Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Page standards status: Informative |
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<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Composition 236537</b></p><a name="236537"> </a><a name="hc236537"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 83; Last updated: 2026-06-08 13:44:03+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-summary-of-findings.html">SummaryOfFindings</a></p></div><p><b>Artifact Description</b>: </p><div><p>Example of SummaryOfFindings Profile for Evidence Based Medicine on FHIR Implementation Guide</p>
</div><p><b>ArtifactPublicationStatus</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}">Active</span></p><p><b>url</b>: <a href="https://fevir.net/resources/Composition/236537">https://fevir.net/resources/Composition/236537</a></p><p><b>identifier</b>: FEvIR Object Identifier/236537, FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-summary-of-findings-85390-85789</p><p><b>status</b>: Final</p><p><b>type</b>: <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 SummaryOfFindings}">Summary of Findings</span></p><p><b>date</b>: 2026-06-08 13:44:03+0000</p><p><b>author</b>: Qiukui Hao</p><p><b>title</b>: SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk</p><p><b>custodian</b>: <a href="Organization-118079.html">Computable Publishing LLC</a></p><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Part Of</p><p><b>target</b>: MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes (Identifier: FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-conversion-report)</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Part Of</p><p><b>target</b>: <a href="Composition-236538.html">ComparativeEvidenceSynthesisReport: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk</a></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cite As</p><p><b>target</b>: </p><div><p>SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk [Database Entry: FHIR Composition Resource]. Contributors: Qiukui Hao [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 236537. Revised 2026-06-08. Available at: https://fevir.net/resources/Composition/236537. Computable resource at: https://fevir.net/resources/Composition/236537#json.</p>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>Outcome</p></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>[No statistic found.]</p></div>
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<reference value="Evidence/557019"/>
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<type>
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<entry>🔗
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<type value="Evidence"/>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>10.7%</p></div>
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<entry>🔗
<reference value="Evidence/557020"/>
<type value="Evidence"/>
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<display
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<text>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>10.71%</p></div>
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<entry>🔗
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<type>
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<entry>🔗
<reference value="Evidence/557019"/>
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<display
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<section>
<title value="Effect Estimate"/>
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<text>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -1.3% (CI95 -1.8% to -0.6%); OR 0.88 (CI95 0.83 to 0.94)</p></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>Moderate certainty -- Due to serious imprecision</p></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists probably reduce the risk of death compared with standard care.</p></div>
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<section>
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<focus>🔗
<reference value="EvidenceVariable/236542"/>
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<assigner>
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<display value="OutcomeDefinition: Cardiovascular mortality"/>
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<section>
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<coding>
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<code value="outcome-measure"/>
<display value="Outcome Measure"/>
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<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Cardiovascular mortality</p></div>
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<entry>🔗
<reference value="EvidenceVariable/236542"/>
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<display value="OutcomeDefinition: Cardiovascular mortality"/>
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<section>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>20 studies, 63455 participants</p></div>
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<entry>🔗
<reference value="Evidence/557022"/>
<type value="Evidence"/>
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<type>
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<display
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<section>
<title value="Result Without Treatment"/>
<code>
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<display value="Result with comparator alone"/>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7.9%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557024"/>
<type value="Evidence"/>
<display
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<section>
<title value="Result With Treatment--Observed"/>
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<coding>
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<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7%</p></div>
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<entry>🔗
<reference value="Evidence/557023"/>
<type value="Evidence"/>
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<type>
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<value
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<assigner>
<display value="Computable Publishing LLC"/>
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<display
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<section>
<title value="Result With Treatment--Derived"/>
<code>
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<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
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<text
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7.02%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557024"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
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</identifier>
<display
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<entry>🔗
<reference value="Evidence/557022"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -0.9% (CI95 -1.5% to -0.3%); OR 0.88 (CI95 0.8 to 0.96)</p></div>
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<entry>🔗
<reference value="Evidence/557022"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
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<assigner>
<display value="Computable Publishing LLC"/>
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</identifier>
<display
value="MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
<section>
<title value="Certainty of Evidence"/>
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<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Moderate certainty -- Due to serious imprecision</p></div>
</text>
<entry>🔗
<reference value="Evidence/557022"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
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<assigner>
<display value="Computable Publishing LLC"/>
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</identifier>
<display
value="MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557022"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
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</identifier>
<display
value="MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
</section>
<section>
<title value="Nonfatal myocardial infarction"/>
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<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
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</code>
<focus>🔗
<reference value="EvidenceVariable/236545"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313878"/>
<assigner>
<display value="Computable Publishing LLC"/>
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</identifier>
<display value="OutcomeDefinition: Nonfatal myocardial infarction"/>
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<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Nonfatal myocardial infarction</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236545"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313878"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Nonfatal myocardial infarction"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>32 studies, 67956 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557025"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10.8%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557027"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557026"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Nonfatal myocardial infarction in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10.02%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557027"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
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<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
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<entry>🔗
