Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Resource Profile: NetEffectEstimate - Detailed Descriptions

Page standards status: Trial-use Maturity Level: 1

Definitions for the net-effect-estimate resource profile.

Guidance on how to interpret the contents of this table can be foundhere

0. Evidence
Definition

The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.

ShortSingle evidence bit
Control0..*
Is Modifierfalse
Must Supportfalse
Summaryfalse
Invariantscnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation (name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$'))
2. Evidence.implicitRules
Definition

A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

ShortA set of rules under which this content was created
Comments

Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.

Control0..1
Typeuri
Is Modifiertrue because This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation
Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
Must Supportfalse
Summarytrue
Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
4. Evidence.contained
Definition

These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.

ShortContained, inline Resources
Comments

This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels. Contained resources may be a resource type defined in the FHIR specification, or an additional resource.

Control0..*
This element is affected by the following invariants: dom-2, dom-4, dom-3, dom-5
TypeResource
Is Modifierfalse
Must Supportfalse
Summaryfalse
Alternate Namesinline resources, anonymous resources, contained resources
6. Evidence.extension
Definition

An Extension


May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

ShortExtensionAdditional content defined by implementations
Comments

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Control0..*
TypeExtension
Is Modifierfalse
Must Supportfalse
Summaryfalse
Alternate Namesextensions, user content
Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
SlicingThis element introduces a set of slices on Evidence.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
  • value @ url
  • 8. Evidence.extension:publicationStatus
    Slice NamepublicationStatus
    Definition

    The status of the processing for making the artifact publicly available, not necessarily the same as artifact status (Resource.status).

    ShortPublication status
    Control0..1
    TypeExtension(ArtifactPublicationStatus) (Extension Type: CodeableConcept)
    Is Modifierfalse
    Must Supportfalse
    Summaryfalse
    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
    10. Evidence.modifierExtension
    Definition

    May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

    ShortExtensions that cannot be ignored
    Comments

    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

    Control0..*
    TypeExtension
    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them
    Must Supportfalse
    Summarytrue
    Requirements

    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

    Alternate Namesextensions, user content
    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
    12. Evidence.status
    Definition

    The status of this summary. Enables tracking the life-cycle of the content.

    Shortdraft | active | retired | unknown
    Comments

    Allows filtering of summaries that are appropriate for use versus not.

    See guidance around (not) making local changes to elements here.


    Allows filtering of summaries that are appropriate for use versus not.

    See guidance around (not) making local changes to elements here.

    Control1..1
    BindingThe codes SHALL be taken from PublicationStatushttp://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3
    (required to http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3)

    The lifecycle status of an artifact.

    Typecode
    Is Modifiertrue because This is labeled as "Is Modifier" because applications should not use a retired Evidence without due consideration
    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
    Must Supportfalse
    Summarytrue
    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
    14. Evidence.variableDefinition
    Definition

    Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

    ShortDescription, classification, and definition of a single variable
    Comments

    Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

    Control30..*
    TypeBackboneElement
    Is Modifierfalse
    Must Supportfalse
    Summaryfalse
    Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
    SlicingThis element introduces a set of slices on Evidence.variableDefinition. The slices areUnordered and Open, and can be differentiated using the following discriminators:
    • value @ variableRole
    • 16. Evidence.variableDefinition.modifierExtension
      Definition

      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

      ShortExtensions that cannot be ignored even if unrecognized
      Comments

      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

      Control0..*
      TypeExtension
      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
      Summarytrue
      Requirements

      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

      Alternate Namesextensions, user content, modifiers
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      18. Evidence.variableDefinition.variableRole
      Definition

      Classification of the role of the variable.

      Shortpopulation | exposure | outcome | covariate
      Control1..1
      BindingThe codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3
      (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

      The role that the variable plays.

      Typecode
      Is Modifierfalse
      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
      Must Supportfalse
      Summarytrue
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      20. Evidence.variableDefinition:population
      Slice Namepopulation
      Definition

      Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

      ShortDescription, classification, and definition of a single variable
      Comments

      Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

      Control10..1*
      TypeBackboneElement
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
      22. Evidence.variableDefinition:population.modifierExtension
      Definition

      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

      ShortExtensions that cannot be ignored even if unrecognized
      Comments

      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

      Control0..*
      TypeExtension
      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
      Summarytrue
      Requirements

      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

      Alternate Namesextensions, user content, modifiers
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      24. Evidence.variableDefinition:population.variableRole
      Definition

      Classification of the role of the variable.

      Shortpopulation | exposure | outcome | covariate
      Control1..1
      BindingThe codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3
      (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

      The role that the variable plays.

      Typecode
      Is Modifierfalse
      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
      Must Supportfalse
      Summarytrue
      Pattern Valuepopulation
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      26. Evidence.variableDefinition:exposure
      Slice Nameexposure
      Definition

      Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

      ShortDescription, classification, and definition of a single variable
      Comments

      Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

      Control10..1*
      TypeBackboneElement
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
      28. Evidence.variableDefinition:exposure.modifierExtension
      Definition

      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

      ShortExtensions that cannot be ignored even if unrecognized
      Comments

      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

      Control0..*
      TypeExtension
      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
      Summarytrue
      Requirements

      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

      Alternate Namesextensions, user content, modifiers
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      30. Evidence.variableDefinition:exposure.variableRole
      Definition

      Classification of the role of the variable.

      Shortpopulation | exposure | outcome | covariate
      Control1..1
      BindingThe codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3
      (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

      The role that the variable plays.

      Typecode
      Is Modifierfalse
      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
      Must Supportfalse
      Summarytrue
      Pattern Valueexposure
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      32. Evidence.variableDefinition:exposure.comparatorCategory
      Definition

      The reference value used for comparison.

      ShortThe reference value used for comparison
      Comments

      Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

      Control10..1
      Typestring
      Is Modifierfalse
      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      34. Evidence.variableDefinition:exposure.observed
      Definition

      Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

      ShortDefinition of the actual variable related to the statistic(s)
      Control0..1
      TypeReference(GroupAssignment, Group, EvidenceVariable)
      Is Modifierfalse
      Must Supportfalse
      Summarytrue
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      36. Evidence.variableDefinition:exposure.intended
      Definition

      Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

      ShortDefinition of the intended variable related to the Evidence
      Control0..1
      TypeReference(GroupAssignment, Group, EvidenceVariable)
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      38. Evidence.variableDefinition:outcome
      Slice Nameoutcome
      Definition

      Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

      ShortDescription, classification, and definition of a single variable
      Comments

      Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

      Control10..1*
      TypeBackboneElement
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
      40. Evidence.variableDefinition:outcome.modifierExtension
      Definition

      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

      ShortExtensions that cannot be ignored even if unrecognized
      Comments

      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

      Control0..*
      TypeExtension
      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
      Summarytrue
      Requirements

      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

      Alternate Namesextensions, user content, modifiers
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      42. Evidence.variableDefinition:outcome.variableRole
      Definition

      Classification of the role of the variable.

      Shortpopulation | exposure | outcome | covariate
      Control1..1
      BindingThe codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3
      (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

      The role that the variable plays.

      Typecode
      Is Modifierfalse
      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
      Must Supportfalse
      Summarytrue
      Pattern Valueoutcome
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      44. Evidence.variableDefinition:outcome.observed
      Definition

      Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

      ShortDefinition of the actual variable related to the statistic(s)
      Control0..1
      TypeReference(NetEffectContributions, Group, EvidenceVariable)
      Is Modifierfalse
      Must Supportfalse
      Summarytrue
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      46. Evidence.variableDefinition:outcome.intended
      Definition

      Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

      ShortDefinition of the intended variable related to the Evidence
      Control0..01
      TypeReference(Group, EvidenceVariable)
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
      48. Evidence.statistic
      Definition

      Values and parameters for a single statistic.

      ShortValues and parameters for a single statistic
      Control10..*
      TypeBackboneElement
      Is Modifierfalse
      Must Supportfalse
      Summaryfalse
      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
      SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
      • value @ statisticType.coding
      • 50. Evidence.statistic.modifierExtension
        Definition

        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

        ShortExtensions that cannot be ignored even if unrecognized
        Comments

        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

        Control0..*
        TypeExtension
        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
        Summarytrue
        Requirements

        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

        Alternate Namesextensions, user content, modifiers
        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
        52. Evidence.statistic:netEffect
        Slice NamenetEffect
        Definition

        Values and parameters for a single statistic.

        ShortValues and parameters for a single statistic
        Control10..1*
        TypeBackboneElement
        Is Modifierfalse
        Must Supporttrue
        Summaryfalse
        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
        54. Evidence.statistic:netEffect.modifierExtension
        Definition

        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

        ShortExtensions that cannot be ignored even if unrecognized
        Comments

        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

        Control0..*
        TypeExtension
        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
        Summarytrue
        Requirements

        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

        Alternate Namesextensions, user content, modifiers
        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
        56. Evidence.statistic:netEffect.attributeEstimate
        Definition

        A statistical attribute of the statistic such as a measure of heterogeneity.

        ShortAn attribute of the Statistic
        Control0..*
        TypeBackboneElement
        Is Modifierfalse
        Must Supportfalse
        Summaryfalse
        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
        SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
        • value @ type.coding
        • 58. Evidence.statistic:netEffect.attributeEstimate.modifierExtension
          Definition

          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

          ShortExtensions that cannot be ignored even if unrecognized
          Comments

          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

          Control0..*
          TypeExtension
          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
          Summarytrue
          Requirements

          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

          Alternate Namesextensions, user content, modifiers
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          60. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
          Slice NameconfidenceInterval
          Definition

          A statistical attribute of the statistic such as a measure of heterogeneity.

          ShortAn attribute of the Statistic
          Control0..*
          TypeBackboneElement
          Is Modifierfalse
          Must Supporttrue
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
          62. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.modifierExtension
          Definition

          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

          ShortExtensions that cannot be ignored even if unrecognized
          Comments

          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

          Control0..*
          TypeExtension
          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
          Summarytrue
          Requirements

          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

          Alternate Namesextensions, user content, modifiers
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          64. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.quantity
          Definition

          The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure.

          ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
          Comments

          Often the p value

          Control0..01
          TypeQuantity
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          66. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.level
          Definition

          Use 0.95 for a 95% confidence interval.

          ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
          Control10..1
          Typedecimal
          Is Modifierfalse
          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          68. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.range
          Definition

          Lower and upper bound values of the attribute estimate.

