Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2024-11-21 |
@prefix fhir: <http://hl7.org/fhir/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "264329"] ; # fhir:meta [ fhir:versionId [ fhir:v "1" ] ; fhir:lastUpdated [ fhir:v "2024-07-25T13:42:36.685Z"^^xsd:dateTime ] ; ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 264329</b></p><a name=\"264329\"> </a><a name=\"hc264329\"> </a><a name=\"264329-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 1; Last updated: 2024-07-25 13:42:36+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-264329.html\">Citation 37024129 Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.</a></p><p><b>identifier</b>: FEvIR Object Identifier/264329, <code>https://pubmed.ncbi.nlm.nih.gov</code>/37024129, <a href=\"http://terminology.hl7.org/6.1.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.11</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: 37024129 Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-11-21 14:09:14+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2023-04-10</p><p><b>lastReviewDate</b>: 2023-04-11</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-epublish}\">PubMed PublicationStatus of epublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2023-04-10 06:42:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2023-04-06 20:43:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2023-04-07 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pmc-release}\">PubMed Pubstatus of PMC release</span></p><p><b>period</b>: ?? --> 2023-04-06</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/37024129, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC10077111, <code>https://doi.org</code>/10.1136/bmj-2022-074068</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p><strong>OBJECTIVE:</strong> To compare the benefits and harms of drug treatments for adults with type 2 diabetes, adding non-steroidal mineralocorticoid receptor antagonists (including finerenone) and tirzepatide (a dual glucose dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonist) to previously existing treatment options.\n<AbstractText Label="DESIGN">Systematic review and network meta-analysis.\n<AbstractText Label="DATA SOURCES">Ovid Medline, Embase, and Cochrane Central up to 14 October 2022.\n<AbstractText Label="ELIGIBILITY CRITERIA FOR SELECTING STUDIES">Eligible randomised controlled trials compared drugs of interest in adults with type 2 diabetes. Eligible trials had a follow-up of 24 weeks or longer. Trials systematically comparing combinations of more than one drug treatment class with no drug, subgroup analyses of randomised controlled trials, and non-English language studies were deemed ineligible. Certainty of evidence was assessed following the GRADE (grading of recommendations, assessment, development and evaluation) approach.\n<strong>RESULTS:</strong> The analysis identified 816 trials with 471 038 patients, together evaluating 13 different drug classes; all subsequent estimates refer to the comparison with standard treatments. Sodium glucose cotransporter-2 (SGLT-2) inhibitors (odds ratio 0.88, 95% confidence interval 0.83 to 0.94; high certainty) and GLP-1 receptor agonists (0.88, 0.82 to 0.93; high certainty) reduce all cause death; non-steroidal mineralocorticoid receptor antagonists, so far tested only with finerenone in patients with chronic kidney disease, probably reduce mortality (0.89, 0.79 to 1.00; moderate certainty); other drugs may not. The study confirmed the benefits of SGLT-2 inhibitors and GLP-1 receptor agonists in reducing cardiovascular death, non-fatal myocardial infarction, admission to hospital for heart failure, and end stage kidney disease. Finerenone probably reduces admissions to hospital for heart failure and end stage kidney disease, and possibly cardiovascular death. Only GLP-1 receptor agonists reduce non-fatal stroke; SGLT-2 inhibitors are superior to other drugs in reducing end stage kidney disease. GLP-1 receptor agonists and probably SGLT-2 inhibitors and tirzepatide improve quality of life. Reported harms were largely specific to drug class (eg, genital infections with SGLT-2 inhibitors, severe gastrointestinal adverse events with tirzepatide and GLP-1 receptor agonists, hyperkalaemia leading to admission to hospital with finerenone). Tirzepatide probably results in the largest reduction in body weight (mean difference -8.57 kg; moderate certainty). Basal insulin (mean difference 2.15 kg; moderate certainty) and thiazolidinediones (mean difference 2.81 kg; moderate certainty) probably result in the largest increases in body weight. Absolute benefits of SGLT-2 inhibitors, GLP-1 receptor agonists, and finerenone vary in people with type 2 diabetes, depending on baseline risks for cardiovascular and kidney outcomes (https://matchit.magicevidence.org/230125dist-diabetes).