Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2024-12-19 |
@prefix fhir: <http://hl7.org/fhir/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "267499"] ; # fhir:meta [ fhir:versionId [ fhir:v "2" ] ; fhir:lastUpdated [ fhir:v "2024-11-22T19:28:54.031Z"^^xsd:dateTime ] ; ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 267499</b></p><a name=\"267499\"> </a><a name=\"hc267499\"> </a><a name=\"267499-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 2; Last updated: 2024-11-22 19:28:54+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-267499.html\">Citation 26681725 Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study.</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/267499, <code>https://pubmed.ncbi.nlm.nih.gov</code>/26681725, <a href=\"http://terminology.hl7.org/6.1.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.35</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: 26681725 Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study.</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-12-19 14:29:51+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2016-07-26</p><p><b>lastReviewDate</b>: 2022-03-30</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --> 2015-07-09</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --> 2015-10-20</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2015-12-19 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2015-12-19 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2016-07-28 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pmc-release}\">PubMed Pubstatus of PMC release</span></p><p><b>period</b>: ?? --> 2017-02-01</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26681725, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC4722945, <code>https://doi.org</code>/10.2337/dc15-1498, pii/dc15-1498</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p><strong>OBJECTIVE:</strong> Treatment of severe hypoglycemia with loss of consciousness or seizure outside of the hospital setting is presently limited to intramuscular glucagon requiring reconstitution immediately prior to injection, a process prone to error or omission. A needle-free intranasal glucagon preparation was compared with intramuscular glucagon for treatment of insulin-induced hypoglycemia.\n<AbstractText Label="RESEARCH DESIGN AND METHODS" NlmCategory="METHODS">At eight clinical centers, a randomized crossover noninferiority trial was conducted involving 75 adults with type 1 diabetes (mean age, 33 ± 12 years; median diabetes duration, 18 years) to compare intranasal (3 mg) versus intramuscular (1 mg) glucagon for treatment of hypoglycemia induced by intravenous insulin. Success was defined as an increase in plasma glucose to ≥70 mg/dL or ≥20 mg/dL from the glucose nadir within 30 min after receiving glucagon.\n<strong>RESULTS:</strong> Mean plasma glucose at time of glucagon administration was 48 ± 8 and 49 ± 8 mg/dL at the intranasal and intramuscular visits, respectively. Success criteria were met at all but one intranasal visit and at all intramuscular visits (98.7% vs. 100%; difference 1.3%, upper end of 1-sided 97.5% CI 4.0%). Mean time to success was 16 min for intranasal and 13 min for intramuscular (P < 0.001). Head/facial discomfort was reported during 25% of intranasal and 9% of intramuscular dosing visits; nausea (with or without vomiting) occurred with 35% and 38% of visits, respectively.\n<strong>CONCLUSIONS:</strong> Intranasal glucagon was highly effective in treating insulin-induced hypoglycemia in adults with type 1 diabetes. Although the trial was conducted in a controlled setting, the results are applicable to real-world management of severe hypoglycemia, which occurs owing to excessive therapeutic insulin relative to the impaired or absent endogenous glucagon response.</p>\n</div></td><td><div><p>© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Cryer PE. The barrier of hypoglycemia in diabetes. Diabetes 2008;57:3169–3176</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19033403/\">https://pubmed.ncbi.nlm.nih.gov/19033403/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19033403</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Brodows RG, Williams C, Amatruda JM. Treatment of insulin reactions in diabetics. JAMA 1984;252:3378–3381</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/6389915/\">https://pubmed.ncbi.nlm.nih.gov/6389915/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/6389915</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Slama G, Traynard PY, Desplanque N, et al. . The search for an optimized treatment of hypoglycemia. Carbohydrates in tablets, solutin, or gel for the correction of insulin reactions. Arch Intern Med 1990;150:589–593</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/2310277/\">https://pubmed.ncbi.nlm.nih.gov/2310277/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/2310277</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gold AE, MacLeod KM, Deary IJ, Frier BM. Hypoglycemia-induced cognitive dysfunction in diabetes mellitus: effect of hypoglycemia unawareness. Physiol