          ShortLower and upper bound values of the attribute estimate
          Control10..1
          TypeRange
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          70. Evidence.statistic:netEffect.attributeEstimate:nnt
          Slice Namennt
          Definition

          A statistical attribute of the statistic such as a measure of heterogeneity.

          ShortAn attribute of the Statistic
          Control0..1*
          TypeBackboneElement
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
          72. Evidence.statistic:netEffect.attributeEstimate:nnt.modifierExtension
          Definition

          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

          ShortExtensions that cannot be ignored even if unrecognized
          Comments

          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

          Control0..*
          TypeExtension
          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
          Summarytrue
          Requirements

          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

          Alternate Namesextensions, user content, modifiers
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          74. Evidence.statistic:netEffect.attributeEstimate:nnt.level
          Definition

          Use 0.95 for a 95% confidence interval.

          ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
          Control0..01
          Typedecimal
          Is Modifierfalse
          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          76. Evidence.statistic:netEffect.modelCharacteristic
          Definition

          A component of the method to generate the statistic.

          ShortAn aspect of the statistical model
          Control10..*
          TypeBackboneElement
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
          SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
          • value @ code.text
          • 78. Evidence.statistic:netEffect.modelCharacteristic.modifierExtension
            Definition

            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

            ShortExtensions that cannot be ignored even if unrecognized
            Comments

            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

            Control0..*
            TypeExtension
            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
            Summarytrue
            Requirements

            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

            Alternate Namesextensions, user content, modifiers
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            80. Evidence.statistic:netEffect.modelCharacteristic.code
            Definition

            Description of a component of the method to generate the statistic.

            ShortModel specification
            Control1..1
            BindingUnless not suitable, these codes SHALL be taken from StatisticModelCodehttp://hl7.org/fhir/ValueSet/statistic-model-code
            (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
            TypeCodeableConcept
            Is Modifierfalse
            Must Supportfalse
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            82. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis
            Slice NamenetEffectAnalysis
            Definition

            A component of the method to generate the statistic.

            ShortAn aspect of the statistical model
            Control10..1*
            TypeBackboneElement
            Is Modifierfalse
            Must Supporttrue
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
            84. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.modifierExtension
            Definition

            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

            ShortExtensions that cannot be ignored even if unrecognized
            Comments

            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

            Control0..*
            TypeExtension
            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
            Summarytrue
            Requirements

            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

            Alternate Namesextensions, user content, modifiers
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            86. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code
            Definition

            Description of a component of the method to generate the statistic.

            ShortModel specification
            Control1..1
            BindingUnless not suitable, these codes SHALL be taken from StatisticModelCodehttp://hl7.org/fhir/ValueSet/statistic-model-code
            (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
            TypeCodeableConcept
            Is Modifierfalse
            Must Supportfalse
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            88. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.text
            Definition

            A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

            ShortPlain text representation of the concept
            Comments

            Very often the text is the same as a displayName of one of the codings.

            Control10..1
            Typestring
            Is Modifierfalse
            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
            Summaryfalse
            Requirements

            The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

            Pattern ValueNet effect analysis
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))

            Guidance on how to interpret the contents of this table can be foundhere

            0. Evidence
            2. Evidence.extension
            SlicingThis element introduces a set of slices on Evidence.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
            • value @ url
            • 4. Evidence.extension:publicationStatus
              Slice NamepublicationStatus
              Control0..1
              TypeExtension(ArtifactPublicationStatus) (Extension Type: CodeableConcept)
              6. Evidence.variableDefinition
              Control3..?
              SlicingThis element introduces a set of slices on Evidence.variableDefinition. The slices areUnordered and Open, and can be differentiated using the following discriminators:
              • value @ variableRole
              • 8. Evidence.variableDefinition:population
                Slice Namepopulation
                Control1..1
                10. Evidence.variableDefinition:population.variableRole
                Pattern Valuepopulation
                12. Evidence.variableDefinition:exposure
                Slice Nameexposure
                Control1..1
                14. Evidence.variableDefinition:exposure.variableRole
                Pattern Valueexposure
                16. Evidence.variableDefinition:exposure.comparatorCategory
                Control1..?
                18. Evidence.variableDefinition:exposure.observed
                TypeReference(GroupAssignment)
                20. Evidence.variableDefinition:exposure.intended
                TypeReference(GroupAssignment)
                22. Evidence.variableDefinition:outcome
                Slice Nameoutcome
                Control1..1
                24. Evidence.variableDefinition:outcome.variableRole
                Pattern Valueoutcome
                26. Evidence.variableDefinition:outcome.observed
                TypeReference(NetEffectContributions)
                28. Evidence.variableDefinition:outcome.intended
                Control0..0
                30. Evidence.statistic
                Control1..?
                SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                • value @ statisticType.coding
                • 32. Evidence.statistic:netEffect
                  Slice NamenetEffect
                  Control1..1
                  Must Supporttrue
                  34. Evidence.statistic:netEffect.statisticType
                  36. Evidence.statistic:netEffect.statisticType.coding
                  Control1..1
                  Pattern Value{
                    "system" : "https://fevir.net/sevco",
                    "code" : "STATO:0000424",
                    "display" : "risk difference"
                  }
                  38. Evidence.statistic:netEffect.attributeEstimate
                  SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                  • value @ type.coding
                  • 40. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
                    Slice NameconfidenceInterval
                    Control0..*
                    Must Supporttrue
                    42. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type
                    44. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.coding
                    Control1..1
                    Pattern Value{
                      "system" : "https://fevir.net/sevco",
                      "code" : "STATO:0000196",
                      "display" : "confidence interval"
                    }
                    46. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.quantity
                    Control0..0
                    48. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.level
                    Control1..?
                    50. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.range
                    Control1..?
                    52. Evidence.statistic:netEffect.attributeEstimate:nnt
                    Slice Namennt
                    Control0..1
                    54. Evidence.statistic:netEffect.attributeEstimate:nnt.type
                    56. Evidence.statistic:netEffect.attributeEstimate:nnt.type.coding
                    Control1..1
                    Pattern Value{
                      "system" : "https://fevir.net/sevco",
                      "code" : "STATO:0000635",
                      "display" : "number needed to treat"
                    }
                    58. Evidence.statistic:netEffect.attributeEstimate:nnt.type.text
                    Pattern ValueNumber needed to treat to prevent 1 composite importance-adjusted outcome
                    60. Evidence.statistic:netEffect.attributeEstimate:nnt.level
                    Control0..0
                    62. Evidence.statistic:netEffect.modelCharacteristic
                    Control1..?
                    SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                    • value @ code.text
                    • 64. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis
                      Slice NamenetEffectAnalysis
                      Control1..1
                      Must Supporttrue
                      66. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code
                      68. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.text
                      Control1..?
                      Pattern ValueNet effect analysis

                      Guidance on how to interpret the contents of this table can be foundhere

                      0. Evidence
                      Definition

                      The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.

                      ShortSingle evidence bit
                      Control0..*
                      Is Modifierfalse
                      Must Supportfalse
                      Summaryfalse
                      Invariantscnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation (name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$'))
                      2. Evidence.id
                      Definition

                      The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.

                      ShortLogical id of this artifact
                      Comments

                      Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.

                      Control0..1
                      Typeid
                      Is Modifierfalse
                      Must Supportfalse
                      Summarytrue
                      4. Evidence.meta
                      Definition

                      The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.

                      ShortMetadata about the resource
                      Control0..1
                      TypeMeta
                      Is Modifierfalse
                      Must Supportfalse
                      Summarytrue
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      6. Evidence.implicitRules
                      Definition

                      A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

                      ShortA set of rules under which this content was created
                      Comments

                      Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.

                      Control0..1
                      Typeuri
                      Is Modifiertrue because This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation
                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                      Must Supportfalse
                      Summarytrue
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      8. Evidence.language
                      Definition

                      The base language in which the resource is written.

                      ShortLanguage of the resource content
                      Comments

                      Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).

                      Control0..1
                      BindingThe codes SHALL be taken from AllLanguages
                      (required to http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot3)

                      IETF language tag for a human language

                      Typecode
                      Is Modifierfalse
                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                      Must Supportfalse
                      Summaryfalse
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      10. Evidence.text
                      Definition

                      A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.

                      ShortText summary of the resource, for human interpretation
                      Comments

                      Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later.

                      Control0..1
                      This element is affected by the following invariants: dom-6
                      TypeNarrative
                      Is Modifierfalse
                      Must Supportfalse
                      Summaryfalse
                      Alternate Namesnarrative, html, xhtml, display
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      12. Evidence.contained
                      Definition

                      These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.

                      ShortContained, inline Resources
                      Comments

                      This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels. Contained resources may be a resource type defined in the FHIR specification, or an additional resource.

                      Control0..*
                      This element is affected by the following invariants: dom-2, dom-4, dom-3, dom-5
                      TypeResource
                      Is Modifierfalse
                      Must Supportfalse
                      Summaryfalse
                      Alternate Namesinline resources, anonymous resources, contained resources
                      14. Evidence.extension
                      Definition

                      An Extension

                      ShortExtension
                      Control0..*
                      TypeExtension
                      Is Modifierfalse
                      Must Supportfalse
                      Summaryfalse
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      SlicingThis element introduces a set of slices on Evidence.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                      • value @ url
                      • 16. Evidence.extension:publicationStatus
                        Slice NamepublicationStatus
                        Definition

                        The status of the processing for making the artifact publicly available, not necessarily the same as artifact status (Resource.status).

                        ShortPublication status
                        Control0..1
                        TypeExtension(ArtifactPublicationStatus) (Extension Type: CodeableConcept)
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                        18. Evidence.modifierExtension
                        Definition

                        May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                        ShortExtensions that cannot be ignored
                        Comments

                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                        Control0..*
                        TypeExtension
                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them
                        Must Supportfalse
                        Summarytrue
                        Requirements

                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                        Alternate Namesextensions, user content
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        20. Evidence.url
                        Definition

                        An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which an authoritative instance of this summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the summary is stored on different servers.

                        ShortCanonical identifier for this evidence, represented as a globally unique URI
                        Comments

                        In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found.

                        Control0..1
                        Typeuri
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Requirements

                        Allows the evidence to be referenced by a single globally unique identifier.

