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version: 21; Last updated: 2025-10-13 12:34:35+0000; Language: en

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url: https://fevir.net/resources/Citation/179623

identifier: FEvIR Object Identifier/179623, https://pubmed.ncbi.nlm.nih.gov/23452809

title: 23452809 Long-term follow-up of a phase II trial of chemotherapy plus hormone therapy for biochemical relapse after definitive local therapy for prostate cancer.

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https://creativecommons.org/licenses/by-nc-sa/4.0/

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identifier: https://pubmed.ncbi.nlm.nih.gov/23452809, https://doi.org/10.1016/j.urology.2012.12.025, pii/S0090-4295(12)01569-5

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Long-term follow-up of a phase II trial of chemotherapy plus hormone therapy for biochemical relapse after definitive local therapy for prostate cancer.

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OBJECTIVE: To evaluate long-term follow-up of a phase II trial of chemohormonal therapy in 62 men with prostate cancer biochemical relapse (BR).\nMETHODS: Treatment was 4 cycles of docetaxel (70 mg/m(2)) every 3 weeks and estramustine 280 mg three times a day (days 1-5) followed by 15 months of goserelin acetate/bicalutamide. The primary endpoint was the proportion with prostate-specific antigen (PSA) <0.1 with recovered testosterone 5 years after completion of therapy. Secondary endpoints included time to progression (TTP), time to reinitiate androgen deprivation therapy (ADT), the proportion with castration-resistant prostate cancer (CRPC), and overall survival (OS).\nRESULTS: Median follow-up was 8.6 years (range 1.3-11.1 years). At 5 year follow-up, 7 patients (11%) had PSA <0.1 (5 undetectable); 8 (13%) had PSA >0.1 but without reinitiation of ADT (median PSA 0.37). Of the 15 (24%) men without reinitiation of ADT, and 14 have recovered testosterone to normal range. Median TTP for the complete cohort was 35.0 months (95% confidence interval [CI] 31.7-39.2). Baseline PSA <3.0 ng/dL, no prior ADT, and prostatectomy (vs radiation) were associated with longer TTP (P = .0001, P = .0055, and P = .0398, respectively). At the time of analysis, 42 men (68%) had restarted ADT, 23 men had CRPC (37%), and 11 (18%) had chemotherapy. Median time to reinitiation of ADT was 32.6 months (range 0-107.6 months). Median OS has not been reached; there were 15 deaths.\nCONCLUSION: Chemotherapy plus ADT for BR resulted in durable (>5 years) complete responses (<0.1 ng/mL) in 7 men (11%). Twenty-four percent of men have not re-initiated ADT 5 years from completion of protocol therapy.

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Copyright © 2013 Elsevier Inc. All rights reserved.

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J Urol. 2013 Sep;190(3):880. doi: 10.1016/j.juro.2013.05.105.

\n
https://pubmed.ncbi.nlm.nih.gov/23931194/

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identifier: Electronic ISSN Type/1527-9995, ISOAbbreviation/Urology, ISSN Linking/0090-4295, Medline Title Abbreviation/Urology, NLM Unique ID/0366151

title: Urology

publisherLocation: United States

citedMedium: Internet

volume: 81

issue: 3

articleDate: 2013-03

pageString: 611-6

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affiliation: Division of Medical Oncology, Department of Medicine, Lank Center for Genitourinary Oncology, Boston, MA 02215, USA.

