Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. - JSON Representation

Active as of 2024-11-21

Raw json | Download

{
  "resourceType" : "Citation",
  "id" : "179627",
  "meta" : {
    "versionId" : "7",
    "lastUpdated" : "2024-07-18T18:00:06.465Z",
    "profile" : [
      🔗 "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179627</b></p><a name=\"179627\"> </a><a name=\"hc179627\"> </a><a name=\"179627-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 7; Last updated: 2024-07-18 18:00:06+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-179627.html\">Citation 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</a></p><p><b>identifier</b>: FEvIR Object Identifier/179627, <code>https://pubmed.ncbi.nlm.nih.gov</code>/19091394, <a href=\"http://terminology.hl7.org/6.1.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.29</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-11-21 14:09:14+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2009-02-05</p><p><b>lastReviewDate</b>: 2022-03-30</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --&gt; 2008-12-19 09:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --&gt; 2008-12-19 09:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --&gt; 2009-02-06 09:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19091394, <code>https://doi.org</code>/10.1016/S0140-6736(08)61815-2, pii/S0140-6736(08)61815-2</p><p><b>relatedIdentifier</b>: ISRCTN01534787</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p><strong>BACKGROUND:</strong> Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression.\n<strong>METHODS:</strong> This randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA&lt;70; N0; M0) were centrally randomly assigned by computer to endocrine treatment alone (3 months of total androgen blockade followed by continuous endocrine treatment using flutamide; 439 patients), or to the same endocrine treatment combined with radiotherapy (436 patients). The primary endpoint was prostate-cancer-specific survival, and analysis was by intention to treat. This study is registered as an international standard randomised controlled trial, number ISRCTN01534787.\n<strong>FINDINGS:</strong> After a median follow-up of 7.6 years, 79 men in the endocrine alone group and 37 men in the endocrine plus radiotherapy group had died of prostate cancer. The cumulative incidence at 10 years for prostate-cancer-specific mortality was 23.9% in the endocrine alone group and 11.9% in the endocrine plus radiotherapy group (difference 12.0%, 95% CI 4.9-19.1%), for a relative risk of 0.44 (0.30-0.66). At 10 years, the cumulative incidence for overall mortality was 39.4% in the endocrine alone group and 29.6% in the endocrine plus radiotherapy group (difference 9.8%, 0.8-18.8%), for a relative risk of 0.68 (0.52-0.89). Cumulative incidence at 10 years for PSA recurrence was substantially higher in men in the endocrine-alone group (74.7%vs 25.9%, p&lt;0.0001; HR 0.16; 0.12-0.20). After 5 years, urinary, rectal, and sexual problems were slightly more frequent in the endocrine plus radiotherapy group.\n<strong>INTERPRETATION:</strong> In patients with locally advanced or high-risk local prostate cancer, addition of local radiotherapy to endocrine treatment halved the 10-year prostate-cancer-specific mortality, and substantially decreased overall mortality with fully acceptable risk of side-effects compared with endocrine treatment alone. In the light of these data, endocrine treatment plus radiotherapy should be the new standard.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: correction-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016425}\">Published Erratum</span></p><p><b>citation</b>: </p><div><p>Lancet. 2009 Apr 4;373(9670):1174</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Lancet. 2009 Jan 24;373(9660):274-6. doi: 10.1016/S0140-6736(08)61816-4</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19091392/\">https://pubmed.ncbi.nlm.nih.gov/19091392/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19091392</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Rev Urol. 2009 May;6(5):250-1. doi: 10.1038/nrurol.2009.56</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19424171/\">https://pubmed.ncbi.nlm.nih.gov/19424171/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19424171</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Ann Intern Med. 2009 Jun 16;150(12):JC6-6. doi: 10.7326/0003-4819-150-12-200906160-02006</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19528551/\">https://pubmed.ncbi.nlm.nih.gov/19528551/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19528551</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2009 May;55(5):1240. doi: 10.1016/j.eururo.2009.01.059</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19650206/\">https://pubmed.ncbi.nlm.nih.gov/19650206/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19650206</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2009 May;55(5):1239-40. doi: 