26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer. - TTL Representation - Evidence Based Medicine on FHIR Implementation Guide v1.0.0-ballot3

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
: 26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.

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fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en\" lang=\"en\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179630</b></p><a name=\"179630\"> </a><a name=\"hc179630\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 19; Last updated: 2025-10-13 12:34:35+0000; Language: en</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Citation/179630\">https://fevir.net/resources/Citation/179630</a></p><p><b>identifier</b>: FEvIR Object Identifier/179630, <code>https://pubmed.ncbi.nlm.nih.gov</code>/26092557</p><p><b>title</b>: 26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.</p><p><b>status</b>: Active</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://terminology.hl7.org/7.1.0/CodeSystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type: fevir-platform-use</a> (FEvIR Platform Use)</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2016-04-14</p><p><b>lastReviewDate</b>: 2024-02-10</p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --&gt; 2015-02-20</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-revised}\">PubMed Pubstatus of Revised</span></p><p><b>period</b>: ?? --&gt; 2015-05-08</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --&gt; 2015-05-11</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --&gt; 2015-06-21 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --&gt; 2015-06-21 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --&gt; 2016-04-15 06:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26092557, <code>https://doi.org</code>/10.1016/j.urolonc.2015.05.012, pii/S1078-1439(15)00235-5</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/title-type primary}\">Primary title</span></td><td><div><p>Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type primary-human-use}\">Primary human use</span></td><td><div><p><strong>BACKGROUND AND OBJECTIVE:</strong> Sequential tissue biopsies taken during clinical trials of novel systemic anticancer therapies for advanced prostate cancer (PCa) may aid pharmacodynamic evaluation and biomarker discovery. We conducted a single institution phase-II open-labeled randomized study to assess the safety, tolerability, and early efficacy of docetaxel chemotherapy plus androgen deprivation therapy (ADT) vs. ADT alone for patients with advanced non-castration-resistant PCa with sequential prostatic biopsies.\n<strong>PATIENTS AND METHODS:</strong> We randomized 30 patients with newly diagnosed high-grade locally advanced or metastatic (cT3-4/N0-1/M0-1) PCa to receive ADT with (n = 15) or without (n = 15) docetaxel. Transrectal ultrasound-guided prostatic biopsies were taken at randomization and ~22 weeks after treatment initiation. Primary end point: biochemical response rate. Secondary end points: time to progression and tumor profiling.\n<strong>RESULTS:</strong> Both treatments appear to be well tolerated, and there was no difference in mean nadir prostate-specific antigen and time to prostate-specific antigen relapse between treatment arms (P&gt;0.05). No adverse effects of pre- and post-treatment prostatic biopsies were observed. The study was neither designed nor sufficiently powered to demonstrate statistically significant differences in oncological outcomes or safety profiles between the 2 treatment arms.\n<strong>CONCLUSIONS:</strong> Despite the lack of statistical power, our study suggests that docetaxel and ADT in combination may be well tolerated with apparently similar short-term efficacy compared with ADT alone for high-grade locally advanced or metastatic non-castration-resistant PCa, Sequential prostatic biopsies may provide tissue for tumor profiling to yield mechanistic or prognostic insights relating to novel systemic anticancer therapies.</p>\n</div></td><td><div><p>Copyright © 2015 Elsevier Inc. All rights reserved.</p>\n</div></td></tr></table><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1873-2496, ISOAbbreviation/Urol Oncol, ISSN Linking/1078-1439, Medline Title Abbreviation/Urol Oncol, NLM Unique ID/9805460</p><p><b>title</b>: Urologic oncology</p><p><b>publisherLocation</b>: United States</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 33</p><p><b>issue</b>: 8</p><p><b>articleDate</b>: 2015-08</p><p><b>pageString</b>: 337.e1-6</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2015-06-16</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26092557/\">https://pubmed.ncbi.nlm.nih.gov/26092557/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/j.urolonc.2015.05.012\">https://doi.org/10.1016/j.urolonc.2015.05.012</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type keyword}\">Keyword</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179630/keywords0\">Keywords provided by NOTNLM</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 15H5577CQD}, {https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179630/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017427}\">Clinical Trial, Phase II</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016428}\">Journal Article</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor0\">Rajan P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Institute of Cancer Sciences, University of Glasgow, UK. Electronic address: p.rajan@beatson.gla.ac.uk.