Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: ExposureDefinition: Therapeutic-dose anticoagulation with heparin - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Group ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "291369"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "2" ] ;
fhir:lastUpdated [ fhir:v "2024-11-16T20:11:23.273Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-definition"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-definition>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "empty" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
  ] ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-author"^^xsd:anyURI ] ;
fhir:value [
a fhir:ContactDetail ;
fhir:name [ fhir:v "Brian S. Alper" ]     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact"^^xsd:anyURI ] ;
fhir:value [
a fhir:RelatedArtifact ;
fhir:type [ fhir:v "cite-as" ] ;
fhir:citation [ fhir:v "ExposureDefinition: Therapeutic-dose anticoagulation with heparin [Database Entry: FHIR Group Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 291369. Revised 2024-11-16. Available at: https://fevir.net/resources/Group/291369. Computable resource at: https://fevir.net/resources/Group/291369." ]     ]
  ] ) ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Group/291369"^^xsd:anyURI] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
fhir:value [ fhir:v "https://fevir.net/FOI/291369" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] ) ; # 
  fhir:title [ fhir:v "ExposureDefinition: Therapeutic-dose anticoagulation with heparin"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:membership [ fhir:v "conceptual"] ; # 
  fhir:combinationMethod [ fhir:v "any-of"] ; # 
  fhir:characteristic ( [
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "ATTACC investigational arm: Therapeutic anticoagulation for 14 days (or until hospital discharge or liberation from the need for supplemental oxygen, whichever comes first) with preference for low-molecular weight heparin (LMWH), or alternative unfractionated heparin (UFH). LMWH dosed according to patient weight and creatinine clearance according to local practice and policy. For UFH, suggested target of aPTT 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ] ;
fhir:duration [
a fhir:Duration ;
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:comparator [ fhir:v "<=" ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]     ] ;
    ( fhir:timing [
fhir:contextCode [
fhir:text [ fhir:v "study enrollment" ]       ] ;
fhir:offset [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ]       ] ;
fhir:text [ fhir:v "Up to 14 days or until hospital discharge or recovery (defined as liberation from supplemental oxygen>24 hours, provided oxygen was required), whichever comes first." ]     ] )
  ] [
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "ACTIV-4a investigational arm: Low-molecular weight heparin (LMWH) dosed according to patient weight and creatinine clearance. For UFH, suggested target of anti-Xa of 0.3-0.7 IU/ml or aPTT 1.5 to 2.5 times the upper limit of normal." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ] ;
fhir:duration [
a fhir:Duration ;
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:comparator [ fhir:v "<=" ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]     ] ;
    ( fhir:timing [
fhir:contextCode [
fhir:text [ fhir:v "study enrollment" ]       ] ;
fhir:offset [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ]       ] ;
fhir:text [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first." ]     ] )
  ] [
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "REMAP-CAP investigational arm: Dosed according to local hospital policy, practice, and guidelines for treatment of venous thromboembolism. Low-molecular weight heparin (LMWH) dosed according to patient weight. For UFH, suggested target for aPTT of 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ] ;
fhir:duration [
a fhir:Duration ;
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:comparator [ fhir:v "<=" ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]     ] ;
    ( fhir:timing [
fhir:contextCode [
fhir:text [ fhir:v "study enrollment" ]       ] ;
fhir:offset [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]         ]       ] ;
fhir:text [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first." ]     ] )
  ] ) . #