                        Invariantscnl-1: URL should not contain | or # - these characters make processing canonical references problematic (exists() implies matches('^[^|# ]+$'))
                        ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        22. Evidence.identifier
                        Definition

                        A formal identifier that is used to identify this summary when it is represented in other formats, or referenced in a specification, model, design or an instance.

                        ShortAdditional identifier for the summary
                        NoteThis is a business identifier, not a resource identifier (see discussion)
                        Control0..*
                        TypeIdentifier
                        Is Modifierfalse
                        Must Supportfalse
                        Summarytrue
                        Requirements

                        Allows externally provided and/or usable business identifiers to be easily associated with the module.

                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        24. Evidence.version
                        Definition

                        The identifier that is used to identify this version of the summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.

                        ShortBusiness version of this summary
                        Comments

                        The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions.

                        NoteThis is a business version Id, not a resource version Id (see discussion)
                        Control0..1
                        Typestring
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        26. Evidence.versionAlgorithm[x]
                        Definition

                        Indicates the mechanism used to compare versions to determine which is more current.

                        ShortHow to compare versions
                        Comments

                        If set as a string, this is a FHIRPath expression that has two additional context variables passed in - %version1 and %version2 and will return a negative number if version1 is newer, a positive number if version2 is newer, and a 0 if the version ordering can't successfully be determined.

                        Control0..1
                        BindingUnless not suitable, these codes SHALL be taken from VersionAlgorithm
                        (extensible to http://hl7.org/fhir/ValueSet/version-algorithm)
                        TypeChoice of: string, Coding
                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        28. Evidence.name
                        Definition

                        A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation.

                        ShortName for this summary (machine friendly)
                        Comments

                        The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly.

                        Control0..1
                        This element is affected by the following invariants: cnl-0
                        Typestring
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        30. Evidence.title
                        Definition

                        A short, descriptive, user-friendly title for the summary.

                        ShortName for this summary (human friendly)
                        Control0..1
                        Typestring
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        32. Evidence.citeAs
                        Definition

                        Display of the suggested method of how to cite this Evidence.

                        ShortDisplay of how to cite this Evidence
                        Control0..1
                        Typemarkdown
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        34. Evidence.status
                        Definition

                        The status of this summary. Enables tracking the life-cycle of the content.

                        Shortdraft | active | retired | unknown
                        Comments

                        Allows filtering of summaries that are appropriate for use versus not.

                        See guidance around (not) making local changes to elements here.

                        Control1..1
                        BindingThe codes SHALL be taken from PublicationStatus
                        (required to http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3)

                        The lifecycle status of an artifact.

                        Typecode
                        Is Modifiertrue because This is labeled as "Is Modifier" because applications should not use a retired Evidence without due consideration
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        36. Evidence.experimental
                        Definition

                        A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and no version of this resource will ever be intended for genuine usage.

                        ShortFor testing only - never for real usage
                        Comments

                        Allows filtering of artifacts that are appropriate for use versus not. Experimental resources might include example instances in implementation guides, instances created solely for testing purposes, etc. If experimental is 'true' for any version of a resource, it should be true for all versions of the resource. (If experimental changes, then it is being misused or a resource that was never intended for real-world use has unexpectedly changed its purpose.).

                        Experimental resources are not expected to be stable and may well have breaking changes without a corresponding change to the 'version' element.

                        Control0..1
                        Typeboolean
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Meaning if MissingIf absent, this resource is treated as though it is not experimental.
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        38. Evidence.date
                        Definition

                        The date (and optionally time) when the summary was last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the summary changes.

                        ShortDate last changed
                        Comments

                        The date is often not tracked until the resource is published, but may be present on draft content. Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the summary. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource.

                        See guidance around (not) making local changes to elements here.

                        Control0..1
                        TypedateTime
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Alternate NamesRevision Date
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        40. Evidence.approvalDate
                        Definition

                        The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.

                        ShortWhen the summary was approved by publisher
                        Comments

                        The 'date' element may be more recent than the approval date because of minor changes or editorial corrections.

                        See guidance around (not) making local changes to elements here.

                        Control0..1
                        Typedate
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        42. Evidence.lastReviewDate
                        Definition

                        The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.

                        ShortWhen the summary was last reviewed by the publisher
                        Comments

                        If specified, this date follows the original approval date.

                        See guidance around (not) making local changes to elements here.

                        Control0..1
                        Typedate
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Requirements

                        Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant.

                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        44. Evidence.author
                        Definition

                        An individiual, organization, or device primarily involved in the creation and maintenance of the content.

                        ShortWho authored the content
                        Comments

                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        46. Evidence.publisher
                        Definition

                        The name of the organization or individual responsible for the release and ongoing maintenance of the evidence.

                        ShortName of the publisher/steward (organization or individual)
                        Comments

                        Usually an organization but may be an individual. The publisher (or steward) of the evidence is the organization or individual primarily responsible for the maintenance and upkeep of the evidence. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence. This item SHOULD be populated unless the information is available from context.

                        Control0..1
                        Typestring
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Requirements

                        Helps establish the "authority/credibility" of the evidence. May also allow for contact.

                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        48. Evidence.contact
                        Definition

                        Contact details to assist a user in finding and communicating with the publisher.

                        ShortContact details for the publisher
                        Comments

                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                        See guidance around (not) making local changes to elements here.

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        50. Evidence.recorder
                        Definition

                        Who entered the data for the evidence.

                        ShortWho entered the data for the evidence
                        Comments

                        The Evidence.recorder element is structured to support a name (with a string datatype) and contact point information for the recorder, and is not structured to support unique identifiers for the recorder. If detailed contributorship data is needed, then one can create a Citation Resource for the Evidence Resource.

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        52. Evidence.editor
                        Definition

                        An individiual, organization, or device primarily responsible for internal coherence of the content.

                        ShortWho edited the content
                        Comments

                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        54. Evidence.reviewer
                        Definition

                        An individiual, organization, or device primarily responsible for review of some aspect of the content.

                        ShortWho reviewed the content
                        Comments

                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                        See guidance around (not) making local changes to elements here.

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        56. Evidence.endorser
                        Definition

                        An individiual, organization, or device responsible for officially endorsing the content for use in some setting.

                        ShortWho endorsed the content
                        Comments

                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                        See guidance around (not) making local changes to elements here.

                        Control0..*
                        TypeContactDetail
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        58. Evidence.useContext
                        Definition

                        The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances.

                        ShortThe context that the content is intended to support
                        Comments

                        When multiple useContexts are specified, there is no expectation that all or any of the contexts apply.

                        Control0..*
                        TypeUsageContext
                        Is Modifierfalse
                        Must Supportfalse
                        Summarytrue
                        Requirements

                        Assist in searching for appropriate content.

                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        60. Evidence.purpose
                        Definition

                        Explanation of why this Evidence is needed and why it has been designed as it has.

                        ShortWhy this Evidence is defined
                        Comments

                        This element does not describe the usage of the Evidence. Instead, it provides traceability of ''why'' the resource is either needed or ''why'' it is defined as it is. This may be used to point to source materials or specifications that drove the structure of this Evidence.

                        Control0..1
                        Typemarkdown
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        62. Evidence.copyright
                        Definition

                        A copyright statement relating to the Evidence and/or its contents. Copyright statements are legal notices of intellectual property ownership and may include restrictions on the use and publishing of the Evidence.

                        ShortIntellectual property ownership, may include restrictions on use
                        Comments

                        The short copyright declaration (e.g. (c) '2015+ xyz organization' should be sent in the copyrightLabel element.

                        Control0..1
                        Typemarkdown
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Requirements

                        Consumers must be able to determine any legal restrictions on the use of the Evidence and/or its content.

                        Alternate NamesLicense, Restrictions
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        64. Evidence.copyrightLabel
                        Definition

                        A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are restricted. (e.g. 'All rights reserved', 'Some rights reserved').

                        ShortCopyright holder and year(s)
                        Comments

                        The (c) symbol should NOT be included in this string. It will be added by software when rendering the notation. Full details about licensing, restrictions, warrantees, etc. goes in the more general 'copyright' element.

                        Control0..1
                        Typestring
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Requirements

                        Defines the content expected to be rendered in all representations of the artifact.

                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        66. Evidence.relatesTo
                        Definition

                        Relationships that this Evidence has with other FHIR or non-FHIR resources that already exist.

                        ShortRelationships to other Resources
                        Control0..*
                        TypeBackboneElement
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                        68. Evidence.relatesTo.id
                        Definition

                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                        ShortUnique id for inter-element referencing
                        Control0..1
                        This element is affected by the following invariants: ele-1
                        Typestring
                        Is Modifierfalse
                        XML FormatIn the XML format, this property is represented as an attribute.
                        Summaryfalse
                        70. Evidence.relatesTo.extension
                        Definition

                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                        ShortAdditional content defined by implementations
                        Comments

                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                        Control0..*
                        TypeExtension
                        Is Modifierfalse
                        Summaryfalse
                        Alternate Namesextensions, user content
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        72. Evidence.relatesTo.modifierExtension
                        Definition

                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                        ShortExtensions that cannot be ignored even if unrecognized
                        Comments

                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                        Control0..*
                        TypeExtension
                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                        Summarytrue
                        Requirements

                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                        Alternate Namesextensions, user content, modifiers
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        74. Evidence.relatesTo.type
                        Definition

                        The type of relationship to the related artifact.

                        Shortdocumentation | justification | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | specification-of | created-with | cite-as | summarizes
                        Control1..1
                        BindingThe codes SHALL be taken from ArtifactRelationshipType
                        (required to http://hl7.org/fhir/ValueSet/artifact-relationship-type|6.0.0-ballot3)

                        The type of relationship to the related artifact.

                        Typecode
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        76. Evidence.relatesTo.target[x]
                        Definition

                        The artifact that is related to this Evidence Resource.

                        ShortThe artifact that is related to this Evidence
                        Control1..1
                        TypeChoice of: uri, Attachment, canonical(Resource), Reference(Resource), markdown
                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        78. Evidence.description
                        Definition

                        A natural language summary of the evidence.

                        ShortDescription of the particular summary
                        Comments

                        This description can be used to capture details such as comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence is presumed to be the predominant language in the place the evidence was created).

                        Control0..1
                        Typemarkdown
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        80. Evidence.assertion
                        Definition

                        Declarative description of the Evidence, such as conclusion or bottom line statement.

                        ShortDeclarative description of the Evidence
                        Control0..1
                        Typemarkdown
                        Is Modifierfalse
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        82. Evidence.note
                        Definition

                        Footnotes and/or explanatory notes.

