Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
{
"resourceType" : "Citation",
"id" : "179625",
"meta" : {
"versionId" : "18",
"lastUpdated" : "2025-10-13T12:34:35.118Z",
"profile" : [
🔗 "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"
]
},
"language" : "en",
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en\" lang=\"en\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179625</b></p><a name=\"179625\"> </a><a name=\"hc179625\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 18; Last updated: 2025-10-13 12:34:35+0000; Language: en</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Citation/179625\">https://fevir.net/resources/Citation/179625</a></p><p><b>identifier</b>: FEvIR Object Identifier/179625, <code>https://pubmed.ncbi.nlm.nih.gov</code>/22502942</p><p><b>title</b>: 22502942 Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial.</p><p><b>status</b>: Active</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://terminology.hl7.org/7.1.0/CodeSystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type: fevir-platform-use</a> (FEvIR Platform Use)</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2012-12-07</p><p><b>lastReviewDate</b>: 2022-03-10</p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --> 2012-02-03</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --> 2012-03-23</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2012-04-17 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2012-04-17 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2012-12-12 06:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/22502942, <code>https://doi.org</code>/10.1016/j.eururo.2012.03.053, pii/S0302-2838(12)00425-3</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/title-type primary}\">Primary title</span></td><td><div><p>Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type primary-human-use}\">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Radiotherapy combined with androgen-deprivation therapy (ADT) is superior to radiotherapy alone in localised prostate cancer; however, data comparing ADT alone are somewhat limited.\n<strong>OBJECTIVE:</strong> To compare 3-yr ADT plus radiotherapy with ADT alone in locally advanced prostate cancer patients.\n<strong>DESIGN, SETTING, AND PARTICIPANTS:</strong> A multicentre randomised open controlled phase 3 trial in 264 histologically confirmed T3-4 or pT3N0M0 prostate cancer patients randomised from March 2000 to December 2003.\n<strong>INTERVENTION:</strong> ADT (11.25mg subcutaneous depot injection of leuprorelin every 3 mo for 3 yr) plus external-beam radiotherapy or ADT alone. Flutamide (750 g/d) was administered for 1 mo.\n<strong>OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:</strong> The primary objective was 5 yr progression-free survival (PFS) according to clinical or biologic criteria, using the American Society for Therapeutic Radiology and Oncology (ASTRO) and the newer (Phoenix) definition (nadir plus 2 ng/ml), by intention to treat. Secondary objectives included time to locoregional recurrence and distant metastases, and overall and disease-specific survival. Our Analyses: intent-to-treat analysis, multivariate analyses using a Cox model with a 5% threshold from univariate analysis, and Kaplan-Meier estimates.\n<strong>RESULTS AND LIMITATIONS:</strong> ADT alone was administered to 130 patients and combined therapy to 133. With a median follow-up of 67 mo, 5-yr PFS was 60.9% for combined therapy versus 8.5% with ADT alone (ASTRO; p<0.0001), and 64.7% versus 15.4%, respectively, for Phoenix (p<0.0011). Locoregional progression was reported in 9.8% of combined-therapy patients versus 29.2% with ADT alone (p<0.0001) and metastatic progression in 3.0% versus 10.8%, respectively (p<0.018). Overall survival was 71.4% with combined therapy versus 71.5% with ADT alone; disease-specific survival was 93.2% versus 86.2%. Limitations included the relatively small population and a relatively short follow-up period.\n<strong>CONCLUSIONS:</strong> Combined therapy strongly favoured improved PFS, locoregional control, and metastasis-free survival. Longer follow-up is needed to assess the potential survival impact.</p>\n</div></td><td><div><p>Copyright © 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.</p>\n</div></td></tr></table><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Citation</b></td><td><b>Target[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Has Comment In</td><td><span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></td><td><div><p>Eur Urol. 2012 Aug;62(2):220-1; author reply 222-3. doi: 10.1016/j.eururo.2012.04.040.</p>\n</div></td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/22552217/\">https://pubmed.ncbi.nlm.nih.gov/22552217/</a></td></tr></table><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1873-7560, ISOAbbreviation/Eur Urol, ISSN Linking/0302-2838, Medline Title Abbreviation/Eur Urol, NLM Unique ID/7512719</p><p><b>title</b>: European urology</p><p><b>publisherLocation</b>: Switzerland</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 62</p><p><b>issue</b>: 2</p><p><b>articleDate</b>: 2012-08</p><p><b>pageString</b>: 213-9</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2012-04-03</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/22502942/\">https://pubmed.ncbi.nlm.nih.gov/22502942/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/j.eururo.2012.03.053\">https://doi.org/10.1016/j.eururo.2012.03.053</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D018931}\">Antineoplastic