Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
<Composition xmlns="http://hl7.org/fhir">
<id value="282931"/>
<meta>
<versionId value="27"/>
<lastUpdated value="2024-10-22T17:03:42.861Z"/>
<profile
value="http://hl7.org/fhir/uv/ebm/StructureDefinition/research-study-data-dictionary"/>
</meta>
<text>
<status value="empty"/>
<div xmlns="http://www.w3.org/1999/xhtml">[No data.]</div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/artifact-description">
<valueMarkdown
value="This Composition summarizes the code key for understanding a research study dataset, including references to EvidenceVariable Resources (VariableDefinition Profile) for each of the data elements (variables) in the dataset."/>
</extension>
<extension
url="http://hl7.org/fhir/StructureDefinition/artifact-approvalDate">
<valueDate value="2020-08"/>
</extension>
<url value="https://fevir.net/resources/Composition/282931"/>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
<text value="FEvIR Object Identifier"/>
</type>
<system value="https://fevir.net"/>
<value value="282931"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<identifier>
<type>
<text value="NHANES Data File Name"/>
</type>
<value value="GLU_J.xpt"/>
</identifier>
<version value="2017-2018"/>
<status value="final"/>
<type>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="ResearchStudyDataDictionary"/>
<display value="ResearchStudyDataDictionary"/>
</coding>
<text value="Research Study Data Dictionary"/>
</type>
<date value="2024-10-22T17:03:42.861Z"/>
<author>
<type value="Practitioner"/>
<display value="Brian S. Alper"/>
</author>
<name value="GLU_J"/>
<title value="NHANES Plasma Fasting Glucose (GLU_J) Data Dictionary"/>
<custodian>🔗
<reference value="Organization/118079"/>
<type value="Organization"/>
<display value="Computable Publishing LLC"/>
</custodian>
<relatesTo>
<type value="derived-from"/>
<resource value="https://wwwn.cdc.gov/Nchs/Nhanes/2017-2018/GLU_J.htm"/>
</relatesTo>
<relatesTo>
<type value="cite-as"/>
<label value="Cite as"/>
<citation
value="NHANES Plasma Fasting Glucose (GLU_J) Data Dictionary [Database Entry: FHIR Composition Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 282931. Revised 2024-10-15. Available at: https://fevir.net/resources/Composition/282931. Computable resource at: https://fevir.net/FLI/DocumentForComposition282931."/>
</relatesTo>
<relatesTo>
<type value="specification-of"/>
<resource value="https://wwwn.cdc.gov/Nchs/Nhanes/2017-2018/GLU_J.htm"/>
</relatesTo>
<section>
<title value="Heading"/>
<code>
<text
value="section created Tue Oct 15 2024 10:35:54 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p>National Health and Nutrition Examination Survey</p><p>2017-2018 Data Documentation and Codebook</p></div>
</text>
</section>
<section>
<title value="Component Description"/>
<code>
<text
value="section created Tue Oct 15 2024 10:37:37 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">In 2015, diabetes was the seventh leading cause of death in the United States. More than 30 million Americans are living with diabetes, and 86 million are living with prediabetes, which is a serious health condition that increases a person’s risk of type-2 diabetes and other chronic diseases. The prevalence of diabetes and overweight (one of the major risk factors for diabetes) continues to increase. Substantial new efforts to prevent or control diabetes have begun, including the Diabetes Prevention Trial and the National Diabetes Education Program.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Diabetes testing provides population data to: 1) determine a national estimate of diabetes prevalence (diagnosed and undiagnosed); 2) identify the risk factors; 3) permit a national cohort to be established for follow-up studies of this condition; and 4) provide critical information to clinicians and public health officials for the development of preventive care and community-based interventions.</p></div>
</text>
</section>
<section>
<title value="Eligible Sample"/>
<code>
<text
value="section created Tue Oct 15 2024 10:38:04 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">Participants aged 12 years and older, who were examined in the morning session, were eligible.</span></p></div>
</text>
</section>
<section>
<title value="Description of Laboratory Methodology"/>
<code>
<text