                        ShortFootnotes and/or explanatory notes
                        Control0..*
                        TypeAnnotation
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        84. Evidence.variableDefinition
                        Definition

                        Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

                        ShortDescription, classification, and definition of a single variable
                        Comments

                        Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

                        Control3..*
                        TypeBackboneElement
                        Is Modifierfalse
                        Must Supportfalse
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                        SlicingThis element introduces a set of slices on Evidence.variableDefinition. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                        • value @ variableRole
                        • 86. Evidence.variableDefinition.id
                          Definition

                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                          ShortUnique id for inter-element referencing
                          Control0..1
                          This element is affected by the following invariants: ele-1
                          Typestring
                          Is Modifierfalse
                          XML FormatIn the XML format, this property is represented as an attribute.
                          Summaryfalse
                          88. Evidence.variableDefinition.extension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                          ShortAdditional content defined by implementations
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifierfalse
                          Summaryfalse
                          Alternate Namesextensions, user content
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          90. Evidence.variableDefinition.modifierExtension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                          ShortExtensions that cannot be ignored even if unrecognized
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                          Summarytrue
                          Requirements

                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                          Alternate Namesextensions, user content, modifiers
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          92. Evidence.variableDefinition.description
                          Definition

                          A text description or summary of the variable.

                          ShortA text description or summary of the variable
                          Control0..1
                          Typemarkdown
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          94. Evidence.variableDefinition.note
                          Definition

                          Footnotes and/or explanatory notes.

                          ShortFootnotes and/or explanatory notes
                          Control0..*
                          TypeAnnotation
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          96. Evidence.variableDefinition.variableRole
                          Definition

                          Classification of the role of the variable.

                          Shortpopulation | exposure | outcome | covariate
                          Control1..1
                          BindingThe codes SHALL be taken from EvidenceVariableRole
                          (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

                          The role that the variable plays.

                          Typecode
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summarytrue
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          98. Evidence.variableDefinition.roleSubtype
                          Definition

                          Sub-classification of the role of the variable.

                          ShortSub-classification of the role of the variable
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRoleSubtype
                          (extensible to http://hl7.org/fhir/ValueSet/variable-role-subtype)

                          The sub-role that the variable plays.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          100. Evidence.variableDefinition.comparatorCategory
                          Definition

                          The reference value used for comparison.

                          ShortThe reference value used for comparison
                          Comments

                          Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                          Control0..1
                          Typestring
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          102. Evidence.variableDefinition.observed
                          Definition

                          Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

                          ShortDefinition of the actual variable related to the statistic(s)
                          Control0..1
                          TypeReference(Group, EvidenceVariable)
                          Is Modifierfalse
                          Must Supportfalse
                          Summarytrue
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          104. Evidence.variableDefinition.intended
                          Definition

                          Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

                          ShortDefinition of the intended variable related to the Evidence
                          Control0..1
                          TypeReference(Group, EvidenceVariable)
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          106. Evidence.variableDefinition.directnessMatch
                          Definition

                          Indication of quality of match between intended variable to actual variable.

                          Shortlow | moderate | high | exact
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                          (extensible to http://terminology.hl7.org/ValueSet/directness)

                          The quality of how direct the match is.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          108. Evidence.variableDefinition:population
                          Slice Namepopulation
                          Definition

                          Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

                          ShortDescription, classification, and definition of a single variable
                          Comments

                          Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

                          Control1..1
                          TypeBackboneElement
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                          110. Evidence.variableDefinition:population.id
                          Definition

                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                          ShortUnique id for inter-element referencing
                          Control0..1
                          This element is affected by the following invariants: ele-1
                          Typestring
                          Is Modifierfalse
                          XML FormatIn the XML format, this property is represented as an attribute.
                          Summaryfalse
                          112. Evidence.variableDefinition:population.extension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                          ShortAdditional content defined by implementations
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifierfalse
                          Summaryfalse
                          Alternate Namesextensions, user content
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          114. Evidence.variableDefinition:population.modifierExtension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                          ShortExtensions that cannot be ignored even if unrecognized
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                          Summarytrue
                          Requirements

                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                          Alternate Namesextensions, user content, modifiers
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          116. Evidence.variableDefinition:population.description
                          Definition

                          A text description or summary of the variable.

                          ShortA text description or summary of the variable
                          Control0..1
                          Typemarkdown
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          118. Evidence.variableDefinition:population.note
                          Definition

                          Footnotes and/or explanatory notes.

                          ShortFootnotes and/or explanatory notes
                          Control0..*
                          TypeAnnotation
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          120. Evidence.variableDefinition:population.variableRole
                          Definition

                          Classification of the role of the variable.

                          Shortpopulation | exposure | outcome | covariate
                          Control1..1
                          BindingThe codes SHALL be taken from EvidenceVariableRole
                          (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

                          The role that the variable plays.

                          Typecode
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summarytrue
                          Pattern Valuepopulation
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          122. Evidence.variableDefinition:population.roleSubtype
                          Definition

                          Sub-classification of the role of the variable.

                          ShortSub-classification of the role of the variable
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRoleSubtype
                          (extensible to http://hl7.org/fhir/ValueSet/variable-role-subtype)

                          The sub-role that the variable plays.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          124. Evidence.variableDefinition:population.comparatorCategory
                          Definition

                          The reference value used for comparison.

                          ShortThe reference value used for comparison
                          Comments

                          Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                          Control0..1
                          Typestring
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          126. Evidence.variableDefinition:population.observed
                          Definition

                          Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

                          ShortDefinition of the actual variable related to the statistic(s)
                          Control0..1
                          TypeReference(Group, EvidenceVariable)
                          Is Modifierfalse
                          Must Supportfalse
                          Summarytrue
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          128. Evidence.variableDefinition:population.intended
                          Definition

                          Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

                          ShortDefinition of the intended variable related to the Evidence
                          Control0..1
                          TypeReference(Group, EvidenceVariable)
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          130. Evidence.variableDefinition:population.directnessMatch
                          Definition

                          Indication of quality of match between intended variable to actual variable.

                          Shortlow | moderate | high | exact
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                          (extensible to http://terminology.hl7.org/ValueSet/directness)

                          The quality of how direct the match is.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          132. Evidence.variableDefinition:exposure
                          Slice Nameexposure
                          Definition

                          Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

                          ShortDescription, classification, and definition of a single variable
                          Comments

                          Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

                          Control1..1
                          TypeBackboneElement
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                          134. Evidence.variableDefinition:exposure.id
                          Definition

                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                          ShortUnique id for inter-element referencing
                          Control0..1
                          This element is affected by the following invariants: ele-1
                          Typestring
                          Is Modifierfalse
                          XML FormatIn the XML format, this property is represented as an attribute.
                          Summaryfalse
                          136. Evidence.variableDefinition:exposure.extension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                          ShortAdditional content defined by implementations
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifierfalse
                          Summaryfalse
                          Alternate Namesextensions, user content
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          138. Evidence.variableDefinition:exposure.modifierExtension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                          ShortExtensions that cannot be ignored even if unrecognized
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                          Summarytrue
                          Requirements

                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                          Alternate Namesextensions, user content, modifiers
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          140. Evidence.variableDefinition:exposure.description
                          Definition

                          A text description or summary of the variable.

                          ShortA text description or summary of the variable
                          Control0..1
                          Typemarkdown
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          142. Evidence.variableDefinition:exposure.note
                          Definition

                          Footnotes and/or explanatory notes.

                          ShortFootnotes and/or explanatory notes
                          Control0..*
                          TypeAnnotation
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          144. Evidence.variableDefinition:exposure.variableRole
                          Definition

                          Classification of the role of the variable.

                          Shortpopulation | exposure | outcome | covariate
                          Control1..1
                          BindingThe codes SHALL be taken from EvidenceVariableRole
                          (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

                          The role that the variable plays.

                          Typecode
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summarytrue
                          Pattern Valueexposure
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          146. Evidence.variableDefinition:exposure.roleSubtype
                          Definition

                          Sub-classification of the role of the variable.

                          ShortSub-classification of the role of the variable
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRoleSubtype
                          (extensible to http://hl7.org/fhir/ValueSet/variable-role-subtype)

                          The sub-role that the variable plays.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          148. Evidence.variableDefinition:exposure.comparatorCategory
                          Definition

                          The reference value used for comparison.

                          ShortThe reference value used for comparison
                          Comments

                          Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                          Control1..1
                          Typestring
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          150. Evidence.variableDefinition:exposure.observed
                          Definition

                          Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

                          ShortDefinition of the actual variable related to the statistic(s)
                          Control0..1
                          TypeReference(GroupAssignment)
                          Is Modifierfalse
                          Must Supportfalse
                          Summarytrue
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          152. Evidence.variableDefinition:exposure.intended
                          Definition

                          Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

                          ShortDefinition of the intended variable related to the Evidence
                          Control0..1
                          TypeReference(GroupAssignment)
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          154. Evidence.variableDefinition:exposure.directnessMatch
                          Definition

                          Indication of quality of match between intended variable to actual variable.

                          Shortlow | moderate | high | exact
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                          (extensible to http://terminology.hl7.org/ValueSet/directness)

                          The quality of how direct the match is.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          156. Evidence.variableDefinition:outcome
                          Slice Nameoutcome
                          Definition

                          Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about.

                          ShortDescription, classification, and definition of a single variable
                          Comments

                          Comparative evidence is often defined with a population variable, an exposure variable and an outcome variable, while non comparative evidence is often defined with a population variable and an outcome variable.

                          Control1..1
                          TypeBackboneElement
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                          158. Evidence.variableDefinition:outcome.id
                          Definition

                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                          ShortUnique id for inter-element referencing
                          Control0..1
                          This element is affected by the following invariants: ele-1
                          Typestring
                          Is Modifierfalse
                          XML FormatIn the XML format, this property is represented as an attribute.
                          Summaryfalse
                          160. Evidence.variableDefinition:outcome.extension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                          ShortAdditional content defined by implementations
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifierfalse
                          Summaryfalse
                          Alternate Namesextensions, user content
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          162. Evidence.variableDefinition:outcome.modifierExtension
                          Definition

                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                          ShortExtensions that cannot be ignored even if unrecognized
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..*
                          TypeExtension
                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                          Summarytrue
                          Requirements

                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                          Alternate Namesextensions, user content, modifiers
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          164. Evidence.variableDefinition:outcome.description
                          Definition

                          A text description or summary of the variable.

