></p><p><b>forenameInitials</b>: L</p><p><b>affiliation</b>: Institut Gustave Roussy, Villejuif, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor2\">Lesaunier F</a></p><p><b>forenameInitials</b>: F</p><p><b>affiliation</b>: Centre François Baclesse, Caen, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor3\">Delva R</a></p><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: Institut de Cancérologie de l'Ouest, Angers, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor4\">Gravis G</a></p><p><b>forenameInitials</b>: G</p><p><b>affiliation</b>: Institut Paoli Calmettes, Marseille, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor5\">Rolland F</a></p><p><b>forenameInitials</b>: F</p><p><b>affiliation</b>: Institut de Cancérologie de l'Ouest, Nantes, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor6\">Priou F</a></p><p><b>forenameInitials</b>: F</p><p><b>affiliation</b>: Centre Hospitalier Départemental, La Roche-sur-Yon, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor7\">Ferrero JM</a></p><p><b>forenameInitials</b>: JM</p><p><b>affiliation</b>: Centre Antoine Lacassagne, Nice, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor8\">Houede N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: Centre Hospitalier de Nimes, Nimes, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor9\">Mourey L</a></p><p><b>forenameInitials</b>: L</p><p><b>affiliation</b>: Institut Claudius Regaud, Toulouse, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor10\">Theodore C</a></p><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: Hôpital Foch, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor11\">Krakowski I</a></p><p><b>forenameInitials</b>: I</p><p><b>affiliation</b>: Centre Alexis Vautrin, Nancy, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor12\">Berdah JF</a></p><p><b>forenameInitials</b>: JF</p><p><b>affiliation</b>: Clinique Sainte-Marguerite, Hyères, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor13\">Baciuchka M</a></p><p><b>forenameInitials</b>: M</p><p><b>affiliation</b>: Centre Hospitalier La Timone, Marseille, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor14\">Laguerre B</a></p><p><b>forenameInitials</b>: B</p><p><b>affiliation</b>: Centre Eugène Marquis, Rennes, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor15\">Fléchon A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Centre Léon Bérard, Lyon, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor16\">Ravaud A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Hôpital Saint-André, Bordeaux, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor17\">Cojean-Zelek I</a></p><p><b>forenameInitials</b>: I</p><p><b>affiliation</b>: Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor18\">Oudard S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Hôpital Européen Georges Pompidou, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor19\">Labourey JL</a></p><p><b>forenameInitials</b>: JL</p><p><b>affiliation</b>: CHU Dupuytren, Limoges, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor20\">Chinet-Charrot P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Centre Henri Becquerel, Rouen, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor21\">Legouffe E</a></p><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: Centre Médical Oncogard, Nimes, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor22\">Lagrange JL</a></p><p><b>forenameInitials</b>: JL</p><p><b>affiliation</b>: Hôpital Henri-Mondor, Créteil, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor23\">Linassier C</a></p><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: Hôpital Bretonneau, Tours, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor24\">Deplanque G</a></p><p><b>forenameInitials</b>: G</p><p><b>affiliation</b>: Hôpital Saint-Joseph, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor25\">Beuzeboc P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Institut Curie, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor26\">Davin JL</a></p><p><b>forenameInitials</b>: JL</p><p><b>affiliation</b>: Clinique Sainte-Catherine, Avignon, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor27\">Martin AL</a></p><p><b>forenameInitials</b>: AL</p><p><b>affiliation</b>: Unicancer, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor28\">Habibian M</a></p><p><b>forenameInitials</b>: M</p><p><b>affiliation</b>: Unicancer, Paris, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor29\">Laplanche A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Institut Gustave Roussy, Villejuif, France.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179621/contributor30\">Culine S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Hôpital Saint-Louis, Paris, France.</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179621/contributor0\"> </a><a name=\"hc179621/contributor0\"> </a><p><b>name</b>: Karim Fizazi </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179621/contributor1\"> </a><a name=\"hc179621/contributor1\"> </a><p><b>name</b>: Laura Faivre </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179621/contributor2\"> </a><a name=\"hc179621/contributor2\"> </a><p><b>name</b>: François Lesaunier </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179621/contributor3\"> </a><a name=\"hc179621/contributor3\"> </a><p><b>name</b>: Remy Delva </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179621/contributor4\"> </a><a name=\"hc179621/contributor4\"> </a><p><b>name</b>: Gwenaëlle Gravis </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"179621/contributor5\"> </a><a