10.1016/j.eururo.2009.01.058</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/19650231/\">https://pubmed.ncbi.nlm.nih.gov/19650231/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19650231</p></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1474-547X, ISOAbbreviation/Lancet, ISSN Linking/0140-6736, Medline Title Abbreviation/Lancet, NLM Unique ID/2985213R</p><p><b>title</b>: Lancet (London, England)</p><p><b>publisherLocation</b>: England</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 373</p><p><b>issue</b>: 9660</p><p><b>articleDate</b>: 2009-01-24</p><p><b>publicationDateText</b>: 2009-Jan-24</p><p><b>language</b>: <span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></p><p><b>pageString</b>: 301-8</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2008-12-16</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19091394/\">https://pubmed.ncbi.nlm.nih.gov/19091394/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/S0140-6736(08)61815-2\">https://doi.org/10.1016/S0140-6736(08)61815-2</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 76W6J0943E}, {https://meshb.nlm.nih.gov/ D005485}\">Flutamide</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179627/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D017428}\">Clinical Trial, Phase III</span>, <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016428}\">Journal Article</span>, <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016448}\">Multicenter Study</span>, <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://meshb.nlm.nih.gov/ D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor0\">Widmark A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor1\">Klepp O</a></p><p><b>forenameInitials</b>: O</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor2\">Solberg A</a></p><p><b>forenameInitials</b>: A</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor3\">Damber JE</a></p><p><b>forenameInitials</b>: JE</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor4\">Angelsen A</a></p><p><b>forenameInitials</b>: A</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor5\">Fransson P</a></p><p><b>forenameInitials</b>: P</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor6\">Lund JA</a></p><p><b>forenameInitials</b>: JA</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor7\">Tasdemir I</a></p><p><b>forenameInitials</b>: I</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor8\">Hoyer M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor9\">Wiklund F</a></p><p><b>forenameInitials</b>: F</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor10\">Fosså SD</a></p><p><b>forenameInitials</b>: SD</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor11\">Scandinavian Prostate Cancer Group Study 7</a></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor12\">Swedish Association for Urological Oncology 3</a></p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor0</b></p><a name=\"179627/contributor0\"> </a><a name=\"hc179627/contributor0\"> </a><a name=\"179627/contributor0-en-US\"> </a><p><b>name</b>: Anders Widmark </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor1</b></p><a name=\"179627/contributor1\"> </a><a name=\"hc179627/contributor1\"> </a><a name=\"179627/contributor1-en-US\"> </a><p><b>name</b>: Olbjørn Klepp </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor2</b></p><a name=\"179627/contributor2\"> </a><a name=\"hc179627/contributor2\"> </a><a name=\"179627/contributor2-en-US\"> </a><p><b>name</b>: Arne Solberg </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor3</b></p><a name=\"179627/contributor3\"> </a><a name=\"hc179627/contributor3\"> </a><a name=\"179627/contributor3-en-US\"> </a><p><b>name</b>: Jan-Erik Damber </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor4</b></p><a name=\"179627/contributor4\"> </a><a name=\"hc179627/contributor4\"> </a><a name=\"179627/contributor4-en-US\"> </a><p><b>name</b>: Anders Angelsen </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor5</b></p><a name=\"179627/contributor5\"> </a><a name=\"hc179627/contributor5\"> </a><a name=\"179627/contributor5-en-US\"> </a><p><b>name</b>: Per Fransson </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor6</b></p><a name=\"179627/contributor6\"> </a><a name=\"hc179627/contributor6\"> </a><a name=\"179627/contributor6-en-US\"> </a><p><b>name</b>: Jo-Asmund Lund </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor7</b></p><a name=\"179627/contributor7\"> </a><a name=\"hc179627/contributor7\"> </a><a name=\"179627/contributor7-en-US\"> </a><p><b>name</b>: Ilker Tasdemir </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor8</b></p><a name=\"179627/contributor8\"> </a><a name=\"hc179627/contributor8\"> </a><a name=\"179627/contributor8-en-US\"> </a><p><b>name</b>: Morten Hoyer </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor9</b></p><a name=\"179627/contributor9\"> </a><a name=\"hc179627/contributor9\"> </a><a name=\"179627/contributor9-en-US\"> </a><p><b>name</b>: Fredrik Wiklund </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner  #contributor10</b></p><a