Agents, Hormonal</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 76W6J0943E}, {https://www.nlm.nih.gov/mesh D005485}\">Flutamide</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances EC 3.4.21.77}, {https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances EFY6W0M8TG}, {https://www.nlm.nih.gov/mesh D016729}\">Leuprolide</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179625/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017428}\">Clinical Trial, Phase III</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016428}\">Journal Article</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016448}\">Multicenter Study</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179625/contributor0\">Mottet N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: Department of Urology, University Hospital, St. Etienne, France. nicolas.mottet@wanadoo.fr</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179625/contributor1\">Peneau M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179625/contributor2\">Mazeron JJ</a></p><p><b>forenameInitials</b>: JJ</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179625/contributor3\">Molinie V</a></p><p><b>forenameInitials</b>: V</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179625/contributor4\">Richaud P</a></p><p><b>forenameInitials</b>: P</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179625/contributor0\"> </a><a name=\"hc179625/contributor0\"> </a><p><b>name</b>: Nicolas Mottet </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179625/contributor1\"> </a><a name=\"hc179625/contributor1\"> </a><p><b>name</b>: Michel Peneau </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179625/contributor2\"> </a><a name=\"hc179625/contributor2\"> </a><p><b>name</b>: Jean-Jacques Mazeron </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179625/contributor3\"> </a><a name=\"hc179625/contributor3\"> </a><p><b>name</b>: Vincent Molinie </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179625/contributor4\"> </a><a name=\"hc179625/contributor4\"> </a><p><b>name</b>: Pierre Richaud </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179625/meshHeading0\"> </a><a name=\"hc179625/meshHeading0\"> </a><p><b>artifact</b>: <a href=\"#hc179625\">Citation 22502942 Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000230}\">Adenocarcinoma</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000532}\">radiotherapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000628}\">therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D018931}\">Antineoplastic Agents, Hormonal</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D059248}\">Chemoradiotherapy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D018572}\">Disease-Free Survival</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D004359}\">Drug Therapy, Combination</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005485}\">Flutamide</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016729}\">Leuprolide</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D060787}\">Neoplasm Grading</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000097}\">blood</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000532}\">radiotherapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000628}\">therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote></blockquote></div>"
},
"contained" : [
{
"resourceType" : "Practitioner",
"id" : "contributor0",
"name" : [
{
"family" : "Mottet",
"given" : [
"Nicolas"
]
}
]
},
{
"resourceType" : "Practitioner",
"id" : "contributor1",
"name" : [
{
"family" : "Peneau",
"given" : [
"Michel"
]
}
]
},
{
"resourceType" : "Practitioner",
"id" : "contributor2",
"name" : [
{
"family" : "Mazeron",
"given" : [
"Jean-Jacques"
]
}
]
},
{
"resourceType" : "Practitioner",
"id" : "contributor3",
"name" : [
{
"family" : "Molinie",
"given" : [
"Vincent"
]
}
]
},
{
"resourceType" : "Practitioner",
"id" : "contributor4",
"name" : [
{
"family" : "Richaud",
"given" : [
"Pierre"
]
}
]
},
{
"resourceType" : "ArtifactAssessment",
"id" : "meshHeading0",
"artifactReference" : {
"reference" : "#",
"type" : "Citation"
},
"content" : [
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D000230",
"display" : "Adenocarcinoma",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000188",
"display" : "drug therapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000532",
"display" : "radiotherapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000628",
"display" : "therapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49488",
"display" : "Yes"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D000368",
"display" : "Aged",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D000726",
"display" : "Androgen Antagonists",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000627",
"display" : "therapeutic use"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D018931",
"display" : "Antineoplastic Agents, Hormonal",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000627",
"display" : "therapeutic use"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49488",
"display" : "Yes"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D059248",
"display" : "Chemoradiotherapy",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D018572",
"display" : "Disease-Free Survival",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D004359",
"display" : "Drug Therapy, Combination",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D005485",
"display" : "Flutamide",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000627",
