Generated Narrative: Composition 370503 version: 25; Last updated: 2025-09-13 09:52:10+0000; Language: en Profile: BaselineMeasureReport ArtifactPublicationStatus: Active url: https://fevir.net/resources/Composition/370503 identifier: FEvIR Object Identifier/370503, FEvIR Linking Identifier/NCT03640312-baseline-measure-report status: Final type: Baseline Measure Report date: 2025-09-13 09:52:10+0000 author: [No author listed.] title: Baseline Characteristics Report for NCT03640312 custodian: Computable Publishing LLC RelatesTos - Type Target[x] * Cite As Baseline Characteristics Report for NCT03640312 [Database Entry: FHIR Composition Resource]. Contributors: [No author listed.] [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 370503. Revised 2025-09-13. Available at: https://fevir.net/resources/Composition/370503. Computable resource at: https://fevir.net/resources/Composition/370503#json. Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-0 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Age, Continuous status: Active Definitions - Concept * Age, Continuous handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-1 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Sex: Female, Male status: Active Definitions - Concept * Sex: Female, Male handling: extension category name: Female category name: Male classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-2 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Race/Ethnicity, Customized status: Active Definitions - Concept * Race/Ethnicity, Customized handling: extension category name: Race/Ethnicity:: Hispanic category name: Race/Ethnicity:: Black/Sub Saharan African category name: Race/Ethnicity:: White/Caucasian/Other classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-3 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Body Mass Index, kg/m^2 status: Active Definitions - Concept * Body Mass Index, kg/m^2 handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-4 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Heart rate, beats per minute status: Active Definitions - Concept * Heart rate, beats per minute handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-5 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: History of diabetes, n (%) status: Active Definitions - Concept * History of diabetes, n (%) handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-6 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: History of smoking, n (%) status: Active Definitions - Concept * History of smoking, n (%) handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-7 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: History of depression, n (%) status: Active Definitions - Concept * History of depression, n (%) handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-8 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Weekly alcohol use, n (%) status: Active Definitions - Concept * Weekly alcohol use, n (%) handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-9 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Systolic Blood Pressure, mm Hg status: Active Definitions - Concept * Systolic Blood Pressure, mm Hg handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: EvidenceVariable #NCT03640312-BaselineMeasure-10 Profile: VariableDefinition EvidenceVariableHandlingDetail: Evidence variable handling not specified title: Diastolic Blood Pressure, mm Hg status: Active Definitions - Concept * Diastolic Blood Pressure, mm Hg handling: extension classifier: Baseline Measure Timings - Offset[x] * No display for Duration (value: 0) Generated Narrative: Group #BG000 Profile: ExposureGroup name: QUARTET LDQT description: Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States. QUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks. type: Person membership: Enumerated code: Participants quantity: 32 Characteristics - Code Value[x] Exclude * Research Study from which this is a baseline group NCT03640312 false Generated Narrative: Group #BG001 Profile: ExposureGroup name: Candesartan description: Patients randomized to the comparison arm took a once daily 8mg candesartan. Candesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks. type: Person membership: Enumerated code: Participants quantity: 30 Characteristics - Code Value[x] Exclude * Research Study from which this is a baseline group NCT03640312 false Generated Narrative: Group #BG002 Profile: ExposureGroup name: Total description: Total of all reporting groups type: Person membership: Enumerated code: Participants quantity: 62 Characteristics - Code Value[x] Exclude * Research Study from which this is a baseline group NCT03640312 false Generated Narrative: Evidence #NCT03640312-BaselineMeasure-0-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_0_BG000 title: Age, Continuous for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Age, Continuous statistic statisticType: mean quantity: 52 years SampleSizes - KnownDataCount * 32 AttributeEstimates - Type Quantity * Standard Deviation 12.6 years Generated Narrative: Evidence #NCT03640312-BaselineMeasure-0-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_0_BG001 title: Age, Continuous