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor1\">Frew JA</a></p><p><b>forenameInitials</b>: JA</p><p><b>affiliation</b>: Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor2\">Wilson JM</a></p><p><b>forenameInitials</b>: JM</p><p><b>affiliation</b>: Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor3\">Azzabi AS</a></p><p><b>forenameInitials</b>: AS</p><p><b>affiliation</b>: Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor4\">McMenemin RM</a></p><p><b>forenameInitials</b>: RM</p><p><b>affiliation</b>: Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor5\">Stockley J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: Institute of Cancer Sciences, University of Glasgow, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor6\">Soomro NA</a></p><p><b>forenameInitials</b>: NA</p><p><b>affiliation</b>: Newcastle Urology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor7\">Durkan G</a></p><p><b>forenameInitials</b>: G</p><p><b>affiliation</b>: Newcastle Urology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor8\">Pedley ID</a></p><p><b>forenameInitials</b>: ID</p><p><b>affiliation</b>: Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179630/contributor9\">Leung HY</a></p><p><b>forenameInitials</b>: HY</p><p><b>affiliation</b>: Institute of Cancer Sciences, University of Glasgow, UK; Cancer Research UK Beatson Institute, Bearsden, UK. Electronic address: h.leung@beatson.gla.ac.uk.</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #keywords0</b></p><a name=\"179630/keywords0\"> </a><a name=\"hc179630/keywords0\"> </a><p><b>artifact</b>: <a href=\"#hc179630\">Citation 26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.</a></p><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Androgen deprivation therapy</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Docetaxel</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Prostate cancer</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Prostatic biopsy</span></p></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179630/contributor0\"> </a><a name=\"hc179630/contributor0\"> </a><p><b>name</b>: Prabhakar Rajan </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179630/contributor1\"> </a><a name=\"hc179630/contributor1\"> </a><p><b>name</b>: John A Frew </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179630/contributor2\"> </a><a name=\"hc179630/contributor2\"> </a><p><b>name</b>: James M Wilson </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179630/contributor3\"> </a><a name=\"hc179630/contributor3\"> </a><p><b>name</b>: Ashraf S T Azzabi </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179630/contributor4\"> </a><a name=\"hc179630/contributor4\"> </a><p><b>name</b>: Rhona M McMenemin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"179630/contributor5\"> </a><a name=\"hc179630/contributor5\"> </a><p><b>name</b>: Jacqueline Stockley </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"179630/contributor6\"> </a><a name=\"hc179630/contributor6\"> </a><p><b>name</b>: Naeem A Soomro </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"179630/contributor7\"> </a><a name=\"hc179630/contributor7\"> </a><p><b>name</b>: Garrett Durkan </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"179630/contributor8\"> </a><a name=\"hc179630/contributor8\"> </a><p><b>name</b>: Ian D Pedley </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"179630/contributor9\"> </a><a name=\"hc179630/contributor9\"> </a><p><b>name</b>: Hing Y Leung </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179630/meshHeading0\"> </a><a name=\"hc179630/meshHeading0\"> </a><p><b>artifact</b>: <a href=\"#hc179630\">Citation 26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000008}\">administration &amp; dosage</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D001706}\">Biopsy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005240}\">Feasibility Studies</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000601}\">surgery</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000008}\">administration &amp; dosage</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
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a fhir:ArtifactAssessment ;
fhir:id [ fhir:v "keywords0" ] ;
fhir:artifact [
a fhir:Reference ;
fhir:l <#> ;
fhir:reference [ fhir:v "#" ] ;
fhir:type [
fhir:v "Citation"^^xsd:anyURI ;
fhir:l fhir:Citation       ]     ] ;
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fhir:text [ fhir:v "Androgen deprivation therapy" ]       ] )     ] [
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fhir:text [ fhir:v "Docetaxel" ]       ] )     ] [
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fhir:text [ fhir:v "Prostate cancer" ]       ] )     ] [
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fhir:text [ fhir:v "Prostatic biopsy" ]       ] )     ] )
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a fhir:Practitioner ;
fhir:id [ fhir:v "contributor0" ] ;
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fhir:family [ fhir:v "Rajan" ] ;
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a fhir:Practitioner ;
fhir:id [ fhir:v "contributor1" ] ;
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fhir:family [ fhir:v "Frew" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor2" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Wilson" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor3" ] ;