\n<strong>CONCLUSIONS:</strong> This network meta-analysis extends knowledge beyond confirming the substantial benefits with the use of SGLT-2 inhibitors and GLP-1 receptor agonists in reducing adverse cardiovascular and kidney outcomes and death by adding information on finerenone and tirzepatide. These findings highlight the need for continuous assessment of scientific progress to introduce cutting edge updates in clinical practice guidelines for people with type 2 diabetes.\n<AbstractText Label="SYSTEMATIC REVIEW REGISTRATION">PROSPERO CRD42022325948.</p>\n</div></td><td><div><p>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gregg EW, Jakicic JM, Blackburn G, et al. Look AHEAD Research Group . Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 2016;4:913-21. 10.1016/S2213-8587(16)30162-0.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/27595918/\">https://pubmed.ncbi.nlm.nih.gov/27595918/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/27595918</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Palmer SC, Tendal B, Mustafa RA, et al. . Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ 2021;372:m4573. 10.1136/bmj.m4573.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/33441402/\">https://pubmed.ncbi.nlm.nih.gov/33441402/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33441402</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Li S, Vandvik PO, Lytvyn L, et al. . SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes: a clinical practice guideline. BMJ 2021;373:n1091. 10.1136/bmj.n1091.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/33975892/\">https://pubmed.ncbi.nlm.nih.gov/33975892/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33975892</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Bakris GL, Agarwal R, Anker SD, et al. FIDELIO-DKD Investigators . Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. N Engl J Med 2020;383:2219-29. 10.1056/NEJMoa2025845.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/33264825/\">https://pubmed.ncbi.nlm.nih.gov/33264825/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33264825</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pitt B, Filippatos G, Agarwal R, et al. FIGARO-DKD Investigators . Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med 2021;385:2252-63. 10.1056/NEJMoa2110956.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34449181/\">https://pubmed.ncbi.nlm.nih.gov/34449181/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34449181</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Rosenstock J, Wysham C, Frías JP, et al. . Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. Lancet 2021;398:143-55. 10.1016/S0140-6736(21)01324-6.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34186022/\">https://pubmed.ncbi.nlm.nih.gov/34186022/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34186022</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Frías JP, Davies MJ, Rosenstock J, et al. SURPASS-2 Investigators . Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med 2021;385:503-15. 10.1056/NEJMoa2107519.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34170647/\">https://pubmed.ncbi.nlm.nih.gov/34170647/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34170647</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Ludvik B, Giorgino F, Jódar E, et al. . Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. Lancet 2021;398:583-98. 10.1016/S0140-6736(21)01443-4.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34370970/\">https://pubmed.ncbi.nlm.nih.gov/34370970/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34370970</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Del Prato S, Kahn SE, Pavo I, et al. SURPASS-4 Investigators . Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet 2021;398:1811-24. 10.1016/S0140-6736(21)02188-7.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34672967/\">https://pubmed.ncbi.nlm.nih.gov/34672967/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34672967</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Dahl D, Onishi Y, Norwood P, et al. . Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial. JAMA 2022;327:534-45. 10.1001/jama.2022.0078.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/35133415/\">https://pubmed.ncbi.nlm.nih.gov/35133415/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35133415</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Rydén L, Standl E. After Metformin - Next Steps for Type 2 Diabetes with Low Cardiovascular Risk. N Engl J Med 2022;387:1136-8. 10.1056/NEJMe2210531.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/36130002/\">https://pubmed.ncbi.nlm.nih.gov/36130002/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/36130002</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Nathan DM, Lachin JM, Balasubramanyam A, et al. GRADE Study Research Group . Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes. N Engl J Med 2022;387:1063-74. 10.1056/NEJMoa2200433.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/36129996/\">https://pubmed.ncbi.nlm.nih.gov/36129996/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/36129996</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Nathan DM, Lachin JM, Bebu I, et al. GRADE Study Research Group . Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. N Engl J Med 2022;387:1075-88. 10.1056/NEJMoa2200436.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/36129997/\">https://pubmed.ncbi.nlm.nih.gov/36129997/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/36129997</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Marx N, Ryden L, Brosius F, et al. . Towards living guidelines on cardiorenal outcomes in diabetes: A pilot project of the Taskforce of the Guideline Workshop 2020. Diabetes Res Clin Pract 2021;177:108870. 10.1016/j.diabres.2021.108870.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34044026/\">https://pubmed.ncbi.nlm.nih.gov/34044026/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34044026</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Page MJ, McKenzie JE, Bossuyt PM, et al. . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. 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The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT). clinicaltrials.gov 2022. https://clinicaltrials.gov/ct2/show/NCT04255433.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Deacon CF. Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus. 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Diabetes Obes Metab 2020;22:1619-27. 10.1111/dom.14075.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/32364674/\">https://pubmed.ncbi.nlm.nih.gov/32364674/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/32364674</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Lin C, Zhu X, Cai X, et al. . SGLT2 inhibitors and lower limb complications: an updated meta-analysis. 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Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor11\">Mao Y</a></p><p><b>forenameInitials</b>: Y</p><p><b>affiliation</b>: Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor12\">Asadollahifar A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor13\">Chowdhury SR</a></p><p><b>forenameInitials</b>: SR</p><p><b>affiliation</b>: Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor14\">Zhai C</a></p><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor15\">Gupta S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor16\">Gao Y</a></p><p><b>forenameInitials</b>: Y</p><p><b>affiliation</b>: </p><ul><li>Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada.</li><li>Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 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Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor21\">Yang Q</a></p><p><b>forenameInitials</b>: Q</p><p><b>affiliation</b>: Department of Nephrology, National Clinical Research Centre for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor22\">Jin Y</a></p><p><b>forenameInitials</b>: Y</p><p><b>affiliation</b>: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor23\">Ge L</a></p><p><b>forenameInitials</b>: L</p><p><b>affiliation</b>: Evidence-Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor24\">Yang Q</a></p><p><b>forenameInitials</b>: Q</p><p><b>affiliation</b>: Evidence-Based Nursing Centre, School of Nursing, Lanzhou University, Lanzhou, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor25\">Zhu H</a></p><p><b>forenameInitials</b>: H</p><p><b>affiliation</b>: Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor26\">Yang F</a></p><p><b>forenameInitials</b>: F</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, Chengdu Fifth People's Hospital, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor27\">Chen Z</a></p><p><b>forenameInitials</b>: Z</p><p><b>affiliation</b>: Evidence-Based Medicine Centre, Tianjin University of Traditional Chinese Medicine, Tianjin, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor28\">Lu X</a></p><p><b>forenameInitials</b>: X</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor29\">He S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor30\">Chen X</a></p><p><b>forenameInitials</b>: X</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, First People's Hospital of Shuangliu District, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor31\">Lyu X</a></p><p><b>forenameInitials</b>: X</p><p><b>affiliation</b>: Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor32\">An X</a></p><p><b>forenameInitials</b>: X</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor33\">Chen Y</a></p><p><b>forenameInitials</b>: Y</p><p><b>affiliation</b>: Evidence-Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor34\">Hao Q</a></p><p><b>forenameInitials</b>: Q</p><p><b>affiliation</b>: School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor35\">Standl E</a></p><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: Forschergruppe Diabetes eV at the Helmholtz Centre, Munich-Neuherberg, Germany.