for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Age, Continuous statistic statisticType: mean quantity: 52 years SampleSizes - KnownDataCount * 30 AttributeEstimates - Type Quantity * Standard Deviation 10.5 years Generated Narrative: Evidence #NCT03640312-BaselineMeasure-0-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_0_BG002 title: Age, Continuous for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Age, Continuous statistic statisticType: mean quantity: 52 years SampleSizes - KnownDataCount * 62 AttributeEstimates - Type Quantity * Standard Deviation 11.5 years Generated Narrative: Evidence #NCT03640312-BaselineMeasure-1-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_1_BG000 title: Sex: Female, Male for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Sex: Female, Male statistic statisticType: Count of Participants category: Female quantity: 15 Participants SampleSizes - KnownDataCount * 32 statistic statisticType: Count of Participants category: Male quantity: 17 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-1-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_1_BG001 title: Sex: Female, Male for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Sex: Female, Male statistic statisticType: Count of Participants category: Female quantity: 13 Participants SampleSizes - KnownDataCount * 30 statistic statisticType: Count of Participants category: Male quantity: 17 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-1-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_1_BG002 title: Sex: Female, Male for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Sex: Female, Male statistic statisticType: Count of Participants category: Female quantity: 28 Participants SampleSizes - KnownDataCount * 62 statistic statisticType: Count of Participants category: Male quantity: 34 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-2-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_2_BG000 title: Race/Ethnicity, Customized for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Race/Ethnicity, Customized statistic statisticType: Count of Participants category: Race/Ethnicity:: Hispanic quantity: 24 Participants SampleSizes - KnownDataCount * 32 statistic statisticType: Count of Participants category: Race/Ethnicity:: Black/Sub Saharan African quantity: 4 Participants SampleSizes - KnownDataCount * 32 statistic statisticType: Count of Participants category: Race/Ethnicity:: White/Caucasian/Other quantity: 4 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-2-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_2_BG001 title: Race/Ethnicity, Customized for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Race/Ethnicity, Customized statistic statisticType: Count of Participants category: Race/Ethnicity:: Hispanic quantity: 21 Participants SampleSizes - KnownDataCount * 30 statistic statisticType: Count of Participants category: Race/Ethnicity:: Black/Sub Saharan African quantity: 7 Participants SampleSizes - KnownDataCount * 30 statistic statisticType: Count of Participants category: Race/Ethnicity:: White/Caucasian/Other quantity: 2 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-2-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_2_BG002 title: Race/Ethnicity, Customized for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Race/Ethnicity, Customized statistic statisticType: Count of Participants category: Race/Ethnicity:: Hispanic quantity: 45 Participants SampleSizes - KnownDataCount * 62 statistic statisticType: Count of Participants category: Race/Ethnicity:: Black/Sub Saharan African quantity: 11 Participants SampleSizes - KnownDataCount * 62 statistic statisticType: Count of Participants category: Race/Ethnicity:: White/Caucasian/Other quantity: 6 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-3-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_3_BG000 title: Body Mass Index, kg/m^2 for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Body Mass Index, kg/m^2 statistic statisticType: mean quantity: 33 kg/m^2 SampleSizes - KnownDataCount * 32 AttributeEstimates - Type Quantity * Standard Deviation 6.9 kg/m^2 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-3-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_3_BG001 title: Body Mass Index, kg/m^2 for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Body Mass Index, kg/m^2 statistic statisticType: mean quantity: 34 kg/m^2 SampleSizes - KnownDataCount * 30 AttributeEstimates - Type Quantity * Standard Deviation 7.9 kg/m^2 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-3-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_3_BG002 title: Body Mass Index, kg/m^2 for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Body Mass Index, kg/m^2 statistic statisticType: mean quantity: 34 kg/m^2 SampleSizes - KnownDataCount * 62 AttributeEstimates - Type Quantity * Standard Deviation 7.3 kg/m^2 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-4-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_4_BG000 title: Heart rate, beats per minute for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Heart rate, beats per minute statistic statisticType: mean quantity: 71.5 beats per minute SampleSizes - KnownDataCount * 32 AttributeEstimates - Type Quantity * Standard Deviation 10 beats per minute Generated Narrative: Evidence #NCT03640312-BaselineMeasure-4-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_4_BG001 title: Heart rate, beats per minute for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Heart rate, beats per minute statistic statisticType: mean quantity: 71.7 beats per minute SampleSizes - KnownDataCount * 30 AttributeEstimates - Type Quantity * Standard Deviation 11.7 beats per minute Generated Narrative: Evidence #NCT03640312-BaselineMeasure-4-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_4_BG002 title: Heart rate, beats per minute for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Heart rate, beats per minute statistic statisticType: mean quantity: 71.6 beats per minute SampleSizes - KnownDataCount * 62 AttributeEstimates - Type Quantity * Standard Deviation 10.8 beats per minute Generated Narrative: Evidence #NCT03640312-BaselineMeasure-5-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_5_BG000 title: History of diabetes, n (%) for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: History of diabetes, n (%) statistic statisticType: Count of Participants quantity: 10 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-5-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_5_BG001 title: History of diabetes, n (%) for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: History of diabetes, n (%) statistic statisticType: Count of Participants quantity: 7 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-5-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_5_BG002 title: History of diabetes, n (%) for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: History of diabetes, n (%) statistic statisticType: Count of Participants quantity: 17 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-6-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_6_BG000 title: History of smoking, n (%) for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: History of smoking, n (%) statistic statisticType: Count of Participants quantity: 11 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-6-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_6_BG001 title: History of smoking, n (%) for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: History of smoking, n (%) statistic statisticType: Count of Participants quantity: 9 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-6-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_6_BG002 title: History of smoking, n (%) for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: History of smoking, n (%) statistic statisticType: Count of Participants quantity: 20 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-7-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_7_BG000 title: History of depression, n (%) for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: History of depression, n (%) statistic statisticType: Count of Participants quantity: 7 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-7-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_7_BG001 title: History of depression, n (%) for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: History of depression, n (%) statistic statisticType: Count of Participants quantity: 9 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-7-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_7_BG002 title: History of depression, n (%) for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: History of depression, n (%) statistic statisticType: Count of Participants quantity: 16 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-8-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_8_BG000 title: Weekly alcohol use, n (%) for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Weekly alcohol use, n (%) statistic statisticType: Count of Participants quantity: 10 Participants SampleSizes - KnownDataCount * 32 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-8-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_8_BG001 title: Weekly alcohol use, n (%) for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Weekly alcohol use, n (%) statistic statisticType: Count of Participants quantity: 9 Participants SampleSizes - KnownDataCount * 30 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-8-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_8_BG002 title: Weekly alcohol use, n (%) for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Weekly alcohol use, n (%) statistic statisticType: Count of Participants quantity: 19 Participants SampleSizes - KnownDataCount * 62 Generated Narrative: Evidence #NCT03640312-BaselineMeasure-9-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_9_BG000 title: Systolic Blood Pressure, mm Hg for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Systolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 137.6 mm Hg SampleSizes - KnownDataCount * 32 AttributeEstimates - Type Quantity * Standard Deviation 11.8 mm Hg Generated Narrative: Evidence #NCT03640312-BaselineMeasure-9-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_9_BG001 