Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

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Resource Profile: MetaanalysisOutcomeDefinition

Profile of Group for Evidence Based Medicine IG. The MetaanalysisOutcomeDefinition Profile is used to express the criteria defining an evidence variable in the role of outcome where the population (dataset) is a set of Evidence Resources. Characteristics define the characteristics of the Evidence Resource to be eligible to be used for this outcome.

Usage:

• Examples for this Resource Profile: MetaanalysisOutcomeDefinition_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_at_end_of_follow_up

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Differential Table
• Key Elements Table
• Snapshot Table
• Statistics/References
• All

This structure is derived from ConceptualCohortDefinition

Name	Flags	Card.	Type	Description & Constraints
Group		0..*	ConceptualCohortDefinition	Group of multiple entities
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints
Group	C	0..*	ConceptualCohortDefinition	Group of multiple entities cnl-2: Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated'
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
Slices for extension				Content/Rules for all slices
author		0..*	ContactDetail	Who authored the artifact URL: http://hl7.org/fhir/StructureDefinition/artifact-author ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc. URL: http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
characteristicExpression		0..1	Expression	Criteria for group membership URL: http://hl7.org/fhir/StructureDefinition/characteristicExpression ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children
status	?!Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact. ele-1: All FHIR elements must have a @value or children
membership	Σ	1..1	code	definitional | conceptual | enumerated Binding: GroupMembershipBasis (required): The basis for membership in a group ele-1: All FHIR elements must have a @value or children Required Pattern: conceptual
combinationMethod	?!Σ	0..1	code	all-of | any-of | at-least | at-most | except-subset Binding: GroupCharacteristicCombination (required) ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Group.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot2 from the FHIR Standard
Group.membership	required	Pattern: conceptual http://hl7.org/fhir/ValueSet/group-membership-basis|6.0.0-ballot2 from the FHIR Standard
Group.combinationMethod	required	GroupCharacteristicCombination http://hl7.org/fhir/ValueSet/group-characteristic-combination|6.0.0-ballot2 from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-2	error	Group	Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated' : Group.type.exists() or (Group.membership = 'conceptual')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
Group	C	0..*	ConceptualCohortDefinition	Group of multiple entities cnl-2: Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated'
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
author		0..*	ContactDetail	Who authored the artifact URL: http://hl7.org/fhir/StructureDefinition/artifact-author
relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc. URL: http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact
characteristicExpression		0..1	Expression	Criteria for group membership URL: http://hl7.org/fhir/StructureDefinition/characteristicExpression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this Group, represented as an absolute URI (globally unique) cnl-1: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Business Identifier for this Group
version	Σ	0..1	string	Business version of the Group
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	Σ	0..1	string	Label for Group
title	Σ	0..1	string	Name for this Group (human friendly)
status	?!Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental	Σ	0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
description		0..1	markdown	Natural language description of the group
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Group is defined
copyright		0..1	markdown	Use and/or publishing restrictions
copyrightLabel		0..1	string	Copyright holder and year(s)
type	Σ	0..1	code	person | animal | practitioner | device | careteam | healthcareservice | location | organization | relatedperson | specimen Binding: GroupType (required): Types of resources that are part of group.
membership	Σ	1..1	code	definitional | conceptual | enumerated Binding: GroupMembershipBasis (required): The basis for membership in a group Required Pattern: conceptual
code	Σ	0..1	CodeableConcept	Use of the Group (and by implication, kind of members) Binding: GroupCode (extensible): A code that describes the kind of group, which usually dictates what kind if entities can be in the group.
managingEntity	Σ	0..1	Reference(Organization | RelatedPerson | Practitioner | PractitionerRole)	Entity that is the custodian of the Group's definition
combinationMethod	?!Σ	0..1	code	all-of | any-of | at-least | at-most | except-subset Binding: GroupCharacteristicCombination (required)
combinationThreshold		0..1	positiveInt	Provides the value of "n" when "at-least" or "at-most" codes are used
characteristic	Σ	0..*	BackboneElement	Include / Exclude group members by Trait
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	Σ	1..1	CodeableConcept	Kind of characteristic Binding Description (No ValueSet): (example): List of characteristics used to describe group members; e.g. gender, age, owner, location, etc.
value[x]	Σ	1..1		Value held by characteristic Binding Description (No ValueSet): (example): Value of descriptive member characteristic; e.g. red, male, pneumonia, Caucasian, etc.
valueCodeableConcept			CodeableConcept
valueBoolean			boolean
valueQuantity			Quantity
valueRange			Range
valueReference			Reference(Any)
valueUri			uri
valueExpression			Expression
exclude	Σ	1..1	boolean	Group includes or excludes
description		0..1	markdown	Natural language description of the characteristic
method		0..*	CodeableConcept	Method for how the characteristic value was determined Binding: DefinitionMethod (example)
determinedBy[x]		0..1		Defines the characteristic
determinedByReference			Reference(Device | DeviceDefinition | DeviceMetric)
determinedByExpression			Expression
offset	?!Σ	0..1	CodeableConcept	Reference point for comparison Binding: CharacteristicOffset (example)
instances[x]		0..1		Number of occurrences meeting the characteristic
instancesQuantity			Quantity
instancesRange			Range
duration[x]		0..1		Length of time in which the characteristic is met
durationDuration			Duration
durationRange			Range
period		0..1	Period	Period over which characteristic is tested
timing		0..*	RelativeTime	Timing in which the characteristic is determined
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Group.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot2 from the FHIR Standard
Group.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm from the FHIR Standard
Group.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot2 from the FHIR Standard
Group.type	required	GroupType http://hl7.org/fhir/ValueSet/group-type|6.0.0-ballot2 from the FHIR Standard
Group.membership	required	Pattern: conceptual http://hl7.org/fhir/ValueSet/group-membership-basis|6.0.0-ballot2 from the FHIR Standard
Group.code	extensible	GroupCode http://hl7.org/fhir/ValueSet/group-code from the FHIR Standard
Group.combinationMethod	required	GroupCharacteristicCombination http://hl7.org/fhir/ValueSet/group-characteristic-combination|6.0.0-ballot2 from the FHIR Standard
Group.characteristic.code	example
Group.characteristic.value[x]	example
Group.characteristic.method	example	DefinitionMethod http://hl7.org/fhir/ValueSet/definition-method from the FHIR Standard
Group.characteristic.offset	example	CharacteristicOffset http://hl7.org/fhir/ValueSet/characteristic-offset from the FHIR Standard
Group.member.involvement	example	GroupInvolvement http://hl7.org/fhir/ValueSet/group-involvement-set from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-1	warning	Group.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
cnl-2	error	Group	Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated' : Group.type.exists() or (Group.membership = 'conceptual')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ConceptualCohortDefinition