                          ShortA text description or summary of the variable
                          Control0..1
                          Typemarkdown
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          166. Evidence.variableDefinition:outcome.note
                          Definition

                          Footnotes and/or explanatory notes.

                          ShortFootnotes and/or explanatory notes
                          Control0..*
                          TypeAnnotation
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          168. Evidence.variableDefinition:outcome.variableRole
                          Definition

                          Classification of the role of the variable.

                          Shortpopulation | exposure | outcome | covariate
                          Control1..1
                          BindingThe codes SHALL be taken from EvidenceVariableRole
                          (required to http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3)

                          The role that the variable plays.

                          Typecode
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summarytrue
                          Pattern Valueoutcome
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          170. Evidence.variableDefinition:outcome.roleSubtype
                          Definition

                          Sub-classification of the role of the variable.

                          ShortSub-classification of the role of the variable
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRoleSubtype
                          (extensible to http://hl7.org/fhir/ValueSet/variable-role-subtype)

                          The sub-role that the variable plays.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          172. Evidence.variableDefinition:outcome.comparatorCategory
                          Definition

                          The reference value used for comparison.

                          ShortThe reference value used for comparison
                          Comments

                          Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                          Control0..1
                          Typestring
                          Is Modifierfalse
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          174. Evidence.variableDefinition:outcome.observed
                          Definition

                          Definition of the actual variable related to the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in the study.

                          ShortDefinition of the actual variable related to the statistic(s)
                          Control0..1
                          TypeReference(NetEffectContributions)
                          Is Modifierfalse
                          Must Supportfalse
                          Summarytrue
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          176. Evidence.variableDefinition:outcome.intended
                          Definition

                          Definition of the intended variable related to the Evidence, i.e., the population, exposure, or outcome for which the statistical finding is being interpreted.

                          ShortDefinition of the intended variable related to the Evidence
                          Control0..0
                          TypeReference(Group, EvidenceVariable)
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          178. Evidence.variableDefinition:outcome.directnessMatch
                          Definition

                          Indication of quality of match between intended variable to actual variable.

                          Shortlow | moderate | high | exact
                          Control0..1
                          BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                          (extensible to http://terminology.hl7.org/ValueSet/directness)

                          The quality of how direct the match is.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          180. Evidence.synthesisType
                          Definition

                          The design of the synthesis (combination of studies) that produced this evidence. The design is described with any number of synthesis characteristics, such as type of meta-analysis.

                          ShortThe design of the synthesis (combination of studies) that produced this evidence
                          Control0..*
                          BindingUnless not suitable, these codes SHALL be taken from StatisticSynthesisType
                          (extensible to http://terminology.hl7.org/ValueSet/synthesis-type)

                          Types of combining results from a body of evidence (e.g. summary data meta-analysis).

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          182. Evidence.studyDesign
                          Definition

                          The design of the study that produced this evidence. The design is described with any number of study design characteristics.

                          ShortThe design of the study that produced this evidence
                          Control0..*
                          BindingUnless not suitable, these codes SHALL be taken from StudyDesign
                          (extensible to http://hl7.org/fhir/ValueSet/study-design)

                          This is a set of terms for study design characteristics.

                          TypeCodeableConcept
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          184. Evidence.statistic
                          Definition

                          Values and parameters for a single statistic.

                          ShortValues and parameters for a single statistic
                          Control1..*
                          TypeBackboneElement
                          Is Modifierfalse
                          Must Supportfalse
                          Summaryfalse
                          Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                          SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                          • value @ statisticType.coding
                          • 186. Evidence.statistic.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            188. Evidence.statistic.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            190. Evidence.statistic.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            192. Evidence.statistic.description
                            Definition

                            A natural language summary of the statistic.

                            ShortA natural language summary of the statistic
                            Control0..1
                            Typemarkdown
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            194. Evidence.statistic.note
                            Definition

                            Footnotes and/or explanatory notes.

                            ShortFootnotes and/or explanatory notes
                            Control0..*
                            TypeAnnotation
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            196. Evidence.statistic.statisticType
                            Definition

                            Type of statistic, e.g., relative risk. The statistic type is a classification that formally defines the relationship between the variables (noted in Evidence.variableDefinition) and the value specification (noted in Evidence.statistic.quantity).

                            ShortType of statistic, e.g., relative risk
                            Control0..1
                            BindingUnless not suitable, these codes SHALL be taken from StatisticType
                            (extensible to http://hl7.org/fhir/ValueSet/statistic-type)
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summarytrue
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            198. Evidence.statistic.category
                            Definition

                            When the measured variable (outcome) is handled categorically, the category element is used to define which category the statistic is reporting.

                            ShortAssociated category for categorical variable
                            Comments

                            Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=outcome].observed=Reference(EvidenceVariable) could facilitate validation within datasets.

                            Control0..1
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            200. Evidence.statistic.quantity
                            Definition

                            Statistic value.

                            ShortStatistic value
                            Control0..1
                            TypeQuantity
                            Is Modifierfalse
                            Must Supportfalse
                            Summarytrue
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            202. Evidence.statistic.numberOfEvents
                            Definition

                            The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                            ShortThe number of events associated with the statistic
                            Comments

                            When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.

                            Control0..1
                            TypeunsignedInt
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            204. Evidence.statistic.numberAffected
                            Definition

                            The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                            ShortThe number of participants affected
                            Comments

                            When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.

                            Control0..1
                            TypeunsignedInt
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            206. Evidence.statistic.sampleSize
                            Definition

                            Count of participants in the study sample.

                            ShortCount of participants in the study sample
                            Control0..1
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                            208. Evidence.statistic.sampleSize.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            210. Evidence.statistic.sampleSize.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            212. Evidence.statistic.sampleSize.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            214. Evidence.statistic.sampleSize.description
                            Definition

                            Human-readable summary of study sample size. A human-readable string to clarify or explain concepts about the sample size.

                            ShortTextual description of sample size for statistic
                            Control0..1
                            Typemarkdown
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            216. Evidence.statistic.sampleSize.note
                            Definition

                            Footnote or explanatory note about the sample size.

                            ShortFootnote or explanatory note about the sample size
                            Control0..*
                            TypeAnnotation
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            218. Evidence.statistic.sampleSize.numberOfStudies
                            Definition

                            Count of studies or samples combined to become the total sample for the statistic.

                            ShortNumber of contributing studies
                            Control0..1
                            TypeunsignedInt
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            220. Evidence.statistic.sampleSize.numberOfParticipants
                            Definition

                            Count of members in the total sample for the statistic.

                            ShortTotal number of participants
                            Control0..1
                            TypeunsignedInt
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            222. Evidence.statistic.sampleSize.knownDataCount
                            Definition

                            Number of participants with known results for measured variables.

                            ShortNumber of participants with known results for measured variables
                            Control0..1
                            TypeunsignedInt
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            224. Evidence.statistic.attributeEstimate
                            Definition

                            A statistical attribute of the statistic such as a measure of heterogeneity.

                            ShortAn attribute of the Statistic
                            Control0..*
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                            226. Evidence.statistic.attributeEstimate.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            228. Evidence.statistic.attributeEstimate.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            230. Evidence.statistic.attributeEstimate.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            232. Evidence.statistic.attributeEstimate.description
                            Definition

                            Human-readable summary of the estimate.

                            ShortTextual description of the attribute estimate
                            Control0..1
                            Typemarkdown
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            234. Evidence.statistic.attributeEstimate.note
                            Definition

                            Footnote or explanatory note about the estimate.

                            ShortFootnote or explanatory note about the estimate
                            Control0..*
                            TypeAnnotation
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            236. Evidence.statistic.attributeEstimate.type
                            Definition

                            The type of attribute estimate, e.g., confidence interval or p value.

                            ShortThe type of attribute estimate, e.g., confidence interval or p value
                            Control0..1
                            BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                            (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            238. Evidence.statistic.attributeEstimate.quantity
                            Definition

                            The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure.

                            ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
                            Comments

                            Often the p value

                            Control0..1
                            TypeQuantity
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            240. Evidence.statistic.attributeEstimate.level
                            Definition

                            Use 0.95 for a 95% confidence interval.

                            ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                            Control0..1
                            Typedecimal
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            242. Evidence.statistic.attributeEstimate.range
                            Definition

                            Lower and upper bound values of the attribute estimate.

                            ShortLower and upper bound values of the attribute estimate
                            Control0..1
                            TypeRange
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            244. Evidence.statistic.attributeEstimate.attributeEstimate
                            Definition

                            A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                            ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                            Comments

                            A nested attribute estimate; which is the attribute estimate of an attribute estimate

                            Control0..*
                            TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            246. Evidence.statistic.modelCharacteristic
                            Definition

                            A component of the method to generate the statistic.

                            ShortAn aspect of the statistical model
                            Control0..*
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                            248. Evidence.statistic.modelCharacteristic.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            250. Evidence.statistic.modelCharacteristic.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            252. Evidence.statistic.modelCharacteristic.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            254. Evidence.statistic.modelCharacteristic.code
                            Definition

                            Description of a component of the method to generate the statistic.

                            ShortModel specification
                            Control1..1
                            BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                            (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            256. Evidence.statistic.modelCharacteristic.value[x]
                            Definition

                            Further specification of the value of the component of the method to generate the statistic.

                            ShortThe specific value (when paired with code)
                            Control0..1
                            TypeChoice of: Quantity(SimpleQuantity), Range, CodeableConcept
                            [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            258. Evidence.statistic.modelCharacteristic.intended
                            Definition

                            The plan for analysis.

                            ShortThe plan for analysis
                            Control0..1
                            Typeboolean
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            260. Evidence.statistic.modelCharacteristic.applied
                            Definition

                            This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan.

                            ShortThis model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
                            Control0..1
                            Typeboolean
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Meaning if MissingTrue, unless modelCharacteristic.intended = true; if modelCharacteristic.intended = true and .applied is missing, then meaning Unknown.
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            262. Evidence.statistic.modelCharacteristic.variable
                            Definition

                            A variable adjusted for in the adjusted analysis.

                            ShortA variable adjusted for in the adjusted analysis
                            Control0..*
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                            264. Evidence.statistic.modelCharacteristic.variable.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            266. Evidence.statistic.modelCharacteristic.variable.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            268. Evidence.statistic.modelCharacteristic.variable.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            270. Evidence.statistic.modelCharacteristic.variable.variableDefinition
                            Definition

                            Description and definition of the variable.