title: Systolic Blood Pressure, mm Hg for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Systolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 138.7 mm Hg SampleSizes - KnownDataCount * 30 AttributeEstimates - Type Quantity * Standard Deviation 10.8 mm Hg Generated Narrative: Evidence #NCT03640312-BaselineMeasure-9-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_9_BG002 title: Systolic Blood Pressure, mm Hg for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Systolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 138.1 mm Hg SampleSizes - KnownDataCount * 62 AttributeEstimates - Type Quantity * Standard Deviation 11.2 mm Hg Generated Narrative: Evidence #NCT03640312-BaselineMeasure-10-BG000 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_10_BG000 title: Diastolic Blood Pressure, mm Hg for QUARTET LDQT at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: QUARTET LDQT variableDefinition variableRole: Outcome observed: Diastolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 84.3 mm Hg SampleSizes - KnownDataCount * 32 AttributeEstimates - Type Quantity * Standard Deviation 9.6 mm Hg Generated Narrative: Evidence #NCT03640312-BaselineMeasure-10-BG001 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_10_BG001 title: Diastolic Blood Pressure, mm Hg for Candesartan at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Candesartan variableDefinition variableRole: Outcome observed: Diastolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 84.3 mm Hg SampleSizes - KnownDataCount * 30 AttributeEstimates - Type Quantity * Standard Deviation 11.5 mm Hg Generated Narrative: Evidence #NCT03640312-BaselineMeasure-10-BG002 Profile: NonComparativeEvidence name: NCT03640312_BaselineMeasure_10_BG002 title: Diastolic Blood Pressure, mm Hg for Total at baseline in NCT03640312 status: Active variableDefinition variableRole: Population observed: Total variableDefinition variableRole: Outcome observed: Diastolic Blood Pressure, mm Hg statistic statisticType: mean quantity: 84.3 mm Hg SampleSizes - KnownDataCount * 62 AttributeEstimates - Type Quantity * Standard Deviation 10.5 mm Hg
Evidence variable handling not specified
Race/Ethnicity:: Black/Sub Saharan African
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States. QUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
Research Study from which this is a baseline group
Patients randomized to the comparison arm took a once daily 8mg candesartan. Candesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
Age, Continuous for QUARTET LDQT at baseline in NCT03640312
Age, Continuous for Candesartan at baseline in NCT03640312
Age, Continuous for Total at baseline in NCT03640312
Sex: Female, Male for QUARTET LDQT at baseline in NCT03640312
Sex: Female, Male for Candesartan at baseline in NCT03640312
Sex: Female, Male for Total at baseline in NCT03640312
Race/Ethnicity, Customized for QUARTET LDQT at baseline in NCT03640312
Race/Ethnicity, Customized for Candesartan at baseline in NCT03640312
Race/Ethnicity, Customized for Total at baseline in NCT03640312
Body Mass Index, kg/m^2 for QUARTET LDQT at baseline in NCT03640312
Body Mass Index, kg/m^2 for Candesartan at baseline in NCT03640312
Body Mass Index, kg/m^2 for Total at baseline in NCT03640312
Heart rate, beats per minute for QUARTET LDQT at baseline in NCT03640312
Heart rate, beats per minute for Candesartan at baseline in NCT03640312
Heart rate, beats per minute for Total at baseline in NCT03640312
History of diabetes, n (%) for QUARTET LDQT at baseline in NCT03640312
History of diabetes, n (%) for Candesartan at baseline in NCT03640312
History of diabetes, n (%) for Total at baseline in NCT03640312
History of smoking, n (%) for QUARTET LDQT at baseline in NCT03640312
History of smoking, n (%) for Candesartan at baseline in NCT03640312
History of smoking, n (%) for Total at baseline in NCT03640312
History of depression, n (%) for QUARTET LDQT at baseline in NCT03640312
History of depression, n (%) for Candesartan at baseline in NCT03640312
History of depression, n (%) for Total at baseline in NCT03640312
Weekly alcohol use, n (%) for QUARTET LDQT at baseline in NCT03640312
Weekly alcohol use, n (%) for Candesartan at baseline in NCT03640312
Weekly alcohol use, n (%) for Total at baseline in NCT03640312
Systolic Blood Pressure, mm Hg for QUARTET LDQT at baseline in NCT03640312
Systolic Blood Pressure, mm Hg for Candesartan at baseline in NCT03640312
Systolic Blood Pressure, mm Hg for Total at baseline in NCT03640312
Diastolic Blood Pressure, mm Hg for QUARTET LDQT at baseline in NCT03640312
Diastolic Blood Pressure, mm Hg for Candesartan at baseline in NCT03640312
Diastolic Blood Pressure, mm Hg for Total at baseline in NCT03640312
Baseline Characteristics Report for NCT03640312
Baseline Characteristics Report for NCT03640312 [Database Entry: FHIR Composition Resource]. Contributors: [No author listed.] [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 370503. Revised 2025-09-13. Available at: https://fevir.net/resources/Composition/370503. Computable resource at: https://fevir.net/resources/Composition/370503#json.
QUARTET LDQT, Candesartan, Total
[No data.]