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fhir:family [ fhir:v "Azzabi" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor4" ] ;
    ( fhir:name [
fhir:family [ fhir:v "McMenemin" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor5" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Stockley" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor6" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Soomro" ] ;
      ( fhir:given [ fhir:v "Naeem A" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor7" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Durkan" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor8" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Pedley" ] ;
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  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor9" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Leung" ] ;
      ( fhir:given [ fhir:v "Hing Y" ] )     ] )
  ] [
a fhir:ArtifactAssessment ;
fhir:id [ fhir:v "meshHeading0" ] ;
fhir:artifact [
a fhir:Reference ;
fhir:l <#> ;
fhir:reference [ fhir:v "#" ] ;
fhir:type [
fhir:v "Citation"^^xsd:anyURI ;
fhir:l fhir:Citation       ]     ] ;
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fhir:type [
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fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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a mesh:D000368 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D000368" ] ;
fhir:display [ fhir:v "Aged" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
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fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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a mesh:D000726 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D000726" ] ;
fhir:display [ fhir:v "Androgen Antagonists" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
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fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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a mesh:Q000008 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000008" ] ;
fhir:display [ fhir:v "administration & dosage" ]           ] )         ] ) ;
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fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
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            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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a mesh:Q000627 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
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fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
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a mesh:D001706 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D001706" ] ;
fhir:display [ fhir:v "Biopsy" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
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fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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a mesh:D000077143 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D000077143" ] ;
fhir:display [ fhir:v "Docetaxel" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
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fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
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fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D005240 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D005240" ] ;
fhir:display [ fhir:v "Feasibility Studies" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D006801 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D006801" ] ;
fhir:display [ fhir:v "Humans" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D008297 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D008297" ] ;
fhir:display [ fhir:v "Male" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
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fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D008875 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D008875" ] ;
fhir:display [ fhir:v "Middle Aged" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D011471 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D011471" ] ;
fhir:display [ fhir:v "Prostatic Neoplasms" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
a mesh:Q000188 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000188" ] ;
fhir:display [ fhir:v "drug therapy" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
a mesh:Q000601 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000601" ] ;
fhir:display [ fhir:v "surgery" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type>           ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
a mesh:D043823 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>           ] ;
fhir:code [ fhir:v "D043823" ] ;
fhir:display [ fhir:v "Taxoids" ] ;
fhir:userSelected [ fhir:v false ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v true ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
a mesh:Q000008 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000008" ] ;
fhir:display [ fhir:v "administration & dosage" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
a mesh:Q000627 ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/mesh>             ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [
fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ;