name=\"179627/contributor10\"> </a><a name=\"hc179627/contributor10\"> </a><a name=\"179627/contributor10-en-US\"> </a><p><b>name</b>: Sophie D Fosså </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Organization  #contributor11</b></p><a name=\"179627/contributor11\"> </a><a name=\"hc179627/contributor11\"> </a><a name=\"179627/contributor11-en-US\"> </a><p><b>name</b>: Scandinavian Prostate Cancer Group Study 7</p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Organization  #contributor12</b></p><a name=\"179627/contributor12\"> </a><a name=\"hc179627/contributor12\"> </a><a name=\"179627/contributor12-en-US\"> </a><p><b>name</b>: Swedish Association for Urological Oncology 3</p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment  #meshHeading0</b></p><a name=\"179627/meshHeading0\"> </a><a name=\"hc179627/meshHeading0\"> </a><a name=\"179627/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc179627\">Citation 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D003131}\">Combined Modality Therapy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D005485}\">Flutamide</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D011468}\">Prostatectomy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000532}\">radiotherapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D012720}\">Severity of Illness Index</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016019}\">Survival Analysis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>"
  },
  "contained" : [
    {
      "resourceType" : "Practitioner",
      "id" : "contributor0",
      "name" : [
        {
          "family" : "Widmark",
          "given" : [
            "Anders"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor1",
      "name" : [
        {
          "family" : "Klepp",
          "given" : [
            "Olbjørn"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor2",
      "name" : [
        {
          "family" : "Solberg",
          "given" : [
            "Arne"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor3",
      "name" : [
        {
          "family" : "Damber",
          "given" : [
            "Jan-Erik"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor4",
      "name" : [
        {
          "family" : "Angelsen",
          "given" : [
            "Anders"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor5",
      "name" : [
        {
          "family" : "Fransson",
          "given" : [
            "Per"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor6",
      "name" : [
        {
          "family" : "Lund",
          "given" : [
            "Jo-Asmund"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor7",
      "name" : [
        {
          "family" : "Tasdemir",
          "given" : [
            "Ilker"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor8",
      "name" : [
        {
          "family" : "Hoyer",
          "given" : [
            "Morten"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor9",
      "name" : [
        {
          "family" : "Wiklund",
          "given" : [
            "Fredrik"
          ]
        }
      ]
    },
    {
      "resourceType" : "Practitioner",
      "id" : "contributor10",
      "name" : [
        {
          "family" : "Fosså",
          "given" : [
            "Sophie D"
          ]
        }
      ]
    },
    {
      "resourceType" : "Organization",
      "id" : "contributor11",
      "name" : "Scandinavian Prostate Cancer Group Study 7"
    },
    {
      "resourceType" : "Organization",
      "id" : "contributor12",
      "name" : "Swedish Association for Urological Oncology 3"
    },
    {
      "resourceType" : "ArtifactAssessment",
      "id" : "meshHeading0",
      "artifactReference" : {
        "reference" : "#",
        "type" : "Citation"
      },
      "content" : [
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D000368",
                  "display" : "Aged",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D000726",
                  "display" : "Androgen Antagonists",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            },
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://meshb.nlm.nih.gov/",
                      "code" : "Q000627",
                      "display" : "therapeutic use"
                    }
                  ]
                }
              ],
              "component" : [
                {
                  "type" : {
                    "text" : "is Major topic"
                  },
                  "classifier" : [
                    {
                      "coding" : [
                        {
                          "system" : "https://ncithesaurus.nci.nih.gov/ncitbrowser",
                          "code" : "C49488",
                          "display" : "Yes"
                        }
                      ]
                    }
                  ]
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D003131",
                  "display" : "Combined Modality Therapy",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D005485",
