Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Quadpill once daily

Page standards status: Informative

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/ActivityDefinition/375159> a fhir:ActivityDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "375159"] ; # 
  fhir:meta [
     fhir:versionId [ fhir:v "17" ] ;
     fhir:lastUpdated [ fhir:v "2025-10-10T19:18:15.913Z"^^xsd:dateTime ]
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "additional" ] ;
     fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><p><b>Title: </b>Quadpill once daily</p>\n<p><b>Description: </b>This is describing an intervention used in the QUARTET USA Trial.</p>\n<p><b>Product: </b>Quadpill (candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg)</p>\n<p><b>Dosage: </b>One pill by mouth once daily</p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:contained ( [
     a fhir:Medication ;
     fhir:id [ fhir:v "Quadpill" ] ;
     fhir:ingredient ( [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
               fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
             ] ;
             fhir:code [ fhir:v "1156611" ] ;
             fhir:display [ fhir:v "candesartan Oral Product" ]
           ] )
         ]
       ] ;
       fhir:strength [
         a fhir:Quantity ;
         fhir:value [ fhir:v "2"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "milligram (mg)" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg" ]
       ]
     ] [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
               fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
             ] ;
             fhir:code [ fhir:v "19484" ] ;
             fhir:display [ fhir:v "bisoprolol" ]
           ] )
         ]
       ] ;
       fhir:strength [
         a fhir:Quantity ;
         fhir:value [ fhir:v 2.5 ] ;
         fhir:unit [ fhir:v "milligram (mg)" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg" ]
       ]
     ] [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
               fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
             ] ;
             fhir:code [ fhir:v "17767" ] ;
             fhir:display [ fhir:v "amlodipine" ]
           ] )
         ]
       ] ;
       fhir:strength [
         a fhir:Quantity ;
         fhir:value [ fhir:v 1.25 ] ;
         fhir:unit [ fhir:v "milligram (mg)" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg" ]
       ]
     ] [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
               fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
             ] ;
             fhir:code [ fhir:v "5764" ] ;
             fhir:display [ fhir:v "indapamide" ]
           ] )
         ]
       ] ;
       fhir:strength [
         a fhir:Quantity ;
         fhir:value [ fhir:v 0.625 ] ;
         fhir:unit [ fhir:v "milligram (mg)" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg" ]
       ]
     ] )
  ] ) ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as>
     ] ;
     fhir:value [
       a fhir:Markdown ;
       fhir:v "Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-06-03. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json."
     ]
  ] [
     fhir:url [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status>
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-status-type>
         ] ;
         fhir:code [ fhir:v "active" ] ;
         fhir:display [ fhir:v "Active" ]
       ] )
     ]
  ] ) ; # 
  fhir:url [
     fhir:v "https://fevir.net/resources/ActivityDefinition/375159"^^xsd:anyURI ;
     fhir:l <https://fevir.net/resources/ActivityDefinition/375159>
  ] ; # 
  fhir:identifier ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>
         ] ;
         fhir:code [ fhir:v "ACSN" ] ;
         fhir:display [ fhir:v "Accession ID" ]
       ] ) ;
       fhir:text [ fhir:v "FEvIR Object Identifier" ]
     ] ;
     fhir:system [
       fhir:v "https://fevir.net/FOI"^^xsd:anyURI ;
       fhir:l <https://fevir.net/FOI>
     ] ;
     fhir:value [ fhir:v "375159" ] ;
     fhir:assigner [
       fhir:display [ fhir:v "Computable Publishing LLC" ]
     ]
  ] [
     fhir:system [
       fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ;
       fhir:l <urn:ietf:rfc:3986>
     ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.11.3" ]
  ] ) ; # 
  fhir:version [ fhir:v "1.0.0-ballot3"] ; # 
  fhir:title [ fhir:v "Quadpill once daily"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:date [ fhir:v "2026-06-26T20:30:55+00:00"^^xsd:dateTime] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
     fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ;
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
     ] )
  ] ) ; # 
  fhir:description [ fhir:v "This is describing an intervention used in the QUARTET USA Trial."] ; # 
  fhir:jurisdiction ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ;
         fhir:l <http://unstats.un.org/unsd/methods/m49/m49.htm>
       ] ;
       fhir:code [ fhir:v "001" ] ;
       fhir:display [ fhir:v "World" ]
     ] )
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:author ( [
     fhir:name [ fhir:v "Joanne Dehnbostel" ]
  ] ) ; # 
  fhir:relatedArtifact ( [
     fhir:type [ fhir:v "cite-as" ] ;
     fhir:citation [ fhir:v "Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-10-10. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json." ]
  ] ) ; # 
  fhir:product [
     a fhir:Reference ;
     fhir:l <#Quadpill> ;
     fhir:reference [ fhir:v "#Quadpill" ] ;
     fhir:type [
       fhir:v "Medication"^^xsd:anyURI ;
       fhir:l fhir:Medication
     ] ;
     fhir:display [ fhir:v "Quadpill (candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg)" ]
  ] ; # 
  fhir:dosage ( [
     fhir:text [ fhir:v "One pill by mouth once daily" ] ;
     fhir:timing [
       fhir:code [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v3-GTSAbbreviation"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v3-GTSAbbreviation>
           ] ;
           fhir:code [ fhir:v "QD" ] ;
           fhir:display [ fhir:v "QD" ]
         ] )
       ]
     ] ;
     fhir:route [
       fhir:coding ( [
         a sct:26643006 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "26643006" ] ;
         fhir:display [ fhir:v "Oral route" ]
       ] )
     ] ;
     fhir:doseAndRate ( [
       fhir:dose [
         a fhir:Quantity ;
         fhir:value [ fhir:v "1"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "pill" ]
       ]
     ] )
  ] ) . #