fhir:l <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>               ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] )
  ] ) ; # 
  fhir:extension ( [
fhir:url [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status>     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-status-type>         ] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]       ] )     ]
  ] ) ; # 
  fhir:url [
fhir:v "https://fevir.net/resources/Citation/179630"^^xsd:anyURI ;
fhir:l <https://fevir.net/resources/Citation/179630>
  ] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>         ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [
fhir:v "https://fevir.net/FOI"^^xsd:anyURI ;
fhir:l <https://fevir.net/FOI>     ] ;
fhir:value [ fhir:v "179630" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] [
fhir:system [
fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ;
fhir:l <https://pubmed.ncbi.nlm.nih.gov>     ] ;
fhir:value [ fhir:v "26092557" ]
  ] ) ; # 
  fhir:title [ fhir:v "26092557 Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer."] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:author ( [
fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ]
  ] ) ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/citation-classification-type>       ] ;
fhir:code [ fhir:v "fevir-platform-use" ] ;
fhir:display [ fhir:v "FEvIR Platform Use" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/citation-artifact-classifier>         ] ;
fhir:code [ fhir:v "medline-base" ] ;
fhir:display [ fhir:v "Medline Base" ] ;
fhir:userSelected [ fhir:v false ]       ] )     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:approvalDate [ fhir:v "2016-04-14"^^xsd:date] ; # 
  fhir:lastReviewDate [ fhir:v "2024-02-10"^^xsd:date] ; # 
  fhir:classification ( [
fhir:type [
      ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/citation-classification-type>         ] ;
fhir:code [ fhir:v "citation-source" ] ;
fhir:display [ fhir:v "Citation Source" ]       ] )     ] ;
    ( fhir:classifier [
fhir:text [ fhir:v "MEDLINE" ]     ] )
  ] [
fhir:type [
      ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/citation-classification-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/citation-classification-type>         ] ;
fhir:code [ fhir:v "medline-owner" ] ;
fhir:display [ fhir:v "MEDLINE Citation Owner" ]       ] )     ] ;
    ( fhir:classifier [
      ( fhir:coding [
fhir:system [
fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value>         ] ;
fhir:code [ fhir:v "NLM" ] ;
fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ;
fhir:userSelected [ fhir:v false ]       ] )     ] )
  ] ) ; # 
  fhir:currentState ( [
    ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>       ] ;
fhir:code [ fhir:v "medline-medline" ] ;
fhir:display [ fhir:v "Medline Citation Status of Medline" ]     ] )
  ] [
    ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>       ] ;
fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ;
fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ]     ] )
  ] ) ; # 
  fhir:statusDate ( [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-received" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Received" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2015-02-20"^^xsd:date ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-revised" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Revised" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2015-05-08"^^xsd:date ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2015-05-11"^^xsd:date ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2015-06-21T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2015-06-21T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [
fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/citation-status-type>         ] ;
fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Medline" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2016-04-15T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] ) ; # 
  fhir:citedArtifact [
    ( fhir:identifier [
fhir:system [
fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ;
fhir:l <https://pubmed.ncbi.nlm.nih.gov>       ] ;
fhir:value [ fhir:v "26092557" ]     ] [
fhir:system [
fhir:v "https://doi.org"^^xsd:anyURI ;
fhir:l <https://doi.org>       ] ;
fhir:value [ fhir:v "10.1016/j.urolonc.2015.05.012" ]     ] [
fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>           ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]         ] ) ;
fhir:text [ fhir:v "pii" ]       ] ;
fhir:value [ fhir:v "S1078-1439(15)00235-5" ]     ] ) ;
    ( fhir:title [
      ( fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/title-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/title-type>           ] ;
fhir:code [ fhir:v "primary" ] ;
fhir:display [ fhir:v "Primary title" ]         ] )       ] ) ;
fhir:text [ fhir:v "Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer." ]     ] ) ;
    ( fhir:abstract [
      ( fhir:type [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type>           ] ;
fhir:code [ fhir:v "primary-human-use" ] ;
fhir:display [ fhir:v "Primary human use" ]         ] )       ] ) ;