<reference value="Evidence/557025"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
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</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -0.8% (CI95 -1.5% to -0.1%); OR 0.92 (CI95 0.85 to 0.99)</p></div>
</text>
<entry>🔗
<reference value="Evidence/557025"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
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</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Moderate certainty -- Due to serious imprecision</p></div>
</text>
<entry>🔗
<reference value="Evidence/557025"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value
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<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal myocardial infarction compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557025"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Nonfatal stroke"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236548"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313879"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Nonfatal stroke"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Nonfatal stroke</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236548"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
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<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313879"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Nonfatal stroke"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>29 studies, 66900 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557028"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10.8%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557030"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>9.2%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557029"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Nonfatal stroke in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>9.23%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557030"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>🔗
<reference value="Evidence/557028"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -1.6% (CI95 -2.4% to -0.7%); OR 0.84 (CI95 0.76 to 0.93)</p></div>
</text>
<entry>🔗
<reference value="Evidence/557028"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Moderate certainty -- Due to serious imprecision</p></div>
</text>
<entry>🔗
<reference value="Evidence/557028"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal stroke compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557028"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="End-stage kidney disease"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236551"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313880"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: End-stage kidney disease"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>End-stage kidney disease</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236551"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313880"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: End-stage kidney disease"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>4 studies, 10762 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557031"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>2%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557033"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>1.6%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557032"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: End-stage kidney disease in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>1.57%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557033"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>🔗
<reference value="Evidence/557031"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -0.4% (CI95 -0.7% to -0.2%); OR 0.78 (CI95 0.67 to 0.92)</p></div>
</text>
<entry>🔗
<reference value="Evidence/557031"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>High certainty</p></div>
</text>
<entry>🔗
<reference value="Evidence/557031"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>There is no important difference between GLP-1 receptor agonists and standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557031"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Heart failure"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236554"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313881"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Heart failure"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Heart failure</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236554"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313881"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Heart failure"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>13 studies, 46696 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557034"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>8%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557036"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7.6%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557035"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Heart failure in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7.56%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557036"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>🔗
<reference value="Evidence/557034"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -0.4% (CI95 -1.1% to 0.2%); OR 0.94 (CI95 0.85 to 1.03)</p></div>
</text>
<entry>🔗
<reference value="Evidence/557034"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Moderate certainty -- Due to serious imprecision</p></div>
</text>
<entry>🔗
<reference value="Evidence/557034"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists probably reduce the risk of heart failure compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557034"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Serious hyperglycaemia"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236557"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313882"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Serious hyperglycaemia"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Serious hyperglycaemia</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236557"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313882"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Serious hyperglycaemia"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>12 studies, 30066 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557037"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>2.5%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557039"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>1%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557038"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Serious hyperglycaemia in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>1.02%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557039"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>🔗
<reference value="Evidence/557037"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Risk Difference -1.5% (CI95 -1.9% to -0.9%); OR 0.4 (CI95 0.25 to 0.64)</p></div>
</text>
<entry>🔗
<reference value="Evidence/557037"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>High certainty</p></div>
</text>
<entry>🔗
<reference value="Evidence/557037"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists reduce the risk of serious hyperglycaemia compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557037"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Severe gastrointestinal events"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236560"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313883"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Severe gastrointestinal events"/>
</focus>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Severe gastrointestinal events</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236560"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313883"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Severe gastrointestinal events"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>7 studies, 24638 participants</p></div>
</text>
<entry>🔗
<reference value="Evidence/557040"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>4.4%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557042"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10.2%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557041"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-intervention-idence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Severe gastrointestinal events in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>10.17%</p></div>
</text>
<entry>🔗
<reference value="Evidence/557042"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparator-onidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>🔗
<reference value="Evidence/557040"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[Not a difference in proportions.]</p></div>
</text>
<entry>🔗
<reference value="Evidence/557040"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Low certainty -- Due to inconsistency and serious imprecision.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557040"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists may increase the risk of severe gastrointestinal events compared with standard care.</p></div>
</text>
<entry>🔗
<reference value="Evidence/557040"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-eidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Health-related quality of life"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236563"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109569"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Health-related quality of life"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Health-related quality of life</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236563"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109569"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Health-related quality of life"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No sample size data.]</p></div>