                            ShortDescription and definition of the variable
                            Control1..1
                            TypeReference(Group, EvidenceVariable)
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            272. Evidence.statistic.modelCharacteristic.variable.handling
                            Definition

                            How the variable is classified for use in adjusted analysis.

                            Shortboolean | continuous | dichotomous | ordinal | polychotomous | extension
                            Control0..1
                            BindingThe codes SHALL be taken from EvidenceVariableHandling
                            (required to http://hl7.org/fhir/ValueSet/variable-handling|6.0.0-ballot3)
                            Typecode
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            274. Evidence.statistic.modelCharacteristic.variable.valueCategory
                            Definition

                            Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                            ShortQualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                            Control0..*
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            276. Evidence.statistic.modelCharacteristic.variable.valueQuantity
                            Definition

                            Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                            ShortQuantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                            Control0..*
                            TypeQuantity
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            278. Evidence.statistic.modelCharacteristic.variable.valueRange
                            Definition

                            Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                            ShortRange of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
                            Control0..*
                            TypeRange
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            280. Evidence.statistic.modelCharacteristic.attribute
                            Definition

                            An attribute of the model characteristic.

                            ShortAn attribute of the model characteristic
                            Control0..*
                            TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            282. Evidence.statistic:netEffect
                            Slice NamenetEffect
                            Definition

                            Values and parameters for a single statistic.

                            ShortValues and parameters for a single statistic
                            Control1..1
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supporttrue
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                            284. Evidence.statistic:netEffect.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typestring
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            286. Evidence.statistic:netEffect.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            288. Evidence.statistic:netEffect.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            290. Evidence.statistic:netEffect.description
                            Definition

                            A natural language summary of the statistic.

                            ShortA natural language summary of the statistic
                            Control0..1
                            Typemarkdown
                            Is Modifierfalse
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            292. Evidence.statistic:netEffect.note
                            Definition

                            Footnotes and/or explanatory notes.

                            ShortFootnotes and/or explanatory notes
                            Control0..*
                            TypeAnnotation
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            294. Evidence.statistic:netEffect.statisticType
                            Definition

                            Type of statistic, e.g., relative risk. The statistic type is a classification that formally defines the relationship between the variables (noted in Evidence.variableDefinition) and the value specification (noted in Evidence.statistic.quantity).

                            ShortType of statistic, e.g., relative risk
                            Control0..1
                            BindingUnless not suitable, these codes SHALL be taken from StatisticType
                            (extensible to http://hl7.org/fhir/ValueSet/statistic-type)
                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summarytrue
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            296. Evidence.statistic:netEffect.statisticType.id
                            Definition

                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                            ShortUnique id for inter-element referencing
                            Control0..1
                            This element is affected by the following invariants: ele-1
                            Typeid
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            298. Evidence.statistic:netEffect.statisticType.extension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            SlicingThis element introduces a set of slices on Evidence.statistic.statisticType.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                            • value @ url
                            • 300. Evidence.statistic:netEffect.statisticType.coding
                              Definition

                              A reference to a code defined by a terminology system.

                              ShortCode defined by a terminology system
                              Comments

                              Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                              Control1..1
                              TypeCoding
                              Is Modifierfalse
                              Summaryfalse
                              Requirements

                              Allows for alternative encodings within a code system, and translations to other code systems.

                              Pattern Value{
                                "system" : "https://fevir.net/sevco",
                                "code" : "STATO:0000424",
                                "display" : "risk difference"
                              }
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              302. Evidence.statistic:netEffect.statisticType.text
                              Definition

                              A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                              ShortPlain text representation of the concept
                              Comments

                              Very often the text is the same as a displayName of one of the codings.

                              Control0..1
                              Typestring
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Summaryfalse
                              Requirements

                              The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              304. Evidence.statistic:netEffect.category
                              Definition

                              When the measured variable (outcome) is handled categorically, the category element is used to define which category the statistic is reporting.

                              ShortAssociated category for categorical variable
                              Comments

                              Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=outcome].observed=Reference(EvidenceVariable) could facilitate validation within datasets.

                              Control0..1
                              TypeCodeableConcept
                              Is Modifierfalse
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              306. Evidence.statistic:netEffect.quantity
                              Definition

                              Statistic value.

                              ShortStatistic value
                              Control0..1
                              TypeQuantity
                              Is Modifierfalse
                              Must Supportfalse
                              Summarytrue
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              308. Evidence.statistic:netEffect.numberOfEvents
                              Definition

                              The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                              ShortThe number of events associated with the statistic
                              Comments

                              When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.

                              Control0..1
                              TypeunsignedInt
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              310. Evidence.statistic:netEffect.numberAffected
                              Definition

                              The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                              ShortThe number of participants affected
                              Comments

                              When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.

                              Control0..1
                              TypeunsignedInt
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              312. Evidence.statistic:netEffect.sampleSize
                              Definition

                              Count of participants in the study sample.

                              ShortCount of participants in the study sample
                              Control0..1
                              TypeBackboneElement
                              Is Modifierfalse
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                              314. Evidence.statistic:netEffect.sampleSize.id
                              Definition

                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                              ShortUnique id for inter-element referencing
                              Control0..1
                              This element is affected by the following invariants: ele-1
                              Typestring
                              Is Modifierfalse
                              XML FormatIn the XML format, this property is represented as an attribute.
                              Summaryfalse
                              316. Evidence.statistic:netEffect.sampleSize.extension
                              Definition

                              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                              ShortAdditional content defined by implementations
                              Comments

                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                              Control0..*
                              TypeExtension
                              Is Modifierfalse
                              Summaryfalse
                              Alternate Namesextensions, user content
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              318. Evidence.statistic:netEffect.sampleSize.modifierExtension
                              Definition

                              May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                              Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                              ShortExtensions that cannot be ignored even if unrecognized
                              Comments

                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                              Control0..*
                              TypeExtension
                              Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                              Summarytrue
                              Requirements

                              Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                              Alternate Namesextensions, user content, modifiers
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              320. Evidence.statistic:netEffect.sampleSize.description
                              Definition

                              Human-readable summary of study sample size. A human-readable string to clarify or explain concepts about the sample size.

                              ShortTextual description of sample size for statistic
                              Control0..1
                              Typemarkdown
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              322. Evidence.statistic:netEffect.sampleSize.note
                              Definition

                              Footnote or explanatory note about the sample size.

                              ShortFootnote or explanatory note about the sample size
                              Control0..*
                              TypeAnnotation
                              Is Modifierfalse
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              324. Evidence.statistic:netEffect.sampleSize.numberOfStudies
                              Definition

                              Count of studies or samples combined to become the total sample for the statistic.

                              ShortNumber of contributing studies
                              Control0..1
                              TypeunsignedInt
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              326. Evidence.statistic:netEffect.sampleSize.numberOfParticipants
                              Definition

                              Count of members in the total sample for the statistic.

                              ShortTotal number of participants
                              Control0..1
                              TypeunsignedInt
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              328. Evidence.statistic:netEffect.sampleSize.knownDataCount
                              Definition

                              Number of participants with known results for measured variables.

                              ShortNumber of participants with known results for measured variables
                              Control0..1
                              TypeunsignedInt
                              Is Modifierfalse
                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              330. Evidence.statistic:netEffect.attributeEstimate
                              Definition

                              A statistical attribute of the statistic such as a measure of heterogeneity.

                              ShortAn attribute of the Statistic
                              Control0..*
                              TypeBackboneElement
                              Is Modifierfalse
                              Must Supportfalse
                              Summaryfalse
                              Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                              SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                              • value @ type.coding
                              • 332. Evidence.statistic:netEffect.attributeEstimate.id
                                Definition

                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                ShortUnique id for inter-element referencing
                                Control0..1
                                This element is affected by the following invariants: ele-1
                                Typestring
                                Is Modifierfalse
                                XML FormatIn the XML format, this property is represented as an attribute.
                                Summaryfalse
                                334. Evidence.statistic:netEffect.attributeEstimate.extension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                ShortAdditional content defined by implementations
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifierfalse
                                Summaryfalse
                                Alternate Namesextensions, user content
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                336. Evidence.statistic:netEffect.attributeEstimate.modifierExtension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                ShortExtensions that cannot be ignored even if unrecognized
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                Summarytrue
                                Requirements

                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                Alternate Namesextensions, user content, modifiers
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                338. Evidence.statistic:netEffect.attributeEstimate.description
                                Definition

                                Human-readable summary of the estimate.

                                ShortTextual description of the attribute estimate
                                Control0..1
                                Typemarkdown
                                Is Modifierfalse
                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                340. Evidence.statistic:netEffect.attributeEstimate.note
                                Definition

                                Footnote or explanatory note about the estimate.

                                ShortFootnote or explanatory note about the estimate
                                Control0..*
                                TypeAnnotation
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                342. Evidence.statistic:netEffect.attributeEstimate.type
                                Definition

                                The type of attribute estimate, e.g., confidence interval or p value.

                                ShortThe type of attribute estimate, e.g., confidence interval or p value
                                Control0..1
                                BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                TypeCodeableConcept
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                344. Evidence.statistic:netEffect.attributeEstimate.quantity
                                Definition

                                The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure.

                                ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
                                Comments

                                Often the p value

                                Control0..1
                                TypeQuantity
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                346. Evidence.statistic:netEffect.attributeEstimate.level
                                Definition

                                Use 0.95 for a 95% confidence interval.

                                ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                Control0..1
                                Typedecimal
                                Is Modifierfalse
                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                348. Evidence.statistic:netEffect.attributeEstimate.range
                                Definition

                                Lower and upper bound values of the attribute estimate.

                                ShortLower and upper bound values of the attribute estimate
                                Control0..1
                                TypeRange
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                350. Evidence.statistic:netEffect.attributeEstimate.attributeEstimate
                                Definition

                                A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                Comments

                                A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                Control0..*
                                TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                352. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
                                Slice NameconfidenceInterval
                                Definition

                                A statistical attribute of the statistic such as a measure of heterogeneity.