Summary

Maturity: 1

Differential View

This structure is derived from ConceptualCohortDefinition

Name	Flags	Card.	Type	Description & Constraints
Group		0..*	ConceptualCohortDefinition	Group of multiple entities
Documentation for this format

Key Elements View

Name	Flags	Card.	Type	Description & Constraints
Group	C	0..*	ConceptualCohortDefinition	Group of multiple entities cnl-2: Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated'
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
Slices for extension				Content/Rules for all slices
author		0..*	ContactDetail	Who authored the artifact URL: http://hl7.org/fhir/StructureDefinition/artifact-author ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc. URL: http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
characteristicExpression		0..1	Expression	Criteria for group membership URL: http://hl7.org/fhir/StructureDefinition/characteristicExpression ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children
status	?!Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact. ele-1: All FHIR elements must have a @value or children
membership	Σ	1..1	code	definitional | conceptual | enumerated Binding: GroupMembershipBasis (required): The basis for membership in a group ele-1: All FHIR elements must have a @value or children Required Pattern: conceptual
combinationMethod	?!Σ	0..1	code	all-of | any-of | at-least | at-most | except-subset Binding: GroupCharacteristicCombination (required) ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Group.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot2 from the FHIR Standard
Group.membership	required	Pattern: conceptual http://hl7.org/fhir/ValueSet/group-membership-basis|6.0.0-ballot2 from the FHIR Standard
Group.combinationMethod	required	GroupCharacteristicCombination http://hl7.org/fhir/ValueSet/group-characteristic-combination|6.0.0-ballot2 from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-2	error	Group	Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated' : Group.type.exists() or (Group.membership = 'conceptual')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Snapshot View