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fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D004961 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D004961" ] ; fhir:display [ fhir:v "Estramustine" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000008 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000008" ] ; fhir:display [ fhir:v "administration & dosage" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D005500 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D005500" ] ; fhir:display [ fhir:v "Follow-Up Studies" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D017273 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D017273" ] ; fhir:display [ fhir:v "Goserelin" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000008 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000008" ] ; fhir:display [ fhir:v "administration & dosage" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D006801 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D006801" ] ; fhir:display [ fhir:v "Humans" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D008297 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D008297" ] ; fhir:display [ fhir:v "Male" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D008875 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D008875" ] ; fhir:display [ fhir:v "Middle Aged" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D009364 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D009364" ] ; fhir:display [ fhir:v "Neoplasm Recurrence, Local" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000188 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D009570 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D009570" ] ; fhir:display [ fhir:v "Nitriles" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D011471 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D011471" ] ; fhir:display [ fhir:v "Prostatic Neoplasms" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000188 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D012189 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D012189" ] ; fhir:display [ fhir:v "Retrospective Studies" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D043823 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D043823" ] ; fhir:display [ fhir:v "Taxoids" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000008 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000008" ] ; fhir:display [ fhir:v "administration & dosage" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D013997 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D013997" ] ; fhir:display [ fhir:v "Time Factors" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D014105 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D014105" ] ; fhir:display [ fhir:v "Tosyl Compounds" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D016896 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D016896" ] ; fhir:display [ fhir:v "Treatment Outcome" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; fhir:component ( [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; fhir:classifier ( [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] ) ] ) ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ; fhir:l ] ; fhir:value [ a fhir:CodeableConcept ; fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "active" ] ; fhir:display [ fhir:v "Active" ] ] ) ] ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/179623"^^xsd:anyURI ; fhir:l ] ; # fhir:identifier ( [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FOI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "179623" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "23452809" ] ] ) ; # fhir:title [ fhir:v "23452809 Long-term follow-up of a phase II trial of chemotherapy plus hormone therapy for biochemical relapse after definitive local therapy for prostate cancer."] ; # fhir:status [ fhir:v "active"] ; # fhir:author ( [ fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ] ] ) ; # fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # fhir:contact ( [ fhir:telecom ( [ fhir:system [ fhir:v "email" ] ; fhir:value [ fhir:v "support@computablepublishing.com" ] ] ) ] ) ; # fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # fhir:useContext ( [ fhir:code [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "medline-base" ] ; fhir:display [ fhir:v "Medline Base" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2013-04-22"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2021-10-21"^^xsd:date] ; # fhir:classification ( [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "citation-source" ] ; fhir:display [ fhir:v "Citation Source" ] ] ) ] ; fhir:classifier ( [ fhir:text [ fhir:v "MEDLINE" ] ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "medline-owner" ] ; fhir:display [ fhir:v "MEDLINE Citation Owner" ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "NLM" ] ; fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; # fhir:currentState ( [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-received" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Received" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2012-11-21"^^xsd:date ] ] ] [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-revised" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Revised" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2012-12-14"^^xsd:date ] ] ] [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2012-12-18"^^xsd:date ] ] ] [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2013-03-05T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2013-03-05T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Medline" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2013-04-23T06:00:00.000Z"^^xsd:dateTime ] ] ] ) ; # fhir:citedArtifact [ fhir:identifier ( [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "23452809" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "10.1016/j.urology.2012.12.025" ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "S0090-4295(12)01569-5" ] ] ) ; fhir:title ( [ fhir:type ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/title-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:text [ fhir:v "Long-term follow-up of a phase II trial of chemotherapy plus hormone therapy for biochemical relapse after definitive local therapy for prostate cancer." ] ] ) ; fhir:abstract ( [ fhir:type ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "primary-human-use" ] ; fhir:display [ fhir:v "Primary human use" ] ] ) ] ) ; fhir:text [ fhir:v "**OBJECTIVE:** To evaluate long-term follow-up of a phase II trial of chemohormonal therapy in 62 men with prostate cancer biochemical relapse (BR).