@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/ebm/Evidence/179635> a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "179635"] ; # 
  fhir:meta [
     fhir:versionId [ fhir:v "7" ] ;
     fhir:lastUpdated [ fhir:v "2024-12-13T21:07:33.593Z"^^xsd:dateTime ] ;
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-participant-flow-evidence"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-participant-flow-evidence>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "empty" ] ;
     fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><p>[No data.]</p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status>
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-status-type>
         ] ;
         fhir:code [ fhir:v "active" ] ;
         fhir:display [ fhir:v "Active" ]
       ] )
     ]
  ] ) ; # 
  fhir:url [
     fhir:v "https://fevir.net/resources/Evidence/179635"^^xsd:anyURI ;
     fhir:l <https://fevir.net/resources/Evidence/179635>
  ] ; # 
  fhir:identifier ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>
         ] ;
         fhir:code [ fhir:v "ACSN" ] ;
         fhir:display [ fhir:v "Accession ID" ]
       ] ) ;
       fhir:text [ fhir:v "FEvIR Object Identifier" ]
     ] ;
     fhir:system [
       fhir:v "https://fevir.net/FOI"^^xsd:anyURI ;
       fhir:l <https://fevir.net/FOI>
     ] ;
     fhir:value [ fhir:v "179635" ] ;
     fhir:assigner [
       fhir:display [ fhir:v "Computable Publishing LLC" ]
     ]
  ] ) ; # 
  fhir:name [ fhir:v "ComparativeParticipantFlowEvidence_Dropout_due_to_stopping_intervention_Lofexidine_vs_Placebo_in_opioid_detoxification_trial"] ; # 
  fhir:title [ fhir:v "ComparativeParticipantFlowEvidence: Dropout due to stopping intervention Lofexidine vs. Placebo in opioid detoxification trial"] ; # 
  fhir:citeAs [ fhir:v "ComparativeParticipantFlowEvidence: Dropout due to stopping intervention Lofexidine vs. Placebo in opioid detoxification trial [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179635. Revised 2024-05-16. Available at: https://fevir.net/resources/Evidence/179635. Computable resource at: https://fevir.net/resources/Evidence/179635#json."] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:author ( [
     fhir:name [ fhir:v "Brian S. Alper" ]
  ] ) ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "email" ] ;
       fhir:value [ fhir:v "support@computablepublishing.com" ]
     ] )
  ] ) ; # 
  fhir:useContext ( [
     fhir:code [
       fhir:system [
         fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ;
         fhir:l <https://fevir.net/resources/CodeSystem/179423>
       ] ;
       fhir:code [ fhir:v "evidence-communication" ] ;
       fhir:display [ fhir:v "Evidence Communication" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ;
           fhir:l <https://fevir.net/resources/CodeSystem/179423>
         ] ;
         fhir:code [ fhir:v "ComparativeParticipantFlowEvidence" ] ;
         fhir:display [ fhir:v "ComparativeParticipantFlowEvidence" ]
       ] )
     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:relatesTo ( [
     fhir:type [ fhir:v "derived-from" ] ;
     fhir:target [
       a fhir:Reference ;
       fhir:l <http://hl7.org/fhir/uv/ebm/Citation/179637> ;
       fhir:reference [ fhir:v "Citation/179637" ] ;
       fhir:type [
         fhir:v "Citation"^^xsd:anyURI ;
         fhir:l fhir:Citation
       ] ;
       fhir:display [ fhir:v "18508207 A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal" ]
     ]
  ] ) ; # 
  fhir:description [ fhir:v "Dropout due to stopping intervention 18/33 with Lofexidine vs. 12/35 with Placebo in opioid detoxification trial"] ; # 
  fhir:variableDefinition ( [
     fhir:description [ fhir:v "Participants in the opioid detoxification trial" ] ;
     fhir:variableRole [ fhir:v "population" ]
  ] [
     fhir:description [ fhir:v "GroupAssignment: Lofexidine vs. Placebo" ] ;
     fhir:variableRole [ fhir:v "exposure" ] ;
     fhir:comparatorCategory [ fhir:v "false" ]
  ] [
     fhir:description [ fhir:v "Dropout due to stopping intervention" ] ;
     fhir:variableRole [ fhir:v "outcome" ] ;
     fhir:observed [
       fhir:l <http://hl7.org/fhir/uv/ebm/EvidenceVariable/179636> ;
       fhir:reference [ fhir:v "EvidenceVariable/179636" ] ;
       fhir:type [
         fhir:v "EvidenceVariable"^^xsd:anyURI ;
         fhir:l fhir:EvidenceVariable
       ] ;
       fhir:display [ fhir:v "PartiicipantFlowMeasure: Dropout due to stopping intervention" ]
     ]
  ] ) ; # 
  fhir:statistic ( [
     fhir:description [ fhir:v "18/33 (54.5%) with Lofexidine vs. 12/35 (34.3%) with Placebo (relative risk 1.59, p < 0.01)" ] ;
     fhir:statisticType [
       fhir:coding ( [
         fhir:system [
           fhir:v "https://fevir.net/sevco"^^xsd:anyURI ;
           fhir:l <https://fevir.net/sevco>
         ] ;
         fhir:code [ fhir:v "STATO:0000245" ] ;
         fhir:display [ fhir:v "Risk Ratio" ]
       ] )
     ] ;
     fhir:quantity [
       fhir:value [ fhir:v 1.59 ]
     ] ;
     fhir:numberAffected [ fhir:v "30"^^xsd:nonNegativeInteger ] ;
     fhir:sampleSize [
       fhir:numberOfParticipants [ fhir:v "68"^^xsd:nonNegativeInteger ]
     ] ;
     fhir:attributeEstimate ( [
       fhir:description [ fhir:v "p < 0.01" ] ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "https://fevir.net/sevco"^^xsd:anyURI ;
             fhir:l <https://fevir.net/sevco>
           ] ;
           fhir:code [ fhir:v "STATO:0000700" ] ;
           fhir:display [ fhir:v "p-value" ]
         ] )
       ] ;
       fhir:quantity [
         fhir:value [ fhir:v 0.01 ] ;
         fhir:comparator [ fhir:v "<" ]
       ]
     ] )
  ] ) . # 

<http://hl7.org/fhir/uv/ebm/Citation/179637> a fhir:Uv .

<http://hl7.org/fhir/uv/ebm/EvidenceVariable/179636> a fhir:Uv .

# -------------------------------------------------------------------------------------