"display" : "therapeutic use"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49488",
"display" : "Yes"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D006801",
"display" : "Humans",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016729",
"display" : "Leuprolide",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000627",
"display" : "therapeutic use"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49488",
"display" : "Yes"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D008297",
"display" : "Male",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D008875",
"display" : "Middle Aged",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D060787",
"display" : "Neoplasm Grading",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D017430",
"display" : "Prostate-Specific Antigen",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000097",
"display" : "blood"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
],
"text" : "components (if present) include qualifier codings"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D011471",
"display" : "Prostatic Neoplasms",
"userSelected" : false
}
]
}
],
"freeToShare" : true,
"component" : [
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"text" : "is not a major topic"
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000188",
"display" : "drug therapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000532",
"display" : "radiotherapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49487",
"display" : "No"
}
]
}
]
}
]
},
{
"type" : {
"text" : "qualifier"
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "Q000628",
"display" : "therapy"
}
]
}
],
"component" : [
{
"type" : {
"text" : "is Major topic"
},
"classifier" : [
{
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C49488",
"display" : "Yes"
}
]
}
]
}
]
}
]
}
]
}
],
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type",
"code" : "active",
"display" : "Active"
}
]
}
}
],
"url" : "https://fevir.net/resources/Citation/179625",
"identifier" : [
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "ACSN",
"display" : "Accession ID"
}
],
"text" : "FEvIR Object Identifier"
},
"system" : "https://fevir.net/FOI",
"value" : "179625",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
{
"system" : "https://pubmed.ncbi.nlm.nih.gov",
"value" : "22502942"
}
],
"title" : "22502942 Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial.",
"status" : "active",
"author" : [
{
"name" : "Computable Publishing®: MEDLINE-to-FEvIR Converter"
}
],
"publisher" : "Computable Publishing LLC",
"contact" : [
{
"telecom" : [
{
"system" : "email",
"value" : "support@computablepublishing.com"
}
]
}
],
"description" : "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.",
"useContext" : [
{
"code" : {
"system" : "http://terminology.hl7.org/CodeSystem/citation-classification-type",
"code" : "fevir-platform-use",
"display" : "FEvIR Platform Use"
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier",
"code" : "medline-base",
"display" : "Medline Base",
"userSelected" : false
}
]
}
}
],
"copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
"approvalDate" : "2012-12-07",
"lastReviewDate" : "2022-03-10",
"classification" : [
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/citation-classification-type",
"code" : "citation-source",
"display" : "Citation Source"
}
]
},
"classifier" : [
{
"text" : "MEDLINE"
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/citation-classification-type",
"code" : "medline-owner",
"display" : "MEDLINE Citation Owner"
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value",
"code" : "NLM",
"display" : "National Library of Medicine, Index Section",
"userSelected" : false
}
]
}
]
}
],
"currentState" : [
{
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "medline-medline",
"display" : "Medline Citation Status of Medline"
}
]
},
{
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-publication-status-ppublish",
"display" : "PubMed PublicationStatus of ppublish"
}
]
}
],
"statusDate" : [
{
"activity" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-pubstatus-received",
"display" : "PubMed Pubstatus of Received"
}
]
},
"period" : {
"end" : "2012-02-03"
}
},
{
"activity" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-pubstatus-accepted",
"display" : "PubMed Pubstatus of Accepted"
}
]
},
"period" : {
"end" : "2012-03-23"
}
},
{
"activity" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-pubstatus-entrez",
"display" : "PubMed Pubstatus of Entrez"
}
]
},
"period" : {
"end" : "2012-04-17T06:00:00.000Z"
}
},
{
"activity" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-pubstatus-pubmed",
"display" : "PubMed Pubstatus of Pubmed"
}
]
},
"period" : {
"end" : "2012-04-17T06:00:00.000Z"
}
},
{
"activity" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-status-type",
"code" : "pubmed-pubstatus-medline",
"display" : "PubMed Pubstatus of Medline"
}
]
},
"period" : {
"end" : "2012-12-12T06:00:00.000Z"
}
}
],
"citedArtifact" : {
"identifier" : [
{
"system" : "https://pubmed.ncbi.nlm.nih.gov",
"value" : "22502942"
},
{
"system" : "https://doi.org",
"value" : "10.1016/j.eururo.2012.03.053"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "ACSN",
"display" : "Accession ID"
}
],
"text" : "pii"
},
"value" : "S0302-2838(12)00425-3"
}
],
"title" : [
{
"type" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/title-type",
"code" : "primary",
"display" : "Primary title"
}
]
}
],
"text" : "Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial."