Name	Flags	Card.	Type	Description & Constraints
Group	C	0..*	ConceptualCohortDefinition	Group of multiple entities cnl-2: Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated'
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
author		0..*	ContactDetail	Who authored the artifact URL: http://hl7.org/fhir/StructureDefinition/artifact-author
relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc. URL: http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact
characteristicExpression		0..1	Expression	Criteria for group membership URL: http://hl7.org/fhir/StructureDefinition/characteristicExpression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this Group, represented as an absolute URI (globally unique) cnl-1: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Business Identifier for this Group
version	Σ	0..1	string	Business version of the Group
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	Σ	0..1	string	Label for Group
title	Σ	0..1	string	Name for this Group (human friendly)
status	?!Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental	Σ	0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
description		0..1	markdown	Natural language description of the group
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Group is defined
copyright		0..1	markdown	Use and/or publishing restrictions
copyrightLabel		0..1	string	Copyright holder and year(s)
type	Σ	0..1	code	person | animal | practitioner | device | careteam | healthcareservice | location | organization | relatedperson | specimen Binding: GroupType (required): Types of resources that are part of group.
membership	Σ	1..1	code	definitional | conceptual | enumerated Binding: GroupMembershipBasis (required): The basis for membership in a group Required Pattern: conceptual
code	Σ	0..1	CodeableConcept	Use of the Group (and by implication, kind of members) Binding: GroupCode (extensible): A code that describes the kind of group, which usually dictates what kind if entities can be in the group.
managingEntity	Σ	0..1	Reference(Organization | RelatedPerson | Practitioner | PractitionerRole)	Entity that is the custodian of the Group's definition
combinationMethod	?!Σ	0..1	code	all-of | any-of | at-least | at-most | except-subset Binding: GroupCharacteristicCombination (required)
combinationThreshold		0..1	positiveInt	Provides the value of "n" when "at-least" or "at-most" codes are used
characteristic	Σ	0..*	BackboneElement	Include / Exclude group members by Trait
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	Σ	1..1	CodeableConcept	Kind of characteristic Binding Description (No ValueSet): (example): List of characteristics used to describe group members; e.g. gender, age, owner, location, etc.
value[x]	Σ	1..1		Value held by characteristic Binding Description (No ValueSet): (example): Value of descriptive member characteristic; e.g. red, male, pneumonia, Caucasian, etc.
valueCodeableConcept			CodeableConcept
valueBoolean			boolean
valueQuantity			Quantity
valueRange			Range
valueReference			Reference(Any)
valueUri			uri
valueExpression			Expression
exclude	Σ	1..1	boolean	Group includes or excludes
description		0..1	markdown	Natural language description of the characteristic
method		0..*	CodeableConcept	Method for how the characteristic value was determined Binding: DefinitionMethod (example)
determinedBy[x]		0..1		Defines the characteristic
determinedByReference			Reference(Device | DeviceDefinition | DeviceMetric)
determinedByExpression			Expression
offset	?!Σ	0..1	CodeableConcept	Reference point for comparison Binding: CharacteristicOffset (example)
instances[x]		0..1		Number of occurrences meeting the characteristic
instancesQuantity			Quantity
instancesRange			Range
duration[x]		0..1		Length of time in which the characteristic is met
durationDuration			Duration
durationRange			Range
period		0..1	Period	Period over which characteristic is tested
timing		0..*	RelativeTime	Timing in which the characteristic is determined
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Group.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot2 from the FHIR Standard
Group.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm from the FHIR Standard
Group.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot2 from the FHIR Standard
Group.type	required	GroupType http://hl7.org/fhir/ValueSet/group-type|6.0.0-ballot2 from the FHIR Standard
Group.membership	required	Pattern: conceptual http://hl7.org/fhir/ValueSet/group-membership-basis|6.0.0-ballot2 from the FHIR Standard
Group.code	extensible	GroupCode http://hl7.org/fhir/ValueSet/group-code from the FHIR Standard
Group.combinationMethod	required	GroupCharacteristicCombination http://hl7.org/fhir/ValueSet/group-characteristic-combination|6.0.0-ballot2 from the FHIR Standard
Group.characteristic.code	example
Group.characteristic.value[x]	example
Group.characteristic.method	example	DefinitionMethod http://hl7.org/fhir/ValueSet/definition-method from the FHIR Standard
Group.characteristic.offset	example	CharacteristicOffset http://hl7.org/fhir/ValueSet/characteristic-offset from the FHIR Standard
Group.member.involvement	example	GroupInvolvement http://hl7.org/fhir/ValueSet/group-involvement-set from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-1	warning	Group.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
cnl-2	error	Group	Group.type SHALL be defined if Group.membership is either 'definitional' or 'enumerated' : Group.type.exists() or (Group.membership = 'conceptual')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ConceptualCohortDefinition

Summary

Maturity: 1

Other representations of profile: CSV, Excel, Schematron