\n**METHODS:** Treatment was 4 cycles of docetaxel (70 mg/m(2)) every 3 weeks and estramustine 280 mg three times a day (days 1-5) followed by 15 months of goserelin acetate/bicalutamide. The primary endpoint was the proportion with prostate-specific antigen (PSA) <0.1 with recovered testosterone 5 years after completion of therapy. Secondary endpoints included time to progression (TTP), time to reinitiate androgen deprivation therapy (ADT), the proportion with castration-resistant prostate cancer (CRPC), and overall survival (OS).\n**RESULTS:** Median follow-up was 8.6 years (range 1.3-11.1 years). At 5 year follow-up, 7 patients (11%) had PSA <0.1 (5 undetectable); 8 (13%) had PSA >0.1 but without reinitiation of ADT (median PSA 0.37). Of the 15 (24%) men without reinitiation of ADT, and 14 have recovered testosterone to normal range. Median TTP for the complete cohort was 35.0 months (95% confidence interval [CI] 31.7-39.2). Baseline PSA <3.0 ng/dL, no prior ADT, and prostatectomy (vs radiation) were associated with longer TTP (P = .0001, P = .0055, and P = .0398, respectively). At the time of analysis, 42 men (68%) had restarted ADT, 23 men had CRPC (37%), and 11 (18%) had chemotherapy. Median time to reinitiation of ADT was 32.6 months (range 0-107.6 months). Median OS has not been reached; there were 15 deaths.\n**CONCLUSION:** Chemotherapy plus ADT for BR resulted in durable (>5 years) complete responses (<0.1 ng/mL) in 7 men (11%). Twenty-four percent of men have not re-initiated ADT 5 years from completion of protocol therapy." ] ; fhir:copyright [ fhir:v "Copyright © 2013 Elsevier Inc. All rights reserved." ] ] ) ; fhir:relatesTo ( [ fhir:type [ fhir:v "comment-in" ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D016420 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D016420" ] ; fhir:display [ fhir:v "Comment" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:citation [ fhir:v "J Urol. 2013 Sep;190(3):880. doi: 10.1016/j.juro.2013.05.105." ] ; fhir:target [ a fhir:Reference ; fhir:l ; fhir:reference [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/23931194/" ] ; fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "23931194" ] ; fhir:assigner [ fhir:display [ fhir:v "NLM" ] ] ] ] ] ) ; fhir:publicationForm ( [ fhir:publishedIn [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/published-in-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D020492" ] ; fhir:display [ fhir:v "Periodical" ] ] ) ] ; fhir:identifier ( [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Electronic" ] ; fhir:display [ fhir:v "Electronic" ] ] ) ; fhir:text [ fhir:v "Electronic ISSN Type" ] ] ; fhir:system [ fhir:v "https://portal.issn.org"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "1527-9995" ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "XX" ] ; fhir:display [ fhir:v "Organization identifier" ] ] ) ; fhir:text [ fhir:v "ISOAbbreviation" ] ] ; fhir:system [ fhir:v "https://www.issn.org/services/online-services/access-to-the-ltwa/"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "Urology" ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "XX" ] ; fhir:display [ fhir:v "Organization identifier" ] ] ) ; fhir:text [ fhir:v "ISSN Linking" ] ] ; fhir:system [ fhir:v "https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "0090-4295" ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "XX" ] ; fhir:display [ fhir:v "Organization identifier" ] ] ) ; fhir:text [ fhir:v "Medline Title Abbreviation" ] ] ; fhir:system [ fhir:v "https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "Urology" ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "XX" ] ; fhir:display [ fhir:v "Organization identifier" ] ] ) ; fhir:text [ fhir:v "NLM Unique ID" ] ] ; fhir:system [ fhir:v "https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "0366151" ] ] ) ; fhir:title [ fhir:v "Urology" ] ; fhir:publisherLocation [ fhir:v "United States" ] ] ; fhir:citedMedium [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-medium"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "internet" ] ; fhir:display [ fhir:v "Internet" ] ] ) ] ; fhir:volume [ fhir:v "81" ] ; fhir:issue [ fhir:v "3" ] ; fhir:articleDate [ fhir:v "2013-03"^^xsd:gYearMonth ] ; fhir:pageString [ fhir:v "611-6" ] ] ) ; fhir:webLocation ( [ fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/artifact-url-classifier"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "abstract" ] ; fhir:display [ fhir:v "Abstract" ] ] ) ] ) ; fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/23452809/"^^xsd:anyURI ; fhir:l ] ] [ fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/artifact-url-classifier"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "doi-based" ] ; fhir:display [ fhir:v "DOI Based" ] ] ) ] ) ; fhir:url [ fhir:v "https://doi.org/10.1016/j.urology.2012.12.025"^^xsd:anyURI ; fhir:l ] ] ) ; fhir:classification ( [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "publishing-model" ] ; fhir:display [ fhir:v "Publishing