name=\"hc179621/contributor5\"> </a><p><b>name</b>: Frédéric Rolland </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"179621/contributor6\"> </a><a name=\"hc179621/contributor6\"> </a><p><b>name</b>: Frank Priou </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"179621/contributor7\"> </a><a name=\"hc179621/contributor7\"> </a><p><b>name</b>: Jean-Marc Ferrero </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"179621/contributor8\"> </a><a name=\"hc179621/contributor8\"> </a><p><b>name</b>: Nadine Houede </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"179621/contributor9\"> </a><a name=\"hc179621/contributor9\"> </a><p><b>name</b>: Loïc Mourey </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor10</b></p><a name=\"179621/contributor10\"> </a><a name=\"hc179621/contributor10\"> </a><p><b>name</b>: Christine Theodore </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor11</b></p><a name=\"179621/contributor11\"> </a><a name=\"hc179621/contributor11\"> </a><p><b>name</b>: Ivan Krakowski </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor12</b></p><a name=\"179621/contributor12\"> </a><a name=\"hc179621/contributor12\"> </a><p><b>name</b>: Jean-François Berdah </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor13</b></p><a name=\"179621/contributor13\"> </a><a name=\"hc179621/contributor13\"> </a><p><b>name</b>: Marjorie Baciuchka </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor14</b></p><a name=\"179621/contributor14\"> </a><a name=\"hc179621/contributor14\"> </a><p><b>name</b>: Brigitte Laguerre </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor15</b></p><a name=\"179621/contributor15\"> </a><a name=\"hc179621/contributor15\"> </a><p><b>name</b>: Aude Fléchon </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor16</b></p><a name=\"179621/contributor16\"> </a><a name=\"hc179621/contributor16\"> </a><p><b>name</b>: Alain Ravaud </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor17</b></p><a name=\"179621/contributor17\"> </a><a name=\"hc179621/contributor17\"> </a><p><b>name</b>: Isabelle Cojean-Zelek </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor18</b></p><a name=\"179621/contributor18\"> </a><a name=\"hc179621/contributor18\"> </a><p><b>name</b>: Stéphane Oudard </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor19</b></p><a name=\"179621/contributor19\"> </a><a name=\"hc179621/contributor19\"> </a><p><b>name</b>: Jean-Luc Labourey </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor20</b></p><a name=\"179621/contributor20\"> </a><a name=\"hc179621/contributor20\"> </a><p><b>name</b>: Paule Chinet-Charrot </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor21</b></p><a name=\"179621/contributor21\"> </a><a name=\"hc179621/contributor21\"> </a><p><b>name</b>: Eric Legouffe </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor22</b></p><a name=\"179621/contributor22\"> </a><a name=\"hc179621/contributor22\"> </a><p><b>name</b>: Jean-Léon Lagrange </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor23</b></p><a name=\"179621/contributor23\"> </a><a name=\"hc179621/contributor23\"> </a><p><b>name</b>: Claude Linassier </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor24</b></p><a name=\"179621/contributor24\"> </a><a name=\"hc179621/contributor24\"> </a><p><b>name</b>: Gaël Deplanque </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor25</b></p><a name=\"179621/contributor25\"> </a><a name=\"hc179621/contributor25\"> </a><p><b>name</b>: Philippe Beuzeboc </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor26</b></p><a name=\"179621/contributor26\"> </a><a name=\"hc179621/contributor26\"> </a><p><b>name</b>: Jean-Louis Davin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor27</b></p><a name=\"179621/contributor27\"> </a><a name=\"hc179621/contributor27\"> </a><p><b>name</b>: Anne-Laure Martin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor28</b></p><a name=\"179621/contributor28\"> </a><a name=\"hc179621/contributor28\"> </a><p><b>name</b>: Muriel Habibian </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor29</b></p><a name=\"179621/contributor29\"> </a><a name=\"hc179621/contributor29\"> </a><p><b>name</b>: Agnès Laplanche </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor30</b></p><a name=\"179621/contributor30\"> </a><a name=\"hc179621/contributor30\"> </a><p><b>name</b>: Stéphane Culine </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179621/meshHeading0\"> </a><a name=\"hc179621/meshHeading0\"> </a><p><b>artifact</b>: <a href=\"#hc179621\">Citation 26028518 Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000971}\">Antineoplastic Combined Chemotherapy Protocols</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D018572}\">Disease-Free Survival</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D004305}\">Dose-Response Relationship, Drug</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D004334}\">Drug Administration Schedule</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D004961}\">Estramustine</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000008}\">administration & dosage</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005500}\">Follow-Up Studies</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005602}\">France</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D053208}\">Kaplan-Meier Estimate</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D020714}\">Maximum Tolerated Dose</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D009361}\">Neoplasm Invasiveness</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D009364}\">Neoplasm