value="section created Tue Oct 15 2024 10:39:06 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Glucose</strong><br></br>In this enzymatic method glucose is converted to glucose-6-phosphate (G-6-P) by hexokinase in the presence of ATP, a phosphate donor. Glucose-6-phosphate dehydrogenase then converts the G-6-P to gluconate-6-P in the presence of NADP+. As the NADP+ is reduced to NADPH during this reaction, the resulting increase in absorbance at 340 nm (secondary wavelength = 700 nm) is measured. This is an endpoint reaction that is specific for glucose.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Refer to the Laboratory Method Files section for a detailed description of the laboratory methods used.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">There were no changes to the lab site or lab method for this component in the NHANES 2017-2018 cycle. There were no changes to the lab equipment since 2015-2016. The Cobas C311 analyzer was used in 2017-2018 and 2015-2016. Refer to analytic note for changes to equipment in earlier survey cycles, which may impact analysis.</p></div>
</text>
</section>
<section>
<title value="Laboratory Method Files"/>
<code>
<text
value="section created Tue Oct 15 2024 10:39:45 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><a href="https://wwwn.cdc.gov/nchs/data/nhanes/2017-2018/labmethods/GLU-J-MET-508.pdf" style="color: rgb(0, 51, 153); text-decoration: none; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal;">Plasma Fasting Glucose Laboratory Procedure Manual</a><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;"><span> </span></span><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">(August 2020)</span></p></div>
</text>
</section>
<section>
<title value="Laboratory Quality Assurance and Monitoring"/>
<code>
<text
value="section created Tue Oct 15 2024 10:40:38 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Plasma specimens are processed, stored, and shipped to the University of Missouri-Columbia, Columbia, MO for analysis.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Detailed instructions on specimen collection and processing are discussed in the NHANES <a href="https://wwwn.cdc.gov/nchs/data/nhanes/2017-2018/manuals/2017_MEC_Laboratory_Procedures_Manual.pdf" style="color: rgb(0, 51, 153); text-decoration: none;">Laboratory Procedures Manual (LPM). </a>Vials are stored under appropriate frozen (–30°C) conditions until they are shipped to University of Missouri-Columbia for testing.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">The NHANES quality assurance and quality control (QA/QC) protocols meet the 1988 Clinical Laboratory Improvement Act mandates. Detailed QA/QC instructions are discussed in the <a href="https://wwwn.cdc.gov/nchs/data/nhanes/2017-2018/manuals/2017_MEC_Laboratory_Procedures_Manual.pdf" style="color: rgb(0, 51, 153); text-decoration: none;">NHANES LPM.</a></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Mobile Examination Centers (MECs)</strong></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Laboratory team performance is monitored using several techniques. NCHS and contract consultants use a structured competency assessment evaluation during visits to evaluate both the quality of the laboratory work and the quality control procedures. Each laboratory staff member is observed for equipment operation, specimen collection and preparation; testing procedures and constructive feedback are given to each staff member. Formal retraining sessions are conducted annually to ensure that required skill levels were maintained.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Analytical Laboratories</strong></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">NHANES uses several methods to monitor the quality of the analyses performed by the contract laboratories. In the MEC, these methods include performing blind split samples collected on “dry run” sessions. In addition, contract laboratories randomly perform repeat testing on 2% of all specimens.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">NCHS developed and distributed a QC protocol for all CDC and contract laboratories, which outlined the use of Westgard rules (Westgard et al, 1981) when running NHANES specimens. Progress reports containing any problems encountered during shipping or receipt of specimens, summary statistics for each control pool, QC graphs, instrument calibration, reagents, and any special considerations are submitted to NCHS quarterly. The reports are reviewed for trends or shifts in the data. The laboratories are required to explain any identified areas of concern.</p></div>
</text>
</section>
<section>
<title value="Data Processing and Editing"/>
<code>
<text
value="section created Tue Oct 15 2024 10:42:36 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">The data were reviewed. Incomplete data or improbable values were sent to the performing laboratory for confirmation.</span></p><p><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">One variable was created in this data file. The variable was created using the following formulas:</span></p><p><strong style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">LBXGLU and LBDGLUSI:</strong></p><p><span style="color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">The fasting glucose value in mg/dL (LBXGLU) was converted to mmol/L (LBDGLUSI) by multiplying by 0.05551 (rounded to 3 decimals).</span></p></div>