                  "display" : "Flutamide",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            },
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://meshb.nlm.nih.gov/",
                      "code" : "Q000627",
                      "display" : "therapeutic use"
                    }
                  ]
                }
              ],
              "component" : [
                {
                  "type" : {
                    "text" : "is Major topic"
                  },
                  "classifier" : [
                    {
                      "coding" : [
                        {
                          "system" : "https://ncithesaurus.nci.nih.gov/ncitbrowser",
                          "code" : "C49488",
                          "display" : "Yes"
                        }
                      ]
                    }
                  ]
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D006801",
                  "display" : "Humans",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D008297",
                  "display" : "Male",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D011468",
                  "display" : "Prostatectomy",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D011471",
                  "display" : "Prostatic Neoplasms",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            },
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://meshb.nlm.nih.gov/",
                      "code" : "Q000188",
                      "display" : "drug therapy"
                    }
                  ]
                }
              ],
              "component" : [
                {
                  "type" : {
                    "text" : "is Major topic"
                  },
                  "classifier" : [
                    {
                      "coding" : [
                        {
                          "system" : "https://ncithesaurus.nci.nih.gov/ncitbrowser",
                          "code" : "C49488",
                          "display" : "Yes"
                        }
                      ]
                    }
                  ]
                }
              ]
            },
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://meshb.nlm.nih.gov/",
                      "code" : "Q000401",
                      "display" : "mortality"
                    }
                  ]
                }
              ],
              "component" : [
                {
                  "type" : {
                    "text" : "is Major topic"
                  },
                  "classifier" : [
                    {
                      "coding" : [
                        {
                          "system" : "https://ncithesaurus.nci.nih.gov/ncitbrowser",
                          "code" : "C49487",
                          "display" : "No"
                        }
                      ]
                    }
                  ]
                }
              ]
            },
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://meshb.nlm.nih.gov/",
                      "code" : "Q000532",
                      "display" : "radiotherapy"
                    }
                  ]
                }
              ],
              "component" : [
                {
                  "type" : {
                    "text" : "is Major topic"
                  },
                  "classifier" : [
                    {
                      "coding" : [
                        {
                          "system" : "https://ncithesaurus.nci.nih.gov/ncitbrowser",
                          "code" : "C49488",
                          "display" : "Yes"
                        }
                      ]
                    }
                  ]
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D012720",
                  "display" : "Severity of Illness Index",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        },
        {
          "informationType" : "classifier",
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                "code" : "mesh-heading",
                "display" : "MeSH heading"
              }
            ],
            "text" : "components (if present) include qualifier codings"
          },
          "classifier" : [
            {
              "coding" : [
                {
                  "system" : "https://meshb.nlm.nih.gov/",
                  "code" : "D016019",
                  "display" : "Survival Analysis",
                  "userSelected" : false
                }
              ]
            }
          ],
          "freeToShare" : true,
          "component" : [
            {
              "type" : {
                "text" : "qualifier"
              },
              "classifier" : [
                {
                  "text" : "is not a major topic"
                }
              ]
            }
          ]
        }
      ]
    }
  ],
  "url" : "https://fevir.net/resources/Citation/179627",
  "identifier" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }
        ],
        "text" : "FEvIR Object Identifier"
      },
      "system" : "https://fevir.net",
      "value" : "179627",
      "assigner" : {
        "display" : "Computable Publishing LLC"
      }
    },
    {
      "system" : "https://pubmed.ncbi.nlm.nih.gov",
      "value" : "19091394"
    },
    {
      "system" : "urn:ietf:rfc:3986",
      "value" : "urn:oid:2.16.840.1.113883.4.642.40.44.15.29"
    }
  ],
  "version" : "2.0.0-ballot",
  "title" : "19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.",
  "status" : "active",
  "date" : "2024-11-21T14:09:14+00:00",
  "publisher" : "HL7 International / Clinical Decision Support",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Decision Support",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/dss"
        }
      ]
    }
  ],
  "description" : "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.",
  "useContext" : [
    {
      "code" : {
        "system" : "http://hl7.org/fhir/citation-classification-type",
        "code" : "fevir-platform-use",
        "display" : "FEvIR Platform Use"
      },
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-artifact-classifier",
            "code" : "medline-base",
            "display" : "Medline Base",
            "userSelected" : false
          }
        ]
      }
    }
  ],
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
        }
      ]
    }
  ],
  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "approvalDate" : "2009-02-05",
  "lastReviewDate" : "2022-03-30",
  "author" : [
    {
      "name" : "Computable Publishing®: MEDLINE-to-FEvIR Converter"
    }
  ],
  "classification" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-classification-type",
            "code" : "citation-source",
            "display" : "Citation Source"
          }
        ]
      },
      "classifier" : [
        {
          "text" : "MEDLINE"
        }
      ]
    },
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-classification-type",
            "code" : "medline-owner",
            "display" : "MEDLINE Citation Owner"
          }
        ]
      },
      "classifier" : [
        {
          "coding" : [
            {
              "system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value",
              "code" : "NLM",
              "display" : "National Library of Medicine, Index Section",
              "userSelected" : false
            }
          ]
        }
      ]
    }
  ],
  "currentState" : [
    {
      "coding" : [
        {
          "system" : "http://hl7.org/fhir/citation-status-type",
          "code" : "medline-medline",
          "display" : "Medline Citation Status of Medline"
        }
      ]
    },
    {
      "coding" : [
        {
          "system" : "http://hl7.org/fhir/citation-status-type",
          "code" : "pubmed-publication-status-ppublish",
          "display" : "PubMed PublicationStatus of ppublish"
        }
      ]
    }
  ],
  "statusDate" : [
    {
      "activity" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-status-type",
            "code" : "pubmed-pubstatus-entrez",
            "display" : "PubMed Pubstatus of Entrez"
          }
        ]
      },
      "period" : {
        "end" : "2008-12-19T09:00:00.000Z"
      }
    },
    {
      "activity" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-status-type",
            "code" : "pubmed-pubstatus-pubmed",
            "display" : "PubMed Pubstatus of Pubmed"
          }
        ]
      },
      "period" : {
        "end" : "2008-12-19T09:00:00.000Z"
      }
    },
    {
      "activity" : {
        "coding" : [
          {
            "system" : "http://hl7.org/fhir/citation-status-type",
            "code" : "pubmed-pubstatus-medline",
            "display" : "PubMed Pubstatus of Medline"
          }
        ]
      },
      "period" : {
        "end" : "2009-02-06T09:00:00.000Z"
      }
    }
  ],
  "citedArtifact" : {
    "identifier" : [
      {
        "system" : "https://pubmed.ncbi.nlm.nih.gov",
        "value" : "19091394"
      },
      {
        "system" : "https://doi.org",
        "value" : "10.1016/S0140-6736(08)61815-2"
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
              "code" : "ACSN",
              "display" : "Accession ID"
            }
          ],
          "text" : "pii"
        },
        "value" : "S0140-6736(08)61815-2"
      }
    ],
    "relatedIdentifier" : [
      {
        "value" : "ISRCTN01534787",
        "assigner" : {
          "display" : "ISRCTN"
        }
      }
    ],
    "title" : [
      {
        "type" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/title-type",
                "code" : "primary",
                "display" : "Primary title"
              }
            ]
          }
        ],
        "language" : {
          "coding" : [
            {
              "system" : "urn:ietf:bcp:47",
              "code" : "en",
              "display" : "English"
            }
          ]
        },
        "text" : "Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial."