Behav 1995;58:501–511</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/8587958/\">https://pubmed.ncbi.nlm.nih.gov/8587958/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/8587958</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009;301:1565–1572</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19366776/\">https://pubmed.ncbi.nlm.nih.gov/19366776/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19366776</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>McCoy RG, Van Houten HK, Ziegenfuss JY, Shah ND, Wermers RA, Smith SA. Increased mortality of patients with diabetes reporting severe hypoglycemia. Diabetes Care 2012;35:1897–1901</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/22699297/\">https://pubmed.ncbi.nlm.nih.gov/22699297/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/22699297</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Weinstock RS, Xing D, Maahs DM, et al. .; T1D Exchange Clinic Network . Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab 2013;98:3411–3419</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/23760624/\">https://pubmed.ncbi.nlm.nih.gov/23760624/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/23760624</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Cariou B, Lièvre M, Huet D, Charbonnel B, Sert C, Gouet D. Hypoglycemia among 3048 insulin-treated patients in real life: frequency and predictive factors: results from the prospective DIALOG study. Presented at European Association for the Study of Diabetes (Abstract). Barcelona, Spain, EASD, 2013. Available from http://www.easdvirtualmeeting.org/resources/hypoglycaemia-among-3048-insulin-treated-patients-in-real-life-frequency-and-predictive-factors-results-from-the-prospective-dialog-study--2. Accessed 3 December 2015</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Khunti K, Alsifri S, Aronson R, et al. . Self-reported hypoglycemia: A global study of 24 countries with 27,585 insulin-treated patients with diabetes: the HAT study. Diabetes Res Clin Pract 2014;106:S105–S106</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 1973;182:171–173</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/4581053/\">https://pubmed.ncbi.nlm.nih.gov/4581053/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/4581053</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Holstein A, Hammer C, Plaschke A, et al. . Hormonal counterregulation during severe hypoglycaemia under everyday conditions in patients with type 1 and insulin-treated type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2004;112:429–434</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/15372362/\">https://pubmed.ncbi.nlm.nih.gov/15372362/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/15372362</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Harrism G, Diment A, Sulway M, Wilkinson M. Glucagon administration - underevaluated and undertaught. Pract Diabetes Int 2001;18:22–25</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pontiroli AE, Alberetto M, Pozza G. Metabolic effects of intranasally administered glucagon: comparison with intramuscular and intravenous injection. Acta Diabetol Lat 1985;22:103–110</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/3907228/\">https://pubmed.ncbi.nlm.nih.gov/3907228/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/3907228</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Freychet L, Rizkalla SW, Desplanque N, et al. . Effect of intranasal glucagon on blood glucose levels in healthy subjects and hypoglycaemic patients with insulin-dependent diabetes. Lancet 1988;1:1364–1366</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/2898045/\">https://pubmed.ncbi.nlm.nih.gov/2898045/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/2898045</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pontiroli AE, Calderara A, Pajetta E, Alberetto M, Pozza G. Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients. Diabetes Care 1989;12:604–608</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/2676430/\">https://pubmed.ncbi.nlm.nih.gov/2676430/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/2676430</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Slama G, Alamowitch C, Desplanque N, Letanoux M, Zirinis P. A new non-invasive method for treating insulin-reaction: intranasal lyophylized glucagon. Diabetologia 1990;33:671–674</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/2076798/\">https://pubmed.ncbi.nlm.nih.gov/2076798/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/2076798</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Rosenfalck AM, Bendtson I, Jørgensen S, Binder C. Nasal glucagon in the treatment of hypoglycaemia in type 1 (insulin-dependent) diabetic patients. Diabetes Res Clin Pract 1992;17:43–50</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/1511660/\">https://pubmed.ncbi.nlm.nih.gov/1511660/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/1511660</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA; T1D Exchange Clinic Network . The T1D Exchange clinic registry. J Clin Endocrinol Metab 