Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "236987"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "61" ] ;
fhir:lastUpdated [ fhir:v "2024-10-03T13:11:20.368Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 236987</b></p><a name=\"236987\"> </a><a name=\"hc236987\"> </a><a name=\"236987-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 61; Last updated: 2024-10-03 13:11:20+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-comparative-evidence.html\">ComparativeEvidence</a></p></div><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/236987\">https://fevir.net/resources/Evidence/236987</a></p><p><b>identifier</b>: FEvIR Object Identifier/236987, outcomeId/109588, picoId/85798, sectionId/73215</p><p><b>name</b>: Body_weightfrom_MAGICapp_109588</p><p><b>title</b>: MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes</p><p><b>status</b>: Active</p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>author</b>: Computable Publishing®: MAGIC-to-FEvIR Converter: </p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidence}\">ComparativeEvidence</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Part Of</td><td>MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes (Identifier: FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-conversion-report)</td></tr></table><p><b>description</b>: </p><div><p>This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><p><b>assertion</b>: </p><div><p>SGLT2 inhibitors probably reduce body weight compared with GLP-1 receptor agonists.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Adults with type 2 diabetes</p>\n</div><p><b>variableRole</b>: Population</p><p><b>observed</b>: <a href=\"Group-236947.html\">Adults with type 2 diabetes and CVD and CKD</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>GroupAssignment: SGLT2 inhibitors vs. GLP-1 RA</p>\n</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: GLP-1 RA</p><p><b>observed</b>: <a href=\"EvidenceVariable-236950.html\">GroupAssignment: SGLT2 inhibitors vs. GLP-1 RA</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Body weight</p>\n</div><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-236986.html\">Body weight</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:\">SYSTEMATIC_REVIEW</span></p><p><b>studyDesign</b>: <span title=\"Codes:\">NOTSET</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>MD -0.47 Kg (CI95 -0.09 Kg to -0.85 Kg)</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type 0000457}\">Mean Difference</span></p><p><b>quantity</b>: -0.47 Kg</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>2</td><td>1139</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">CI95</span></td><td>-0.09--0.85 Kg</td></tr></table></blockquote><blockquote><p><b>certainty</b></p><p><b>description</b>: </p><div><p>Due to serious inconsistency</p>\n</div><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Overall}\">Overall certainty</span></p><p><b>rating</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/27834 RJCS-2004}\">Moderate certainty</span></p><h3>Subcomponents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Rating</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Risk of Bias</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Inconsistency</span></td><td><span title=\"Codes:\">SERIOUS</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Indirectness</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Imprecision</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Publication Bias</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr></table></blockquote></div>"
  ] ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Evidence/236987"^^xsd:anyURI] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "236987" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] [
fhir:type [
fhir:text [ fhir:v "outcomeId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "109588" ]
  ] [
fhir:type [
fhir:text [ fhir:v "picoId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "85798" ]
  ] [
fhir:type [
fhir:text [ fhir:v "sectionId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "73215" ]
  ] ) ; # 
  fhir:name [ fhir:v "Body_weightfrom_MAGICapp_109588"] ; # 
  fhir:title [ fhir:v "MAGIC-derived Evidence: Body weight with SGLT2 inhibitors vs. GLP-1 RA in Adults with type 2 diabetes"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]     ] )
  ] ) ; # 
  fhir:author ( [
fhir:name [ fhir:v "Computable Publishing®: MAGIC-to-FEvIR Converter" ]
  ] ) ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
fhir:display [ fhir:v "Evidence Communication" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ComparativeEvidence" ] ;
fhir:display [ fhir:v "ComparativeEvidence" ]       ] )     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:relatedArtifact ( [
fhir:type [ fhir:v "part-of" ] ;
fhir:resourceReference [
fhir:type [ fhir:v "Composition"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-conversion-report" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes" ]     ]
  ] ) ; # 
  fhir:description [ fhir:v "This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:assertion [ fhir:v "SGLT2 inhibitors probably reduce body weight compared with GLP-1 receptor agonists."] ; # 
  fhir:variableDefinition ( [
fhir:description [ fhir:v "Adults with type 2 diabetes" ] ;
fhir:variableRole [ fhir:v "population" ] ;
fhir:observed [
fhir:reference [ fhir:v "Group/236947" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-population-group-85394-85798" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "Adults with type 2 diabetes and CVD and CKD" ]     ]
  ] [
fhir:description [ fhir:v "GroupAssignment: SGLT2 inhibitors vs. GLP-1 RA" ] ;
fhir:variableRole [ fhir:v "exposure" ] ;
fhir:comparatorCategory [ fhir:v "GLP-1 RA" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/236950" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-group-assignment-85394-85798" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "GroupAssignment: SGLT2 inhibitors vs. GLP-1 RA" ]     ]
  ] [
fhir:description [ fhir:v "Body weight" ] ;
fhir:variableRole [ fhir:v "outcome" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/236986" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-109588" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "Body weight" ]     ]
  ] ) ; # 
  fhir:synthesisType [
fhir:text [ fhir:v "SYSTEMATIC_REVIEW" ]
  ] ; # 
  fhir:studyDesign ( [
fhir:text [ fhir:v "NOTSET" ]
  ] ) ; # 
  fhir:statistic ( [
fhir:description [ fhir:v "MD -0.47 Kg (CI95 -0.09 Kg to -0.85 Kg)" ] ;
fhir:statisticType [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
fhir:version [ fhir:v "5.0.0-cibuild" ] ;
fhir:code [ fhir:v "0000457" ] ;
fhir:display [ fhir:v "Mean Difference" ]       ] )     ] ;
fhir:quantity [
fhir:value [ fhir:v "-0.47"^^xsd:decimal ] ;
fhir:unit [ fhir:v "Kg" ]     ] ;
fhir:sampleSize [
fhir:numberOfStudies [ fhir:v "2"^^xsd:nonNegativeInteger ] ;
fhir:numberOfParticipants [ fhir:v "1139"^^xsd:nonNegativeInteger ]     ] ;
    ( fhir:attributeEstimate [
fhir:type [
fhir:text [ fhir:v "CI95" ]       ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v "-0.09"^^xsd:decimal ] ;
fhir:unit [ fhir:v "Kg" ]         ] ;
fhir:high [
fhir:value [ fhir:v "-0.85"^^xsd:decimal ] ;
fhir:unit [ fhir:v "Kg" ]         ]       ]     ] )
  ] ) ; # 
  fhir:certainty ( [
fhir:description [ fhir:v "Due to serious inconsistency" ] ;
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Overall" ] ;
fhir:display [ fhir:v "Overall certainty" ]       ] )     ] ;
fhir:rating [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/27834"^^xsd:anyURI ] ;
fhir:code [ fhir:v "RJCS-2004" ] ;
fhir:display [ fhir:v "Moderate certainty" ]       ] )     ] ;
    ( fhir:subcomponent [
fhir:type [
fhir:text [ fhir:v "Risk of Bias" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Inconsistency" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "SERIOUS" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Indirectness" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Imprecision" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Publication Bias" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] )
  ] ) . #