@prefix fhir: . @prefix owl: . @prefix rdf: . @prefix rdfs: . @prefix xsd: . # - resource ------------------------------------------------------------------- a fhir:Composition ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "370504"] ; # fhir:meta [ fhir:versionId [ fhir:v "24" ] ; fhir:lastUpdated [ fhir:v "2025-08-18T13:22:42.074Z"^^xsd:dateTime ] ; fhir:profile ( [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/outcome-measure-report"^^xsd:anyURI ; fhir:l ] ) ] ; # fhir:language [ fhir:v "en"] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div [ fhir:v "

Generated Narrative: Composition 370504

version: 24; Last updated: 2025-08-18 13:22:42+0000; Language: en

Profile: OutcomeMeasureReport

ArtifactPublicationStatus: Active

url: https://fevir.net/resources/Composition/370504

identifier: FEvIR Object Identifier/370504, FEvIR Linking Identifier/NCT03640312-outcome-measure-report

status: Final

type: Outcome Measure Report

date: 2025-08-18 13:22:42+0000

author: [No author listed.]

title: Outcome Measures Report for NCT03640312

custodian: Computable Publishing LLC

RelatesTos

-TypeTarget[x]
*Cite As

Outcome Measures Report for NCT03640312 [Database Entry: FHIR Composition Resource]. Contributors: [No author listed.] [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 370504. Revised 2025-08-18. Available at: https://fevir.net/resources/Composition/370504. Computable resource at: https://fevir.net/resources/Composition/370504.

