{
  "resourceType" : "Evidence",
  "id" : "375907",
  "meta" : {
    "versionId" : "11",
    "lastUpdated" : "2025-08-15T10:17:51.868Z",
    "profile" : ["http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence"]
  },
  "language" : "en",
  "text" : {
    "status" : "empty",
    "div" : "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><p>[No data.]</p></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status",
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type",
        "code" : "active",
        "display" : "Active"
      }]
    }
  }],
  "url" : "https://fevir.net/resources/Evidence/375907",
  "identifier" : [{
    "type" : {
      "coding" : [{
        "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
        "code" : "ACSN",
        "display" : "Accession ID"
      }],
      "text" : "FEvIR Object Identifier"
    },
    "system" : "https://fevir.net/FOI",
    "value" : "375907",
    "assigner" : {
      "display" : "Computable Publishing LLC"
    }
  }],
  "name" : "Evidence_for_Results_for_Systolic_blood_pressure_at_12_weeks_in_GroupAssignment_Quadpill_vs_Candesartan",
  "title" : "Evidence for Results for Systolic blood pressure at 12 weeks in GroupAssignment: Quadpill vs. Candesartan",
  "citeAs" : "Evidence for Results for Systolic blood pressure at 12 weeks in GroupAssignment: Quadpill vs. Candesartan [Database Entry: FHIR Evidence Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375907. Revised 2025-08-15. Available at: https://fevir.net/resources/Evidence/375907. Computable resource at: https://fevir.net/resources/Evidence/375907#json.",
  "status" : "active",
  "author" : [{
    "name" : "Joanne Dehnbostel"
  }],
  "publisher" : "Computable Publishing LLC",
  "contact" : [{
    "telecom" : [{
      "system" : "email",
      "value" : "support@computablepublishing.com"
    }]
  }],
  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "relatesTo" : [{
    "type" : "part-of",
    "targetReference" : {
      "reference" : "Composition/375280",
      "type" : "Composition",
      "display" : "Outcome Measure Report for QUARTET USA Trial"
    }
  }],
  "description" : "This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.",
  "variableDefinition" : [{
    "variableRole" : "exposure",
    "comparatorCategory" : "Candesartan 8 mg once daily",
    "observed" : {
      "reference" : "EvidenceVariable/375183",
      "type" : "EvidenceVariable",
      "display" : "GroupAssignment: Quadpill vs. Candesartan"
    }
  },
  {
    "variableRole" : "outcome",
    "observed" : {
      "reference" : "EvidenceVariable/375185",
      "type" : "EvidenceVariable",
      "display" : "Systolic blood pressure at 12 weeks"
    }
  },
  {
    "variableRole" : "population",
    "observed" : {
      "reference" : "Group/372797",
      "type" : "Group",
      "display" : "Enrolled Group for QUARTET USA Trial (372797)"
    }
  }],
  "statistic" : [{
    "statisticType" : {
      "coding" : [{
        "system" : "https://fevir.net/sevco",
        "code" : "STATO:0000457",
        "display" : "difference in means"
      }]
    },
    "quantity" : {
      "value" : -4.5,
      "unit" : "mm Hg"
    },
    "sampleSize" : {
      "extension" : [{
        "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/number-analyzed",
        "valueUnsignedInt" : 60
      }],
      "numberOfParticipants" : 62,
      "knownDataCount" : 53
    },
    "attributeEstimate" : [{
      "type" : {
        "coding" : [{
          "system" : "https://fevir.net/sevco",
          "code" : "STATO:0000196",
          "display" : "confidence interval"
        }]
      },
      "level" : 0.95,
      "range" : {
        "low" : {
          "value" : -10.82,
          "unit" : "mm Hg"
        },
        "high" : {
          "value" : 1.32,
          "unit" : "mm Hg"
        }
      }
    },
    {
      "type" : {
        "coding" : [{
          "system" : "https://fevir.net/sevco",
          "code" : "STATO:0000700",
          "display" : "p-value"
        }]
      },
      "quantity" : {
        "value" : 0.123
      }
    }]
  }]
}