      }
    ],
    "abstract" : [
      {
        "text" : "**BACKGROUND:** Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression.\n**METHODS:** This randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA&lt;70; N0; M0) were centrally randomly assigned by computer to endocrine treatment alone (3 months of total androgen blockade followed by continuous endocrine treatment using flutamide; 439 patients), or to the same endocrine treatment combined with radiotherapy (436 patients). The primary endpoint was prostate-cancer-specific survival, and analysis was by intention to treat. This study is registered as an international standard randomised controlled trial, number ISRCTN01534787.\n**FINDINGS:** After a median follow-up of 7.6 years, 79 men in the endocrine alone group and 37 men in the endocrine plus radiotherapy group had died of prostate cancer. The cumulative incidence at 10 years for prostate-cancer-specific mortality was 23.9% in the endocrine alone group and 11.9% in the endocrine plus radiotherapy group (difference 12.0%, 95% CI 4.9-19.1%), for a relative risk of 0.44 (0.30-0.66). At 10 years, the cumulative incidence for overall mortality was 39.4% in the endocrine alone group and 29.6% in the endocrine plus radiotherapy group (difference 9.8%, 0.8-18.8%), for a relative risk of 0.68 (0.52-0.89). Cumulative incidence at 10 years for PSA recurrence was substantially higher in men in the endocrine-alone group (74.7%vs 25.9%, p&lt;0.0001; HR 0.16; 0.12-0.20). After 5 years, urinary, rectal, and sexual problems were slightly more frequent in the endocrine plus radiotherapy group.\n**INTERPRETATION:** In patients with locally advanced or high-risk local prostate cancer, addition of local radiotherapy to endocrine treatment halved the 10-year prostate-cancer-specific mortality, and substantially decreased overall mortality with fully acceptable risk of side-effects compared with endocrine treatment alone. In the light of these data, endocrine treatment plus radiotherapy should be the new standard."
      }
    ],
    "relatesTo" : [
      {
        "type" : "correction-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016425",
                "display" : "Published Erratum",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Lancet. 2009 Apr 4;373(9670):1174"
      },
      {
        "type" : "comment-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016420",
                "display" : "Comment",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Lancet. 2009 Jan 24;373(9660):274-6. doi: 10.1016/S0140-6736(08)61816-4",
        "document" : {
          "url" : "https://pubmed.ncbi.nlm.nih.gov/19091392/"
        },
        "resourceReference" : {
          "identifier" : {
            "system" : "https://pubmed.ncbi.nlm.nih.gov",
            "value" : "19091392",
            "assigner" : {
              "display" : "NLM"
            }
          }
        }
      },
      {
        "type" : "comment-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016420",
                "display" : "Comment",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Nat Rev Urol. 2009 May;6(5):250-1. doi: 10.1038/nrurol.2009.56",
        "document" : {
          "url" : "https://pubmed.ncbi.nlm.nih.gov/19424171/"
        },
        "resourceReference" : {
          "identifier" : {
            "system" : "https://pubmed.ncbi.nlm.nih.gov",
            "value" : "19424171",
            "assigner" : {
              "display" : "NLM"
            }
          }
        }
      },
      {
        "type" : "comment-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016420",
                "display" : "Comment",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Ann Intern Med. 2009 Jun 16;150(12):JC6-6. doi: 10.7326/0003-4819-150-12-200906160-02006",
        "document" : {
          "url" : "https://pubmed.ncbi.nlm.nih.gov/19528551/"
        },
        "resourceReference" : {
          "identifier" : {
            "system" : "https://pubmed.ncbi.nlm.nih.gov",
            "value" : "19528551",
            "assigner" : {
              "display" : "NLM"
            }
          }
        }
      },
      {
        "type" : "comment-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016420",
                "display" : "Comment",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Eur Urol. 2009 May;55(5):1240. doi: 10.1016/j.eururo.2009.01.059",
        "document" : {
          "url" : "https://pubmed.ncbi.nlm.nih.gov/19650206/"
        },
        "resourceReference" : {
          "identifier" : {
            "system" : "https://pubmed.ncbi.nlm.nih.gov",
            "value" : "19650206",
            "assigner" : {
              "display" : "NLM"
            }
          }
        }
      },
      {
        "type" : "comment-in",
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016420",
                "display" : "Comment",
                "userSelected" : false
              }
            ]
          }
        ],
        "citation" : "Eur Urol. 2009 May;55(5):1239-40. doi: 10.1016/j.eururo.2009.01.058",
        "document" : {
          "url" : "https://pubmed.ncbi.nlm.nih.gov/19650231/"
        },
        "resourceReference" : {
          "identifier" : {
            "system" : "https://pubmed.ncbi.nlm.nih.gov",
            "value" : "19650231",
