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    v: Generated Narrative: Citation 7638 version: 39; Last updated: 2025-10-13 16:59:33+0000; Language: en ArtifactPublicationStatus: Active url: https://fevir.net/resources/Citation/7638 identifier: FEvIR Object Identifier/7638 title: Citation for FEvIR Evidence 7637: Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19 status: Active date: 2022-01-10 13:30:43+0000 author: Brian S. Alper: publisher: Computable Publishing LLC contact: support@computablepublishing.com description: A Evidence Resource to demonstrate complex evidence reporting UseContexts - Code Value[x] * UsageContextType: program (Program) EBMonFHIR/COKA Demonstration * Citation Classification Type: fevir-platform-use (FEvIR Platform Use) Evidence copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/ Summaries - Style Text * Computable Publishing Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-19 [FHIR Resource]. Contributors: Brian S Alper, Harold Lehmann, Ahmad Sofi-Mahmudi, Joanne Dehnbostel, Ilkka Kunnamo [Authors]; Janice Tufte, Vignesh Subbian, Bhagvan Kommadi, Alfonso Iorio, Muhammad Afzal, Kenneth J Wilkins, Surbhi Shah, Amy Price [Reviewers]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 7637. Published August 05, 2021. Created August 05, 2021. Revised August 25, 2021. Available at: https://fevir.net/resources/Evidence/7637. Computable resource at: https://fevir.net/resources/Evidence/7637. Classifications - Type Classifier * FEvIR Platform Use Project Specific citedArtifact identifier: FEvIR Object Identifier/7637 relatedIdentifier: https://doi.org/10.1056/NEJMoa2105911 StatusDates - Activity Actual Period * Created true 2021-08-05 --> (ongoing) title type: Primary title, Human use text: Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-1…
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    v: Patients who were hospitalized for COVID-19 and who were not critically ill were randomized in a response-adaptive manner to therapeutic-dose anticoagulation with heparin vs. usual-care pharmacologic thromboprophylaxis. The outcome reported here is the effect on organ support-free days (i.e. days without oxygen delivered by high-flow nasal cannula, noninvasive or invasive mechanical ventilation, or the use of vasopressors or inotropes). The statistical result was a median adjusted odds ratio 1.27 (95% credible interval 1.03 to 1.58), based on 1,740 events among 2,219 participants with known outcome out of 2,244 enrolled participants. The probability of superiority of therapeutic-dose anticoagulation with heparin was 98.6%. The risk of bias in this effect estimate is of extremely serious concern based on a serious concern for confounding covariate bias (confounding difference in calendar time), a very serious concern for performance bias (inadequate blinding of intervention deliverers who may determine the outcome based in part on exposure status), and very serious concern for analysis bias (bias related to selection of the analysis, and early trial termination).
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      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: validation
    display:
      v: Validation
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer

contributor:
  l: contributor8
  reference:
    v: #contributor8
  type:
    v: Practitioner
    l: Practitioner
affiliation:
  display:
    v: McMaster University
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: formal-analysis
    display:
      v: Formal analysis
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: writing-review-editing
    display:
      v: Writing - review & editing
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer

contributor:
  l: contributor9
  reference:
    v: #contributor9
  type:
    v: Practitioner
    l: Practitioner
affiliation:
  display:
    v: Sejong University, Seoul, South Korea
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: formal-analysis
    display:
      v: Formal analysis
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: writing-review-editing
    display:
      v: Writing - review & editing
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer

contributor:
  l: contributor10
  reference:
    v: #contributor10
  type:
    v: Practitioner
    l: Practitioner
affiliation:
  display:
    v: National Institute of Diabetes & Digestive & Kidney Diseases
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: formal-analysis
    display:
      v: Formal analysis
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: writing-review-editing
    display:
      v: Writing - review & editing
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer

contributor:
  l: contributor11
  reference:
    v: #contributor11
  type:
    v: Practitioner
    l: Practitioner
affiliation:
  display:
    v: Mayo Clinic Arizona
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: writing-review-editing
    display:
      v: Writing - review & editing
contribution type:
  text:
    v: defined-in-text
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer

contributor:
  l: contributor12
  reference:
    v: #contributor12
  type:
    v: Practitioner
    l: Practitioner
contribution type:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/cited-artifact-contribution-type
      l: cited-artifact-contribution-type
    code:
      v: writing-review-editing
    display:
      v: Writing - review & editing
role:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/contributor-role
      l: contributor-role
    code:
      v: reviewer
    display:
      v: Reviewer