</text>
</section>
<section>
<title value="Analytic Notes"/>
<code>
<text
value="section created Tue Oct 15 2024 10:43:11 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Refer to the <a href="https://wwwn.cdc.gov/nchs/nhanes/continuousnhanes/overviewlab.aspx?BeginYear=2017" style="color: rgb(0, 51, 153); text-decoration: none;">2017 - 2018 Laboratory Data Overview </a>for general information on NHANES laboratory data.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">There are over 800 laboratory tests performed on NHANES participants. However, not all participants provided biospecimens or enough volume for all the tests to be performed. The specimen availability can also vary by age or other population characteristics. For example, in 2017-2018, approximately 80% of children aged 1-17 years who were examined in the MEC provided a blood specimen through phlebotomy, while 95% of examined adults age 18 and older provided a blood specimen. Analysts should evaluate the extent of missing data in the dataset related to the outcome of interest as well as any predictor variables used in the analyses to determine whether additional re-weighting for item non-response is necessary.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Please refer to the NHANES <a href="https://wwwn.cdc.gov/nchs/nhanes/analyticguidelines.aspx" style="color: rgb(0, 51, 153); text-decoration: none;">Analytic Guidelines</a> and the on-line <a href="https://wwwn.cdc.gov/nchs/nhanes/tutorials/default.aspx" style="color: rgb(0, 51, 153); text-decoration: none;">NHANES Tutorial </a>for further details on the use of sample weights and other analytic issues.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Subsample Weights<br></br><br></br></strong>Glucose was measured in a fasting subsample of participants 12 years and older. Specific sample weights (WTSAF2YR) for this subsample are included in this data file and should be used when analyzing these data. Participants included in the fasting subsample but did not provide a blood specimen (n=145) have an assigned sample weight value of “0” in their records. In addition, participants whom provided blood specimen but did not meet the 8 to less than 24 hour fasting criteria (n=180) have the sample weight value assigned as “0” (WTSAF2YR =0) as well. Glucose measurements for these 180 participants are included in the dataset. However, to include these data in the analysis, a reweighting would be required.<br></br><br></br><strong>Demographic and Other Related Variables</strong></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">The analysis of NHANES laboratory data must be conducted using the appropriate survey design and demographic variables. The <a href="https://wwwn.cdc.gov/nchs/nhanes/search/datapage.aspx?Component=Demographics&CycleBeginYear=2017" style="color: rgb(0, 51, 153); text-decoration: none;">NHANES 2017-2018 Demographics File</a> contains demographic data, health indicators, and other related information collected during household interviews as well as the sample design variables. The recommended procedure for variance estimation requires use of stratum and PSU variables (SDMVSTRA and SDMVPSU, respectively) in the demographic data file.</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">In the 2017-2018 NHANES cycle, the variables PHAFSTHR (total length of “food fast”, hours) and PHAFSTMN (Total length of “food fast”, minutes) will not be reported in this file. PHAFSTHR and PHAFSTMN can be found in the <a href="https://wwwn.cdc.gov/nchs/nhanes/2017-2018/fastqx_j.htm" style="color: rgb(0, 51, 153); text-decoration: none;">Fasting Questionnaire File</a> (FASTQX_J). The fasting questionnaire data file also includes additional auxiliary information such as fasting status, and the time of venipuncture. </p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">This laboratory data file can be linked to the other NHANES data files using the unique survey participant identifier (i.e., SEQN).</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Detection Limits</strong></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">The detection limits were constant for all of the analytes in the data set. Two variables are provided for each of these analytes. The variable name ending “LC” (ex., LBDGLULC<em>) </em>indicates whether the result was below the limit of detection: the value “0” means that the result was at or above the limit of detection, “1” indicates that the result was below the limit of detection. The other variable prefixed LBX (ex., LBXGLU<em>) </em>provides the analytic result for that analyte. For analytes with analytic results below the lower limit of detection (ex., LBDGLULC=1), an imputed fill value was placed in the analyte results field. This value is the lower limit of detection divided by the square root of 2 (LLOD/sqrt[2]).