2012;97:4383–4389</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/22996145/\">https://pubmed.ncbi.nlm.nih.gov/22996145/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/22996145</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Novo Nordisk. GlucaGen prescribing information [Internet]. Available from http://www.novonordiskmedicalinformation.com//file_upload/GlucaGen%20HypoKit%20Prescribing%20Information,April%202014%20.pdf. Accessed 9 September 2015</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Locemia Solutions ULC. Safety and efficacy of a novel glucagon formulation in type 1 diabetic patients following insulin-induced hypoglycemia (AMG102) [Internet]. Available from https://clinicaltrials.gov/ct2/show/study/NCT01556594?term=amg+medical&rank=1. Accessed 23 June 2015</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Hepburn DA, Deary IJ, Frier BM, Patrick AW, Quinn JD, Fisher BM. Symptoms of acute insulin-induced hypoglycemia in humans with and without IDDM. Factor-analysis approach. Diabetes Care 1991;14:949–957</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/1797507/\">https://pubmed.ncbi.nlm.nih.gov/1797507/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/1797507</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Yale JF, Piche C, Lafontaine M, et al. Needlefree nasal delivery of glucagon is superior to injectable delivery in simulated hypoglycaemia rescue. Poster presented at European Association for the Study of Diabetes (Abstract). Stockholm, Sweden, September 2015. Available from http://www.easdvirtualmeeting.org/resources/needle-free-nasal-delivery-of-glucagon-is-superior-to-injectable-delivery-in-simulated-hypoglycaemia-rescue--3. Accessed 3 December 2015</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pacchioni M, Orena C, Panizza P, Cucchi E, Del Maschio A, Pontiroli AE. The hypotonic effect of intranasal and intravenous glucagon in gastrointestinal radiology. Abdom Imaging 1995;20:44–46</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/7894298/\">https://pubmed.ncbi.nlm.nih.gov/7894298/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/7894298</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Diabetes Care. 2016 Oct;39(10):e192. doi: 10.2337/dc16-0955</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/27660134/\">https://pubmed.ncbi.nlm.nih.gov/27660134/</a></td></tr></table><p><b>resourceReference</b>: Identifier: 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href=\"https://pubmed.ncbi.nlm.nih.gov/26681725/\">https://pubmed.ncbi.nlm.nih.gov/26681725/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.2337/dc15-1498\">https://doi.org/10.2337/dc15-1498</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D001786}\">Blood Glucose</span>, <span 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title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor0\">Rickels MR</a></p><p><b>forenameInitials</b>: MR</p><p><b>affiliation</b>: University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor1\">Ruedy KJ</a></p><p><b>forenameInitials</b>: KJ</p><p><b>affiliation</b>: Jaeb Center for Health Research, Tampa, FL.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor2\">Foster NC</a></p><p><b>forenameInitials</b>: NC</p><p><b>affiliation</b>: Jaeb Center for Health Research, Tampa, FL t1dstats@jaeb.org.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor3\">Piché CA</a></p><p><b>forenameInitials</b>: CA</p><p><b>affiliation</b>: Locemia Solutions ULC, Montreal, QC, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor4\">Dulude H</a></p><p><b>forenameInitials</b>: H</p><p><b>affiliation</b>: Locemia Solutions ULC, Montreal, QC, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor5\">Sherr JL</a></p><p><b>forenameInitials</b>: JL</p><p><b>affiliation</b>: Yale School of Medicine, New Haven, CT.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor6\">Tamborlane WV</a></p><p><b>forenameInitials</b>: WV</p><p><b>affiliation</b>: Yale School of Medicine, New Haven, CT.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor7\">Bethin KE</a></p><p><b>forenameInitials</b>: KE</p><p><b>affiliation</b>: Jacobs 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MJ</a></p><p><b>forenameInitials</b>: MJ</p><p><b>affiliation</b>: University of Florida, Gainesville, FL.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor12\">Nathan BM</a></p><p><b>forenameInitials</b>: BM</p><p><b>affiliation</b>: University of Minnesota, Minneapolis, MN.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor13\">Marcovina SM</a></p><p><b>forenameInitials</b>: SM</p><p><b>affiliation</b>: Northwest Lipid Metabolism and Diabetes Research Laboratories, Seattle, WA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor14\">Rampakakis E</a></p><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: JSS Medical Research, St. Laurent, QC, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor15\">Meng L</a></p><p><b>forenameInitials</b>: L</p><p><b>affiliation</b>: JSS Medical Research, St. Laurent, QC, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor16\">Beck RW</a></p><p><b>forenameInitials</b>: RW</p><p><b>affiliation</b>: Jaeb Center for Health Research, Tampa, FL.