}
],
"abstract" : [
{
"type" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type",
"code" : "primary-human-use",
"display" : "Primary human use"
}
]
}
],
"text" : "**BACKGROUND:** Radiotherapy combined with androgen-deprivation therapy (ADT) is superior to radiotherapy alone in localised prostate cancer; however, data comparing ADT alone are somewhat limited.\n**OBJECTIVE:** To compare 3-yr ADT plus radiotherapy with ADT alone in locally advanced prostate cancer patients.\n**DESIGN, SETTING, AND PARTICIPANTS:** A multicentre randomised open controlled phase 3 trial in 264 histologically confirmed T3-4 or pT3N0M0 prostate cancer patients randomised from March 2000 to December 2003.\n**INTERVENTION:** ADT (11.25mg subcutaneous depot injection of leuprorelin every 3 mo for 3 yr) plus external-beam radiotherapy or ADT alone. Flutamide (750 g/d) was administered for 1 mo.\n**OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:** The primary objective was 5 yr progression-free survival (PFS) according to clinical or biologic criteria, using the American Society for Therapeutic Radiology and Oncology (ASTRO) and the newer (Phoenix) definition (nadir plus 2 ng/ml), by intention to treat. Secondary objectives included time to locoregional recurrence and distant metastases, and overall and disease-specific survival. Our Analyses: intent-to-treat analysis, multivariate analyses using a Cox model with a 5% threshold from univariate analysis, and Kaplan-Meier estimates.\n**RESULTS AND LIMITATIONS:** ADT alone was administered to 130 patients and combined therapy to 133. With a median follow-up of 67 mo, 5-yr PFS was 60.9% for combined therapy versus 8.5% with ADT alone (ASTRO; p<0.0001), and 64.7% versus 15.4%, respectively, for Phoenix (p<0.0011). Locoregional progression was reported in 9.8% of combined-therapy patients versus 29.2% with ADT alone (p<0.0001) and metastatic progression in 3.0% versus 10.8%, respectively (p<0.018). Overall survival was 71.4% with combined therapy versus 71.5% with ADT alone; disease-specific survival was 93.2% versus 86.2%. Limitations included the relatively small population and a relatively short follow-up period.\n**CONCLUSIONS:** Combined therapy strongly favoured improved PFS, locoregional control, and metastasis-free survival. Longer follow-up is needed to assess the potential survival impact.",
"copyright" : "Copyright © 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved."
}
],
"relatesTo" : [
{
"type" : "comment-in",
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016420",
"display" : "Comment",
"userSelected" : false
}
]
}
],
"citation" : "Eur Urol. 2012 Aug;62(2):220-1; author reply 222-3. doi: 10.1016/j.eururo.2012.04.040.",
"targetReference" : {
"reference" : "https://pubmed.ncbi.nlm.nih.gov/22552217/",
"identifier" : {
"system" : "https://pubmed.ncbi.nlm.nih.gov",
"value" : "22552217",
"assigner" : {
"display" : "NLM"
}
}
}
}
],
"publicationForm" : [
{
"publishedIn" : {
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/published-in-type",
"code" : "D020492",
"display" : "Periodical"
}
]
},
"identifier" : [
{
"type" : {
"coding" : [
{
"system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn",
"code" : "Electronic",
"display" : "Electronic"
}
],
"text" : "Electronic ISSN Type"
},
"system" : "https://portal.issn.org",
"value" : "1873-7560"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "XX",
"display" : "Organization identifier"
}
],
"text" : "ISOAbbreviation"
},
"system" : "https://www.issn.org/services/online-services/access-to-the-ltwa/",
"value" : "Eur Urol"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "XX",
"display" : "Organization identifier"
}
],
"text" : "ISSN Linking"
},
"system" : "https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/",
"value" : "0302-2838"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "XX",
"display" : "Organization identifier"
}
],
"text" : "Medline Title Abbreviation"
},
"system" : "https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html",
"value" : "Eur Urol"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "XX",
"display" : "Organization identifier"
}
],
"text" : "NLM Unique ID"
},
"system" : "https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local",
"value" : "7512719"
}
],
"title" : "European urology",
"publisherLocation" : "Switzerland"
},
"citedMedium" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-medium",
"code" : "internet",
"display" : "Internet"
}