</p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">The lower limit of detection (LLOD, in mg/dL) for fasting glucose:</p><table border="1" cellspacing="0" cellpadding="0" style="border: 1px solid rgb(0, 0, 0); border-collapse: collapse; margin: 0px auto 1em; max-width: 600px; padding: 2px; break-inside: avoid; table-layout: auto; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><tbody><tr><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"><strong>Variable Name</strong></p></td><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"> <strong>SAS LABEL</strong></p></td><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"> <strong>LLOD</strong></p></td></tr><tr><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"> LBXGLU</p></td><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"> Fasting glucose</p></td><td valign="top" style="border: 1px solid rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; padding: 5px; text-align: left; vertical-align: top;"><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 1em; line-height: 1.33em; margin: inherit; padding: 0px; text-align: left;"> 2.0</p></td></tr></tbody></table><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 15.95pt; margin: 0in 0.5in 12pt 0in; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong> </strong></p><br></br><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 15.95pt; margin: 0in 0.5in 12pt 0in; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong>Comparability with previous cycles </strong></p><p style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 1.33em; margin: 0px 3em 1em; padding: 0px; text-align: left; color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">There were equipment changes during the 2015-2016, 2007-2008, and 2005-2006 survey cycles. For analysis involving 2015-2016 data and data collected prior to 2007-2008 cycle, please refer to the documentation accompanying those data for additional information on any needed adjustments to the data prior to analysis. If 2017-2018 data are compared or combined with the 2015-2016 data, no adjustments are needed for equipment changes. As mentioned in the 2015-2016 documentation, most of the 2015-2016 samples were measured using the Cobas C311, which is the same instrument used in 2017-2018. Some of the samples were collected using the Cobas C501. Results for these specimens have already been adjusted using the forward regression equation for comparability. Please see the 2015-2016 fasting plasma glucose documentation for more information about using backwards or forwards regression models to account for equipment changes between cycles (include link to documentation here).</p></div>
</text>
</section>
<section>
<title value="References"/>
<code>
<text
value="section created Tue Oct 15 2024 10:43:34 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><ul style="list-style-type: disc; margin: 0px 3em 1em; padding: 0px; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><li style="margin-left: 1.5em; margin-top: 0.7em;">Westgard J.O., Barry P.L., Hunt M.R., Groth T. A multi-rule Shewhart chart for quality control in clinical chemistry. Clin Chem (1981) 27:493-501.</li></ul></div>
</text>
</section>
<section>
<title value="Codebook (Variable Definitions)"/>
<code>
<text
value="section created Tue Oct 15 2024 10:43:50 GMT-0400 (Eastern Daylight Time)"/>
</code>
<text>
<status value="additional"/>
<div xmlns="http://www.w3.org/1999/xhtml"><ul><li>SEQN - Respondent sequence number</li><li>WTSAF2YR - Fasting Subsample 2 Year MEC Weight</li><li>LBXGLU - Fasting Glucose (mg/dL)</li><li>LBDGLUSI - Fasting Glucose (mmol/L)</li></ul></div>
</text>
<entry>🔗
<reference value="EvidenceVariable/282880"/>
<type value="EvidenceVariable"/>
<display value="NHANES SEQN Respondent Sequence Number"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/282881"/>
<type value="EvidenceVariable"/>
<display value="NHANES LBXGLU: Fasting Glucose (mg/dL)"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/282897"/>
<type value="EvidenceVariable"/>
<display value="NHANES LBDGLUSI: Fasting Glucose (mmol/L)"/>
</entry>
<entry>🔗
<reference value="EvidenceVariable/282898"/>
<type value="EvidenceVariable"/>
<display value="NHANES WTSAF2YR: Fasting Subsample 2 Year MEC Weight"/>
</entry>
</section>
</Composition>
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-11-21
Links: Table of Contents |
QA Report
| Version History |
|
Propose a change