Model" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "Print" ] ; fhir:display [ fhir:v "Print" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "chemical" ] ; fhir:display [ fhir:v "Chemical" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D000726 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D000726" ] ; fhir:display [ fhir:v "Androgen Antagonists" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D000813 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D000813" ] ; fhir:display [ fhir:v "Anilides" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D000970 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D000970" ] ; fhir:display [ fhir:v "Antineoplastic Agents" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D018931 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D018931" ] ; fhir:display [ fhir:v "Antineoplastic Agents, Hormonal" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D009570 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D009570" ] ; fhir:display [ fhir:v "Nitriles" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D043823 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D043823" ] ; fhir:display [ fhir:v "Taxoids" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D014105 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D014105" ] ; fhir:display [ fhir:v "Tosyl Compounds" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "0F65R8P09N" ] ; fhir:userSelected [ fhir:v false ] ] [ a mesh:D017273 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D017273" ] ; fhir:display [ fhir:v "Goserelin" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "15H5577CQD" ] ; fhir:userSelected [ fhir:v false ] ] [ a mesh:D000077143 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D000077143" ] ; fhir:display [ fhir:v "Docetaxel" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "35LT29625A" ] ; fhir:userSelected [ fhir:v false ] ] [ a mesh:D004961 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D004961" ] ; fhir:display [ fhir:v "Estramustine" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "A0Z3NAU9DP" ] ; fhir:userSelected [ fhir:v false ] ] [ a mesh:C053541 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "C053541" ] ; fhir:display [ fhir:v "bicalutamide" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ] ; fhir:artifactAssessment ( [ fhir:l <#meshHeading0> ; fhir:reference [ fhir:v "#meshHeading0" ] ; fhir:type [ fhir:v "ArtifactAssessment"^^xsd:anyURI ; fhir:l fhir:ArtifactAssessment ] ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "publication-type" ] ; fhir:display [ fhir:v "Publication type" ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ a mesh:D017427 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D017427" ] ; fhir:display [ fhir:v "Clinical Trial, Phase II" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D016428 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ fhir:coding ( [ a mesh:D013485 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D013485" ] ; fhir:display [ fhir:v "Research Support, Non-U.S. Gov't" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "knowledge-artifact-type" ] ; fhir:display [ fhir:v "Knowledge Artifact Type" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:artifactAssessment ( [ fhir:display [ fhir:v "Classifier added by Computable Publishing LLC" ] ] ) ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "citation-subset" ] ; fhir:display [ fhir:v "Citation subset" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; fhir:classifier ( [ fhir:coding ( [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "IM" ] ; fhir:display [ fhir:v "IM" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; fhir:contributorship [ fhir:complete [ fhir:v true ] ; fhir:entry ( [ fhir:contributor [ fhir:l <#contributor0> ; fhir:reference [ fhir:v "#contributor0" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Nakabayashi M" ] ] ; fhir:forenameInitials [ fhir:v "M" ] ; fhir:affiliation ( [ fhir:display [ fhir:v "Division of Medical Oncology, Department of Medicine, Lank Center for Genitourinary Oncology, Boston, MA 02215, USA." ] ] ) ] [ fhir:contributor [ fhir:l <#contributor1> ; fhir:reference [ fhir:v "#contributor1" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Xie W" ] ] ; fhir:forenameInitials [ fhir:v "W" ] ] [ fhir:contributor [ fhir:l <#contributor2> ; fhir:reference [ fhir:v "#contributor2" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Buckle G" ] ] ; fhir:forenameInitials [ fhir:v "G" ] ] [ fhir:contributor [ fhir:l <#contributor3> ; fhir:reference [ fhir:v "#contributor3" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Bubley G" ] ] ; fhir:forenameInitials [ fhir:v "G" ] ] [ fhir:contributor [ fhir:l <#contributor4> ; fhir:reference [ fhir:v "#contributor4" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Ernstoff MS" ] ] ; fhir:forenameInitials [ fhir:v "MS" ] ] [ fhir:contributor [ fhir:l <#contributor5> ; fhir:reference [ fhir:v "#contributor5" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Walsh W" ] ] ; fhir:forenameInitials [ fhir:v "W" ] ] [ fhir:contributor [ fhir:l <#contributor6> ; fhir:reference [ fhir:v "#contributor6" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Morganstern DE" ] ] ; fhir:forenameInitials [ fhir:v "DE" ] ] [ fhir:contributor [ fhir:l <#contributor7> ; fhir:reference [ fhir:v "#contributor7" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Kantoff PW" ] ] ; fhir:forenameInitials [ fhir:v "PW" ] ] [ fhir:contributor [ fhir:l <#contributor8> ; fhir:reference [ fhir:v "#contributor8" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ; fhir:l fhir:Practitioner ] ; fhir:display [ fhir:v "Taplin ME" ] ] ; fhir:forenameInitials [ fhir:v "ME" ] ] ) ] ] . # # -------------------------------------------------------------------------------------