ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort) - TTL Representation - Evidence Based Medicine on FHIR Implementation Guide v2.0.0-ballot

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
: ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort) - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

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    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence-report"^^xsd:anyURI ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Composition 178426</b></p><a name=\"178426\"> </a><a name=\"hc178426\"> </a><a name=\"178426-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 85; Last updated: 2024-11-19 18:07:59+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-comparative-evidence-report.html\">ComparativeEvidenceReport</a></p></div><p><b>Artifact Description</b>: </p><div><p>This example of a ComparativeEvidenceReport Profile shows a report from a single observational study with 2 baseline measures, 2 participant flow measures, and 4 outcome measures.</p>\n</div><p><b>url</b>: <a href=\"https://fevir.net/resources/Composition/178426\">https://fevir.net/resources/Composition/178426</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/178426</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidenceReport}\">Comparative Evidence Report</span></p><p><b>date</b>: 2024-11-19 18:07:59+0000</p><p><b>author</b>: </p><ul><li>Brian S. Alper</li><li>Khalid Shahin</li><li>Joanne Dehnbostel</li></ul><p><b>title</b>: ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort)</p><p><b>custodian</b>: <a href=\"Organization-118079.html\">Computable Publishing LLC</a></p><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Label</b></td><td><b>Citation</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Cite As</td><td> </td><td>Cite as</td><td><div><p>ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort) [Database Entry: FHIR Composition Resource]. Contributors: Brian S. Alper, Khalid Shahin, Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 178426. Revised 2024-08-21. Available at: https://fevir.net/resources/Composition/178426. Computable resource at: https://fevir.net/FLI/DocumentForComposition178426.</p>\n</div></td><td> </td></tr><tr><td style=\"display: none\">*</td><td>Derived From</td><td> </td><td>Derived from</td><td> </td><td><a href=\"Citation-104116.html\">JournalArticleCitation: Association of Bariatric Surgery with Complications and Comorbidities JAMA 2018 Norwegian Cohort</a></td></tr><tr><td style=\"display: none\">*</td><td>Composed Of</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 GroupAssignment}\">GroupAssignment</span></td><td>Group Assignment</td><td> </td><td><a href=\"EvidenceVariable-183637.html\">GroupAssignment: ExposureDefinition: Bariatric Surgery (RYGB, VSG, LAGB, BPD) vs. ComparatorDefinition: NOT Bariatric Surgery (RYGB, VSG, LAGB, BPD)</a></td></tr></table></div>"
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  ] [
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  fhir:title [ fhir:v "ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort)"] ; # 
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fhir:citation [ fhir:v "ComparativeEvidenceReport: Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities (2018 Norwegian Cohort) [Database Entry: FHIR Composition Resource]. Contributors: Brian S. Alper, Khalid Shahin, Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 178426. Revised 2024-08-21. Available at: https://fevir.net/resources/Composition/178426. Computable resource at: https://fevir.net/FLI/DocumentForComposition178426." ]
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  fhir:section ( [
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fhir:code [
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><b>StudyGroup: Severely Obese Adults 2018 Norwegian Cohort</b> Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included). (1888 participants)</div>"     ] ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">Bariatric surgery, mostly gastric bypass (92%) or sleeve gastrectomy (7%)</div>"       ] ;
      ( fhir:entry [
fhir:reference [ fhir:v "Group/172423" ] ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">932 patients opted for bariatric surgery</div>"       ] ;
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fhir:reference [ fhir:v "Group/172934" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
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fhir:code [
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">medical treatment without surgery</div>"       ] ;
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fhir:reference [ fhir:v "Group/172424" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:display [ fhir:v "ComparatorDefinition: NOT Bariatric Surgery (RYGB, VSG, LAGB, BPD)" ]       ] )     ] [
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fhir:text [
fhir:status [ fhir:v "additional" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">956 opted for medical management without surgery</div>"       ] ;
      ( fhir:entry [
fhir:reference [ fhir:v "Group/172939" ] ;
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  ] [
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fhir:code [