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor36\">Siemieniuk R</a></p><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor37\">Agoritsas T</a></p><p><b>forenameInitials</b>: T</p><p><b>affiliation</b>: </p><ul><li>Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada.</li><li>Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland.</li></ul></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor38\">Tian H</a></p><p><b>forenameInitials</b>: H</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc264329/contributor39\">Li S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China lisheyu@gmail.com.</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"264329/contributor0\"> </a><a name=\"hc264329/contributor0\"> </a><a name=\"264329/contributor0-en-US\"> </a><p><b>identifier</b>: ORCID/0000-0003-4299-5889</p><p><b>name</b>: Qingyang Shi </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"264329/contributor1\"> </a><a name=\"hc264329/contributor1\"> </a><a name=\"264329/contributor1-en-US\"> </a><p><b>name</b>: Kailei Nong </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"264329/contributor2\"> </a><a name=\"hc264329/contributor2\"> </a><a name=\"264329/contributor2-en-US\"> </a><p><b>name</b>: Per Olav Vandvik </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"264329/contributor3\"> </a><a name=\"hc264329/contributor3\"> </a><a name=\"264329/contributor3-en-US\"> </a><p><b>name</b>: Gordon H Guyatt </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"264329/contributor4\"> </a><a name=\"hc264329/contributor4\"> </a><a name=\"264329/contributor4-en-US\"> </a><p><b>name</b>: Oliver Schnell </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"264329/contributor5\"> </a><a name=\"hc264329/contributor5\"> </a><a name=\"264329/contributor5-en-US\"> </a><p><b>name</b>: Lars Rydén </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"264329/contributor6\"> </a><a name=\"hc264329/contributor6\"> </a><a name=\"264329/contributor6-en-US\"> </a><p><b>name</b>: Nikolaus Marx </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"264329/contributor7\"> </a><a name=\"hc264329/contributor7\"> </a><a name=\"264329/contributor7-en-US\"> </a><p><b>name</b>: Frank C Brosius </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"264329/contributor8\"> </a><a name=\"hc264329/contributor8\"> </a><a name=\"264329/contributor8-en-US\"> </a><p><b>name</b>: Reem A Mustafa </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"264329/contributor9\"> </a><a name=\"hc264329/contributor9\"> </a><a name=\"264329/contributor9-en-US\"> </a><p><b>name</b>: Arnav Agarwal </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor10</b></p><a name=\"264329/contributor10\"> </a><a name=\"hc264329/contributor10\"> </a><a name=\"264329/contributor10-en-US\"> </a><p><b>name</b>: Xinyu Zou </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor11</b></p><a name=\"264329/contributor11\"> </a><a name=\"hc264329/contributor11\"> </a><a name=\"264329/contributor11-en-US\"> </a><p><b>name</b>: Yunhe Mao </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor12</b></p><a name=\"264329/contributor12\"> </a><a name=\"hc264329/contributor12\"> </a><a name=\"264329/contributor12-en-US\"> </a><p><b>name</b>: Aminreza Asadollahifar </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor13</b></p><a name=\"264329/contributor13\"> </a><a name=\"hc264329/contributor13\"> </a><a name=\"264329/contributor13-en-US\"> </a><p><b>name</b>: Saifur Rahman Chowdhury </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor14</b></p><a name=\"264329/contributor14\"> </a><a name=\"hc264329/contributor14\"> </a><a name=\"264329/contributor14-en-US\"> </a><p><b>name</b>: Chunjuan Zhai </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor15</b></p><a name=\"264329/contributor15\"> </a><a name=\"hc264329/contributor15\"> </a><a name=\"264329/contributor15-en-US\"> </a><p><b>name</b>: Sana Gupta </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor16</b></p><a name=\"264329/contributor16\"> </a><a name=\"hc264329/contributor16\"> </a><a name=\"264329/contributor16-en-US\"> </a><p><b>name</b>: Ya Gao </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor17</b></p><a name=\"264329/contributor17\"> </a><a name=\"hc264329/contributor17\"> </a><a