Recurrence, Local</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000453}\">epidemiology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D009367}\">Neoplasm Staging</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016016}\">Proportional Hazards Models</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000097}\">blood</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016019}\">Survival Analysis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000008}\">administration & dosage</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016896}\">Treatment Outcome</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>"^^rdf:XMLLiteral ] ] ; # fhir:contained ( [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor0" ] ; ( fhir:name [ fhir:family [ fhir:v "Fizazi" ] ; ( fhir:given [ fhir:v "Karim" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor1" ] ; ( fhir:name [ fhir:family [ fhir:v "Faivre" ] ; ( fhir:given [ fhir:v "Laura" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor2" ] ; ( fhir:name [ fhir:family [ fhir:v "Lesaunier" ] ; ( fhir:given [ fhir:v "François" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor3" ] ; ( fhir:name [ fhir:family [ fhir:v "Delva" ] ; ( fhir:given [ fhir:v "Remy" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor4" ] ; ( fhir:name [ fhir:family [ fhir:v "Gravis" ] ; ( fhir:given [ fhir:v "Gwenaëlle" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor5" ] ; ( fhir:name [ fhir:family [ fhir:v "Rolland" ] ; ( fhir:given [ fhir:v "Frédéric" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor6" ] ; ( fhir:name [ fhir:family [ fhir:v "Priou" ] ; ( fhir:given [ fhir:v "Frank" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor7" ] ; ( fhir:name [ fhir:family [ fhir:v "Ferrero" ] ; ( fhir:given [ fhir:v "Jean-Marc" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor8" ] ; ( fhir:name [ fhir:family [ fhir:v "Houede" ] ; ( fhir:given [ fhir:v "Nadine" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor9" ] ; ( fhir:name [ fhir:family [ fhir:v "Mourey" ] ; ( fhir:given [ fhir:v "Loïc" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor10" ] ; ( fhir:name [ fhir:family [ fhir:v "Theodore" ] ; ( fhir:given [ fhir:v "Christine" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor11" ] ; ( fhir:name [ fhir:family [ fhir:v "Krakowski" ] ; ( fhir:given [ fhir:v "Ivan" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor12" ] ; ( fhir:name [ fhir:family [ fhir:v "Berdah" ] ; ( fhir:given [ fhir:v "Jean-François" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor13" ] ; ( fhir:name [ fhir:family [ fhir:v "Baciuchka" ] ; ( fhir:given [ fhir:v "Marjorie" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor14" ] ; ( fhir:name [ fhir:family [ fhir:v "Laguerre" ] ; ( fhir:given [ fhir:v "Brigitte" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor15" ] ; ( fhir:name [ fhir:family [ fhir:v "Fléchon" ] ; ( fhir:given [ fhir:v "Aude" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor16" ] ; ( fhir:name [ fhir:family [ fhir:v "Ravaud" ] ; ( fhir:given [ fhir:v "Alain" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor17" ] ; ( fhir:name [ fhir:family [ fhir:v "Cojean-Zelek" ] ; ( fhir:given [ fhir:v "Isabelle" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor18" ] ; ( fhir:name [ fhir:family [ fhir:v "Oudard" ] ; ( fhir:given [ fhir:v "Stéphane" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor19" ] ; ( fhir:name [ fhir:family [ fhir:v "Labourey" ] ; ( fhir:given [ fhir:v "Jean-Luc" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor20" ] ; ( fhir:name [ fhir:family [ fhir:v "Chinet-Charrot" ] ; ( fhir:given [ fhir:v "Paule" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor21" ] ; ( fhir:name [ fhir:family [ fhir:v "Legouffe" ] ; ( fhir:given [ fhir:v "Eric" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor22" ] ; ( fhir:name [ fhir:family [ fhir:v "Lagrange" ] ; ( fhir:given [ fhir:v "Jean-Léon" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor23" ] ; ( fhir:name [ fhir:family [ fhir:v "Linassier" ] ; ( fhir:given [ fhir:v "Claude" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor24" ] ; ( fhir:name [ fhir:family [ fhir:v "Deplanque" ] ; ( fhir:given [ fhir:v "Gaël" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor25" ] ; ( fhir:name [ fhir:family [ fhir:v "Beuzeboc" ] ; ( fhir:given [ fhir:v "Philippe" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor26" ] ; ( fhir:name [ fhir:family [ fhir:v "Davin" ] ; ( fhir:given [ fhir:v "Jean-Louis" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor27" ] ; ( fhir:name [ fhir:family [ fhir:v "Martin" ] ; ( fhir:given [ fhir:v "Anne-Laure" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor28" ] ; ( fhir:name [ fhir:family [ fhir:v "Habibian" ] ; ( fhir:given [ fhir:v "Muriel" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor29" ] ; ( fhir:name [ fhir:family [ fhir:v "Laplanche" ] ; ( fhir:given [ fhir:v "Agnès" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor30" ] ; ( fhir:name [ fhir:family [ fhir:v "Culine" ] ; ( fhir:given [ fhir:v "Stéphane" ] ) ] ) ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:l <#> ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ; fhir:l fhir:Citation ] ] ; ( fhir:content [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type> ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000368 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l <https://www.nlm.nih.gov/mesh> ] ; fhir:code [ fhir:v "D000368" ] ; fhir:display [ fhir:v "Aged" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type> ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000726 