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Title:</b> Norwegian Cohort Study Comparing Bariatric Surgery vs Medical Obesity Treatment for Long-term Medical Complications and Obesity-Related Comorbidities</p><br/><p><b>Description:</b> The main purpose of this study is, in combination with data from the Register and Biobank study and follow-up data from the Norwegian Prescription Database, to compare the long-term effects (4-10 years) of surgical and non-surgical treatment of morbid obesity on obesity\nrelated comorbidities by studying changes in medicine usage after treatment.\n\nHypotheses\n1. Primary hypothesis: As compared to non-surgical treatment, bariatric surgery will be associated with higher rates of remission, and lower rates of new-onset drug treated hypertension during a follow-up period of ≤ 10 years.\n2. Secondary hypotheses: Changes in the usage of other drugs, particularly drugs related to obesity related comorbidities, will differ significantly between patients undergoing bariatric surgery or non-surgical treatment during the follow-up period. </p><br/><p><b>Study Design:</b> Observational research (coded as: SEVCO:01002 from https://fevir.net/sevco); Parallel cohort design (coded as: SEVCO:01011 from https://fevir.net/sevco); Longitudinal data collection (coded as: SEVCO:01028 from https://fevir.net/sevco)</p></div>"     ] ;
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fhir:display [ fhir:v "Norwegian Cohort Study Comparing Bariatric Surgery vs Medical Obesity Treatment for Long-term Medical Complications and Obesity-Related Comorbidities" ]     ] )
  ] [
fhir:title [ fhir:v "Methods Section" ] ;
fhir:code [
      ( fhir:coding [
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">As compared with medical patients, surgically treated patients were significantly younger with a higher BMI. Mean age 41.2 in Surgical Group vs. 45.7 in Medical Group (p &lt; 0.001). Mean BMI 45.4 in Surgical Group vs. 42.9 in Medical Group (p &lt; 0.001).</div>"     ] ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">2109 patients included in baseline registry, 221 patients excluded, 1888 patients included in analysis (932 had opted for bariatric surgery, 956 had opted for medical treatment)</div>"     ] ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">Risk of Remission of diabetes in control group was 14.8%. Risk of Remission of diabetes in intervention group was 57.5%. Greater likelihood of diabetes remission: AR, 57.5% vs 14.8%; RD, 42.7% [95% CI, 35.8%-49.7%], RR, 3.9 [95% CI, 2.8-5.4]<br/>Compared with specialized medical treatment, bariatric surgery appears to induce remission of diabetes.<br/><br/>Risk of New onset depression in control group was 6.5%. Risk of New onset depression in intervention group was 8.9%. Greater risk of new-onset depression: AR, 8.9% vs 6.5%; RD, 2.4% [95% CI, 1.3%-3.5%], RR, 1.5 [95% CI, 1.4-1.7].<br/>Compared with specialized medical treatment, bariatric surgery may slightly increase the incidence of depression.<br/><br/>Risk of Treatment with opioids in control group was 15.8%. Risk of Treatment with opioids in intervention group was 19.4%. Greater risk of treatment with opioids: AR, 19.4% vs 15.8%, RD, 3.6% [95% CI, 2.3%-4.9%], RR, 1.3 [95% CI, 1.2-1.4].<br/>Compared with specialized medical treatment, bariatric surgery may slightly increase the use of opioids.<br/><br/>Risk of additional GI surgical procedure in control group was 15.5%. Risk of additional GI surgical procedure in intervention group was 31.3%. Surgical patients had a greater risk for undergoing at least 1 additional gastrointestinal surgical procedure (AR, 31.3% vs 15.5%; RD, 15.8% [95% CI, 13.1%-18.5%]; RR, 2.0 [95% CI, 1.7-2.4]).<br/>Compared with specialized medical treatment, bariatric surgery appears to increase the rate of additional gastrointestinal surgical procedures.</div>"     ] ;
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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">[No data.]</div>"     ] ;
fhir:emptyReason [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/list-empty-reason"^^xsd:anyURI ] ;
fhir:code [ fhir:v "notstarted" ] ;
fhir:display [ fhir:v "Not Started" ]       ] )     ]
  ] [
fhir:title [ fhir:v "Competing Interests Section" ] ;
fhir:code [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "competing-interests" ] ;
fhir:display [ fhir:v "Competing Interests" ]       ] )     ] ;
fhir:text [
fhir:status [ fhir:v "empty" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">[No data.]</div>"     ] ;
fhir:emptyReason [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/list-empty-reason"^^xsd:anyURI ] ;
fhir:code [ fhir:v "notstarted" ] ;
fhir:display [ fhir:v "Not Started" ]       ] )     ]
  ] [
fhir:title [ fhir:v "Acknowledgements Section" ] ;
fhir:code [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "acknowledgements" ] ;
fhir:display [ fhir:v "Acknowledgements" ]       ] )     ] ;
fhir:text [
fhir:status [ fhir:v "empty" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">[No data.]</div>"     ] ;
fhir:emptyReason [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/list-empty-reason"^^xsd:anyURI ] ;
fhir:code [ fhir:v "notstarted" ] ;
fhir:display [ fhir:v "Not Started" ]       ] )     ]
  ] [
fhir:title [ fhir:v "Appendices Section" ] ;
fhir:code [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "appendices" ] ;
fhir:display [ fhir:v "Appendices" ]       ] )     ] ;
fhir:text [
fhir:status [ fhir:v "empty" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">[No data.]</div>"     ] ;
fhir:emptyReason [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/list-empty-reason"^^xsd:anyURI ] ;
fhir:code [ fhir:v "notstarted" ] ;
fhir:display [ fhir:v "Not Started" ]       ] )     ]
  ] ) . #