\n
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
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12 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Change in Mean Systolic Blood Pressure at 12 weeks (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367882" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-primaryOutcome-0" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Change in Mean Systolic Blood Pressure at 12 weeks (NCT03640312)" ] ] ; fhir:entry ( [ fhir:l ; fhir:reference [ fhir:v "Evidence/367903" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-primaryOutcomeMeasure-0--OG000" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Change in Mean Systolic Blood Pressure at 12 weeks for QUARTET LDQT in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367904" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-primaryOutcomeMeasure-0--OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Change in Mean Systolic Blood Pressure at 12 weeks for Candesartan in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367941" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-primaryOutcomeMeasure-0-OutcomeAnalysis-0-BetweenGroupAnalysis-OG000-OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Change in Mean Systolic Blood Pressure at 12 weeks Statistical Analysis for QUARTET LDQT vs Candesartan in NCT03640312" ] ] ) ] ) ] ) ] [ fhir:title [ fhir:v "Mean Systolic Blood Pressure at 6 weeks" ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367883" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-0" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks (NCT03640312)" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Outcome Measure Population Description" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasurePopulationDescription" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
6 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Mean Systolic Blood Pressure at 6 weeks (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367883" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-0" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks (NCT03640312)" ] ] ; fhir:entry ( [ fhir:l ; fhir:reference [ fhir:v "Evidence/367905" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-0--OG000" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367906" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-0--OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks for Candesartan in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367942" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-0-OutcomeAnalysis-1-BetweenGroupAnalysis-OG000-OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks Statistical Analysis for QUARTET LDQT vs Candesartan in NCT03640312" ] ] ) ] ) ] ) ] [ fhir:title [ fhir:v "Change in Mean Diastolic Blood Pressure at 6 weeks" ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367884" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-1" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Change in Mean Diastolic Blood Pressure at 6 weeks (NCT03640312)" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Outcome Measure Population Description" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasurePopulationDescription" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
6 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
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Posted
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6 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
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Posted
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6 and 12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Proportion of Patients With Hypertension Control at 6 and 12 weeks - 6 weeks at (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/370506" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-3-6-weeks-" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Proportion of Patients With Hypertension Control at 6 and 12 weeks - 6 weeks at (NCT03640312)" ] ] ; 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fhir:display [ fhir:v "Proportion of Patients With Hypertension Control at 6 and 12 weeks - 6 weeks for Candesartan in NCT03640312" ] ] ) ] [ fhir:title [ fhir:v "Proportion of Patients With Hypertension Control at 6 and 12 weeks - 12 weeks at (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/370507" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-3-12-weeks-" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Proportion of Patients With Hypertension Control at 6 and 12 weeks - 12 weeks at (NCT03640312)" ] ] ; 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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
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Posted
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6 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
12 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Medication Adherence at 12 weeks (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367889" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-6" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Medication Adherence at 12 weeks (NCT03640312)" ] ] ; fhir:entry ( [ fhir:l ; fhir:reference [ fhir:v "Evidence/367919" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-6--OG000" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Medication Adherence at 12 weeks for QUARTET LDQT in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367920" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-6--OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Medication Adherence at 12 weeks for Candesartan in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367948" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcomeMeasure-6-OutcomeAnalysis-7-BetweenGroupAnalysis-OG000-OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Medication Adherence at 12 weeks Statistical Analysis for QUARTET LDQT vs Candesartan in NCT03640312" ] ] ) ] ) ] ) ] [ fhir:title [ fhir:v "Health-related Quality of Life at 12 weeks" ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367890" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-7" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Health-related Quality of Life at 12 weeks (NCT03640312)" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Outcome Measure Population Description" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasurePopulationDescription" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Data are available on only 28 participants in the intervention group for the mental health T score.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
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12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Health-related Quality of Life at 12 weeks - Change in Physical Health T score (PROMIS) at (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/370508" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-secondaryOutcome-7-Change-in-Physical-Health-T-score--OPEN---PROMIS---CLOSE--" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Health-related Quality of Life at 12 weeks - Change in Physical Health T score (PROMIS) at (NCT03640312)" ] ] ; 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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
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6 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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All randomized participants
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Posted
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12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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All randomized participants
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Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
12 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
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Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Posted
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12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
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Posted
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12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
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Posted
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12 weeks
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Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
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Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
12 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Mean Change in Blood Urea Nitrogen at 12 weeks (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367901" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcome-5" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Blood Urea Nitrogen at 12 weeks (NCT03640312)" ] ] ; fhir:entry ( [ fhir:l ; fhir:reference [ fhir:v "Evidence/367937" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-5--OG000" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Blood Urea Nitrogen at 12 weeks for QUARTET LDQT in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367938" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-5--OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Blood Urea Nitrogen at 12 weeks for Candesartan in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367957" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-5-OutcomeAnalysis-16-BetweenGroupAnalysis-OG000-OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Blood Urea Nitrogen at 12 weeks Statistical Analysis for QUARTET LDQT vs Candesartan in NCT03640312" ] ] ) ] ) ] ) ] [ fhir:title [ fhir:v "Mean Change in Serum Creatinine at 12 weeks" ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367902" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcome-6" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Serum Creatinine at 12 weeks (NCT03640312)" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Outcome Measure Population Description" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasurePopulationDescription" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Reporting Status" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureReportingStatus" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Posted
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Measure Time Frame" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeMeasureTimeFrame" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
12 weeks
"^^rdf:XMLLiteral ] ] ] [ fhir:title [ fhir:v "Outcome Group List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeGroupList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "QUARTET LDQT" ] ; fhir:code [ fhir:text [ fhir:v "OG000" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ] ] ) ] [ fhir:title [ fhir:v "Candesartan" ] ; fhir:code [ fhir:text [ fhir:v "OG001" ] ] ; fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div [ fhir:v "
Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks.
"^^rdf:XMLLiteral ] ] ; fhir:entry ( [ fhir:display [ fhir:v "Patients randomized to the comparison arm took a once daily 8mg candesartan.\n\nCandesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks." ] ] ) ] ) ] [ fhir:title [ fhir:v "Outcome Class List" ] ; fhir:code [ fhir:text [ fhir:v "OutcomeClassList" ] ] ; fhir:section ( [ fhir:title [ fhir:v "Mean Change in Serum Creatinine at 12 weeks (NCT03640312)" ] ; fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ; fhir:l ] ; fhir:code [ fhir:v "results" ] ; fhir:display [ fhir:v "Results" ] ] ) ] ; fhir:focus [ fhir:l ; fhir:reference [ fhir:v "EvidenceVariable/367902" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ; fhir:l fhir:EvidenceVariable ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcome-6" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Serum Creatinine at 12 weeks (NCT03640312)" ] ] ; fhir:entry ( [ fhir:l ; fhir:reference [ fhir:v "Evidence/367939" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-6--OG000" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Serum Creatinine at 12 weeks for QUARTET LDQT in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367940" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-6--OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Serum Creatinine at 12 weeks for Candesartan in NCT03640312" ] ] [ fhir:l ; fhir:reference [ fhir:v "Evidence/367958" ] ; fhir:type [ fhir:v "Evidence"^^xsd:anyURI ; fhir:l fhir:Evidence ] ; fhir:identifier [ fhir:type [ fhir:text [ fhir:v "FEvIR Linking Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ; fhir:l ] ; fhir:value [ fhir:v "NCT03640312-otherOutcomeMeasure-6-OutcomeAnalysis-17-BetweenGroupAnalysis-OG000-OG001" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] ; fhir:display [ fhir:v "Mean Change in Serum Creatinine at 12 weeks Statistical Analysis for QUARTET LDQT vs Candesartan in NCT03640312" ] ] ) ] ) ] ) ] ) . # a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . a fhir:Uv . # -------------------------------------------------------------------------------------