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l <https://www.nlm.nih.gov/mesh> ] ; fhir:code [ fhir:v "D000726" ] ; fhir:display [ fhir:v "Androgen Antagonists" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l 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<http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status> ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-status-type> ] ; fhir:code [ fhir:v "active" ] ; fhir:display [ fhir:v "Active" ] ] ) ] ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/179621"^^xsd:anyURI ; fhir:l <https://fevir.net/resources/Citation/179621> ] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203> ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FOI"^^xsd:anyURI ; fhir:l <https://fevir.net/FOI> ] ; fhir:value [ fhir:v "179621" ] ; fhir:assigner [ 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"http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/citation-classification-type> ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/citation-artifact-classifier> ] ; fhir:code [ fhir:v "medline-base" ] ; fhir:display [ fhir:v "Medline Base" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2015-09-28"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2024-08-05"^^xsd:date] ; # fhir:classification ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ; fhir:l 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"http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-received" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Received" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-04-15"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-revised" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Revised" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-05-06"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-05-08"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-06-02T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-06-02T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l <http://hl7.org/fhir/citation-status-type> ] ; fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Medline" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-09-29T06:00:00.000Z"^^xsd:dateTime ] ] ] ) ; # fhir:citedArtifact [ ( fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ; fhir:l <https://pubmed.ncbi.nlm.nih.gov> ] ; fhir:value [ fhir:v "26028518" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ; fhir:l <https://doi.org> ] ; fhir:value [ fhir:v "10.1016/S1470-2045(15)00011-X" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203> ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "S1470-2045(15)00011-X" ] ] ) ; ( fhir:relatedIdentifier [ fhir:system [ fhir:v "https://clinicaltrials.gov"^^xsd:anyURI ; fhir:l <https://clinicaltrials.gov> ] ; fhir:value [ fhir:v "NCT00055731" ] ; fhir:assigner [ fhir:display [ fhir:v "ClinicalTrials.gov" ] ] ] ) ; ( fhir:title [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/title-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/title-type> ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:text [ fhir:v "Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial." ] ] ) ; ( fhir:abstract [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type"^^xsd:anyURI ; fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type> ] ; fhir:code [ fhir:v "primary-human-use" ] ; fhir:display [ fhir:v "Primary human use" ] ] ) ] ) ; fhir:text [ fhir:v "**BACKGROUND:** Early risk-stratified chemotherapy is a standard treatment for breast, colorectal, and lung cancers, but not for high-risk localised prostate cancer. Combined docetaxel and estramustine improves survival in patients with castration-resistant prostate cancer. We assessed the effects of combined docetaxel and estramustine on relapse in patients with high-risk localised prostate cancer.\n**METHODS:** We did this randomised phase 3 trial at 26 hospitals in France. We enrolled patients with treatment-naive prostate cancer and at least one risk factor (ie, stage T3-T4 disease, Gleason score of ≥8, prostate-specific antigen concentration >20 ng/mL, or pathological node-positive). All patients underwent a staging pelvic lymph node dissection. Patients were randomly assigned (1:1) to either androgen deprivation therapy (ADT; goserelin 10·8 mg every 3 months for 3 years) plus four cycles of docetaxel on day 2 at a dose of 70 mg/m(2) and estramustine 10 mg/kg per day on days 1-5, every 3 weeks, or ADT only. The randomisation was done centrally by computer, stratified by risk factor. Local treatment was administered at 3 months. Neither patients nor investigators were masked to treatment allocation. The primary endpoint was relapse-free survival in the intention-to-treat population. Follow-up for other endpoints is ongoing. This study is registered with ClinicalTrials.gov, number NCT00055731.\n**FINDINGS:** We randomly assigned 207 patients to the ADT plus docetaxel and estramustine group and 206 to the ADT only group. Median follow-up was 8·8 years (IQR 8·1-9·7). 88 (43%) of 207 patients in the ADT plus docetaxel and estramustine group had an event (relapse or death) versus 111 (54%) of 206 in the ADT only group. 8-year relapse-free survival was 62% (95% CI 55-69) in the ADT plus docetaxel and estramustine group versus 50% (44-57) in the ADT only group (adjusted hazard ratio [HR] 0·71, 95% CI 0·54-0·94, p=0·017). Of patients who were treated with radiotherapy and had data available, 31 (21%) of 151 in the ADT plus docetaxel and estramustine group versus 26 (18%) of 143 in the ADT only group reported a grade 2 or higher long-term side-effect (p=0·61). We recorded no excess second cancers (26 [13%] of 207 vs 22 [11%] of 206; p=0·57), and there were no treatment-related deaths.