            "assigner" : {
              "display" : "NLM"
            }
          }
        }
      }
    ],
    "publicationForm" : [
      {
        "publishedIn" : {
          "type" : {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/published-in-type",
                "code" : "D020492",
                "display" : "Periodical"
              }
            ]
          },
          "identifier" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn",
                    "code" : "Electronic",
                    "display" : "Electronic"
                  }
                ],
                "text" : "Electronic ISSN Type"
              },
              "system" : "https://portal.issn.org",
              "value" : "1474-547X"
            },
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                    "code" : "XX",
                    "display" : "Organization identifier"
                  }
                ],
                "text" : "ISOAbbreviation"
              },
              "system" : "https://www.issn.org/services/online-services/access-to-the-ltwa/",
              "value" : "Lancet"
            },
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                    "code" : "XX",
                    "display" : "Organization identifier"
                  }
                ],
                "text" : "ISSN Linking"
              },
              "system" : "https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/",
              "value" : "0140-6736"
            },
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                    "code" : "XX",
                    "display" : "Organization identifier"
                  }
                ],
                "text" : "Medline Title Abbreviation"
              },
              "system" : "https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html",
              "value" : "Lancet"
            },
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                    "code" : "XX",
                    "display" : "Organization identifier"
                  }
                ],
                "text" : "NLM Unique ID"
              },
              "system" : "https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local",
              "value" : "2985213R"
            }
          ],
          "title" : "Lancet (London, England)",
          "publisherLocation" : "England"
        },
        "citedMedium" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-medium",
              "code" : "internet",
              "display" : "Internet"
            }
          ]
        },
        "volume" : "373",
        "issue" : "9660",
        "articleDate" : "2009-01-24",
        "publicationDateText" : "2009-Jan-24",
        "language" : [
          {
            "coding" : [
              {
                "system" : "urn:ietf:bcp:47",
                "code" : "en",
                "display" : "English"
              }
            ]
          }
        ],
        "pageString" : "301-8"
      },
      {
        "citedMedium" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-medium",
              "code" : "internet-without-issue",
              "display" : "Internet without issue"
            }
          ]
        },
        "articleDate" : "2008-12-16"
      }
    ],
    "webLocation" : [
      {
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/artifact-url-classifier",
                "code" : "abstract",
                "display" : "Abstract"
              }
            ]
          }
        ],
        "url" : "https://pubmed.ncbi.nlm.nih.gov/19091394/"
      },
      {
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/artifact-url-classifier",
                "code" : "doi-based",
                "display" : "DOI Based"
              }
            ]
          }
        ],
        "url" : "https://doi.org/10.1016/S0140-6736(08)61815-2"
      }
    ],
    "classification" : [
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "publishing-model",
              "display" : "Publishing Model",
              "userSelected" : false
            }
          ]
        },
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/citation-artifact-classifier",
                "code" : "Print-Electronic",
                "display" : "Print Electronic",
                "userSelected" : false
              }
            ]
          }
        ]
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "chemical",
              "display" : "Chemical",
              "userSelected" : false
            }
          ]
        },
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D000726",
                "display" : "Androgen Antagonists",
                "userSelected" : false
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://www.cas.org/support/documentation/chemical-substances",
                "code" : "76W6J0943E",
                "userSelected" : false
              },
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D005485",
                "display" : "Flutamide",
                "userSelected" : false
              }
            ]
          }
        ]
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "mesh-heading",
              "display" : "MeSH heading"
            }
          ]
        },
        "artifactAssessment" : [
          {