                                ShortAn attribute of the Statistic
                                Control0..*
                                TypeBackboneElement
                                Is Modifierfalse
                                Must Supporttrue
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                354. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.id
                                Definition

                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                ShortUnique id for inter-element referencing
                                Control0..1
                                This element is affected by the following invariants: ele-1
                                Typestring
                                Is Modifierfalse
                                XML FormatIn the XML format, this property is represented as an attribute.
                                Summaryfalse
                                356. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.extension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                ShortAdditional content defined by implementations
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifierfalse
                                Summaryfalse
                                Alternate Namesextensions, user content
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                358. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.modifierExtension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                ShortExtensions that cannot be ignored even if unrecognized
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                Summarytrue
                                Requirements

                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                Alternate Namesextensions, user content, modifiers
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                360. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.description
                                Definition

                                Human-readable summary of the estimate.

                                ShortTextual description of the attribute estimate
                                Control0..1
                                Typemarkdown
                                Is Modifierfalse
                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                362. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.note
                                Definition

                                Footnote or explanatory note about the estimate.

                                ShortFootnote or explanatory note about the estimate
                                Control0..*
                                TypeAnnotation
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                364. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type
                                Definition

                                The type of attribute estimate, e.g., confidence interval or p value.

                                ShortThe type of attribute estimate, e.g., confidence interval or p value
                                Control0..1
                                BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                TypeCodeableConcept
                                Is Modifierfalse
                                Must Supportfalse
                                Summaryfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                366. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.id
                                Definition

                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                ShortUnique id for inter-element referencing
                                Control0..1
                                This element is affected by the following invariants: ele-1
                                Typeid
                                Is Modifierfalse
                                XML FormatIn the XML format, this property is represented as an attribute.
                                Summaryfalse
                                368. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.extension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                ShortAdditional content defined by implementations
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifierfalse
                                Summaryfalse
                                Alternate Namesextensions, user content
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate.type.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                • value @ url
                                • 370. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.coding
                                  Definition

                                  A reference to a code defined by a terminology system.

                                  ShortCode defined by a terminology system
                                  Comments

                                  Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                  Control1..1
                                  TypeCoding
                                  Is Modifierfalse
                                  Summaryfalse
                                  Requirements

                                  Allows for alternative encodings within a code system, and translations to other code systems.

                                  Pattern Value{
                                    "system" : "https://fevir.net/sevco",
                                    "code" : "STATO:0000196",
                                    "display" : "confidence interval"
                                  }
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  372. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.text
                                  Definition

                                  A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                  ShortPlain text representation of the concept
                                  Comments

                                  Very often the text is the same as a displayName of one of the codings.

                                  Control0..1
                                  Typestring
                                  Is Modifierfalse
                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                  Summaryfalse
                                  Requirements

                                  The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  374. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.quantity
                                  Definition

                                  The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure.

                                  ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
                                  Comments

                                  Often the p value

                                  Control0..0
                                  TypeQuantity
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  376. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.level
                                  Definition

                                  Use 0.95 for a 95% confidence interval.

                                  ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                  Control1..1
                                  Typedecimal
                                  Is Modifierfalse
                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  378. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.range
                                  Definition

                                  Lower and upper bound values of the attribute estimate.

                                  ShortLower and upper bound values of the attribute estimate
                                  Control1..1
                                  TypeRange
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  380. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.attributeEstimate
                                  Definition

                                  A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                  ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                  Comments

                                  A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                  Control0..*
                                  TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  382. Evidence.statistic:netEffect.attributeEstimate:nnt
                                  Slice Namennt
                                  Definition

                                  A statistical attribute of the statistic such as a measure of heterogeneity.

                                  ShortAn attribute of the Statistic
                                  Control0..1
                                  TypeBackboneElement
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                  384. Evidence.statistic:netEffect.attributeEstimate:nnt.id
                                  Definition

                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                  ShortUnique id for inter-element referencing
                                  Control0..1
                                  This element is affected by the following invariants: ele-1
                                  Typestring
                                  Is Modifierfalse
                                  XML FormatIn the XML format, this property is represented as an attribute.
                                  Summaryfalse
                                  386. Evidence.statistic:netEffect.attributeEstimate:nnt.extension
                                  Definition

                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                  ShortAdditional content defined by implementations
                                  Comments

                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                  Control0..*
                                  TypeExtension
                                  Is Modifierfalse
                                  Summaryfalse
                                  Alternate Namesextensions, user content
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  388. Evidence.statistic:netEffect.attributeEstimate:nnt.modifierExtension
                                  Definition

                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                  ShortExtensions that cannot be ignored even if unrecognized
                                  Comments

                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                  Control0..*
                                  TypeExtension
                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                  Summarytrue
                                  Requirements

                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                  Alternate Namesextensions, user content, modifiers
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  390. Evidence.statistic:netEffect.attributeEstimate:nnt.description
                                  Definition

                                  Human-readable summary of the estimate.

                                  ShortTextual description of the attribute estimate
                                  Control0..1
                                  Typemarkdown
                                  Is Modifierfalse
                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  392. Evidence.statistic:netEffect.attributeEstimate:nnt.note
                                  Definition

                                  Footnote or explanatory note about the estimate.

                                  ShortFootnote or explanatory note about the estimate
                                  Control0..*
                                  TypeAnnotation
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  394. Evidence.statistic:netEffect.attributeEstimate:nnt.type
                                  Definition

                                  The type of attribute estimate, e.g., confidence interval or p value.

                                  ShortThe type of attribute estimate, e.g., confidence interval or p value
                                  Control0..1
                                  BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                  (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                  TypeCodeableConcept
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  396. Evidence.statistic:netEffect.attributeEstimate:nnt.type.id
                                  Definition

                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                  ShortUnique id for inter-element referencing
                                  Control0..1
                                  This element is affected by the following invariants: ele-1
                                  Typeid
                                  Is Modifierfalse
                                  XML FormatIn the XML format, this property is represented as an attribute.
                                  Summaryfalse
                                  398. Evidence.statistic:netEffect.attributeEstimate:nnt.type.extension
                                  Definition

                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                  ShortAdditional content defined by implementations
                                  Comments

                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                  Control0..*
                                  TypeExtension
                                  Is Modifierfalse
                                  Summaryfalse
                                  Alternate Namesextensions, user content
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate.type.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                  • value @ url
                                  • 400. Evidence.statistic:netEffect.attributeEstimate:nnt.type.coding
                                    Definition

                                    A reference to a code defined by a terminology system.

                                    ShortCode defined by a terminology system
                                    Comments

                                    Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                    Control1..1
                                    TypeCoding
                                    Is Modifierfalse
                                    Summaryfalse
                                    Requirements

                                    Allows for alternative encodings within a code system, and translations to other code systems.

                                    Pattern Value{
                                      "system" : "https://fevir.net/sevco",
                                      "code" : "STATO:0000635",
                                      "display" : "number needed to treat"
                                    }
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    402. Evidence.statistic:netEffect.attributeEstimate:nnt.type.text
                                    Definition

                                    A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                    ShortPlain text representation of the concept
                                    Comments

                                    Very often the text is the same as a displayName of one of the codings.

                                    Control0..1
                                    Typestring
                                    Is Modifierfalse
                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                    Summaryfalse
                                    Requirements

                                    The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                    Pattern ValueNumber needed to treat to prevent 1 composite importance-adjusted outcome
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    404. Evidence.statistic:netEffect.attributeEstimate:nnt.quantity
                                    Definition

                                    The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure.

                                    ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
                                    Comments

                                    Often the p value

                                    Control0..1
                                    TypeQuantity
                                    Is Modifierfalse
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    406. Evidence.statistic:netEffect.attributeEstimate:nnt.level
                                    Definition

                                    Use 0.95 for a 95% confidence interval.

                                    ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                    Control0..0
                                    Typedecimal
                                    Is Modifierfalse
                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    408. Evidence.statistic:netEffect.attributeEstimate:nnt.range
                                    Definition

                                    Lower and upper bound values of the attribute estimate.

                                    ShortLower and upper bound values of the attribute estimate
                                    Control0..1
                                    TypeRange
                                    Is Modifierfalse
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    410. Evidence.statistic:netEffect.attributeEstimate:nnt.attributeEstimate
                                    Definition

                                    A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                    ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                    Comments

                                    A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                    Control0..*
                                    TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                    Is Modifierfalse
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    412. Evidence.statistic:netEffect.modelCharacteristic
                                    Definition

                                    A component of the method to generate the statistic.

                                    ShortAn aspect of the statistical model
                                    Control1..*
                                    TypeBackboneElement
                                    Is Modifierfalse
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                    SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                    • value @ code.text
                                    • 414. Evidence.statistic:netEffect.modelCharacteristic.id
                                      Definition

                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                      ShortUnique id for inter-element referencing
                                      Control0..1
                                      This element is affected by the following invariants: ele-1
                                      Typestring
                                      Is Modifierfalse
                                      XML FormatIn the XML format, this property is represented as an attribute.
                                      Summaryfalse
                                      416. Evidence.statistic:netEffect.modelCharacteristic.extension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                      ShortAdditional content defined by implementations
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifierfalse
                                      Summaryfalse
                                      Alternate Namesextensions, user content
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      418. Evidence.statistic:netEffect.modelCharacteristic.modifierExtension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                      ShortExtensions that cannot be ignored even if unrecognized
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                      Summarytrue
                                      Requirements

                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                      Alternate Namesextensions, user content, modifiers
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      420. Evidence.statistic:netEffect.modelCharacteristic.code
                                      Definition

                                      Description of a component of the method to generate the statistic.

                                      ShortModel specification
                                      Control1..1
                                      BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                                      (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                      TypeCodeableConcept
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      422. Evidence.statistic:netEffect.modelCharacteristic.value[x]
                                      Definition

                                      Further specification of the value of the component of the method to generate the statistic.

                                      ShortThe specific value (when paired with code)
                                      Control0..1
                                      TypeChoice of: Quantity(SimpleQuantity), Range, CodeableConcept
                                      [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      424. Evidence.statistic:netEffect.modelCharacteristic.intended
                                      Definition

                                      The plan for analysis.

                                      ShortThe plan for analysis
                                      Control0..1
                                      Typeboolean
                                      Is Modifierfalse
                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      426. Evidence.statistic:netEffect.modelCharacteristic.applied
                                      Definition

                                      This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan.

                                      ShortThis model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
                                      Control0..1
                                      Typeboolean
                                      Is Modifierfalse
                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                      Must Supportfalse
                                      Summaryfalse
                                      Meaning if MissingTrue, unless modelCharacteristic.intended = true; if modelCharacteristic.intended = true and .applied is missing, then meaning Unknown.
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      428. Evidence.statistic:netEffect.modelCharacteristic.variable
                                      Definition

                                      A variable adjusted for in the adjusted analysis.