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc267499/contributor17\">T1D Exchange Intranasal Glucagon Investigators</a></p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"267499/contributor0\"> </a><a name=\"hc267499/contributor0\"> </a><a name=\"267499/contributor0-en-US\"> </a><p><b>name</b>: Michael R Rickels </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"267499/contributor1\"> </a><a name=\"hc267499/contributor1\"> </a><a name=\"267499/contributor1-en-US\"> </a><p><b>name</b>: Katrina J Ruedy 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</a><a name=\"267499/contributor5-en-US\"> </a><p><b>name</b>: Jennifer L Sherr </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"267499/contributor6\"> </a><a name=\"hc267499/contributor6\"> </a><a name=\"267499/contributor6-en-US\"> </a><p><b>name</b>: William V Tamborlane </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"267499/contributor7\"> </a><a name=\"hc267499/contributor7\"> </a><a name=\"267499/contributor7-en-US\"> </a><p><b>name</b>: Kathleen E Bethin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"267499/contributor8\"> </a><a name=\"hc267499/contributor8\"> </a><a name=\"267499/contributor8-en-US\"> </a><p><b>name</b>: Linda A DiMeglio </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"267499/contributor9\"> </a><a name=\"hc267499/contributor9\"> </a><a name=\"267499/contributor9-en-US\"> </a><p><b>name</b>: R Paul Wadwa </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor10</b></p><a name=\"267499/contributor10\"> </a><a name=\"hc267499/contributor10\"> </a><a name=\"267499/contributor10-en-US\"> </a><p><b>name</b>: Andrew J Ahmann </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor11</b></p><a name=\"267499/contributor11\"> </a><a name=\"hc267499/contributor11\"> </a><a name=\"267499/contributor11-en-US\"> </a><p><b>name</b>: Michael J Haller </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor12</b></p><a name=\"267499/contributor12\"> </a><a name=\"hc267499/contributor12\"> </a><a name=\"267499/contributor12-en-US\"> </a><p><b>name</b>: Brandon M Nathan </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor13</b></p><a name=\"267499/contributor13\"> </a><a name=\"hc267499/contributor13\"> </a><a name=\"267499/contributor13-en-US\"> </a><p><b>name</b>: Santica M Marcovina </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor14</b></p><a name=\"267499/contributor14\"> </a><a name=\"hc267499/contributor14\"> </a><a name=\"267499/contributor14-en-US\"> </a><p><b>name</b>: Emmanouil Rampakakis </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor15</b></p><a name=\"267499/contributor15\"> </a><a name=\"hc267499/contributor15\"> </a><a name=\"267499/contributor15-en-US\"> </a><p><b>name</b>: Linyan Meng </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor16</b></p><a name=\"267499/contributor16\"> </a><a name=\"hc267499/contributor16\"> </a><a name=\"267499/contributor16-en-US\"> </a><p><b>name</b>: Roy W Beck </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Organization #contributor17</b></p><a name=\"267499/contributor17\"> </a><a name=\"hc267499/contributor17\"> </a><a name=\"267499/contributor17-en-US\"> </a><p><b>name</b>: T1D Exchange Intranasal Glucagon Investigators</p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"267499/meshHeading0\"> </a><a name=\"hc267499/meshHeading0\"> </a><a name=\"267499/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc267499\">Citation 26681725 Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000281}\">Administration, Intranasal</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000328}\">Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D001786}\">Blood Glucose</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000187}\">drug effects</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D018592}\">Cross-Over Studies</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D003922}\">Diabetes Mellitus, Type 1</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000097}\">blood</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D005260}\">Female</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D005934}\">Glucagon</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000008}\">administration & dosage</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D006728}\">Hormones</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D007003}\">Hypoglycemia</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000139}\">chemically induced</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D007328}\">Insulin</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D055815}\">Young Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>" ] ; # fhir:contained ( [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor0" ] ; ( fhir:name [ fhir:family [ fhir:v "Rickels" ] ; ( fhir:given [ fhir:v "Michael R" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor1" ] ; ( fhir:name [ fhir:family [ fhir:v "Ruedy" ] ; ( fhir:given [ fhir:v "Katrina J" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor2" ] ; ( fhir:name [ fhir:family [ fhir:v "Foster" ] ; ( fhir:given [ fhir:v "Nicole C" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor3" ] ; ( fhir:name [ fhir:family [ fhir:v "Piché" ] ; ( fhir:given [ fhir:v "Claude A" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor4" ] ; ( fhir:name [ fhir:family [ fhir:v "Dulude" ] ; ( fhir:given [ fhir:v "Hélène" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor5" ] ; ( fhir:name [ fhir:family [ fhir:v "Sherr" ] ; ( fhir:given [ fhir:v "Jennifer L" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor6" ] ; ( fhir:name [ fhir:family [ fhir:v "Tamborlane" ] ; ( fhir:given [ fhir:v "William V" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor7" ] ; ( fhir:name [ fhir:family [ fhir:v "Bethin" ] ; ( fhir:given [ fhir:v "Kathleen E" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor8" ] ; ( fhir:name [ fhir:family [ fhir:v "DiMeglio" ] ; ( fhir:given [ fhir:v "Linda A" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor9" ] ; ( fhir:name [ fhir:family [ fhir:v "Wadwa" ] ; ( fhir:given [ fhir:v "R Paul" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor10" ] ; ( fhir:name [ fhir:family [ fhir:v "Ahmann" ] ; ( fhir:given [ fhir:v "Andrew J" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor11" ] ; ( fhir:name [ fhir:family [ fhir:v "Haller" ] ; ( fhir:given [ fhir:v "Michael J" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor12" ] ; ( fhir:name [ fhir:family [ fhir:v "Nathan" ] ; ( fhir:given [ fhir:v "Brandon M" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor13" ] ; ( fhir:name [ fhir:family [ fhir:v "Marcovina" ] ; ( fhir:given [ fhir:v "Santica M" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor14" ] ; ( fhir:name [ fhir:family [ fhir:v "Rampakakis" ] ; ( fhir:given [ fhir:v "Emmanouil" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor15" ] ; ( fhir:name [ fhir:family [ fhir:v "Meng" ] ; ( fhir:given [ fhir:v "Linyan" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor16" ] ; ( fhir:name [ fhir:family [ fhir:v "Beck" ] ; ( fhir:given [ fhir:v "Roy W" ] ) ] ) ] [ a fhir:Organization ; fhir:id [ fhir:v "contributor17" ] ; fhir:name [ fhir:v "T1D Exchange Intranasal Glucagon Investigators" ] ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000281" ] ; fhir:display [ fhir:v "Administration, Intranasal" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000328" ] ; fhir:display [ fhir:v "Adult" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D001786" ] ; fhir:display [ fhir:v "Blood Glucose" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000187" ] ; fhir:display [ fhir:v "drug effects" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D018592" ] ; fhir:display [ fhir:v "Cross-Over Studies" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D003922" ] ; fhir:display [ fhir:v "Diabetes Mellitus, Type 1" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000097" ] ; fhir:display [ fhir:v "blood" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; 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fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v 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( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D055815" ] ; fhir:display [ fhir:v "Young Adult" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] ) ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/267499"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "https://fevir.net/FOI/267499" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "26681725" ] ] [ fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.15.35" ] ] ) ; # fhir:version [ fhir:v "2.0.0-ballot"] ; # fhir:title [ fhir:v "26681725 Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study."] ; # fhir:status [ fhir:v "active"] ; # fhir:date [ fhir:v "2024-12-19T14:29:51+00:00"^^xsd:dateTime] ; # fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # fhir:contact ( [ fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ; ( fhir:telecom [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] ) ] ) ; # fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # fhir:useContext ( [ fhir:code [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-base" ] ; fhir:display [ fhir:v "Medline Base" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ] ) ; # fhir:jurisdiction ( [ ( fhir:coding [ fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ; fhir:code [ fhir:v "001" ] ; fhir:display [ fhir:v "World" ] ] ) ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2016-07-26"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2022-03-30"^^xsd:date] ; # fhir:author ( [ fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ] ] ) ; # fhir:classification ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-source" ] ; fhir:display [ fhir:v "Citation Source" ] ] ) ] ; ( fhir:classifier [ fhir:text [ fhir:v "MEDLINE" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-owner" ] ; fhir:display [ fhir:v "MEDLINE Citation Owner" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ] ; fhir:code [ fhir:v "NLM" ] ; fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ] ) ; # fhir:currentState ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-received" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Received" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-07-09"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-10-20"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-12-19T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2015-12-19T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Medline" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2016-07-28T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-pmc-release" ] ; fhir:display [ fhir:v "PubMed Pubstatus of PMC release" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2017-02-01"^^xsd:date ] ] ] ) ; # fhir:citedArtifact [ ( fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "26681725" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/pmc/"^^xsd:anyURI ] ; fhir:value [ fhir:v "PMC4722945" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "10.2337/dc15-1498" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "dc15-1498" ] ] ) ; ( fhir:title [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en" ] ; fhir:display [ fhir:v "English" ] ] ) ] ; fhir:text [ fhir:v "Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study." ] ] ) ; ( fhir:abstract [ fhir:text [ fhir:v "**OBJECTIVE:** Treatment of severe hypoglycemia with loss of consciousness or seizure outside of the hospital setting is presently limited to intramuscular glucagon requiring reconstitution immediately prior to injection, a process prone to error or omission. A needle-free intranasal glucagon preparation was compared with intramuscular glucagon for treatment of insulin-induced hypoglycemia.\n<AbstractText Label=\"RESEARCH DESIGN AND METHODS\" NlmCategory=\"METHODS\">At eight clinical centers, a randomized crossover noninferiority trial was conducted involving 75 adults with type 1 diabetes (mean age, 33 ± 12 years; median diabetes duration, 18 years) to compare intranasal (3 mg) versus intramuscular (1 mg) glucagon for treatment of hypoglycemia induced by intravenous insulin. Success was defined as an increase in plasma glucose to ≥70 mg/dL or ≥20 mg/dL from the glucose nadir within 30 min after receiving glucagon.\n**RESULTS:** Mean plasma glucose at time of glucagon administration was 48 ± 8 and 49 ± 8 mg/dL at the intranasal and intramuscular visits, respectively. Success criteria were met at all but one intranasal visit and at all intramuscular visits (98.7% vs. 100%; difference 1.3%, upper end of 1-sided 97.5% CI 4.0%). Mean time to success was 16 min for intranasal and 13 min for intramuscular (P < 0.001). Head/facial discomfort was reported during 25% of intranasal and 9% of intramuscular dosing visits; nausea (with or without vomiting) occurred with 35% and 38% of visits, respectively.\n**CONCLUSIONS:** Intranasal glucagon was highly effective in treating insulin-induced hypoglycemia in adults with type 1 diabetes. Although the trial was conducted in a controlled setting, the results are applicable to real-world management of severe hypoglycemia, which occurs owing to excessive therapeutic insulin relative to the impaired or absent endogenous glucagon response." ] ; fhir:copyright [ fhir:v "© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered." ] ] ) ; ( fhir:relatesTo [ fhir:type [ fhir:v "cites" ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ] ) ] ) ; fhir:citation [ fhir:v "Cryer PE. The barrier of hypoglycemia in diabetes. Diabetes 2008;57:3169–3176" ] ; fhir:document [ fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/19033403/"^^xsd:anyURI ] ] ; fhir:resourceReference [ fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "19033403" ] ; fhir:assigner [ fhir:display [ fhir:v "NLM" ] ] ] ] ] [ fhir:type [ fhir:v "cites" ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ] ) ] ) ; fhir:citation [ fhir:v "Brodows RG, Williams C, Amatruda JM. Treatment of insulin reactions in diabetics. 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fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ] ; ( fhir:artifactAssessment [ fhir:reference [ fhir:v "#meshHeading0" ] ; fhir:type [ fhir:v "ArtifactAssessment"^^xsd:anyURI ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "publication-type" ] ; fhir:display [ fhir:v "Publication type" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016448" ] ; fhir:display [ fhir:v "Multicenter Study" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016449" ] ; fhir:display [ fhir:v "Randomized Controlled Trial" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D052061" ] ; fhir:display [ fhir:v "Research Support, N.I.H., Extramural" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D013485" ] ; fhir:display [ fhir:v "Research Support, Non-U.S. Gov't" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "knowledge-artifact-type" ] ; fhir:display [ fhir:v "Knowledge Artifact Type" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; ( fhir:artifactAssessment [ fhir:display [ fhir:v "Classifier added by Computable