]
},
"volume" : "62",
"issue" : "2",
"articleDate" : "2012-08",
"pageString" : "213-9"
},
{
"citedMedium" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-medium",
"code" : "internet-without-issue",
"display" : "Internet without issue"
}
]
},
"articleDate" : "2012-04-03"
}
],
"webLocation" : [
{
"classifier" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/artifact-url-classifier",
"code" : "abstract",
"display" : "Abstract"
}
]
}
],
"url" : "https://pubmed.ncbi.nlm.nih.gov/22502942/"
},
{
"classifier" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/artifact-url-classifier",
"code" : "doi-based",
"display" : "DOI Based"
}
]
}
],
"url" : "https://doi.org/10.1016/j.eururo.2012.03.053"
}
],
"classification" : [
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "publishing-model",
"display" : "Publishing Model",
"userSelected" : false
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier",
"code" : "Print-Electronic",
"display" : "Print Electronic",
"userSelected" : false
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "chemical",
"display" : "Chemical",
"userSelected" : false
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D000726",
"display" : "Androgen Antagonists",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D018931",
"display" : "Antineoplastic Agents, Hormonal",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.cas.org/support/documentation/chemical-substances",
"code" : "76W6J0943E",
"userSelected" : false
},
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D005485",
"display" : "Flutamide",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.cas.org/support/documentation/chemical-substances",
"code" : "EC 3.4.21.77",
"userSelected" : false
},
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D017430",
"display" : "Prostate-Specific Antigen",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.cas.org/support/documentation/chemical-substances",
"code" : "EFY6W0M8TG",
"userSelected" : false
},
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016729",
"display" : "Leuprolide",
"userSelected" : false
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "mesh-heading",
"display" : "MeSH heading"
}
]
},
"artifactAssessment" : [
{
"reference" : "#meshHeading0",
"type" : "ArtifactAssessment"
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "publication-type",
"display" : "Publication type"
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D017428",
"display" : "Clinical Trial, Phase III",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016428",
"display" : "Journal Article",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016448",
"display" : "Multicenter Study",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D016449",
"display" : "Randomized Controlled Trial",
"userSelected" : false
}
]
},
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/mesh",
"code" : "D013485",
"display" : "Research Support, Non-U.S. Gov't",
"userSelected" : false
}
]
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "knowledge-artifact-type",
"display" : "Knowledge Artifact Type",
"userSelected" : false
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/citation-artifact-classifier",
"code" : "D016428",
"display" : "Journal Article",
"userSelected" : false
}
]
}
],
"artifactAssessment" : [
{
"display" : "Classifier added by Computable Publishing LLC"
}
]
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type",
"code" : "citation-subset",
"display" : "Citation subset",
"userSelected" : false
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset",
"code" : "IM",
"display" : "IM",
"userSelected" : false
}
]
}
]
}
],
"contributorship" : {
"complete" : true,
"entry" : [
{
"contributor" : {
"reference" : "#contributor0",
"type" : "Practitioner",
"display" : "Mottet N"
},
"forenameInitials" : "N",
"affiliation" : [
{
"display" : "Department of Urology, University Hospital, St. Etienne, France. nicolas.mottet@wanadoo.fr"
}
]
},
{
"contributor" : {
"reference" : "#contributor1",
"type" : "Practitioner",
"display" : "Peneau M"
},
"forenameInitials" : "M"
},
{
"contributor" : {
"reference" : "#contributor2",
"type" : "Practitioner",
"display" : "Mazeron JJ"
},
"forenameInitials" : "JJ"
},
{
"contributor" : {
"reference" : "#contributor3",
"type" : "Practitioner",
"display" : "Molinie V"
},
"forenameInitials" : "V"
},
{
"contributor" : {
"reference" : "#contributor4",
"type" : "Practitioner",
"display" : "Richaud P"
},
"forenameInitials" : "P"
}
]
}
}
}