                                      ShortA variable adjusted for in the adjusted analysis
                                      Control0..*
                                      TypeBackboneElement
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                      430. Evidence.statistic:netEffect.modelCharacteristic.variable.id
                                      Definition

                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                      ShortUnique id for inter-element referencing
                                      Control0..1
                                      This element is affected by the following invariants: ele-1
                                      Typestring
                                      Is Modifierfalse
                                      XML FormatIn the XML format, this property is represented as an attribute.
                                      Summaryfalse
                                      432. Evidence.statistic:netEffect.modelCharacteristic.variable.extension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                      ShortAdditional content defined by implementations
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifierfalse
                                      Summaryfalse
                                      Alternate Namesextensions, user content
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      434. Evidence.statistic:netEffect.modelCharacteristic.variable.modifierExtension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                      ShortExtensions that cannot be ignored even if unrecognized
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                      Summarytrue
                                      Requirements

                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                      Alternate Namesextensions, user content, modifiers
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      436. Evidence.statistic:netEffect.modelCharacteristic.variable.variableDefinition
                                      Definition

                                      Description and definition of the variable.

                                      ShortDescription and definition of the variable
                                      Control1..1
                                      TypeReference(Group, EvidenceVariable)
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      438. Evidence.statistic:netEffect.modelCharacteristic.variable.handling
                                      Definition

                                      How the variable is classified for use in adjusted analysis.

                                      Shortboolean | continuous | dichotomous | ordinal | polychotomous | extension
                                      Control0..1
                                      BindingThe codes SHALL be taken from EvidenceVariableHandling
                                      (required to http://hl7.org/fhir/ValueSet/variable-handling|6.0.0-ballot3)
                                      Typecode
                                      Is Modifierfalse
                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      440. Evidence.statistic:netEffect.modelCharacteristic.variable.valueCategory
                                      Definition

                                      Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                      ShortQualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                      Control0..*
                                      TypeCodeableConcept
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      442. Evidence.statistic:netEffect.modelCharacteristic.variable.valueQuantity
                                      Definition

                                      Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                      ShortQuantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                      Control0..*
                                      TypeQuantity
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      444. Evidence.statistic:netEffect.modelCharacteristic.variable.valueRange
                                      Definition

                                      Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                      ShortRange of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                      Control0..*
                                      TypeRange
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      446. Evidence.statistic:netEffect.modelCharacteristic.attribute
                                      Definition

                                      An attribute of the model characteristic.

                                      ShortAn attribute of the model characteristic
                                      Control0..*
                                      TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      448. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis
                                      Slice NamenetEffectAnalysis
                                      Definition

                                      A component of the method to generate the statistic.

                                      ShortAn aspect of the statistical model
                                      Control1..1
                                      TypeBackboneElement
                                      Is Modifierfalse
                                      Must Supporttrue
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                      450. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.id
                                      Definition

                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                      ShortUnique id for inter-element referencing
                                      Control0..1
                                      This element is affected by the following invariants: ele-1
                                      Typestring
                                      Is Modifierfalse
                                      XML FormatIn the XML format, this property is represented as an attribute.
                                      Summaryfalse
                                      452. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.extension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                      ShortAdditional content defined by implementations
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifierfalse
                                      Summaryfalse
                                      Alternate Namesextensions, user content
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      454. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.modifierExtension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                      ShortExtensions that cannot be ignored even if unrecognized
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                      Summarytrue
                                      Requirements

                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                      Alternate Namesextensions, user content, modifiers
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      456. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code
                                      Definition

                                      Description of a component of the method to generate the statistic.

                                      ShortModel specification
                                      Control1..1
                                      BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                                      (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                      TypeCodeableConcept
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      458. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.id
                                      Definition

                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                      ShortUnique id for inter-element referencing
                                      Control0..1
                                      This element is affected by the following invariants: ele-1
                                      Typeid
                                      Is Modifierfalse
                                      XML FormatIn the XML format, this property is represented as an attribute.
                                      Summaryfalse
                                      460. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.extension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                      ShortAdditional content defined by implementations
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifierfalse
                                      Summaryfalse
                                      Alternate Namesextensions, user content
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.code.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                      • value @ url
                                      • 462. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.coding
                                        Definition

                                        A reference to a code defined by a terminology system.

                                        ShortCode defined by a terminology system
                                        Comments

                                        Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                        Control0..*
                                        TypeCoding
                                        Is Modifierfalse
                                        Summaryfalse
                                        Requirements

                                        Allows for alternative encodings within a code system, and translations to other code systems.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        464. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.code.text
                                        Definition

                                        A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                        ShortPlain text representation of the concept
                                        Comments

                                        Very often the text is the same as a displayName of one of the codings.

                                        Control1..1
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Summaryfalse
                                        Requirements

                                        The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                        Pattern ValueNet effect analysis
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        466. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.value[x]
                                        Definition

                                        Further specification of the value of the component of the method to generate the statistic.

                                        ShortThe specific value (when paired with code)
                                        Control0..1
                                        TypeChoice of: Quantity(SimpleQuantity), Range, CodeableConcept
                                        [x] NoteSeeChoice of Data Typesfor further information about how to use [x]
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        468. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.intended
                                        Definition

                                        The plan for analysis.

                                        ShortThe plan for analysis
                                        Control0..1
                                        Typeboolean
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        470. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.applied
                                        Definition

                                        This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan.

                                        ShortThis model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
                                        Control0..1
                                        Typeboolean
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Meaning if MissingTrue, unless modelCharacteristic.intended = true; if modelCharacteristic.intended = true and .applied is missing, then meaning Unknown.
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        472. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable
                                        Definition

                                        A variable adjusted for in the adjusted analysis.

                                        ShortA variable adjusted for in the adjusted analysis
                                        Control0..*
                                        TypeBackboneElement
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                        474. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.id
                                        Definition

                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                        ShortUnique id for inter-element referencing
                                        Control0..1
                                        This element is affected by the following invariants: ele-1
                                        Typestring
                                        Is Modifierfalse
                                        XML FormatIn the XML format, this property is represented as an attribute.
                                        Summaryfalse
                                        476. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.extension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                        ShortAdditional content defined by implementations
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifierfalse
                                        Summaryfalse
                                        Alternate Namesextensions, user content
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        478. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.modifierExtension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                        ShortExtensions that cannot be ignored even if unrecognized
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                        Summarytrue
                                        Requirements

                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                        Alternate Namesextensions, user content, modifiers
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        480. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.variableDefinition
                                        Definition

                                        Description and definition of the variable.

                                        ShortDescription and definition of the variable
                                        Control1..1
                                        TypeReference(Group, EvidenceVariable)
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        482. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.handling
                                        Definition

                                        How the variable is classified for use in adjusted analysis.

                                        Shortboolean | continuous | dichotomous | ordinal | polychotomous | extension
                                        Control0..1
                                        BindingThe codes SHALL be taken from EvidenceVariableHandling
                                        (required to http://hl7.org/fhir/ValueSet/variable-handling|6.0.0-ballot3)
                                        Typecode
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        484. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.valueCategory
                                        Definition

                                        Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                        ShortQualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                        Control0..*
                                        TypeCodeableConcept
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        486. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.valueQuantity
                                        Definition

                                        Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                        ShortQuantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                        Control0..*
                                        TypeQuantity
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        488. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.variable.valueRange
                                        Definition

                                        Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable.

                                        ShortRange of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
                                        Control0..*
                                        TypeRange
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        490. Evidence.statistic:netEffect.modelCharacteristic:netEffectAnalysis.attribute
                                        Definition

                                        An attribute of the model characteristic.

                                        ShortAn attribute of the model characteristic
                                        Control0..*
                                        TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        492. Evidence.certainty
                                        Definition

                                        Assessment of certainty, confidence in the estimates, or quality of the evidence.

                                        ShortCertainty or quality of the evidence
                                        Control0..*
                                        TypeBackboneElement
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children or both (hasValue() or (children().count() > id.count()))
                                        494. Evidence.certainty.id
                                        Definition

                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                        ShortUnique id for inter-element referencing
                                        Control0..1
                                        This element is affected by the following invariants: ele-1
                                        Typestring
                                        Is Modifierfalse
                                        XML FormatIn the XML format, this property is represented as an attribute.
                                        Summaryfalse
                                        496. Evidence.certainty.extension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                        ShortAdditional content defined by implementations
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifierfalse
                                        Summaryfalse
                                        Alternate Namesextensions, user content
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        498. Evidence.certainty.modifierExtension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                        ShortExtensions that cannot be ignored even if unrecognized
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                        Summarytrue
                                        Requirements

                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                        Alternate Namesextensions, user content, modifiers
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        500. Evidence.certainty.description
                                        Definition

                                        Textual description of certainty.

                                        ShortTextual description of certainty
                                        Control0..1
                                        Typemarkdown
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        502. Evidence.certainty.note
                                        Definition

                                        Footnotes and/or explanatory notes.

                                        ShortFootnotes and/or explanatory notes
                                        Control0..*
                                        TypeAnnotation
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        504. Evidence.certainty.type
                                        Definition

                                        Aspect of certainty being rated.

                                        ShortAspect of certainty being rated
                                        Control0..1
                                        BindingUnless not suitable, these codes SHALL be taken from EvidenceCertaintyType
                                        (extensible to http://hl7.org/fhir/ValueSet/certainty-type)

                                        The aspect of quality, confidence, or certainty.

                                        TypeCodeableConcept
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        506. Evidence.certainty.rating
                                        Definition

                                        Assessment or judgement of the aspect.

                                        ShortAssessment or judgement of the aspect
                                        Control0..1
                                        BindingUnless not suitable, these codes SHALL be taken from EvidenceCertaintyRating
                                        (extensible to http://hl7.org/fhir/ValueSet/certainty-rating)

                                        The assessment of quality, confidence, or certainty.

                                        TypeCodeableConcept
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        508. Evidence.certainty.rater
                                        Definition

                                        Individual or group who did the rating.

                                        ShortIndividual or group who did the rating
                                        Control0..*
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        510. Evidence.certainty.subcomponent
                                        Definition

                                        A domain or subdomain of certainty.

                                        ShortA domain or subdomain of certainty
                                        Control0..*
                                        TypeSeettp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.certainty
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))