name=\"264329/contributor17-en-US\"> </a><p><b>name</b>: João Pedro Lima </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor18</b></p><a name=\"264329/contributor18\"> </a><a name=\"hc264329/contributor18\"> </a><a name=\"264329/contributor18-en-US\"> </a><p><b>name</b>: Kenji Numata </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor19</b></p><a name=\"264329/contributor19\"> </a><a name=\"hc264329/contributor19\"> </a><a name=\"264329/contributor19-en-US\"> </a><p><b>name</b>: Zhi Qiao </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor20</b></p><a name=\"264329/contributor20\"> </a><a name=\"hc264329/contributor20\"> </a><a name=\"264329/contributor20-en-US\"> </a><p><b>name</b>: Qinlin Fan </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor21</b></p><a name=\"264329/contributor21\"> </a><a name=\"hc264329/contributor21\"> </a><a name=\"264329/contributor21-en-US\"> </a><p><b>name</b>: Qinbo Yang </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor22</b></p><a name=\"264329/contributor22\"> </a><a name=\"hc264329/contributor22\"> </a><a name=\"264329/contributor22-en-US\"> </a><p><b>name</b>: Yinghui Jin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor23</b></p><a name=\"264329/contributor23\"> </a><a name=\"hc264329/contributor23\"> </a><a name=\"264329/contributor23-en-US\"> </a><p><b>name</b>: Long Ge </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor24</b></p><a name=\"264329/contributor24\"> </a><a name=\"hc264329/contributor24\"> </a><a name=\"264329/contributor24-en-US\"> </a><p><b>name</b>: Qiuyu Yang </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor25</b></p><a name=\"264329/contributor25\"> </a><a name=\"hc264329/contributor25\"> </a><a name=\"264329/contributor25-en-US\"> </a><p><b>name</b>: Hongfei Zhu </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor26</b></p><a name=\"264329/contributor26\"> </a><a name=\"hc264329/contributor26\"> </a><a name=\"264329/contributor26-en-US\"> </a><p><b>name</b>: Fan Yang </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor27</b></p><a name=\"264329/contributor27\"> </a><a name=\"hc264329/contributor27\"> </a><a name=\"264329/contributor27-en-US\"> </a><p><b>name</b>: Zhe Chen </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor28</b></p><a name=\"264329/contributor28\"> </a><a name=\"hc264329/contributor28\"> </a><a name=\"264329/contributor28-en-US\"> </a><p><b>name</b>: Xi Lu </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor29</b></p><a name=\"264329/contributor29\"> </a><a name=\"hc264329/contributor29\"> </a><a name=\"264329/contributor29-en-US\"> </a><p><b>name</b>: Siyu He </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor30</b></p><a name=\"264329/contributor30\"> </a><a name=\"hc264329/contributor30\"> </a><a name=\"264329/contributor30-en-US\"> </a><p><b>name</b>: Xiangyang Chen </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor31</b></p><a name=\"264329/contributor31\"> </a><a name=\"hc264329/contributor31\"> </a><a name=\"264329/contributor31-en-US\"> </a><p><b>name</b>: Xiafei Lyu </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor32</b></p><a name=\"264329/contributor32\"> </a><a name=\"hc264329/contributor32\"> </a><a name=\"264329/contributor32-en-US\"> </a><p><b>name</b>: Xingxing An </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor33</b></p><a name=\"264329/contributor33\"> </a><a name=\"hc264329/contributor33\"> </a><a name=\"264329/contributor33-en-US\"> </a><p><b>name</b>: Yaolong Chen </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor34</b></p><a name=\"264329/contributor34\"> </a><a name=\"hc264329/contributor34\"> </a><a name=\"264329/contributor34-en-US\"> </a><p><b>name</b>: Qiukui Hao </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor35</b></p><a name=\"264329/contributor35\"> </a><a name=\"hc264329/contributor35\"> </a><a name=\"264329/contributor35-en-US\"> </a><p><b>name</b>: Eberhard Standl </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor36</b></p><a name=\"264329/contributor36\"> </a><a name=\"hc264329/contributor36\"> </a><a name=\"264329/contributor36-en-US\"> </a><p><b>name</b>: Reed Siemieniuk </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor37</b></p><a name=\"264329/contributor37\"> </a><a name=\"hc264329/contributor37\"> </a><a name=\"264329/contributor37-en-US\"> </a><p><b>name</b>: Thomas Agoritsas </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor38</b></p><a name=\"264329/contributor38\"> </a><a name=\"hc264329/contributor38\"> </a><a name=\"264329/contributor38-en-US\"> </a><p><b>name</b>: Haoming Tian </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor39</b></p><a name=\"264329/contributor39\"> </a><a name=\"hc264329/contributor39\"> </a><a name=\"264329/contributor39-en-US\"> </a><p><b>identifier</b>: ORCID/0000-0003-0060-0287</p><p><b>name</b>: Sheyu Li </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"264329/meshHeading0\"> </a><a name=\"hc264329/meshHeading0\"> </a><a name=\"264329/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc264329\">Citation 37024129 Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000328}\">Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D003924}\">Diabetes Mellitus, Type 2</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is Major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000077203}\">Sodium-Glucose Transporter 2 Inhibitors</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is Major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000009}\">adverse effects</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000451}\">Mineralocorticoid Receptor Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000009}\">adverse effects</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000071076}\">Network Meta-Analysis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000067757}\">Glucagon-Like Peptide-1 Receptor</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D011788}\">Quality of Life</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D007676}\">Kidney Failure, Chronic</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is Major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D006333}\">Heart Failure</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is Major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016032}\">Randomized Controlled Trials as Topic</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>" ] ; # fhir:contained ( [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor0" ] ; ( fhir:identifier [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "PRN" ] ; fhir:display [ fhir:v "Provider number" ] ] ) ; fhir:text [ fhir:v "ORCID" ] ] ; fhir:system [ fhir:v "https://orcid.org/"^^xsd:anyURI ] ; fhir:value [ fhir:v "0000-0003-4299-5889" ] ] ) ; ( fhir:name [ fhir:family [ fhir:v "Shi" ] ; ( fhir:given [ fhir:v "Qingyang" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor1" ] ; ( fhir:name [ fhir:family [ fhir:v "Nong" ] ; ( fhir:given [ fhir:v "Kailei" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor2" ] ; ( fhir:name [ fhir:family [ fhir:v "Vandvik" ] ; ( fhir:given [ fhir:v "Per Olav" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor3" ] ; ( fhir:name [ fhir:family [ fhir:v "Guyatt" ] ; ( fhir:given [ fhir:v "Gordon H" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor4" ] ; ( fhir:name [ fhir:family [ fhir:v "Schnell" ] ; ( fhir:given [ fhir:v "Oliver" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor5" ] ; ( fhir:name [ fhir:family [ fhir:v "Rydén" ] ; ( fhir:given [ fhir:v "Lars" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor6" ] ; ( fhir:name [ fhir:family [ fhir:v "Marx" ] ; ( fhir:given [ fhir:v "Nikolaus" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor7" ] ; ( fhir:name [ fhir:family [ fhir:v "Brosius" ] ; ( fhir:given [ fhir:v "Frank C" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor8" ] ; ( fhir:name [ fhir:family [ fhir:v "Mustafa" ] ; ( fhir:given [ fhir:v "Reem A" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor9" ] ; ( fhir:name [ fhir:family [ fhir:v "Agarwal" ] ; ( fhir:given [ fhir:v "Arnav" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor10" ] ; ( fhir:name [ fhir:family [ fhir:v "Zou" ] ; ( fhir:given [ fhir:v "Xinyu" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor11" ] ; ( fhir:name [ fhir:family [ fhir:v "Mao" ] ; ( fhir:given [ fhir:v "Yunhe" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor12" ] ; ( fhir:name [ fhir:family [ fhir:v "Asadollahifar" ] ; ( fhir:given [ fhir:v "Aminreza" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor13" ] ; ( fhir:name [ fhir:family [ fhir:v "Chowdhury" ] ; ( fhir:given [ fhir:v "Saifur Rahman" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor14" ] ; ( fhir:name [ fhir:family [ fhir:v "Zhai" ] ; ( fhir:given [ fhir:v "Chunjuan" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor15" ] ; ( fhir:name [ fhir:family [ fhir:v "Gupta" ] ; ( fhir:given [ fhir:v "Sana" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor16" ] ; ( fhir:name [ fhir:family [ fhir:v "Gao" ] ; ( fhir:given [ fhir:v "Ya" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor17" ] ; ( fhir:name [ fhir:family [ fhir:v "Lima" ] ; ( fhir:given [ fhir:v "João Pedro" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor18" ] ; ( fhir:name [ fhir:family [ fhir:v "Numata" ] ; ( fhir:given [ fhir:v "Kenji" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor19" ] ; ( fhir:name [ fhir:family [ fhir:v "Qiao" ] ; ( fhir:given [ fhir:v "Zhi" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor20" ] ; ( fhir:name [ fhir:family [ fhir:v "Fan" ] ; ( fhir:given [ fhir:v "Qinlin" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor21" ] ; ( fhir:name [ fhir:family [ fhir:v "Yang" ] ; ( fhir:given [ fhir:v "Qinbo" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor22" ] ; ( fhir:name [ fhir:family [ fhir:v "Jin" ] ; ( fhir:given [ fhir:v "Yinghui" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor23" ] ; ( fhir:name [ fhir:family [ fhir:v "Ge" ] ; ( fhir:given [ fhir:v "Long" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor24" ] ; ( fhir:name [ fhir:family [ fhir:v "Yang" ] ; ( fhir:given [ fhir:v "Qiuyu" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor25" ] ; ( fhir:name [ fhir:family [ fhir:v "Zhu" ] ; ( fhir:given [ fhir:v "Hongfei" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor26" ] ; ( fhir:name [ fhir:family [ fhir:v "Yang" ] ; ( fhir:given [ fhir:v "Fan" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor27" ] ; ( fhir:name [ fhir:family [ fhir:v "Chen" ] ; ( fhir:given [ fhir:v "Zhe" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor28" ] ; ( fhir:name [ fhir:family [ fhir:v "Lu" ] ; ( fhir:given [ fhir:v "Xi" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor29" ] ; ( fhir:name [ fhir:family [ fhir:v "He" ] ; ( fhir:given [ fhir:v "Siyu" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor30" ] ; ( fhir:name [ fhir:family [ fhir:v "Chen" ] ; ( fhir:given [ fhir:v "Xiangyang" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor31" ] ; ( fhir:name [ fhir:family [ fhir:v "Lyu" ] ; ( fhir:given [ fhir:v "Xiafei" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor32" ] ; ( fhir:name [ fhir:family [ fhir:v "An" ] ; ( fhir:given [ fhir:v "Xingxing" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor33" ] ; ( fhir:name [ fhir:family [ fhir:v "Chen" ] ; ( fhir:given [ fhir:v "Yaolong" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor34" ] ; ( fhir:name [ fhir:family [ fhir:v "Hao" ] ; ( fhir:given [ fhir:v "Qiukui" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor35" ] ; ( fhir:name [ fhir:family [ fhir:v "Standl" ] ; ( fhir:given [ fhir:v "Eberhard" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor36" ] ; ( fhir:name [ fhir:family [ fhir:v "Siemieniuk" ] ; ( fhir:given [ fhir:v "Reed" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor37" ] ; ( fhir:name [ fhir:family [ fhir:v "Agoritsas" ] ; ( fhir:given [ fhir:v "Thomas" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor38" ] ; ( fhir:name [ fhir:family [ fhir:v "Tian" ] ; ( fhir:given [ fhir:v "Haoming" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor39" ] ; ( fhir:identifier [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "PRN" ] ; fhir:display [ fhir:v "Provider number" ] ] ) ; fhir:text [ fhir:v "ORCID" ] ] ; fhir:system [ fhir:v "https://orcid.org/"^^xsd:anyURI ] ; fhir:value [ fhir:v "0000-0003-0060-0287" ] ] ) ; ( fhir:name [ fhir:family [ fhir:v "Li" ] ; ( fhir:given [ fhir:v "Sheyu" ] ) ] ) ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000328" ] ; fhir:display [ fhir:v "Adult" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006801" ] ; fhir:display [ fhir:v "Humans" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D003924" ] ; fhir:display [ fhir:v "Diabetes Mellitus, Type 2" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000077203" ] ; fhir:display [ fhir:v "Sodium-Glucose Transporter 2 Inhibitors" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000009" ] ; fhir:display [ fhir:v "adverse effects" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000451" ] ; fhir:display [ fhir:v "Mineralocorticoid Receptor Antagonists" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000009" ] ; fhir:display [ fhir:v "adverse effects" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000071076" ] ; fhir:display [ fhir:v "Network Meta-Analysis" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000067757" ] ; fhir:display [ fhir:v "Glucagon-Like Peptide-1 Receptor" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011788" ] ; fhir:display [ fhir:v "Quality of Life" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D007676" ] ; fhir:display [ fhir:v "Kidney Failure, Chronic" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006333" ] ; fhir:display [ fhir:v "Heart Failure" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016032" ] ; fhir:display [ fhir:v "Randomized Controlled Trials as Topic" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] ) ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/264329"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ; fhir:value [ 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fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en" ] ; fhir:display [ fhir:v "English" ] ] ) ] ; fhir:text [ fhir:v "Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials." ] ] ) ; ( fhir:abstract [ fhir:text [ fhir:v "**OBJECTIVE:** To compare the benefits and harms of drug treatments for adults with type 2 diabetes, adding non-steroidal mineralocorticoid receptor antagonists (including finerenone) and tirzepatide (a dual glucose dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonist) to previously existing treatment options.