</text>
<entry>
<reference value="Evidence/236564"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>MEAN 51 </p></div>
</text>
<entry>🔗
<reference value="Evidence/557044"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>MEAN 51.91 </p></div>
</text>
<entry>🔗
<reference value="Evidence/557043"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-intervention-oidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Health-related quality of life in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[Not a proportion.]</p></div>
</text>
<entry>🔗
<reference value="Evidence/557044"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparator-onlidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>
<reference value="Evidence/236564"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>SMD 0.13 (CI95 0.03 to 0.23 )</p></div>
</text>
<entry>
<reference value="Evidence/236564"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Low certainty -- Due to very serious imprecision</p></div>
</text>
<entry>
<reference value="Evidence/236564"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists may have little or no impact on health-related quality of life.</p></div>
</text>
<entry>
<reference value="Evidence/236564"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
<section>
<title value="Body weight"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="summary-of-findings-entry-for-a-single-outcome"/>
<display value="Summary of findings entry for a single outcome"/>
</coding>
</code>
<focus>🔗
<reference value="EvidenceVariable/236566"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109570"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Body weight"/>
</focus>
<section>
<title value="Outcome"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="outcome-measure"/>
<display value="Outcome Measure"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Body weight</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236566"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109570"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Body weight"/>
</entry>
</section>
<section>
<title value="Sample Size"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="sample-size"/>
<display value="Sample Size"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>60 studies, 44432 participants</p></div>
</text>
<entry>
<reference value="Evidence/236567"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result Without Treatment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-comparator-alone"/>
<display value="Result with comparator alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>MEAN 88 Kg</p></div>
</text>
<entry>🔗
<reference value="Evidence/557046"/>
<type value="Evidence"/>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Observed"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone"/>
<display value="Result with intervention alone"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>MEAN 86.55 Kg</p></div>
</text>
<entry>🔗
<reference value="Evidence/557045"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-intervention-oidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived InterventionOnlyEvidence: Body weight in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Result With Treatment--Derived"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-alone-calculated"/>
<display value="Result with intervention alone (calculated)"/>
</coding>
<text
value="result with intervention with calculated value derived from the control group and effect estimate"/>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[Not a proportion.]</p></div>
</text>
<entry>🔗
<reference value="Evidence/557046"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparator-onlidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
<entry>
<reference value="Evidence/236567"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Effect Estimate"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="result-with-intervention-vs-comparator"/>
<display value="Result with intervention vs. comparator"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>MD -1.45 Kg (CI95 -1.72 Kg to -1.18 Kg)</p></div>
</text>
<entry>
<reference value="Evidence/236567"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Certainty of Evidence"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="certainty-of-evidence"/>
<display value="Certainty of Evidence"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>Low certainty -- Due to very serious inconsistency</p></div>
</text>
<entry>
<reference value="Evidence/236567"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
<section>
<title value="Assertion"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="assertion"/>
<display value="Assertion"/>
</coding>
</code>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>GLP-1 receptor agonists may reduce body weight compared with standard care.</p></div>
</text>
<entry>
<reference value="Evidence/236567"/>
<type value="Evidence"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value
value="MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display
value="MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"/>
</entry>
</section>
</section>
</section>
<section>
<title value="Groups"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="groups"/>
<display value="Groups"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No narrative text.]</p></div>
</text>
<section>
<title value="Total Group"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="population"/>
<display value="Population"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<emptyReason>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/list-empty-reason"/>
<code value="notstarted"/>
<display value="Not Started"/>
</coding>
</emptyReason>
</section>
<section>
<title value="Intervention Group"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="intervention-group"/>
<display value="Intervention Group"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<emptyReason>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/list-empty-reason"/>
<code value="notstarted"/>
<display value="Not Started"/>
</coding>
</emptyReason>
</section>
<section>
<title value="Comparator Group"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="comparator-group"/>
<display value="Comparator Group"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<emptyReason>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/list-empty-reason"/>
<code value="notstarted"/>
<display value="Not Started"/>
</coding>
</emptyReason>
</section>
<section>
<title value="Group Assignment"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="GroupAssignment"/>
<display value="GroupAssignment"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<emptyReason>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/list-empty-reason"/>
<code value="notstarted"/>
<display value="Not Started"/>
</coding>
</emptyReason>
</section>
</section>
<section>
<title value="Variables (Measures)"/>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="variables"/>
<display value="Variables"/>
</coding>
</code>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/236539"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313876"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: All-cause mortality"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236542"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313877"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Cardiovascular mortality"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236545"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313878"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Nonfatal myocardial infarction"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236548"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313879"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Nonfatal stroke"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236551"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313880"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: End-stage kidney disease"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236554"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313881"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Heart failure"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236557"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313882"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Serious hyperglycaemia"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236560"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-313883"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Severe gastrointestinal events"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236563"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109569"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Health-related quality of life"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/236566"/>
<type value="EvidenceVariable"/>
<identifier>
<type>
<text value="FEvIR Linking Identifier"/>
</type>
<system value="https://fevir.net/FLI"/>
<value value="MAGIC-5288-j1Wqrn-109570"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<display value="OutcomeDefinition: Body weight"/>
</entry>
</section>
</Composition>
IG © 2024+ HL7 International / Clinical Decision Support.
Package hl7.fhir.uv.ebm#1.0.0-ballot3 based on FHIR 6.0.0-ballot3.
Generated
2026-06-12
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