fhir:text [ fhir:v "**BACKGROUND AND OBJECTIVE:** Sequential tissue biopsies taken during clinical trials of novel systemic anticancer therapies for advanced prostate cancer (PCa) may aid pharmacodynamic evaluation and biomarker discovery. We conducted a single institution phase-II open-labeled randomized study to assess the safety, tolerability, and early efficacy of docetaxel chemotherapy plus androgen deprivation therapy (ADT) vs. ADT alone for patients with advanced non-castration-resistant PCa with sequential prostatic biopsies.\n**PATIENTS AND METHODS:** We randomized 30 patients with newly diagnosed high-grade locally advanced or metastatic (cT3-4/N0-1/M0-1) PCa to receive ADT with (n = 15) or without (n = 15) docetaxel. Transrectal ultrasound-guided prostatic biopsies were taken at randomization and ~22 weeks after treatment initiation. Primary end point: biochemical response rate. Secondary end points: time to progression and tumor profiling.\n**RESULTS:** Both treatments appear to be well tolerated, and there was no difference in mean nadir prostate-specific antigen and time to prostate-specific antigen relapse between treatment arms (P&gt;0.05). No adverse effects of pre- and post-treatment prostatic biopsies were observed. The study was neither designed nor sufficiently powered to demonstrate statistically significant differences in oncological outcomes or safety profiles between the 2 treatment arms.\n**CONCLUSIONS:** Despite the lack of statistical power, our study suggests that docetaxel and ADT in combination may be well tolerated with apparently similar short-term efficacy compared with ADT alone for high-grade locally advanced or metastatic non-castration-resistant PCa, Sequential prostatic biopsies may provide tissue for tumor profiling to yield mechanistic or prognostic insights relating to novel systemic anticancer therapies." ] ;
fhir:copyright [ fhir:v "Copyright © 2015 Elsevier Inc. All rights reserved." ]     ] ) ;
    ( fhir:publicationForm [
fhir:publishedIn [
fhir:type [
          ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/published-in-type"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/published-in-type>             ] ;
fhir:code [ fhir:v "D020492" ] ;
fhir:display [ fhir:v "Periodical" ]           ] )         ] ;
        ( fhir:identifier [
fhir:type [
            ( fhir:coding [
fhir:system [
fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn>               ] ;
fhir:code [ fhir:v "Electronic" ] ;
fhir:display [ fhir:v "Electronic" ]             ] ) ;
fhir:text [ fhir:v "Electronic ISSN Type" ]           ] ;
fhir:system [
fhir:v "https://portal.issn.org"^^xsd:anyURI ;
fhir:l <https://portal.issn.org>           ] ;
fhir:value [ fhir:v "1873-2496" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>               ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "ISOAbbreviation" ]           ] ;
fhir:system [
fhir:v "https://www.issn.org/services/online-services/access-to-the-ltwa/"^^xsd:anyURI ;
fhir:l <https://www.issn.org/services/online-services/access-to-the-ltwa/>           ] ;
fhir:value [ fhir:v "Urol Oncol" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>               ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "ISSN Linking" ]           ] ;
fhir:system [
fhir:v "https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/"^^xsd:anyURI ;
fhir:l <https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/>           ] ;
fhir:value [ fhir:v "1078-1439" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>               ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "Medline Title Abbreviation" ]           ] ;
fhir:system [
fhir:v "https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"^^xsd:anyURI ;
fhir:l <https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html>           ] ;
fhir:value [ fhir:v "Urol Oncol" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>               ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "NLM Unique ID" ]           ] ;
fhir:system [
fhir:v "https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"^^xsd:anyURI ;
fhir:l <https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local>           ] ;
fhir:value [ fhir:v "9805460" ]         ] ) ;
fhir:title [ fhir:v "Urologic oncology" ] ;
fhir:publisherLocation [ fhir:v "United States" ]       ] ;
fhir:citedMedium [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-medium"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-medium>           ] ;
fhir:code [ fhir:v "internet" ] ;
fhir:display [ fhir:v "Internet" ]         ] )       ] ;
fhir:volume [ fhir:v "33" ] ;
fhir:issue [ fhir:v "8" ] ;
fhir:articleDate [ fhir:v "2015-08"^^xsd:gYearMonth ] ;
fhir:pageString [ fhir:v "337.e1-6" ]     ] [
fhir:citedMedium [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/cited-medium"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/cited-medium>           ] ;
fhir:code [ fhir:v "internet-without-issue" ] ;
fhir:display [ fhir:v "Internet without issue" ]         ] )       ] ;
fhir:articleDate [ fhir:v "2015-06-16"^^xsd:date ]     ] ) ;
    ( fhir:webLocation [
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/artifact-url-classifier"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/artifact-url-classifier>           ] ;
fhir:code [ fhir:v "abstract" ] ;
fhir:display [ fhir:v "Abstract" ]         ] )       ] ) ;
fhir:url [
fhir:v "https://pubmed.ncbi.nlm.nih.gov/26092557/"^^xsd:anyURI ;
fhir:l <https://pubmed.ncbi.nlm.nih.gov/26092557/>       ]     ] [
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [
fhir:v "http://terminology.hl7.org/CodeSystem/artifact-url-classifier"^^xsd:anyURI ;
fhir:l <http://terminology.hl7.org/CodeSystem/artifact-url-classifier>           ] ;
fhir:code [ fhir:v "doi-based" ] ;
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  ] . #