            "reference" : "#meshHeading0",
            "type" : "ArtifactAssessment"
          }
        ]
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "publication-type",
              "display" : "Publication type"
            }
          ]
        },
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D017428",
                "display" : "Clinical Trial, Phase III",
                "userSelected" : false
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016428",
                "display" : "Journal Article",
                "userSelected" : false
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016448",
                "display" : "Multicenter Study",
                "userSelected" : false
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D016449",
                "display" : "Randomized Controlled Trial",
                "userSelected" : false
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://meshb.nlm.nih.gov/",
                "code" : "D013485",
                "display" : "Research Support, Non-U.S. Gov't",
                "userSelected" : false
              }
            ]
          }
        ]
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "knowledge-artifact-type",
              "display" : "Knowledge Artifact Type",
              "userSelected" : false
            }
          ]
        },
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/citation-artifact-classifier",
                "code" : "D016428",
                "display" : "Journal Article",
                "userSelected" : false
              }
            ]
          }
        ],
        "artifactAssessment" : [
          {
            "display" : "Classifier added by Computable Publishing LLC"
          }
        ]
      },
      {
        "type" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
              "code" : "citation-subset",
              "display" : "Citation subset",
              "userSelected" : false
            }
          ]
        },
        "classifier" : [
          {
            "coding" : [
              {
                "system" : "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset",
                "code" : "IM",
                "display" : "IM",
                "userSelected" : false
              }
            ]
          }
        ]
      }
    ],
    "contributorship" : {
      "complete" : true,
      "entry" : [
        {
          "contributor" : {
            "reference" : "#contributor0",
            "type" : "Practitioner",
            "display" : "Widmark A"
          },
          "forenameInitials" : "A",
          "affiliation" : [
            {
              "display" : "Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden."
            }
          ]
        },
        {
          "contributor" : {
            "reference" : "#contributor1",
            "type" : "Practitioner",
            "display" : "Klepp O"
          },
          "forenameInitials" : "O"
        },
        {
          "contributor" : {
            "reference" : "#contributor2",
            "type" : "Practitioner",
            "display" : "Solberg A"
          },
          "forenameInitials" : "A"
        },
        {
          "contributor" : {
            "reference" : "#contributor3",
            "type" : "Practitioner",
            "display" : "Damber JE"
          },
          "forenameInitials" : "JE"
        },
        {
          "contributor" : {
            "reference" : "#contributor4",
            "type" : "Practitioner",
            "display" : "Angelsen A"
          },
          "forenameInitials" : "A"
        },
        {
          "contributor" : {
            "reference" : "#contributor5",
            "type" : "Practitioner",
            "display" : "Fransson P"
          },
          "forenameInitials" : "P"
        },
        {
          "contributor" : {
            "reference" : "#contributor6",
            "type" : "Practitioner",
            "display" : "Lund JA"
          },
          "forenameInitials" : "JA"
        },
        {
          "contributor" : {
            "reference" : "#contributor7",
            "type" : "Practitioner",
            "display" : "Tasdemir I"
          },
          "forenameInitials" : "I"
        },
        {
          "contributor" : {
            "reference" : "#contributor8",
            "type" : "Practitioner",
            "display" : "Hoyer M"
          },
          "forenameInitials" : "M"
        },
        {
          "contributor" : {
            "reference" : "#contributor9",
            "type" : "Practitioner",
            "display" : "Wiklund F"
          },
          "forenameInitials" : "F"
        },
        {
          "contributor" : {
            "reference" : "#contributor10",
            "type" : "Practitioner",
            "display" : "Fosså SD"
          },
          "forenameInitials" : "SD"
        },
        {
          "contributor" : {
            "reference" : "#contributor11",
            "type" : "Organization",
            "display" : "Scandinavian Prostate Cancer Group Study 7"
          }
        },
        {
          "contributor" : {
            "reference" : "#contributor12",
            "type" : "Organization",
            "display" : "Swedish Association for Urological Oncology 3"
          }
        }
      ]
    }
  }
}