Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
<Evidence xmlns="http://hl7.org/fhir">
<id value="179590"/>
<meta>
<versionId value="4"/>
<lastUpdated value="2023-12-08T13:32:44.405Z"/>
<profile
value="http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Evidence 179590</b></p><a name="179590"> </a><a name="hc179590"> </a><a name="179590-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 4; Last updated: 2023-12-08 13:32:44+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-net-effect-contribution.html">NetEffectContribution</a></p></div><p><b>url</b>: <a href="https://fevir.net/resources/Evidence/179590">https://fevir.net/resources/Evidence/179590</a></p><p><b>identifier</b>: FEvIR Object Identifier/179590</p><p><b>name</b>: NetEffectContribution_Treatment_with_opioids_for_Example_for_GIN_2022</p><p><b>title</b>: NetEffectContribution: Treatment with opioids for Example for GIN 2022</p><p><b>status</b>: Active</p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href="mailto:support@computablepublishing.com">support@computablepublishing.com</a></p><p><b>author</b>: Brian S. Alper: </p><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><a href="CodeSystem-179423.html#179423-evidence-communication">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidence}">ComparativeEvidence</span></td></tr><tr><td style="display: none">*</td><td><a href="CodeSystem-179423.html#179423-evidence-communication">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/179423 NetEffectContribution}">NetEffectContribution</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Citation</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Cite As</td><td><div><p>NetEffectContribution: Treatment with opioids for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179590. Revised 2023-12-04. Available at: https://fevir.net/resources/Evidence/179590. Computable resource at: https://fevir.net/resources/Evidence/179590.</p>
</div></td><td> </td></tr><tr><td style="display: none">*</td><td>Amended With</td><td> </td><td><a href="ArtifactAssessment-104195.html">Outcome Importance Rating (default value 5) of Treatment with opioids</a></td></tr></table><p><b>description</b>: </p><div><p>-0.24 (-0.32 to -0.16)</p>
</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included).</p>
</div><p><b>variableRole</b>: Population</p><p><b>observed</b>: <a href="Group-178427.html">StudyGroup: Severely Obese Adults 2018 Norwegian Cohort</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>comparison groups of bariatric surgery vs. no bariatric surgery</p>
</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: no bariatric surgery</p><p><b>observed</b>: <a href="EvidenceVariable-172427.html">GroupAssignment: Bariatric Surgery vs. no bariatric surgery</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Treatment with opioids</p>
</div><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href="EvidenceVariable-104119.html">OutcomeVariable: Treatment with opioids</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Relative Importance Multiplier</p>
</div><p><b>variableRole</b>: Covariate</p><p><b>roleSubtype</b>: <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 importance-multiplier}">Relative importance multiplier</span></p><p><b>observed</b>: Relative Importance Multiplier</p></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>risk difference -0.24 (95% CI -0.32 to -0.16)</p>
</div><p><b>statisticType</b>: <span title="Codes:{https://fevir.net/resources/CodeSystem/181513 STATO:0000424}">Risk Difference</span></p><p><b>quantity</b>: -0.24</p><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Description</b></td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td><div><p>95% CI -0.32 to -0.16</p>
</div></td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/181513 STATO:0000196}">confidence interval</span></td><td>0.95</td><td>-0.32--0.16</td></tr></table><h3>ModelCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/181513 TBD:net-effect-contribution-analysis}">Net effect contribution analysis</span></td></tr></table></blockquote></div>
</text>
<url value="https://fevir.net/resources/Evidence/179590"/>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
<text value="FEvIR Object Identifier"/>
</type>
<system value="https://fevir.net"/>
<value value="179590"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<name
value="NetEffectContribution_Treatment_with_opioids_for_Example_for_GIN_2022"/>
<title
value="NetEffectContribution: Treatment with opioids for Example for GIN 2022"/>
<status value="active"/>
<publisher value="Computable Publishing LLC"/>
<contact>
<telecom>
<system value="email"/>
<value value="support@computablepublishing.com"/>
</telecom>
</contact>
<author>
<name value="Brian S. Alper"/>
</author>
<useContext>
<code>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="evidence-communication"/>
<display value="Evidence Communication"/>
</code>
<valueCodeableConcept>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="ComparativeEvidence"/>
<display value="ComparativeEvidence"/>
</coding>
</valueCodeableConcept>
</useContext>
<useContext>
<code>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="evidence-communication"/>
<display value="Evidence Communication"/>
</code>
<valueCodeableConcept>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="NetEffectContribution"/>
<display value="NetEffectContribution"/>
</coding>
</valueCodeableConcept>
</useContext>
<copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
<relatedArtifact>
<type value="cite-as"/>
<citation
value="NetEffectContribution: Treatment with opioids for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179590. Revised 2023-12-04. Available at: https://fevir.net/resources/Evidence/179590. Computable resource at: https://fevir.net/resources/Evidence/179590."/>
</relatedArtifact>
<relatedArtifact>
<type value="amended-with"/>
<resourceReference>🔗
<reference value="ArtifactAssessment/104195"/>
<type value="ArtifactAssessment"/>
<display
value="Outcome Importance Rating (default value 5) of Treatment with opioids"/>
</resourceReference>
</relatedArtifact>
<description value="-0.24 (-0.32 to -0.16)"/>
<variableDefinition>
<description
value="Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included)."/>
<variableRole value="population"/>
<observed>🔗
<reference value="Group/178427"/>
<type value="Group"/>
<display
value="StudyGroup: Severely Obese Adults 2018 Norwegian Cohort"/>
</observed>
</variableDefinition>
<variableDefinition>
<description
value="comparison groups of bariatric surgery vs. no bariatric surgery"/>
<variableRole value="exposure"/>
<comparatorCategory value="no bariatric surgery"/>
<observed>🔗
<reference value="EvidenceVariable/172427"/>
<type value="EvidenceVariable"/>
<display
value="GroupAssignment: Bariatric Surgery vs. no bariatric surgery"/>
</observed>
</variableDefinition>
<variableDefinition>
<description value="Treatment with opioids"/>
<variableRole value="outcome"/>
<observed>🔗
<reference value="EvidenceVariable/104119"/>
<type value="EvidenceVariable"/>
<display value="OutcomeVariable: Treatment with opioids"/>
</observed>
</variableDefinition>
<variableDefinition>
<description value="Relative Importance Multiplier"/>
<variableRole value="covariate"/>
<roleSubtype>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="importance-multiplier"/>
<display value="Relative importance multiplier"/>
</coding>
</roleSubtype>
<observed>
<display value="Relative Importance Multiplier"/>
</observed>
</variableDefinition>
<statistic>
<description value="risk difference -0.24 (95% CI -0.32 to -0.16)"/>
<statisticType>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="STATO:0000424"/>
<display value="Risk Difference"/>
</coding>
</statisticType>
<quantity>
<value value="-0.24"/>
</quantity>
<attributeEstimate>
<description value="95% CI -0.32 to -0.16"/>
<type>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="STATO:0000196"/>
<display value="confidence interval"/>
</coding>
</type>
<level value="0.95"/>
<range>
<low>
<value value="-0.32"/>
</low>
<high>
<value value="-0.16"/>
</high>
</range>
</attributeEstimate>
<modelCharacteristic>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="TBD:net-effect-contribution-analysis"/>
<display value="Net effect contribution analysis"/>
</coding>
</code>
</modelCharacteristic>
</statistic>
</Evidence>