\n<AbstractText Label=\"DESIGN\">Systematic review and network meta-analysis.\n<AbstractText Label=\"DATA SOURCES\">Ovid Medline, Embase, and Cochrane Central up to 14 October 2022.\n<AbstractText Label=\"ELIGIBILITY CRITERIA FOR SELECTING STUDIES\">Eligible randomised controlled trials compared drugs of interest in adults with type 2 diabetes. Eligible trials had a follow-up of 24 weeks or longer. Trials systematically comparing combinations of more than one drug treatment class with no drug, subgroup analyses of randomised controlled trials, and non-English language studies were deemed ineligible. Certainty of evidence was assessed following the GRADE (grading of recommendations, assessment, development and evaluation) approach.\n**RESULTS:** The analysis identified 816 trials with 471 038 patients, together evaluating 13 different drug classes; all subsequent estimates refer to the comparison with standard treatments. Sodium glucose cotransporter-2 (SGLT-2) inhibitors (odds ratio 0.88, 95% confidence interval 0.83 to 0.94; high certainty) and GLP-1 receptor agonists (0.88, 0.82 to 0.93; high certainty) reduce all cause death; non-steroidal mineralocorticoid receptor antagonists, so far tested only with finerenone in patients with chronic kidney disease, probably reduce mortality (0.89, 0.79 to 1.00; moderate certainty); other drugs may not. The study confirmed the benefits of SGLT-2 inhibitors and GLP-1 receptor agonists in reducing cardiovascular death, non-fatal myocardial infarction, admission to hospital for heart failure, and end stage kidney disease. Finerenone probably reduces admissions to hospital for heart failure and end stage kidney disease, and possibly cardiovascular death. Only GLP-1 receptor agonists reduce non-fatal stroke; SGLT-2 inhibitors are superior to other drugs in reducing end stage kidney disease. GLP-1 receptor agonists and probably SGLT-2 inhibitors and tirzepatide improve quality of life. Reported harms were largely specific to drug class (eg, genital infections with SGLT-2 inhibitors, severe gastrointestinal adverse events with tirzepatide and GLP-1 receptor agonists, hyperkalaemia leading to admission to hospital with finerenone). Tirzepatide probably results in the largest reduction in body weight (mean difference -8.57 kg; moderate certainty). Basal insulin (mean difference 2.15 kg; moderate certainty) and thiazolidinediones (mean difference 2.81 kg; moderate certainty) probably result in the largest increases in body weight. Absolute benefits of SGLT-2 inhibitors, GLP-1 receptor agonists, and finerenone vary in people with type 2 diabetes, depending on baseline risks for cardiovascular and kidney outcomes (https://matchit.magicevidence.org/230125dist-diabetes).\n**CONCLUSIONS:** This network meta-analysis extends knowledge beyond confirming the substantial benefits with the use of SGLT-2 inhibitors and GLP-1 receptor agonists in reducing adverse cardiovascular and kidney outcomes and death by adding information on finerenone and tirzepatide. These findings highlight the need for continuous assessment of scientific progress to introduce cutting edge updates in clinical practice guidelines for people with type 2 diabetes.\n<AbstractText Label=\"SYSTEMATIC REVIEW REGISTRATION\">PROSPERO CRD42022325948." ] ; fhir:copyright [ fhir:v "© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ." ] ] ) ; ( fhir:relatesTo [ fhir:type [ fhir:v "cites" ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ] ) ] ) ; fhir:citation [ fhir:v "Gregg EW, Jakicic JM, Blackburn G, et al. Look AHEAD Research Group . Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. 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fhir:display [ fhir:v "Agoritsas T" ] ] ; fhir:forenameInitials [ fhir:v "T" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Canada." ] ] [ fhir:display [ fhir:v "Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor38" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Tian H" ] ] ; fhir:forenameInitials [ fhir:v "H" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor39" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Li S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Endocrinology and Metabolism, Division of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China lisheyu@gmail.com." ] ] ) ] ) ] ] . #
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-11-21
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