Publishing LLC" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-subset" ] ; fhir:display [ fhir:v "Citation subset" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"^^xsd:anyURI ] ; fhir:code [ fhir:v "IM" ] ; fhir:display [ fhir:v "IM" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ] ) ; fhir:contributorship [ fhir:complete [ fhir:v "true"^^xsd:boolean ] ; ( fhir:entry [ fhir:contributor [ fhir:reference [ fhir:v "#contributor0" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Rickels MR" ] ] ; fhir:forenameInitials [ fhir:v "MR" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of Pennsylvania Perelman School of Medicine, Philadelphia, PA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor1" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Ruedy KJ" ] ] ; fhir:forenameInitials [ fhir:v "KJ" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Jaeb Center for Health Research, Tampa, FL." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor2" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Foster NC" ] ] ; fhir:forenameInitials [ fhir:v "NC" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Jaeb Center for Health Research, Tampa, FL t1dstats@jaeb.org." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor3" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Piché CA" ] ] ; fhir:forenameInitials [ fhir:v "CA" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Locemia Solutions ULC, Montreal, QC, Canada." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor4" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Dulude H" ] ] ; fhir:forenameInitials [ fhir:v "H" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Locemia Solutions ULC, Montreal, QC, Canada." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor5" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Sherr JL" ] ] ; fhir:forenameInitials [ fhir:v "JL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Yale School of Medicine, New Haven, CT." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor6" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Tamborlane WV" ] ] ; fhir:forenameInitials [ fhir:v "WV" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Yale School of Medicine, New Haven, CT." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor7" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Bethin KE" ] ] ; fhir:forenameInitials [ fhir:v "KE" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor8" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "DiMeglio LA" ] ] ; fhir:forenameInitials [ fhir:v "LA" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Indiana University School of Medicine, Indianapolis, IN." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor9" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Wadwa RP" ] ] ; fhir:forenameInitials [ fhir:v "RP" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Barbara Davis Center for Childhood Diabetes, Aurora, CO." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor10" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Ahmann AJ" ] ] ; fhir:forenameInitials [ fhir:v "AJ" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Harold Schnitzer Diabetes Health Center, Oregon Health & Science University, Portland, OR." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor11" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Haller MJ" ] ] ; fhir:forenameInitials [ fhir:v "MJ" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of Florida, Gainesville, FL." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor12" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Nathan BM" ] ] ; fhir:forenameInitials [ fhir:v "BM" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of Minnesota, Minneapolis, MN." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor13" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Marcovina SM" ] ] ; fhir:forenameInitials [ fhir:v "SM" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Northwest Lipid Metabolism and Diabetes Research Laboratories, Seattle, WA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor14" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Rampakakis E" ] ] ; fhir:forenameInitials [ fhir:v "E" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "JSS Medical Research, St. Laurent, QC, Canada." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor15" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Meng L" ] ] ; fhir:forenameInitials [ fhir:v "L" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "JSS Medical Research, St. Laurent, QC, Canada." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor16" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Beck RW" ] ] ; fhir:forenameInitials [ fhir:v "RW" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Jaeb Center for Health Research, Tampa, FL." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor17" ] ; fhir:type [ fhir:v "Organization"^^xsd:anyURI ] ; fhir:display [ fhir:v "T1D Exchange Intranasal Glucagon Investigators" ] ] ] ) ] ] . #
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-12-19
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