\n**INTERPRETATION:** Docetaxel-based chemotherapy improves relapse-free survival in patients with high-risk localised prostate cancer. Longer follow-up is needed to assess whether this benefit translates into improved metastasis-free survival and overall survival.\n**FUNDING:** Ligue Contre le Cancer, Sanofi-Aventis, AstraZeneca, Institut National du Cancer." ] ; fhir:copyright [ fhir:v "Copyright © 2015 Elsevier Ltd. 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fhir:reference [ fhir:v "#contributor13" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Baciuchka M" ] ] ; fhir:forenameInitials [ fhir:v "M" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Centre Hospitalier La Timone, Marseille, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor14> ; fhir:reference [ fhir:v "#contributor14" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Laguerre B" ] ] ; fhir:forenameInitials [ fhir:v "B" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Centre Eugène Marquis, Rennes, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor15> ; fhir:reference [ fhir:v "#contributor15" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Fléchon A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Centre Léon Bérard, Lyon, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor16> ; fhir:reference [ fhir:v "#contributor16" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Ravaud A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Saint-André, Bordeaux, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor17> ; fhir:reference [ fhir:v "#contributor17" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Cojean-Zelek I" ] ] ; fhir:forenameInitials [ fhir:v "I" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor18> ; fhir:reference [ fhir:v "#contributor18" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Oudard S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Européen Georges Pompidou, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor19> ; fhir:reference [ fhir:v "#contributor19" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Labourey JL" ] ] ; fhir:forenameInitials [ fhir:v "JL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "CHU Dupuytren, Limoges, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor20> ; fhir:reference [ fhir:v "#contributor20" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Chinet-Charrot P" ] ] ; fhir:forenameInitials [ fhir:v "P" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Centre Henri Becquerel, Rouen, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor21> ; fhir:reference [ fhir:v "#contributor21" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Legouffe E" ] ] ; fhir:forenameInitials [ fhir:v "E" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Centre Médical Oncogard, Nimes, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor22> ; fhir:reference [ fhir:v "#contributor22" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Lagrange JL" ] ] ; fhir:forenameInitials [ fhir:v "JL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Henri-Mondor, Créteil, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor23> ; fhir:reference [ fhir:v "#contributor23" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Linassier C" ] ] ; fhir:forenameInitials [ fhir:v "C" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Bretonneau, Tours, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor24> ; fhir:reference [ fhir:v "#contributor24" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Deplanque G" ] ] ; fhir:forenameInitials [ fhir:v "G" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Saint-Joseph, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor25> ; fhir:reference [ fhir:v "#contributor25" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Beuzeboc P" ] ] ; fhir:forenameInitials [ fhir:v "P" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institut Curie, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor26> ; fhir:reference [ fhir:v "#contributor26" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Davin JL" ] ] ; fhir:forenameInitials [ fhir:v "JL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Clinique Sainte-Catherine, Avignon, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor27> ; fhir:reference [ fhir:v "#contributor27" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Martin AL" ] ] ; fhir:forenameInitials [ fhir:v "AL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Unicancer, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor28> ; fhir:reference [ fhir:v "#contributor28" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Habibian M" ] ] ; fhir:forenameInitials [ fhir:v "M" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Unicancer, Paris, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor29> ; fhir:reference [ fhir:v "#contributor29" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Laplanche A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institut Gustave Roussy, Villejuif, France." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor30> ; fhir:reference [ fhir:v "#contributor30" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Culine S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hôpital Saint-Louis, Paris, France." ] ] ) ] ) ] ] . #
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Package hl7.fhir.uv.ebm#1.0.0-ballot3 based on FHIR 6.0.0-ballot3.
Generated
2026-03-27
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