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    v: Generated Narrative: Citation 179617 version: 20; Last updated: 2025-10-13 12:34:35+0000; Language: en Profile: JournalArticleCitation ArtifactPublicationStatus: Active url: https://fevir.net/resources/Citation/179617 identifier: FEvIR Object Identifier/179617, https://pubmed.ncbi.nlm.nih.gov/25301760 title: 25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). status: Active author: Computable Publishing®: MEDLINE-to-FEvIR Converter: publisher: Computable Publishing LLC contact: support@computablepublishing.com description: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide. UseContexts - Code Value[x] * Citation Classification Type: fevir-platform-use (FEvIR Platform Use) Medline Base copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/ approvalDate: 2016-04-07 lastReviewDate: 2022-12-08 classification type: Citation Source classifier: MEDLINE classification type: MEDLINE Citation Owner classifier: National Library of Medicine, Index Section currentState: Medline Citation Status of Medline, PubMed PublicationStatus of ppublish statusDate activity: PubMed Pubstatus of Received period: ?? --> 2014-07-23 statusDate activity: PubMed Pubstatus of Accepted period: ?? --> 2014-09-19 statusDate activity: PubMed Pubstatus of Entrez period: ?? --> 2014-10-11 06:00:00+0000 statusDate activity: PubMed Pubstatus of Pubmed period: ?? --> 2014-10-11 06:00:00+0000 statusDate activity: PubMed Pubstatus of Medline period: ?? --> 2016-04-08 06:00:00+0000 citedArtifact identifier: https://pubmed.ncbi.nlm.nih.gov/25301760, https://doi.org/10.1016/j.eururo.2014.09.032, pii/S0302-2838(14)00969-5 Titles - Type Text * Primary title Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). Abstracts - Type Tex…
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    v: Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).
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    v: **BACKGROUND:** Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease. Recruitment for the largest therapeutic randomised controlled trial in PCa--the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)--includes men with newly diagnosed metastatic PCa who are commencing long-term androgen deprivation therapy (ADT); the control arm provides valuable data for a prospective cohort. **OBJECTIVE:** Describe survival outcomes, along with current treatment standards and factors associated with prognosis, to inform future trial design in this patient group. **DESIGN, SETTING, AND PARTICIPANTS:** STAMPEDE trial control arm comprising men newly diagnosed with M1 disease who were recruited between October 2005 and January 2014. **OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:** Overall survival (OS) and failure-free survival (FFS) were reported by primary disease characteristics using Kaplan-Meier methods. Hazard ratios and 95% confidence intervals (CIs) were derived from multivariate Cox models. **RESULTS AND LIMITATIONS:** A cohort of 917 men with newly diagnosed M1 disease was recruited to the control arm in the specified interval. Median follow-up was 20 mo. Median age at randomisation was 66 yr (interquartile range [IQR]: 61-71), and median prostate-specific antigen level was 112 ng/ml (IQR: 34-373). Most men (n=574; 62%) had bone-only metastases, whereas 237 (26%) had both bone and soft tissue metastases; soft tissue metastasis was found mainly in distant lymph nodes. There were 238 deaths, 202 (85%) from PCa. Median FFS was 11 mo; 2-yr FFS was 29% (95% CI, 25-33). Median OS was 42 mo; 2-yr OS was 72% (95% CI, 68-76). Survival time was influenced by performance status, age, Gleason score, and metastases distribution. Median survival after FFS event was 22 mo. Trial el…
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l: Practitioner

v: Parmar MKB

v: MKB

display:
  v: Medical Research Council Clinical Trials Unit at University College London, London, UK.

contributor:
  l: contributor14
  reference:
    v: #contributor14
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Ritchie AWS
forename initials:
  v: AWS
affiliation:
  display:
    v: Medical Research Council Clinical Trials Unit at University College London, London, UK.

contributor:
  l: contributor15
  reference:
    v: #contributor15
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Russell JM
forename initials:
  v: JM
affiliation:
  display:
    v: Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

contributor:
  l: contributor16
  reference:
    v: #contributor16
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Strebel RT
forename initials:
  v: RT
affiliation:
  display:
    v: Kantonsspital Graübunden, Chur, Switzerland.

contributor:
  l: contributor17
  reference:
    v: #contributor17
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Thalmann GN
forename initials:
  v: GN
affiliation:
  display:
    v: Department of Urology, University Hospital, Bern, Switzerland.

contributor:
  l: contributor18
  reference:
    v: #contributor18
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Mason MD
forename initials:
  v: MD
affiliation:
  display:
    v: Velindre Hospital, Cardiff, UK.

contributor:
  l: contributor19
  reference:
    v: #contributor19
  type:
    v: Practitioner
    l: Practitioner
  display:
    v: Sydes MR
forename initials:
  v: MR
affiliation:
  display:
    v: Medical Research Council Clinical Trials Unit at University College London, London, UK.